Publicação
Biological activity of 6,7-dehydroroyleanone derivatives from Plectranthus aliciae
| Resumo: | Plectranthus genus (Lamiaceae) is known to be rich in bioactive abietane royleanone-type diterpenes, such as 6,7-dehydroxyroyleanone (1, Fig. 1), which have been previously found in P. madagascariensis (var. aliciae Codd). This abietane royleanone presents moderate to significant to cytoxic activity against several cancer cell lines. Moreover, 1 has one hydroxyl group suitable for deri- vatization that can be explored to enhance the cytotoxic activity of lead com- pound 1. Based on this, the aim of the present work is to explore the obtention of 1, from P. aliciae aliciae (Codd) van Jaarsv. & T.J.Edwards., a subspecies of P. madagascariensis to be further used in the preparation of new derivatives with enhanced biological activities. |
|---|---|
| Autores principais: | Filipe, Márcia Santos |
| Outros Autores: | Dominguez, Eva; Isca, Vera; Pereira, Raquel; Mandim, Filipa; Calhelha, Ricardo C.; Diaz-Lanza, Ana María; Barros, Lillian; Rijo, Patrícia |
| Ano: | 2023 |
| País: | Portugal |
| Tipo de documento: | documento de conferência |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Instituto Politécnico de Bragança |
| Idioma: | inglês |
| Origem: | Biblioteca Digital do IPB |
| _version_ | 1867172729853050880 |
|---|---|
| author | Filipe, Márcia Santos |
| author2 | Dominguez, Eva Isca, Vera Pereira, Raquel Mandim, Filipa Calhelha, Ricardo C. Diaz-Lanza, Ana María Barros, Lillian Rijo, Patrícia |
| author2_role | author author author author author author author author |
| author_facet | Filipe, Márcia Santos Dominguez, Eva Isca, Vera Pereira, Raquel Mandim, Filipa Calhelha, Ricardo C. Diaz-Lanza, Ana María Barros, Lillian Rijo, Patrícia |
| author_role | author |
| contributor_name_str_mv | Biblioteca Digital do IPB |
| country_str | PT |
| creators_json_txt | [{\"Person.name\":\"Filipe, Márcia Santos\"},{\"Person.name\":\"Dominguez, Eva\"},{\"Person.name\":\"Isca, Vera\"},{\"Person.name\":\"Pereira, Raquel\"},{\"Person.name\":\"Mandim, Filipa\",\"Person.identifier.orcid\":\"0000-0002-6494-2326\"},{\"Person.name\":\"Calhelha, Ricardo C.\",\"Person.identifier.orcid\":\"0000-0002-6801-4578\"},{\"Person.name\":\"Diaz-Lanza, Ana María\"},{\"Person.name\":\"Barros, Lillian\",\"Person.identifier.orcid\":\"0000-0002-9050-5189\"},{\"Person.name\":\"Rijo, Patrícia\"}] |
| datacite.contributors.contributor.contributorName.fl_str_mv | Biblioteca Digital do IPB |
| datacite.creators.creator.creatorName.fl_str_mv | Filipe, Márcia Santos Dominguez, Eva Isca, Vera Pereira, Raquel Mandim, Filipa Calhelha, Ricardo C. Diaz-Lanza, Ana María Barros, Lillian Rijo, Patrícia |
| datacite.date.Accepted.fl_str_mv | 2023-01-01T00:00:00Z |
| datacite.date.available.fl_str_mv | 2024-05-06T13:56:37Z |
| datacite.date.embargoed.fl_str_mv | 2024-05-06T13:56:37Z |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| datacite.titles.title.fl_str_mv | Biological activity of 6,7-dehydroroyleanone derivatives from Plectranthus aliciae |
| dc.contributor.none.fl_str_mv | Biblioteca Digital do IPB |
