Publicação
Relationship between ADD1 Gly460Trp gene polymorphism and essential hypertension in Madeira Island
| Resumo: | Essential hypertension (EH) is a complex disease in which physiological, environmental, and genetic factors are involved in its genesis. The genetic variant of the alpha-adducin gene (ADD1) has been described as a risk factor for EH, but with controversial results.The objective of this study was to evaluate the association of ADD1 (Gly460Trp) gene polymorphism with the EH risk in a population from Madeira Island.A case-control study with 1614 individuals of Caucasian origin was performed, including 817 individuals with EH and 797 controls. Cases and controls were matched for sex and age, by frequency-matching method. All participants collected blood for biochemical and genotypic analysis for the Gly460Trp polymorphism. We further investigated which variables were independently associated to EH, and, consequently, analyzed their interactions.In our study, we found a significant association between the ADD1 gene polymorphism and EH (odds ratio 2.484, P = .01). This association remained statistically significant after the multivariate analysis (odds ratio 2.548, P = .02).The ADD1 Gly460Trp gene polymorphism is significantly and independently associated with EH risk in our population. The knowledge of genetic polymorphisms associated with EH is of paramount importance because it leads to a better understanding of the etiology and pathophysiology of this pathology. |
|---|---|
| Autores principais: | Sousa, Ana Célia |
| Outros Autores: | Palma dos Reis, Roberto; Pereira, Andreia; Borges, Sofia; Freitas, Ana Isabel; Guerra, Graça; Góis, Teresa; Rodrigues, Mariana; Henriques, Eva; Freitas, Sónia; Ornelas, Ilídio; Pereira, Décio; Brehm, António; Mendonça, Maria Isabel |
| Assunto: | ADD1 Gly460Trp gene polymorphism Case-control study Essential hypertension Madeira Island (Portugal) . Faculdade de Ciências da Vida |
| Ano: | 2017 |
| País: | Portugal |
| Tipo de documento: | artigo |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Universidade da Madeira |
| Idioma: | inglês |
| Origem: | DigitUMa - Repositório da Universidade da Madeira |
| _version_ | 1863852059182235648 |
|---|---|
| author | Sousa, Ana Célia |
| author2 | Palma dos Reis, Roberto Pereira, Andreia Borges, Sofia Freitas, Ana Isabel Guerra, Graça Góis, Teresa Rodrigues, Mariana Henriques, Eva Freitas, Sónia Ornelas, Ilídio Pereira, Décio Brehm, António Mendonça, Maria Isabel |
| author2_role | author author author author author author author author author author author author author |
| author_facet | Sousa, Ana Célia Palma dos Reis, Roberto Pereira, Andreia Borges, Sofia Freitas, Ana Isabel Guerra, Graça Góis, Teresa Rodrigues, Mariana Henriques, Eva Freitas, Sónia Ornelas, Ilídio Pereira, Décio Brehm, António Mendonça, Maria Isabel |
| author_role | author |
| contributor_name_str_mv | DigitUMa |
| country_str | PT |
| creators_json_str | [{\"Person.name\":\"Sousa, Ana Célia\"},{\"Person.name\":\"Palma dos Reis, Roberto\"},{\"Person.name\":\"Pereira, Andreia\"},{\"Person.name\":\"Borges, Sofia\"},{\"Person.name\":\"Freitas, Ana Isabel\"},{\"Person.name\":\"Guerra, Graça\"},{\"Person.name\":\"Góis, Teresa\"},{\"Person.name\":\"Rodrigues, Mariana\"},{\"Person.name\":\"Henriques, Eva\"},{\"Person.name\":\"Freitas, Sónia\"},{\"Person.name\":\"Ornelas, Ilídio\"},{\"Person.name\":\"Pereira, Décio\"},{\"Person.name\":\"Brehm, António\",\"Person.identifier.orcid\":\"0000-0003-3168-5340\"},{\"Person.name\":\"Mendonça, Maria Isabel\"}] |
| datacite.contributors.contributor.contributorName.fl_str_mv | DigitUMa |
| datacite.creators.creator.creatorName.fl_str_mv | Sousa, Ana Célia Palma dos Reis, Roberto Pereira, Andreia Borges, Sofia Freitas, Ana Isabel Guerra, Graça Góis, Teresa Rodrigues, Mariana Henriques, Eva Freitas, Sónia Ornelas, Ilídio Pereira, Décio Brehm, António Mendonça, Maria Isabel |
| datacite.date.Accepted.fl_str_mv | 2017-01-01T00:00:00Z |
| datacite.date.available.fl_str_mv | 2020-11-13T14:48:14Z |
