Publicação
Chemical composition and pharmacological effects of geopropolis produced by Melipona quadrifasciata anthidioides.
| Resumo: | Stingless bees produce geopropolis, which is popularly described for its medicinal properties, but for which few scientific studies have demonstrated pharmacological effects. The objective of this study was to investigate the chemical composition of the geopropolis of Melipona quadrifasciata anthidioides and to evaluate its antioxidant, antimutagenic, anti-inflammatory, and antimicrobial activities. The composition of the hydroethanolic extract of geopropolis (HEG) included di- and trigalloyl and phenylpropanyl heteroside derivatives, flavanones, diterpenes, and triterpenes. HEG showed antioxidant action via the direct capture of free radicals and by inhibiting the levels of oxidative hemolysis and malondialdehyde in human erythrocytes under oxidative stress. HEG also reduced the frequency of gene conversion and the number of mutant colonies of S. cerevisiae. The anti-inflammatory action of HEG was demonstrated by the inhibition of hyaluronidase enzyme activity. In addition, HEG induced cell death in all evaluated gram-positive bacteria, gram-negative bacteria, and yeasts, including clinical isolates with antimicrobial drug resistance. Collectively, these results demonstrate the potential of M. q. anthidioides geopropolis for the prevention and treatment of various diseases related to oxidative stress, mutagenesis, inflammatory processes, and microbial infections. |
|---|---|
| Autores principais: | Santos, Cintia Miranda |
| Outros Autores: | Campos, Jaqueline Ferreira; Santos, Jaqueline Freitas dos; Balestieri, José Benedito Perrella; Silva, Denise Brentan; Souza, Kely de Picoli; Carollo, Carlos Alexandre; Estevinho, Leticia M.; Santos, Edson Lucas dos |
| Assunto: | Antioxidant activity Brazilian propolis Free-radicals Antibacterial |
| Ano: | 2017 |
| País: | Portugal |
| Tipo de documento: | artigo |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Instituto Politécnico de Bragança |
| Idioma: | inglês |
| Origem: | Biblioteca Digital do IPB |
| _version_ | 1867172754664456192 |
|---|---|
| author | Santos, Cintia Miranda |
| author2 | Campos, Jaqueline Ferreira Santos, Jaqueline Freitas dos Balestieri, José Benedito Perrella Silva, Denise Brentan Souza, Kely de Picoli Carollo, Carlos Alexandre Estevinho, Leticia M. Santos, Edson Lucas dos |
| author2_role | author author author author author author author author |
| author_facet | Santos, Cintia Miranda Campos, Jaqueline Ferreira Santos, Jaqueline Freitas dos Balestieri, José Benedito Perrella Silva, Denise Brentan Souza, Kely de Picoli Carollo, Carlos Alexandre Estevinho, Leticia M. Santos, Edson Lucas dos |
| author_role | author |
| contributor_name_str_mv | Biblioteca Digital do IPB |
| country_str | PT |
| creators_json_txt | [{\"Person.name\":\"Santos, Cintia Miranda\"},{\"Person.name\":\"Campos, Jaqueline Ferreira\"},{\"Person.name\":\"Santos, Jaqueline Freitas dos\"},{\"Person.name\":\"Balestieri, José Benedito Perrella\"},{\"Person.name\":\"Silva, Denise Brentan\"},{\"Person.name\":\"Souza, Kely de Picoli\"},{\"Person.name\":\"Carollo, Carlos Alexandre\"},{\"Person.name\":\"Estevinho, Leticia M.\",\"Person.identifier.orcid\":\"0000-0002-9249-1948\"},{\"Person.name\":\"Santos, Edson Lucas dos\"}] |
| datacite.contributors.contributor.contributorName.fl_str_mv | Biblioteca Digital do IPB |
| datacite.creators.creator.creatorName.fl_str_mv | Santos, Cintia Miranda Campos, Jaqueline Ferreira Santos, Jaqueline Freitas dos Balestieri, José Benedito Perrella Silva, Denise Brentan Souza, Kely de Picoli Carollo, Carlos Alexandre Estevinho, Leticia M. Santos, Edson Lucas dos |
| datacite.date.Accepted.fl_str_mv | 2017-01-01T00:00:00Z |
| datacite.date.available.fl_str_mv | 2020-06-05T09:23:09Z |
| datacite.date.embargoed.fl_str_mv | 2020-06-05T09:23:09Z |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| datacite.subjects.subject.fl_str_mv | Antioxidant activity Brazilian propolis Free-radicals Antibacterial |
