Publication
An umbrella review of the evidence linking oral health and systemic noncommunicable diseases
| Summary: | Oral diseases are highly prevalent worldwide. Recent studies have been supporting a potential bidirectional association of oral diseases with systemic noncommunicable diseases (NCDs). Available evidence supports that people with NCDs have a greater prevalence of oral diseases particularly those with limited ability of oral self-care. Regarding the reverse relationship, the lines of evidence pointing out NCDs as putative risk factors for oral diseases have increased significantly but not with a consistent agreement. This umbrella review of meta-analyses appraises the strength and validity of the evidence for the association between oral health and systemic health (registered at PROSPERO, ID: CRD42022300740). An extensive search included systematic reviews that have provided meta-analytic estimates on the association of oral diseases with NCDs. The overall strength of evidence was found to be unfavorable and with methodological inconsistencies. Twenty-eight NCDs were strongly associated with oral diseases. Among those NCDs are five types of cancer, diabetes mellitus, cardiovascular diseases, depression, neurodegenerative conditions, rheumatic diseases, inflammatory bowel disease, gastric helicobacter pylori, obesity, and asthma. According to fail-safe number statistics, the evidence levels are unlikely to change in the future, indicating a fairly robust consistency. |
|---|---|
| Main Authors: | Botelho, João |
| Other Authors: | Mascarenhas, Paulo; Viana, João; Proença, Luís; Orlandi, Marco; Leira, Yago; Chambrone, Leandro; Mendes, José João; Machado, Vanessa |
| Subject: | Dental diseases Diagnostic markers Epidemiology Health care |
| Year: | 2022 |
| Country: | Portugal |
| Document type: | contribution to journal |
| Access type: | open access |
| Associated institution: | Egas Moniz - Cooperativa de Ensino Superior, CRL |
| Language: | English |
| Origin: | Egas Moniz - Cooperativa de Ensino Superior, CRL |
| _version_ | 1868695851201724416 |
|---|---|
| author | Botelho, João |
| author2 | Mascarenhas, Paulo Viana, João Proença, Luís Orlandi, Marco Leira, Yago Chambrone, Leandro Mendes, José João Machado, Vanessa |
| author2_role | author author author author author author author author |
| author_facet | Botelho, João Mascarenhas, Paulo Viana, João Proença, Luís Orlandi, Marco Leira, Yago Chambrone, Leandro Mendes, José João Machado, Vanessa |
| author_role | author |
| contributor_name_str_mv | Repositório Comum |
| country_str | PT |
| creators_json_txt | [{\"Person.name\":\"Botelho, João\"},{\"Person.name\":\"Mascarenhas, Paulo\"},{\"Person.name\":\"Viana, João\"},{\"Person.name\":\"Proença, Luís\"},{\"Person.name\":\"Orlandi, Marco\"},{\"Person.name\":\"Leira, Yago\"},{\"Person.name\":\"Chambrone, Leandro\"},{\"Person.name\":\"Mendes, José João\"},{\"Person.name\":\"Machado, Vanessa\"}] |
| datacite.contributors.contributor.contributorName.fl_str_mv | Repositório Comum |
| datacite.creators.creator.creatorName.fl_str_mv | Botelho, João Mascarenhas, Paulo Viana, João Proença, Luís Orlandi, Marco Leira, Yago Chambrone, Leandro Mendes, José João Machado, Vanessa |
| datacite.date.Accepted.fl_str_mv | 2022-12-01T00:00:00Z |
| datacite.date.available.fl_str_mv | 2025-10-22T11:16:12Z |
| datacite.date.embargoed.fl_str_mv | 2025-10-22T11:16:12Z |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| datacite.subjects.subject.fl_str_mv | Dental diseases Diagnostic markers Epidemiology Health care |
| datacite.titles.title.fl_str_mv | An umbrella review of the evidence linking oral health and systemic noncommunicable diseases |
| dc.contributor.none.fl_str_mv | Repositório Comum |
| dc.creator.none.fl_str_mv | Botelho, João Mascarenhas, Paulo Viana, João Proença, Luís Orlandi, Marco Leira, Yago Chambrone, Leandro Mendes, José João Machado, Vanessa |
| dc.date.Accepted.fl_str_mv | 2022-12-01T00:00:00Z |
| dc.date.available.fl_str_mv | 2025-10-22T11:16:12Z |
| dc.date.embargoed.fl_str_mv | 2025-10-22T11:16:12Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | http://hdl.handle.net/10400.26/59342 |
| dc.language.none.fl_str_mv | eng |
| dc.publisher.none.fl_str_mv | Springer Nature |
| dc.rights.cclincense.fl_str_mv | http://creativecommons.org/licenses/by/4.0/ |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| dc.subject.none.fl_str_mv | Dental diseases Diagnostic markers Epidemiology Health care |
| dc.title.fl_str_mv | An umbrella review of the evidence linking oral health and systemic noncommunicable diseases |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_3e5a |
