Publicação
Monitoring of non-steroidal anti-inflammatory drugs in hydric media from the Bragança region
| Resumo: | Emerging micropollutants are substances found in the environment in very low concentrations, at scales ranging from nanograms to micrograms per liter. Usually, wastewater treatment plants are not designed with the purpose of removing these pollutants. Non-steroidal anti-inflammatory drugs (NSAIDs) are some of the most prescribed drugs worldwide in order to relief pain and inflammatory conditions. Several studies report the presence of these pharmaceuticals in different aqueous matrices. Therefore, in this work will be presented an extensive set of experimental results obtained for the development and validation of a complete methodology used to identify and quantify five selected NSAIDs (acetylsalicylic acid, diclofenac, ibuprofen, ketoprofen and naproxen) in samples collected from different hydric media of the Bragança region, northern Portugal. Experimental results includes the optimization of solid phase extraction (SPE) and high performance liquid chromatography with diode array detector (HPLC-DAD) operating conditions, namely, SPE recoveries, HPLC mobile phase composition and pH based on different acetonitrile/water/trifluoroacetic acid contents under isocratic or gradient modes, and optimum wavelengths to improve limits of detection and quantification, among others. The SPE extraction is performed using Chromabond® HLB cartridges, and the optimized extraction process resulted in mass recovery values between 86.5% and 99.3%. After SPE extraction the samples were analyzed by HPLC-DAD using a C18 column, a 60%acetonitrile:40%water:0.01%trifluoroacetic acid solvent composition and a flow-rate of 1.2 mL/min. The selected wavelengths were 219 nm for ibuprofen, 224 nm for acetylsalicylic acid and naproxen, 254 nm for ketoprofen and 275 nm for diclofenac. The experimental methodology was validated using real samples from different aqueous matrices collected in the Bragança region. |
|---|---|
| Autores principais: | Nemoto, Ana |
| Outros Autores: | Oliveira, Ana Teresa Lopes Branco de; Queiroz, Ana; Brito, Paulo; Ribeiro, António E. |
| Ano: | 2019 |
| País: | Portugal |
| Tipo de documento: | documento de conferência |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Instituto Politécnico de Bragança |
| Idioma: | inglês |
| Origem: | Biblioteca Digital do IPB |
| _version_ | 1867172853572435968 |
|---|---|
| author | Nemoto, Ana |
| author2 | Oliveira, Ana Teresa Lopes Branco de Queiroz, Ana Brito, Paulo Ribeiro, António E. |
| author2_role | author author author author |
| author_facet | Nemoto, Ana Oliveira, Ana Teresa Lopes Branco de Queiroz, Ana Brito, Paulo Ribeiro, António E. |
| author_role | author |
| contributor_name_str_mv | Biblioteca Digital do IPB |
| country_str | PT |
| creators_json_txt | [{\"Person.name\":\"Nemoto, Ana\"},{\"Person.name\":\"Oliveira, Ana Teresa Lopes Branco de\"},{\"Person.name\":\"Queiroz, Ana\",\"Person.identifier.orcid\":\"0000-0003-4761-0618\"},{\"Person.name\":\"Brito, Paulo\",\"Person.identifier.orcid\":\"0000-0003-1805-0252\"},{\"Person.name\":\"Ribeiro, António E.\",\"Person.identifier.orcid\":\"0000-0003-4569-7887\"}] |
| datacite.contributors.contributor.contributorName.fl_str_mv | Biblioteca Digital do IPB |
| datacite.creators.creator.creatorName.fl_str_mv | Nemoto, Ana Oliveira, Ana Teresa Lopes Branco de Queiroz, Ana Brito, Paulo Ribeiro, António E. |
| datacite.date.Accepted.fl_str_mv | 2019-01-01T00:00:00Z |
| datacite.date.available.fl_str_mv | 2020-01-21T11:44:03Z |
| datacite.date.embargoed.fl_str_mv | 2020-01-21T11:44:03Z |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| datacite.titles.title.fl_str_mv | Monitoring of non-steroidal anti-inflammatory drugs in hydric media from the Bragança region |
| dc.contributor.none.fl_str_mv | Biblioteca Digital do IPB |
| dc.creator.none.fl_str_mv | Nemoto, Ana Oliveira, Ana Teresa Lopes Branco de Queiroz, Ana Brito, Paulo Ribeiro, António E. |
| dc.date.Accepted.fl_str_mv | 2019-01-01T00:00:00Z |
