Publicação
Relatórios de Estágio Curricular e Monografia intitulada "Doença de Alzheimer, resistência à insulina e diabetes mellitus tipo II: relações funcionais e novas estratégias terapêuticas"
| Resumo: | Alzheimer's disease and type 2 diabetes mellitus are aging-related diseases whose prevalence has reached alarming levels worldwide. Various studies have demonstrated that Alzheimer's disease and type 2 diabetes mellitus shared pathophysiological mechanisms, both being linked to alterations in the insulin signaling pathway and insulin resistance. In turn, insulin resistance is associated with an increased deposition of amyloid plaques, tau protein hyperphosphorylation, Alzheimer's disease pathophysiological lesions, oxidative stress and neuroinflammation.While the drugs used in clinical practice for Alzheimer's disease provide symptomatic relief, the majority of them target a single mechanism of the disease and are unable to prevent its progression. Therefore, the development of therapeutic alternatives capable of acting simultaneously on the different mechanisms responsible for the pathogenesis of Alzheimer's disease is regarded as a promising approach to modify the progression of this disease. In this context, polyphenols such as resveratrol, quercetin and curcumin have been the subject of growing interest from several researchers as multi-target agents capable of acting on both Alzheimer's disease and type 2 diabetes mellitus. Due to their antioxidant, anti-inflammatory and anti-amyloidogenic potential and their ability to modulate tau phosphorylation, these polyphenols might exhibit a neuroprotective action associated with an improvement in cognition in patients with these diseases, provided that their properties described in cellular models can be translated to an in vivo setting.Thus, the aim of this dissertation is to critically address this new concept encompassing the link between Alzheimer's disease, insulin resistance and type 2 diabetes mellitus, and to explore the use of polyphenols as therapeutic agents in Alzheimer's disease. |
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| Autores principais: | Rodrigues, Marlene da Mota |
| Assunto: | Alzheimer's disease Type 2 diabetes mellitus Insulin resistance Polyphenols Resveratrol, Quercetin, Curcumin Doença de Alzheimer Diabetes mellitus tipo 2 Resistência à insulina Polifenóis Resveratrol, Quercetina, Curcumina |
| Ano: | 2024 |
| País: | Portugal |
| Tipo de documento: | dissertação de mestrado |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Universidade de Coimbra |
| Idioma: | português |
| Origem: | Estudo Geral - Universidade de Coimbra |
| Resumo: | Alzheimer's disease and type 2 diabetes mellitus are aging-related diseases whose prevalence has reached alarming levels worldwide. Various studies have demonstrated that Alzheimer's disease and type 2 diabetes mellitus shared pathophysiological mechanisms, both being linked to alterations in the insulin signaling pathway and insulin resistance. In turn, insulin resistance is associated with an increased deposition of amyloid plaques, tau protein hyperphosphorylation, Alzheimer's disease pathophysiological lesions, oxidative stress and neuroinflammation.While the drugs used in clinical practice for Alzheimer's disease provide symptomatic relief, the majority of them target a single mechanism of the disease and are unable to prevent its progression. Therefore, the development of therapeutic alternatives capable of acting simultaneously on the different mechanisms responsible for the pathogenesis of Alzheimer's disease is regarded as a promising approach to modify the progression of this disease. In this context, polyphenols such as resveratrol, quercetin and curcumin have been the subject of growing interest from several researchers as multi-target agents capable of acting on both Alzheimer's disease and type 2 diabetes mellitus. Due to their antioxidant, anti-inflammatory and anti-amyloidogenic potential and their ability to modulate tau phosphorylation, these polyphenols might exhibit a neuroprotective action associated with an improvement in cognition in patients with these diseases, provided that their properties described in cellular models can be translated to an in vivo setting.Thus, the aim of this dissertation is to critically address this new concept encompassing the link between Alzheimer's disease, insulin resistance and type 2 diabetes mellitus, and to explore the use of polyphenols as therapeutic agents in Alzheimer's disease. |
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