Publicação
The reinfection threshold regulates pathogen diversity: the case of influenza
| Resumo: | The awareness that pathogens can adapt and evolve over relatively short time-scales is changing our view of infectious disease epidemiology and control. Research on the transmission dynamics of antigenically diverse pathogens is progressing and there is increasing recognition for the need of new concepts and theories. Mathematical models have been developed considering the modelling unit in two extreme scales: either diversity is not explicitly represented or diversity is represented at the finest scale of single variants. Here, we use an intermediate approach and construct a model at the scale of clusters of variants. The model captures essential properties of more detailed systems and is much more amenable to mathematical treatment. Specificities of pathogen clusters and the overall potential for transmission determine the reinfection rates. These are, in turn, important regulators of cluster dynamics. Ultimately, we detect a reinfection threshold (RT) that separates different behaviours along the transmissibility axis: below RT, levels of infection are low and cluster substitutions are probable; while above RT, levels of infection are high and multiple cluster coexistence is the most probable outcome. |
|---|---|
| Autores principais: | Gokaydin, D. |
| Outros Autores: | Oliveira-Martins, J.B.; Gordo, I.; Gomes, M.G.M. |
| Assunto: | Antigenic Variation/genetics/immunology Disease Outbreaks/statistics & numerical data Disease Transmission, Infectious/statistics & numerical data Genetic Variation/genetics Influenza A virus/genetics/immunology Influenza, Human/epidemiology/genetics/immunology Models, Immunological |
| Ano: | 2007 |
| País: | Portugal |
| Tipo de documento: | artigo |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Repositório do GIMM – Gulbenkian Institute for Molecular Medicine |
| Idioma: | inglês |
| Origem: | ARCA |
| _version_ | 1867149334024290304 |
|---|---|
| author | Gokaydin, D. |
| author2 | Oliveira-Martins, J.B. Gordo, I. Gomes, M.G.M. |
| author2_role | author author author |
| author_facet | Gokaydin, D. Oliveira-Martins, J.B. Gordo, I. Gomes, M.G.M. |
| author_role | author |
| contributor_name_str_mv | ARCA |
| country_str | PT |
| creators_json_txt | [{\"Person.name\":\"Gokaydin, D.\"},{\"Person.name\":\"Oliveira-Martins, J.B.\"},{\"Person.name\":\"Gordo, I.\"},{\"Person.name\":\"Gomes, M.G.M.\"}] |
| datacite.contributors.contributor.contributorName.fl_str_mv | ARCA |
| datacite.creators.creator.creatorName.fl_str_mv | Gokaydin, D. Oliveira-Martins, J.B. Gordo, I. Gomes, M.G.M. |
| datacite.date.Accepted.fl_str_mv | 2007-02-22T00:00:00Z |
| datacite.date.available.fl_str_mv | 2010-03-25T11:06:21Z |
| datacite.date.embargoed.fl_str_mv | 2010-03-25T11:06:21Z |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| datacite.subjects.subject.fl_str_mv | Antigenic Variation/genetics/immunology Disease Outbreaks/statistics & numerical data Disease Transmission, Infectious/statistics & numerical data Genetic Variation/genetics Influenza A virus/genetics/immunology Influenza, Human/epidemiology/genetics/immunology Models, Immunological |
| datacite.titles.title.fl_str_mv | The reinfection threshold regulates pathogen diversity: the case of influenza |
| dc.contributor.none.fl_str_mv | ARCA |
| dc.creator.none.fl_str_mv | Gokaydin, D. Oliveira-Martins, J.B. Gordo, I. Gomes, M.G.M. |
| dc.date.Accepted.fl_str_mv | 2007-02-22T00:00:00Z |
| dc.date.available.fl_str_mv | 2010-03-25T11:06:21Z |
| dc.date.embargoed.fl_str_mv | 2010-03-25T11:06:21Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | http://hdl.handle.net/10400.7/82 |
| dc.language.none.fl_str_mv | eng |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| dc.subject.none.fl_str_mv | Antigenic Variation/genetics/immunology Disease Outbreaks/statistics & numerical data Disease Transmission, Infectious/statistics & numerical data Genetic Variation/genetics Influenza A virus/genetics/immunology Influenza, Human/epidemiology/genetics/immunology Models, Immunological |
| dc.title.fl_str_mv | The reinfection threshold regulates pathogen diversity: the case of influenza |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_6501 |
| description | The awareness that pathogens can adapt and evolve over relatively short time-scales is changing our view of infectious disease epidemiology and control. Research on the transmission dynamics of antigenically diverse pathogens is progressing and there is increasing recognition for the need of new concepts and theories. Mathematical models have been developed considering the modelling unit in two extreme scales: either diversity is not explicitly represented or diversity is represented at the finest scale of single variants. Here, we use an intermediate approach and construct a model at the scale of clusters of variants. The model captures essential properties of more detailed systems and is much more amenable to mathematical treatment. Specificities of pathogen clusters and the overall potential for transmission determine the reinfection rates. These are, in turn, important regulators of cluster dynamics. Ultimately, we detect a reinfection threshold (RT) that separates different behaviours along the transmissibility axis: below RT, levels of infection are low and cluster substitutions are probable; while above RT, levels of infection are high and multiple cluster coexistence is the most probable outcome. |