| datacite.titles.title.fl_str_mv | Chemical composition and pharmacological effects of geopropolis produced by Melipona quadrifasciata anthidioides. |
| dc.contributor.none.fl_str_mv | Biblioteca Digital do IPB |
| dc.creator.none.fl_str_mv | Santos, Cintia Miranda Campos, Jaqueline Ferreira Santos, Jaqueline Freitas dos Balestieri, José Benedito Perrella Silva, Denise Brentan Souza, Kely de Picoli Carollo, Carlos Alexandre Estevinho, Leticia M. Santos, Edson Lucas dos |
| dc.date.Accepted.fl_str_mv | 2017-01-01T00:00:00Z |
| dc.date.available.fl_str_mv | 2020-06-05T09:23:09Z |
| dc.date.embargoed.fl_str_mv | 2020-06-05T09:23:09Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | http://hdl.handle.net/10198/22025 |
| dc.language.none.fl_str_mv | eng |
| dc.publisher.none.fl_str_mv | Hindawi |
| dc.rights.cclincense.fl_str_mv | http://creativecommons.org/licenses/by-nc/4.0/ |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| dc.subject.none.fl_str_mv | Antioxidant activity Brazilian propolis Free-radicals Antibacterial |
| dc.title.fl_str_mv | Chemical composition and pharmacological effects of geopropolis produced by Melipona quadrifasciata anthidioides. |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_6501 |
| description | Stingless bees produce geopropolis, which is popularly described for its medicinal properties, but for which few scientific studies have demonstrated pharmacological effects. The objective of this study was to investigate the chemical composition of the geopropolis of Melipona quadrifasciata anthidioides and to evaluate its antioxidant, antimutagenic, anti-inflammatory, and antimicrobial activities. The composition of the hydroethanolic extract of geopropolis (HEG) included di- and trigalloyl and phenylpropanyl heteroside derivatives, flavanones, diterpenes, and triterpenes. HEG showed antioxidant action via the direct capture of free radicals and by inhibiting the levels of oxidative hemolysis and malondialdehyde in human erythrocytes under oxidative stress. HEG also reduced the frequency of gene conversion and the number of mutant colonies of S. cerevisiae. The anti-inflammatory action of HEG was demonstrated by the inhibition of hyaluronidase enzyme activity. In addition, HEG induced cell death in all evaluated gram-positive bacteria, gram-negative bacteria, and yeasts, including clinical isolates with antimicrobial drug resistance. Collectively, these results demonstrate the potential of M. q. anthidioides geopropolis for the prevention and treatment of various diseases related to oxidative stress, mutagenesis, inflammatory processes, and microbial infections. |
| dirty | 0 |
| eu_rights_str_mv | openAccess |
| format | article |
| fulltext.url.fl_str_mv | https://bibliotecadigital.ipb.pt/bitstreams/560d1d9b-41b7-4c95-bcad-9c1a7ebeaef3/download |
| id | ipb_042cca9be63b2d4f1dde066468ca609f |
| identifier.url.fl_str_mv | http://hdl.handle.net/10198/22025 |
| instacron_str | ipb |
| institution | Instituto Politécnico de Bragança |
| instname_str | Instituto Politécnico de Bragança |
| language | eng |
| network_acronym_str | ipb |
| network_name_str | Biblioteca Digital do IPB |
| oai_identifier_str | oai:bibliotecadigital.ipb.pt:10198/22025 |
| organization_str_mv | urn:organizationAcronym:ipb |
| person_str_mv | Santos, Cintia Miranda Campos, Jaqueline Ferreira Santos, Jaqueline Freitas dos Balestieri, José Benedito Perrella Silva, Denise Brentan Souza, Kely de Picoli Carollo, Carlos Alexandre Estevinho, Leticia M. Estevinho, Leticia M. https://www.ciencia-id.pt/BA14-09D6-A406 BA14-09D6-A406 http://orcid.org/0000-0002-9249-1948 0000-0002-9249-1948 Santos, Edson Lucas dos |
| publishDate | 2017 |
| publisher.none.fl_str_mv | Hindawi |
| reponame_str | Biblioteca Digital do IPB |
| repository_id_str | urn:repositoryAcronym:ipb |
| service_str_mv | urn:repositoryAcronym:ipb |
