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Postingestive Modulation of Food Seeking Depends on Vagus-Mediated Dopamine Neuron Activity

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Resumo:Postingestive nutrient sensing can induce food preferences. However, much less is known about the ability of postingestive signals to modulate food-seeking behaviors. Here we report a causal connection between postingestive sucrose sensing and vagus-mediated dopamine neuron activity in the ventral tegmental area (VTA), supporting food seeking. The activity of VTA dopamine neurons increases significantly after administration of intragastric sucrose, and deletion of the NMDA receptor in these neurons, which affects bursting and plasticity, abolishes lever pressing for postingestive sucrose delivery. Furthermore, lesions of the hepatic branch of the vagus nerve significantly impair postingestive-dependent VTA dopamine neuron activity and food seeking, whereas optogenetic stimulation of left vagus nerve neurons significantly increases VTA dopamine neuron activity. These data establish a necessary role of vagus-mediated dopamine neuron activity in postingestive-dependent food seeking, which is independent of taste signaling.
Autores principais:Fernandes, Ana B.
Outros Autores:Alves da Silva, Joaquim; Almeida, Joana; Cui, Guohong; Gerfen, Charles R.; Costa, Rui M.; Oliveira-Maia, Albino J.
Assunto:Animals Appetitive Behavior Conditioning, Operant Dopaminergic Neurons Food Mice Mice, Knockout Non-Nutritive Sweeteners Nutritive Sweeteners Optogenetics Reinforcement, Psychology Stomach Sucrose Taste Vagus Nerve Ventral Tegmental Area
Ano:2020
País:Portugal
Tipo de documento:artigo
Tipo de acesso:acesso aberto
Instituição associada:Champalimaud Foundation
Idioma:inglês
Origem:Champalimaud Foundation

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