| datacite.date.embargoed.fl_str_mv | 2020-11-13T14:48:14Z |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| datacite.subjects.subject.fl_str_mv | ADD1 Gly460Trp gene polymorphism Case-control study Essential hypertension Madeira Island (Portugal) . Faculdade de Ciências da Vida |
| datacite.titles.title.fl_str_mv | Relationship between ADD1 Gly460Trp gene polymorphism and essential hypertension in Madeira Island |
| dc.contributor.none.fl_str_mv | DigitUMa |
| dc.creator.none.fl_str_mv | Sousa, Ana Célia Palma dos Reis, Roberto Pereira, Andreia Borges, Sofia Freitas, Ana Isabel Guerra, Graça Góis, Teresa Rodrigues, Mariana Henriques, Eva Freitas, Sónia Ornelas, Ilídio Pereira, Décio Brehm, António Mendonça, Maria Isabel |
| dc.date.Accepted.fl_str_mv | 2017-01-01T00:00:00Z |
| dc.date.available.fl_str_mv | 2020-11-13T14:48:14Z |
| dc.date.embargoed.fl_str_mv | 2020-11-13T14:48:14Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | http://hdl.handle.net/10400.13/2978 |
| dc.language.none.fl_str_mv | eng |
| dc.publisher.none.fl_str_mv | Wolters Kluwer Health |
| dc.rights.cclincense.fl_str_mv | http://creativecommons.org/licenses/by/4.0/ |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| dc.subject.none.fl_str_mv | ADD1 Gly460Trp gene polymorphism Case-control study Essential hypertension Madeira Island (Portugal) . Faculdade de Ciências da Vida |
| dc.title.fl_str_mv | Relationship between ADD1 Gly460Trp gene polymorphism and essential hypertension in Madeira Island |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_6501 |
| description | Essential hypertension (EH) is a complex disease in which physiological, environmental, and genetic factors are involved in its genesis. The genetic variant of the alpha-adducin gene (ADD1) has been described as a risk factor for EH, but with controversial results.The objective of this study was to evaluate the association of ADD1 (Gly460Trp) gene polymorphism with the EH risk in a population from Madeira Island.A case-control study with 1614 individuals of Caucasian origin was performed, including 817 individuals with EH and 797 controls. Cases and controls were matched for sex and age, by frequency-matching method. All participants collected blood for biochemical and genotypic analysis for the Gly460Trp polymorphism. We further investigated which variables were independently associated to EH, and, consequently, analyzed their interactions.In our study, we found a significant association between the ADD1 gene polymorphism and EH (odds ratio 2.484, P = .01). This association remained statistically significant after the multivariate analysis (odds ratio 2.548, P = .02).The ADD1 Gly460Trp gene polymorphism is significantly and independently associated with EH risk in our population. The knowledge of genetic polymorphisms associated with EH is of paramount importance because it leads to a better understanding of the etiology and pathophysiology of this pathology. |
| dirty | 0 |
| eu_rights_str_mv | openAccess |
| format | article |
| fulltext.url.fl_str_mv | https://digituma.uma.pt/bitstreams/80837897-1697-42ca-8c3d-e7eff94d2b47/download |
| id | digituma_37f479216c0254da39a67b9efcfca799 |
| identifier.url.fl_str_mv | http://hdl.handle.net/10400.13/2978 |
| instacron_str | digituma |
| institution | Universidade da Madeira |
| instname_str | Universidade da Madeira |
| language | eng |
| network_acronym_str | digituma |
| network_name_str | DigitUMa - Repositório da Universidade da Madeira |
| oai_identifier_str | oai:digituma.uma.pt:10400.13/2978 |
| organization_str_mv | urn:organizationAcronym:digituma |
| person_str_mv | Sousa, Ana Célia Palma dos Reis, Roberto Pereira, Andreia Borges, Sofia Freitas, Ana Isabel Guerra, Graça Góis, Teresa Rodrigues, Mariana Henriques, Eva Freitas, Sónia Ornelas, Ilídio Pereira, Décio Brehm, António Brehm, António https://www.ciencia-id.pt/3613-8D1F-0EDF 3613-8D1F-0EDF http://orcid.org/0000-0003-3168-5340 0000-0003-3168-5340 Mendonça, Maria Isabel |
| publishDate | 2017 |
| publisher.none.fl_str_mv | Wolters Kluwer Health |
| reponame_str | DigitUMa - Repositório da Universidade da Madeira |
| repository_id_str | urn:repositoryAcronym:digituma |
| service_str_mv | urn:repositoryAcronym:digituma |