| dirty | 0 |
| eu_rights_str_mv | openAccess |
| format | article |
| fulltext.url.fl_str_mv | https://arca.gimm.pt/bitstreams/6b7a9a75-47f6-4098-bc92-6d6933d86158/download |
| id | arca_f42e1ff0fecfd00a80a594465ca36f59 |
| identifier.url.fl_str_mv | http://hdl.handle.net/10400.7/82 |
| instacron_str | arca |
| institution | Repositório do GIMM – Gulbenkian Institute for Molecular Medicine |
| instname_str | Repositório do GIMM – Gulbenkian Institute for Molecular Medicine |
| language | eng |
| network_acronym_str | arca |
| network_name_str | ARCA |
| oai_identifier_str | oai:arca.gimm.pt:10400.7/82 |
| organization_str_mv | urn:organizationAcronym:arca |
| person_str_mv | Gokaydin, D. Oliveira-Martins, J.B. Gordo, I. Gomes, M.G.M. |
| publishDate | 2007 |
| reponame_str | ARCA |
| repository_id_str | urn:repositoryAcronym:arca |
| service_str_mv | urn:repositoryAcronym:arca |
| spelling | engptThe awareness that pathogens can adapt and evolve over relatively short time-scales is changing our view of infectious disease epidemiology and control. Research on the transmission dynamics of antigenically diverse pathogens is progressing and there is increasing recognition for the need of new concepts and theories. Mathematical models have been developed considering the modelling unit in two extreme scales: either diversity is not explicitly represented or diversity is represented at the finest scale of single variants. Here, we use an intermediate approach and construct a model at the scale of clusters of variants. The model captures essential properties of more detailed systems and is much more amenable to mathematical treatment. Specificities of pathogen clusters and the overall potential for transmission determine the reinfection rates. These are, in turn, important regulators of cluster dynamics. Ultimately, we detect a reinfection threshold (RT) that separates different behaviours along the transmissibility axis: below RT, levels of infection are low and cluster substitutions are probable; while above RT, levels of infection are high and multiple cluster coexistence is the most probable outcome.application/pdfptThe reinfection threshold regulates pathogen diversity: the case of influenzaGokaydin, D.Oliveira-Martins, J.B.Gordo, I.Gomes, M.G.M.HostingInstitutionOrganizationalARCAe-mailmailto:arca.repository@gimm.ptarca.repository@gimm.ptISSNIsPartOf1742-5662DOIIsPartOf10.1098/rsif.2006.01592010-03-25T11:06:21Z2007-02-222007-02-22T00:00:00ZHandlehttp://hdl.handle.net/10400.7/82http://purl.org/coar/access_right/c_abf2open accessAntigenic Variation/genetics/immunologyDisease Outbreaks/statistics & numerical dataDisease Transmission, Infectious/statistics & numerical dataGenetic Variation/geneticsInfluenza A virus/genetics/immunologyInfluenza, Human/epidemiology/genetics/immunologyModels, Immunological187976 bytesliteraturehttp://purl.org/coar/resource_type/c_6501journal articlehttp://purl.org/coar/access_right/c_abf2application/pdffulltexthttps://arca.gimm.pt/bitstreams/6b7a9a75-47f6-4098-bc92-6d6933d86158/downloadJournal of the Royal Society Interface137142 |
| spellingShingle | The reinfection threshold regulates pathogen diversity: the case of influenza Gokaydin, D. Antigenic Variation/genetics/immunology Disease Outbreaks/statistics & numerical data Disease Transmission, Infectious/statistics & numerical data Genetic Variation/genetics Influenza A virus/genetics/immunology Influenza, Human/epidemiology/genetics/immunology Models, Immunological |
| status | SINGLETON |
| subject.fl_str_mv | Antigenic Variation/genetics/immunology Disease Outbreaks/statistics & numerical data Disease Transmission, Infectious/statistics & numerical data Genetic Variation/genetics Influenza A virus/genetics/immunology Influenza, Human/epidemiology/genetics/immunology Models, Immunological |
| title | The reinfection threshold regulates pathogen diversity: the case of influenza |
| title_full | The reinfection threshold regulates pathogen diversity: the case of influenza |
| title_fullStr | The reinfection threshold regulates pathogen diversity: the case of influenza |
| title_full_unstemmed | The reinfection threshold regulates pathogen diversity: the case of influenza |
| title_short | The reinfection threshold regulates pathogen diversity: the case of influenza |
| title_sort | The reinfection threshold regulates pathogen diversity: the case of influenza |
| topic | Antigenic Variation/genetics/immunology Disease Outbreaks/statistics & numerical data Disease Transmission, Infectious/statistics & numerical data Genetic Variation/genetics Influenza A virus/genetics/immunology Influenza, Human/epidemiology/genetics/immunology Models, Immunological |
| topic_facet | Antigenic Variation/genetics/immunology Disease Outbreaks/statistics & numerical data Disease Transmission, Infectious/statistics & numerical data Genetic Variation/genetics Influenza A virus/genetics/immunology Influenza, Human/epidemiology/genetics/immunology Models, Immunological |
| url | http://hdl.handle.net/10400.7/82 |
| visible | 1 |