| dc.creator.none.fl_str_mv | Filipe, Márcia Santos Dominguez, Eva Isca, Vera Pereira, Raquel Mandim, Filipa Calhelha, Ricardo C. Diaz-Lanza, Ana María Barros, Lillian Rijo, Patrícia |
| dc.date.Accepted.fl_str_mv | 2023-01-01T00:00:00Z |
| dc.date.available.fl_str_mv | 2024-05-06T13:56:37Z |
| dc.date.embargoed.fl_str_mv | 2024-05-06T13:56:37Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | http://hdl.handle.net/10198/29718 |
| dc.language.none.fl_str_mv | eng |
| dc.publisher.none.fl_str_mv | Thieme |
| dc.rights.cclincense.fl_str_mv | http://creativecommons.org/licenses/by/4.0/ |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| dc.title.fl_str_mv | Biological activity of 6,7-dehydroroyleanone derivatives from Plectranthus aliciae |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_c94f |
| description | Plectranthus genus (Lamiaceae) is known to be rich in bioactive abietane royleanone-type diterpenes, such as 6,7-dehydroxyroyleanone (1, Fig. 1), which have been previously found in P. madagascariensis (var. aliciae Codd). This abietane royleanone presents moderate to significant to cytoxic activity against several cancer cell lines. Moreover, 1 has one hydroxyl group suitable for deri- vatization that can be explored to enhance the cytotoxic activity of lead com- pound 1. Based on this, the aim of the present work is to explore the obtention of 1, from P. aliciae aliciae (Codd) van Jaarsv. & T.J.Edwards., a subspecies of P. madagascariensis to be further used in the preparation of new derivatives with enhanced biological activities. |
| dirty | 0 |
| eu_rights_str_mv | openAccess |
| format | conferenceObject |
| fulltext.url.fl_str_mv | https://bibliotecadigital.ipb.pt/bitstreams/a5d9d218-e6c9-4b0f-80a4-b98186351c8a/download |
| id | ipb_0206d3a86c9169a8a7efefcf1d29df29 |
| identifier.url.fl_str_mv | http://hdl.handle.net/10198/29718 |
| instacron_str | ipb |
| institution | Instituto Politécnico de Bragança |
| instname_str | Instituto Politécnico de Bragança |
| language | eng |
| network_acronym_str | ipb |
| network_name_str | Biblioteca Digital do IPB |
| oai_identifier_str | oai:bibliotecadigital.ipb.pt:10198/29718 |
| organization_str_mv | urn:organizationAcronym:ipb |
| person_str_mv | Filipe, Márcia Santos Dominguez, Eva Isca, Vera Pereira, Raquel Mandim, Filipa Mandim, Filipa https://www.ciencia-id.pt/F318-9049-EB99 F318-9049-EB99 http://orcid.org/0000-0002-6494-2326 0000-0002-6494-2326 Calhelha, Ricardo C. Calhelha, Ricardo C. https://www.ciencia-id.pt/F313-E3CE-554E F313-E3CE-554E http://orcid.org/0000-0002-6801-4578 0000-0002-6801-4578 Diaz-Lanza, Ana María Barros, Lillian Barros, Lillian https://www.ciencia-id.pt/9616-35CB-D001 9616-35CB-D001 http://orcid.org/0000-0002-9050-5189 0000-0002-9050-5189 Rijo, Patrícia |
| publishDate | 2023 |
| publisher.none.fl_str_mv | Thieme |
| reponame_str | Biblioteca Digital do IPB |
| repository_id_str | urn:repositoryAcronym:ipb |
| service_str_mv | urn:repositoryAcronym:ipb |