| spelling | engWolters Kluwer Healthpt_PTEssential hypertension (EH) is a complex disease in which physiological, environmental, and genetic factors are involved in its genesis. The genetic variant of the alpha-adducin gene (ADD1) has been described as a risk factor for EH, but with controversial results.The objective of this study was to evaluate the association of ADD1 (Gly460Trp) gene polymorphism with the EH risk in a population from Madeira Island.A case-control study with 1614 individuals of Caucasian origin was performed, including 817 individuals with EH and 797 controls. Cases and controls were matched for sex and age, by frequency-matching method. All participants collected blood for biochemical and genotypic analysis for the Gly460Trp polymorphism. We further investigated which variables were independently associated to EH, and, consequently, analyzed their interactions.In our study, we found a significant association between the ADD1 gene polymorphism and EH (odds ratio 2.484, P = .01). This association remained statistically significant after the multivariate analysis (odds ratio 2.548, P = .02).The ADD1 Gly460Trp gene polymorphism is significantly and independently associated with EH risk in our population. The knowledge of genetic polymorphisms associated with EH is of paramount importance because it leads to a better understanding of the etiology and pathophysiology of this pathology.application/pdfpt_PTRelationship between ADD1 Gly460Trp gene polymorphism and essential hypertension in Madeira IslandSousa, Ana CéliaPalma dos Reis, RobertoPereira, AndreiaBorges, SofiaFreitas, Ana IsabelGuerra, GraçaGóis, TeresaRodrigues, MarianaHenriques, EvaFreitas, SóniaOrnelas, IlídioPereira, DécioPersonalBrehm, AntónioDSpacehttp://dspace.org/items/62d279e2-247a-4652-a370-3e8c2a846e31DSpacehttp://dspace.org/items/62d279e2-247a-4652-a370-3e8c2a846e31BrehmAntonioCiência IDhttps://www.ciencia-id.pt3613-8D1F-0EDFORCIDhttp://orcid.org0000-0003-3168-5340Scopus Author IDhttps://www.scopus.comAuthor ID 7006085833Mendonça, Maria IsabelHostingInstitutionOrganizationalDigitUMae-mailmailto:digituma@uma.ptdigituma@uma.ptDOIIsPartOf10.1097/MD.00000000000078612020-11-13T14:48:14Z20172017-01-01T00:00:00ZHandlehttp://hdl.handle.net/10400.13/2978http://purl.org/coar/access_right/c_abf2open accessADD1 Gly460Trp gene polymorphismCase-control studyEssential hypertensionMadeira Island (Portugal).Faculdade de Ciências da Vida207189 bytesliteraturehttp://purl.org/coar/resource_type/c_6501journal article2017http://creativecommons.org/licenses/by/4.0/http://purl.org/coar/access_right/c_abf2application/pdffulltexthttps://digituma.uma.pt/bitstreams/80837897-1697-42ca-8c3d-e7eff94d2b47/downloadMedicine96(42)e7861 |
| spellingShingle | Relationship between ADD1 Gly460Trp gene polymorphism and essential hypertension in Madeira Island Sousa, Ana Célia ADD1 Gly460Trp gene polymorphism Case-control study Essential hypertension Madeira Island (Portugal) . Faculdade de Ciências da Vida |
| subject.fl_str_mv | ADD1 Gly460Trp gene polymorphism Case-control study Essential hypertension Madeira Island (Portugal) . Faculdade de Ciências da Vida |
| title | Relationship between ADD1 Gly460Trp gene polymorphism and essential hypertension in Madeira Island |
| title_full | Relationship between ADD1 Gly460Trp gene polymorphism and essential hypertension in Madeira Island |
| title_fullStr | Relationship between ADD1 Gly460Trp gene polymorphism and essential hypertension in Madeira Island |
| title_full_unstemmed | Relationship between ADD1 Gly460Trp gene polymorphism and essential hypertension in Madeira Island |
| title_short | Relationship between ADD1 Gly460Trp gene polymorphism and essential hypertension in Madeira Island |
| title_sort | Relationship between ADD1 Gly460Trp gene polymorphism and essential hypertension in Madeira Island |
| topic | ADD1 Gly460Trp gene polymorphism Case-control study Essential hypertension Madeira Island (Portugal) . Faculdade de Ciências da Vida |
| topic_facet | ADD1 Gly460Trp gene polymorphism Case-control study Essential hypertension Madeira Island (Portugal) . Faculdade de Ciências da Vida |
| url | http://hdl.handle.net/10400.13/2978 |
| visible | 1 |