Publicação

Gut status in Parkinson’s disease: the GutSPark protocol

Ver documento

Detalhes bibliográficos
Resumo:The neuropathological hallmark of Parkinson’s disease (PD) is the accumulation of alpha–synuclein (AS) aggregates. The identification of AS aggregates in gut biopsy specimens from people with PD may provide an opportunity to identify PD at a very early stage, prior to symptom onset. Changes in gut microbiota and inflammatory conditions (such as periodontitis) may be linked with PD onset/evolution. This project aims to explore the concept of microbiota–gut–brain axis in PD, studying gut biopsy specimens for AS aggregates, oral and intestinal microbiota, associated digestive disorders and oral health, of both patients with PD and controls.
Autores principais:Grunho, Miguel
Outros Autores:Godinho, Catarina; Matos, António Alves de; Barroso, Helena; Carregosa, Ricardo; Marx, Frederico; Tomé, Morgane; Domingos, Josefa; Sousa-catita, Diogo; Botelho, João; Machado, Vanessa; Mendes, José João; Outeiro, Tiago; Fonseca, Jorge
Assunto:Parkinson’s disease alpha-synuclein Microbiota–gut–brain axis
Ano:2021
País:Portugal
Tipo de documento:outro
Tipo de acesso:acesso aberto
Instituição associada:Egas Moniz - Cooperativa de Ensino Superior, CRL
Idioma:inglês
Origem:Egas Moniz - Cooperativa de Ensino Superior, CRL

Registos relacionados

Registos relacionados