| dc.date.available.fl_str_mv | 2020-01-21T11:44:03Z |
| dc.date.embargoed.fl_str_mv | 2020-01-21T11:44:03Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | http://hdl.handle.net/10198/20447 |
| dc.language.none.fl_str_mv | eng |
| dc.publisher.none.fl_str_mv | Sociedade Portuguesa de Química |
| dc.rights.cclincense.fl_str_mv | http://creativecommons.org/licenses/by-nc/4.0/ |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| dc.title.fl_str_mv | Monitoring of non-steroidal anti-inflammatory drugs in hydric media from the Bragança region |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_c94f |
| description | Emerging micropollutants are substances found in the environment in very low concentrations, at scales ranging from nanograms to micrograms per liter. Usually, wastewater treatment plants are not designed with the purpose of removing these pollutants. Non-steroidal anti-inflammatory drugs (NSAIDs) are some of the most prescribed drugs worldwide in order to relief pain and inflammatory conditions. Several studies report the presence of these pharmaceuticals in different aqueous matrices. Therefore, in this work will be presented an extensive set of experimental results obtained for the development and validation of a complete methodology used to identify and quantify five selected NSAIDs (acetylsalicylic acid, diclofenac, ibuprofen, ketoprofen and naproxen) in samples collected from different hydric media of the Bragança region, northern Portugal. Experimental results includes the optimization of solid phase extraction (SPE) and high performance liquid chromatography with diode array detector (HPLC-DAD) operating conditions, namely, SPE recoveries, HPLC mobile phase composition and pH based on different acetonitrile/water/trifluoroacetic acid contents under isocratic or gradient modes, and optimum wavelengths to improve limits of detection and quantification, among others. The SPE extraction is performed using Chromabond® HLB cartridges, and the optimized extraction process resulted in mass recovery values between 86.5% and 99.3%. After SPE extraction the samples were analyzed by HPLC-DAD using a C18 column, a 60%acetonitrile:40%water:0.01%trifluoroacetic acid solvent composition and a flow-rate of 1.2 mL/min. The selected wavelengths were 219 nm for ibuprofen, 224 nm for acetylsalicylic acid and naproxen, 254 nm for ketoprofen and 275 nm for diclofenac. The experimental methodology was validated using real samples from different aqueous matrices collected in the Bragança region. |
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| eu_rights_str_mv | openAccess |
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| institution | Instituto Politécnico de Bragança |
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| language | eng |
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| person_str_mv | Nemoto, Ana Oliveira, Ana Teresa Lopes Branco de Queiroz, Ana Queiroz, Ana https://www.ciencia-id.pt/2611-D40C-3472 2611-D40C-3472 http://orcid.org/0000-0003-4761-0618 0000-0003-4761-0618 Brito, Paulo Brito, Paulo https://www.ciencia-id.pt/A31A-D845-A6E2 A31A-D845-A6E2 http://orcid.org/0000-0003-1805-0252 0000-0003-1805-0252 Ribeiro, António E. Ribeiro, António E. https://www.ciencia-id.pt/3211-D5B0-870D 3211-D5B0-870D http://orcid.org/0000-0003-4569-7887 0000-0003-4569-7887 |
| publishDate | 2019 |
| publisher.none.fl_str_mv | Sociedade Portuguesa de Química |
| reponame_str | Biblioteca Digital do IPB |
