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Association between periodontal disease and Alzheimer’s disease : a cross-sectional study

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Resumo:Objectives: To evaluate whether periodontal disease is more prevalent in adults diagnosed with Alzheimer's disease compared to adults without the condition. Methods: A total of 72 individuals were included in the study: 36 patients diagnosed with Alzheimer's disease (test group) and 36 matched individuals without Alzheimer's disease (control group). The diagnosis of periodontal disease was established through a comprehensive periodontal assessment. Additionally, a microbiological analysis of subgingival plaque samples was conducted to detect the main periodontal pathogens. Results: Statistically significant differences were observed in periodontitis extent between the two groups: 82.4% of patients in the test group and 56.3% in the control group presented generalized periodontitis. No association was found between the stage and extent of periodontitis and the severity of Alzheimer's disease. Furthermore, no significant associations were observed between the number of years since Alzheimer's diagnosis and periodontal parameters, including the stage (p=0.659), extent (p=0.551), and grade of periodontitis (p=0.769). Prevotella intermedia was found in 25% of the test group and 5.6% of the control group (p=0.022). Campylobacter rectus appeared in 16.7% of the cases, with a significant difference between groups (p=0.011). Fusobacterium nucleatum was more common in the control group (75%) than in the test group (27.8%), with a significant difference (p<0.001). Eikenella corrodens was detected only in the control group (22.2%) (p=0.005). Conclusions: Although the overall prevalence of periodontitis was similar between groups, individuals with Alzheimer’s disease tended to present a greater extent of generalized periodontitis.
Autores principais:Rodrigues, Vanessa Rocha
Outros Autores:Amorim, Mónica; Alcoforado, Gil; Noronha, Susana
Assunto:Alzheimer's disease Periodontal disease Periodontitis
Ano:2026
País:Portugal
Tipo de documento:contribuição para revista
Tipo de acesso:acesso aberto
Instituição associada:Egas Moniz - Cooperativa de Ensino Superior, CRL
Idioma:inglês
Origem:Egas Moniz - Cooperativa de Ensino Superior, CRL

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