| spelling | engThiemept_PTPlectranthus genus (Lamiaceae) is known to be rich in bioactive abietane royleanone-type diterpenes, such as 6,7-dehydroxyroyleanone (1, Fig. 1), which have been previously found in P. madagascariensis (var. aliciae Codd). This abietane royleanone presents moderate to significant to cytoxic activity against several cancer cell lines. Moreover, 1 has one hydroxyl group suitable for deri- vatization that can be explored to enhance the cytotoxic activity of lead com- pound 1. Based on this, the aim of the present work is to explore the obtention of 1, from P. aliciae aliciae (Codd) van Jaarsv. & T.J.Edwards., a subspecies of P. madagascariensis to be further used in the preparation of new derivatives with enhanced biological activities.application/pdfpt_PTBiological activity of 6,7-dehydroroyleanone derivatives from Plectranthus aliciaeFilipe, Márcia SantosDominguez, EvaIsca, VeraPereira, RaquelPersonalMandim, FilipaDSpacehttp://dspace.org/items/bcc274d4-7e6c-46a8-8e49-2752f9dbfbcdDSpacehttp://dspace.org/items/bcc274d4-7e6c-46a8-8e49-2752f9dbfbcdMandimFilipaCiência IDhttps://www.ciencia-id.ptF318-9049-EB99ORCIDhttp://orcid.org0000-0002-6494-2326PersonalCalhelha, Ricardo C.DSpacehttp://dspace.org/items/2d5d1a41-7561-4a01-871c-b4c97da35053DSpacehttp://dspace.org/items/2d5d1a41-7561-4a01-871c-b4c97da35053CalhelhaRicardo C.Ciência IDhttps://www.ciencia-id.ptF313-E3CE-554EORCIDhttp://orcid.org0000-0002-6801-4578Researcher IDhttps://www.researcherid.comJ-2172-2014Scopus Author IDhttps://www.scopus.com6507978333Diaz-Lanza, Ana MaríaPersonalBarros, LillianDSpacehttp://dspace.org/items/3af07ffe-f914-48ba-a5d5-efcf70fdce01DSpacehttp://dspace.org/items/3af07ffe-f914-48ba-a5d5-efcf70fdce01BarrosLillianCiência IDhttps://www.ciencia-id.pt9616-35CB-D001ORCIDhttp://orcid.org0000-0002-9050-5189Researcher IDhttps://www.researcherid.comJ-3600-2013Researcher IDhttps://www.researcherid.comJ-3600-2013Scopus Author IDhttps://www.scopus.com35236343600Scopus Author IDhttps://www.scopus.com57194900801Rijo, PatríciaHostingInstitutionOrganizationalBiblioteca Digital do IPBe-mailmailto:dspace@ipb.ptdspace@ipb.ptISSNIsPartOf0032-09432024-05-06T13:56:37Z20232023-01-01T00:00:00ZHandlehttp://hdl.handle.net/10198/29718http://purl.org/coar/access_right/c_abf2open access207971 bytesother research producthttp://purl.org/coar/resource_type/c_c94fconference object2023http://creativecommons.org/licenses/by/4.0/http://purl.org/coar/access_right/c_abf2application/pdffulltexthttps://bibliotecadigital.ipb.pt/bitstreams/a5d9d218-e6c9-4b0f-80a4-b98186351c8a/downloadPlanta Médica8914 |
| spellingShingle | Biological activity of 6,7-dehydroroyleanone derivatives from Plectranthus aliciae Filipe, Márcia Santos |
| status | SINGLETON |
| title | Biological activity of 6,7-dehydroroyleanone derivatives from Plectranthus aliciae |
| title_full | Biological activity of 6,7-dehydroroyleanone derivatives from Plectranthus aliciae |
| title_fullStr | Biological activity of 6,7-dehydroroyleanone derivatives from Plectranthus aliciae |
| title_full_unstemmed | Biological activity of 6,7-dehydroroyleanone derivatives from Plectranthus aliciae |
| title_short | Biological activity of 6,7-dehydroroyleanone derivatives from Plectranthus aliciae |
| title_sort | Biological activity of 6,7-dehydroroyleanone derivatives from Plectranthus aliciae |
| url | http://hdl.handle.net/10198/29718 |
| visible | 1 |