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Effects of endrocrine disruptors on polycystic ovary syndrome and new therapeutic approaches

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Resumo:Polycystic ovary syndrome (PCOS) is an endocrine disease affecting around 10% of women worldwide. Clinical signs and associated alterations include hyperandrogenism, irregular menstrual cycles, infertility, insulin resistance associated with a risk of type 2 diabetes mellitus, cardiovascular disease, metabolic disease, anxiety and depression. However, the causes and pathology are still poorly understood. No effective curative treatment for this syndrome has yet been described, so therapeutic approaches are based on managing clinical signs. Some scientific studies highlight the toxicity of certain endocrine disruptors (EDCs), such as bisphenol A and phthalates, showing their effects on hormonal and ovarian functions associated with infertility disorders such as PCOS. Studies have shown that bisphenol is frequently present in the plasma, urine and follicular fluid of women with PCOS. Traditional terapies, such as contraceptive pills and metformin, are increasingly supplemented by other therapeutic approaches such as GLP-1 receptor agonist, Cytokine, SGLT2 inhibitors. Recent studies have been discussing some therapeutic options that aim to eliminate or neutralize EDCs, as well as gene therapy, epigenetic therapy, nanotechnologies and EDCscavenging enzymes, to reduce the toxicity of these disruptors. A better understanding of the impact of EDCs and other causes on PCOS would enable the development of new therapeutic approaches to treat these patients and reduce the clinical signs of PCOS. Therefore, the aim of this work is to provide an updated review of PCOS, focusing on the effects of EDCs on its etiology and on new therapeutic approaches to this syndrome.
Autores principais:Robert, Adèle Lemogne
Assunto:Polycystic ovary syndrome (PCOS) Endocrine disruptors (EDCs) Bisphenol A Toxicity Hyperandrogenism Infertility New therapeutic approaches
Ano:2025
País:Portugal
Tipo de documento:dissertação de mestrado
Tipo de acesso:acesso aberto
Instituição associada:Egas Moniz - Cooperativa de Ensino Superior, CRL
Idioma:inglês
Origem:Egas Moniz - Cooperativa de Ensino Superior, CRL

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