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| spelling | engSociedade Portuguesa de Químicapt_PTEmerging micropollutants are substances found in the environment in very low concentrations, at scales ranging from nanograms to micrograms per liter. Usually, wastewater treatment plants are not designed with the purpose of removing these pollutants. Non-steroidal anti-inflammatory drugs (NSAIDs) are some of the most prescribed drugs worldwide in order to relief pain and inflammatory conditions. Several studies report the presence of these pharmaceuticals in different aqueous matrices. Therefore, in this work will be presented an extensive set of experimental results obtained for the development and validation of a complete methodology used to identify and quantify five selected NSAIDs (acetylsalicylic acid, diclofenac, ibuprofen, ketoprofen and naproxen) in samples collected from different hydric media of the Bragança region, northern Portugal. Experimental results includes the optimization of solid phase extraction (SPE) and high performance liquid chromatography with diode array detector (HPLC-DAD) operating conditions, namely, SPE recoveries, HPLC mobile phase composition and pH based on different acetonitrile/water/trifluoroacetic acid contents under isocratic or gradient modes, and optimum wavelengths to improve limits of detection and quantification, among others. The SPE extraction is performed using Chromabond® HLB cartridges, and the optimized extraction process resulted in mass recovery values between 86.5% and 99.3%. After SPE extraction the samples were analyzed by HPLC-DAD using a C18 column, a 60%acetonitrile:40%water:0.01%trifluoroacetic acid solvent composition and a flow-rate of 1.2 mL/min. The selected wavelengths were 219 nm for ibuprofen, 224 nm for acetylsalicylic acid and naproxen, 254 nm for ketoprofen and 275 nm for diclofenac. The experimental methodology was validated using real samples from different aqueous matrices collected in the Bragança region.application/pdfpt_PTMonitoring of non-steroidal anti-inflammatory drugs in hydric media from the Bragança regionNemoto, AnaOliveira, Ana Teresa Lopes Branco dePersonalQueiroz, AnaDSpacehttp://dspace.org/items/508436a2-5db1-481e-9c48-eab160333d61DSpacehttp://dspace.org/items/508436a2-5db1-481e-9c48-eab160333d61QueirozAnaCiência IDhttps://www.ciencia-id.pt2611-D40C-3472ORCIDhttp://orcid.org0000-0003-4761-0618Researcher IDhttps://www.researcherid.comO-8367-2015PersonalBrito, PauloDSpacehttp://dspace.org/items/0370deac-dc4e-4b3d-8e1f-fc2d117794d2DSpacehttp://dspace.org/items/0370deac-dc4e-4b3d-8e1f-fc2d117794d2BritoPauloCiência IDhttps://www.ciencia-id.ptA31A-D845-A6E2ORCIDhttp://orcid.org0000-0003-1805-0252Scopus Author IDhttps://www.scopus.com31168231800PersonalRibeiro, António E.DSpacehttp://dspace.org/items/52666376-f100-4407-87ef-dc5df3613761DSpacehttp://dspace.org/items/52666376-f100-4407-87ef-dc5df3613761RibeiroAntónio E.Ciência IDhttps://www.ciencia-id.pt3211-D5B0-870DORCIDhttp://orcid.org0000-0003-4569-7887Scopus Author IDhttps://www.scopus.com23390701300Scopus Author IDhttps://www.scopus.com57202082018HostingInstitutionOrganizationalBiblioteca Digital do IPBe-mailmailto:dspace@ipb.ptdspace@ipb.ptISBNIsPartOf978-989-8124-28-92020-01-21T11:44:03Z20192019-01-01T00:00:00ZHandlehttp://hdl.handle.net/10198/20447http://purl.org/coar/access_right/c_abf2open access762667 bytesother research producthttp://purl.org/coar/resource_type/c_c94fconference object2019http://creativecommons.org/licenses/by-nc/4.0/http://purl.org/coar/access_right/c_abf2application/pdffulltexthttps://bibliotecadigital.ipb.pt/bitstreams/50385803-4069-405e-b884-4adde5bf9a8a/downloadXXVI Encontro Nacional da Sociedade Portuguesa de Química230Porto |
| spellingShingle | Monitoring of non-steroidal anti-inflammatory drugs in hydric media from the Bragança region Nemoto, Ana |
| status | SINGLETON |
| title | Monitoring of non-steroidal anti-inflammatory drugs in hydric media from the Bragança region |
| title_full | Monitoring of non-steroidal anti-inflammatory drugs in hydric media from the Bragança region |
| title_fullStr | Monitoring of non-steroidal anti-inflammatory drugs in hydric media from the Bragança region |
| title_full_unstemmed | Monitoring of non-steroidal anti-inflammatory drugs in hydric media from the Bragança region |
| title_short | Monitoring of non-steroidal anti-inflammatory drugs in hydric media from the Bragança region |
| title_sort | Monitoring of non-steroidal anti-inflammatory drugs in hydric media from the Bragança region |
| url | http://hdl.handle.net/10198/20447 |
| visible | 1 |