| spelling | engHindawipt_PTStingless bees produce geopropolis, which is popularly described for its medicinal properties, but for which few scientific studies have demonstrated pharmacological effects. The objective of this study was to investigate the chemical composition of the geopropolis of Melipona quadrifasciata anthidioides and to evaluate its antioxidant, antimutagenic, anti-inflammatory, and antimicrobial activities. The composition of the hydroethanolic extract of geopropolis (HEG) included di- and trigalloyl and phenylpropanyl heteroside derivatives, flavanones, diterpenes, and triterpenes. HEG showed antioxidant action via the direct capture of free radicals and by inhibiting the levels of oxidative hemolysis and malondialdehyde in human erythrocytes under oxidative stress. HEG also reduced the frequency of gene conversion and the number of mutant colonies of S. cerevisiae. The anti-inflammatory action of HEG was demonstrated by the inhibition of hyaluronidase enzyme activity. In addition, HEG induced cell death in all evaluated gram-positive bacteria, gram-negative bacteria, and yeasts, including clinical isolates with antimicrobial drug resistance. Collectively, these results demonstrate the potential of M. q. anthidioides geopropolis for the prevention and treatment of various diseases related to oxidative stress, mutagenesis, inflammatory processes, and microbial infections.application/pdfpt_PTChemical composition and pharmacological effects of geopropolis produced by Melipona quadrifasciata anthidioides.Santos, Cintia MirandaCampos, Jaqueline FerreiraSantos, Jaqueline Freitas dosBalestieri, José Benedito PerrellaSilva, Denise BrentanSouza, Kely de PicoliCarollo, Carlos AlexandrePersonalEstevinho, Leticia M.DSpacehttp://dspace.org/items/4a1d5ba2-1854-4ca5-89a4-73f35e964df9DSpacehttp://dspace.org/items/4a1d5ba2-1854-4ca5-89a4-73f35e964df9EstevinhoLetícia M.Ciência IDhttps://www.ciencia-id.ptBA14-09D6-A406ORCIDhttp://orcid.org0000-0002-9249-1948Scopus Author IDhttps://www.scopus.com6506577664Scopus Author IDhttps://www.scopus.com57211945650Santos, Edson Lucas dosHostingInstitutionOrganizationalBiblioteca Digital do IPBe-mailmailto:dspace@ipb.ptdspace@ipb.ptISSNIsPartOf1942-0900DOIIsPartOf10.1155/2017/83208042020-06-05T09:23:09Z20172017-01-01T00:00:00ZHandlehttp://hdl.handle.net/10198/22025http://purl.org/coar/access_right/c_abf2open accessAntioxidant activityBrazilian propolisFree-radicalsAntibacterial2037146 bytesliteraturehttp://purl.org/coar/resource_type/c_6501journal article2017http://creativecommons.org/licenses/by-nc/4.0/http://purl.org/coar/access_right/c_abf2application/pdffulltexthttps://bibliotecadigital.ipb.pt/bitstreams/560d1d9b-41b7-4c95-bcad-9c1a7ebeaef3/downloadOxidative Medicine and Cellular Longevity8320804113 |
| spellingShingle | Chemical composition and pharmacological effects of geopropolis produced by Melipona quadrifasciata anthidioides. Santos, Cintia Miranda Antioxidant activity Brazilian propolis Free-radicals Antibacterial |
| status | SINGLETON |
| subject.fl_str_mv | Antioxidant activity Brazilian propolis Free-radicals Antibacterial |
| title | Chemical composition and pharmacological effects of geopropolis produced by Melipona quadrifasciata anthidioides. |
| title_full | Chemical composition and pharmacological effects of geopropolis produced by Melipona quadrifasciata anthidioides. |
| title_fullStr | Chemical composition and pharmacological effects of geopropolis produced by Melipona quadrifasciata anthidioides. |
| title_full_unstemmed | Chemical composition and pharmacological effects of geopropolis produced by Melipona quadrifasciata anthidioides. |
| title_short | Chemical composition and pharmacological effects of geopropolis produced by Melipona quadrifasciata anthidioides. |
| title_sort | Chemical composition and pharmacological effects of geopropolis produced by Melipona quadrifasciata anthidioides. |
| topic | Antioxidant activity Brazilian propolis Free-radicals Antibacterial |
| topic_facet | Antioxidant activity Brazilian propolis Free-radicals Antibacterial |
| url | http://hdl.handle.net/10198/22025 |
| visible | 1 |