| description | Oral diseases are highly prevalent worldwide. Recent studies have been supporting a potential bidirectional association of oral diseases with systemic noncommunicable diseases (NCDs). Available evidence supports that people with NCDs have a greater prevalence of oral diseases particularly those with limited ability of oral self-care. Regarding the reverse relationship, the lines of evidence pointing out NCDs as putative risk factors for oral diseases have increased significantly but not with a consistent agreement. This umbrella review of meta-analyses appraises the strength and validity of the evidence for the association between oral health and systemic health (registered at PROSPERO, ID: CRD42022300740). An extensive search included systematic reviews that have provided meta-analytic estimates on the association of oral diseases with NCDs. The overall strength of evidence was found to be unfavorable and with methodological inconsistencies. Twenty-eight NCDs were strongly associated with oral diseases. Among those NCDs are five types of cancer, diabetes mellitus, cardiovascular diseases, depression, neurodegenerative conditions, rheumatic diseases, inflammatory bowel disease, gastric helicobacter pylori, obesity, and asthma. According to fail-safe number statistics, the evidence levels are unlikely to change in the future, indicating a fairly robust consistency. |
| dirty | 0 |
| eu_rights_str_mv | openAccess |
| format | contributionToPeriodical |
| fulltext.url.fl_str_mv | https://comum.rcaap.pt/bitstreams/affcaf74-562d-4358-9486-23553459db01/download |
| id | em_ebcc1fee8a26f34ca4e1412c24f4edab |
| identifier.url.fl_str_mv | http://hdl.handle.net/10400.26/59342 |
| instacron_str | em |
| institution | Egas Moniz - Cooperativa de Ensino Superior, CRL |
| instname_str | Egas Moniz - Cooperativa de Ensino Superior, CRL |
| language | eng |
| network_acronym_str | em |
| network_name_str | Egas Moniz - Cooperativa de Ensino Superior, CRL |
| oai_identifier_str | oai:comum.rcaap.pt:10400.26/59342 |
| organization_str_mv | urn:organizationAcronym:em |
| person_str_mv | Botelho, João Mascarenhas, Paulo Viana, João Proença, Luís Orlandi, Marco Leira, Yago Chambrone, Leandro Mendes, José João Machado, Vanessa |
| publishDate | 2022 |
| publisher.none.fl_str_mv | Springer Nature |
| reponame_str | Egas Moniz - Cooperativa de Ensino Superior, CRL |
| repository_id_str | urn:repositoryAcronym:em |
| service_str_mv | urn:repositoryAcronym:em |
| spelling | engSpringer NatureengOral diseases are highly prevalent worldwide. Recent studies have been supporting a potential bidirectional association of oral diseases with systemic noncommunicable diseases (NCDs). Available evidence supports that people with NCDs have a greater prevalence of oral diseases particularly those with limited ability of oral self-care. Regarding the reverse relationship, the lines of evidence pointing out NCDs as putative risk factors for oral diseases have increased significantly but not with a consistent agreement. This umbrella review of meta-analyses appraises the strength and validity of the evidence for the association between oral health and systemic health (registered at PROSPERO, ID: CRD42022300740). An extensive search included systematic reviews that have provided meta-analytic estimates on the association of oral diseases with NCDs. The overall strength of evidence was found to be unfavorable and with methodological inconsistencies. Twenty-eight NCDs were strongly associated with oral diseases. Among those NCDs are five types of cancer, diabetes mellitus, cardiovascular diseases, depression, neurodegenerative conditions, rheumatic diseases, inflammatory bowel disease, gastric helicobacter pylori, obesity, and asthma. According to fail-safe number statistics, the evidence levels are unlikely to change in the future, indicating a fairly robust consistency.application/pdfengAn umbrella review of the evidence linking oral health and systemic noncommunicable diseasesBotelho, JoãoMascarenhas, PauloViana, JoãoProença, LuísOrlandi, MarcoLeira, YagoChambrone, LeandroMendes, José JoãoMachado, VanessaHostingInstitutionOrganizationalRepositório Comume-mailmailto:comum@rcaap.ptcomum@rcaap.ptISSNIsPartOf2041-1723DOIIsPartOf10.1038/s41467-022-35337-82025-10-22T11:16:12Z2022-122022-12-01T00:00:00ZHandlehttp://hdl.handle.net/10400.26/59342http://purl.org/coar/access_right/c_abf2open accessDental diseasesDiagnostic markersEpidemiologyHealth care1799700 bytesother research producthttp://purl.org/coar/resource_type/c_3e5acontribution to journal2022-12http://creativecommons.org/licenses/by/4.0/http://purl.org/coar/access_right/c_abf2application/pdffulltexthttps://comum.rcaap.pt/bitstreams/affcaf74-562d-4358-9486-23553459db01/downloadNature Communications137614 |
| spellingShingle | An umbrella review of the evidence linking oral health and systemic noncommunicable diseases Botelho, João Dental diseases Diagnostic markers Epidemiology Health care |
| status | SINGLETON |
| subject.fl_str_mv | Dental diseases Diagnostic markers Epidemiology Health care |
| title | An umbrella review of the evidence linking oral health and systemic noncommunicable diseases |
| title_full | An umbrella review of the evidence linking oral health and systemic noncommunicable diseases |
| title_fullStr | An umbrella review of the evidence linking oral health and systemic noncommunicable diseases |
| title_full_unstemmed | An umbrella review of the evidence linking oral health and systemic noncommunicable diseases |
| title_short | An umbrella review of the evidence linking oral health and systemic noncommunicable diseases |
| title_sort | An umbrella review of the evidence linking oral health and systemic noncommunicable diseases |
| topic | Dental diseases Diagnostic markers Epidemiology Health care |
| topic_facet | Dental diseases Diagnostic markers Epidemiology Health care |
| url | http://hdl.handle.net/10400.26/59342 |
| visible | 1 |