Publicação
Inhibitory Effects of Aqueous and Hydroalcoholic Extracts from Jatobá Coat (Hymenaea courbaril L.) on Pancreatic Amylase and Starch Absorption
| Resumo: | Jatobá (Hymenaea courbaril) is a native tree abundant in Brazil. The fruit coat is an industrial by-product of jatobá flour processing, typically discarded. Presently, within the circular bioeconomy concept, there are efforts underway that aim at finding economically viable applications for the bio-residues of jatobá. Within this context, the present work attempts to find possible applications for the jatobá coat in glycemic control through inhibition of α-amylase activity. Aqueous and hydroethanolic extracts were used. In vitro experiments included detailed kinetic studies with an α-amylase catalyzed reaction. Starch absorption in vivo was assessed by means of a starch tolerance test in mice. Both extracts inhibited α-amylase. The IC50 values for the aqueous and hydroalcoholic extracts were 81.98 ± 3.53 µg/mL and 51.06 ± 0.42 µg/mL, respectively. The inhibition was of the non-competitive type. Both extracts reduced hyperglycemia caused by starch administration in mice, the aqueous extract being effective over a larger dose range. This action can be attributed to the α-amylase inhibition. In silico studies suggested that procyanidin dimers, taxifolin 7-O-rhamnoside, and quercetin 7-rhamnoside contribute, but several other not-yet-identified substances may be involved. The findings suggest that aqueous and hydroalcoholic extracts from jatobá coat warrant further investigations as potential modulators of glycemia following starch ingestion. |
|---|---|
| Autores principais: | Polo, Ana Caroline |
| Outros Autores: | Uber, Thaís Marques; Souza, Gustavo Henrique; Corrêa, Rúbia C.G.; Santos Filho, José Rivaldo dos; Sá-Nakanishi, Anacharis Babeto de; Seixas, Flávio Augusto Vicente; Bracht, Adelar; Peralta, Rosane Marina |
| Assunto: | Diabetes α-amylase inhibition Starch absorption Glycemia Tannins |
| Ano: | 2025 |
| País: | Portugal |
| Tipo de documento: | artigo |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Instituto Politécnico de Bragança |
| Idioma: | inglês |
| Origem: | Biblioteca Digital do IPB |
| _version_ | 1867172879196487680 |
|---|---|
| author | Polo, Ana Caroline |
| author2 | Uber, Thaís Marques Souza, Gustavo Henrique Corrêa, Rúbia C.G. Santos Filho, José Rivaldo dos Sá-Nakanishi, Anacharis Babeto de Seixas, Flávio Augusto Vicente Bracht, Adelar Peralta, Rosane Marina |
| author2_role | author author author author author author author author |
| author_facet | Polo, Ana Caroline Uber, Thaís Marques Souza, Gustavo Henrique Corrêa, Rúbia C.G. Santos Filho, José Rivaldo dos Sá-Nakanishi, Anacharis Babeto de Seixas, Flávio Augusto Vicente Bracht, Adelar Peralta, Rosane Marina |
| author_role | author |
| contributor_name_str_mv | Biblioteca Digital do IPB |
| country_str | PT |
| creators_json_txt | [{\"Person.name\":\"Polo, Ana Caroline\"},{\"Person.name\":\"Uber, Thaís Marques\"},{\"Person.name\":\"Souza, Gustavo Henrique\"},{\"Person.name\":\"Corrêa, Rúbia C.G.\",\"Person.identifier.orcid\":\"0000-0003-0269-4344\"},{\"Person.name\":\"Santos Filho, José Rivaldo dos\"},{\"Person.name\":\"Sá-Nakanishi, Anacharis Babeto de\"},{\"Person.name\":\"Seixas, Flávio Augusto Vicente\"},{\"Person.name\":\"Bracht, Adelar\"},{\"Person.name\":\"Peralta, Rosane Marina\"}] |
| datacite.contributors.contributor.contributorName.fl_str_mv | Biblioteca Digital do IPB |
| datacite.creators.creator.creatorName.fl_str_mv | Polo, Ana Caroline Uber, Thaís Marques Souza, Gustavo Henrique Corrêa, Rúbia C.G. Santos Filho, José Rivaldo dos Sá-Nakanishi, Anacharis Babeto de Seixas, Flávio Augusto Vicente Bracht, Adelar Peralta, Rosane Marina |
| datacite.date.Accepted.fl_str_mv | 2025-01-01T00:00:00Z |
| datacite.date.available.fl_str_mv | 2025-05-30T08:20:49Z |
| datacite.date.embargoed.fl_str_mv | 2025-05-30T08:20:49Z |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| datacite.subjects.subject.fl_str_mv | Diabetes α-amylase inhibition Starch absorption Glycemia Tannins |
| datacite.titles.title.fl_str_mv | Inhibitory Effects of Aqueous and Hydroalcoholic Extracts from Jatobá Coat (Hymenaea courbaril L.) on Pancreatic Amylase and Starch Absorption |
| dc.contributor.none.fl_str_mv | Biblioteca Digital do IPB |
| dc.creator.none.fl_str_mv | Polo, Ana Caroline Uber, Thaís Marques Souza, Gustavo Henrique Corrêa, Rúbia C.G. Santos Filho, José Rivaldo dos Sá-Nakanishi, Anacharis Babeto de Seixas, Flávio Augusto Vicente Bracht, Adelar Peralta, Rosane Marina |
| dc.date.Accepted.fl_str_mv | 2025-01-01T00:00:00Z |
| dc.date.available.fl_str_mv | 2025-05-30T08:20:49Z |
| dc.date.embargoed.fl_str_mv | 2025-05-30T08:20:49Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | http://hdl.handle.net/10198/34518 |
| dc.language.none.fl_str_mv | eng |
| dc.publisher.none.fl_str_mv | MDPI |
| dc.rights.cclincense.fl_str_mv | http://creativecommons.org/licenses/by/4.0/ |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| dc.subject.none.fl_str_mv | Diabetes α-amylase inhibition Starch absorption Glycemia Tannins |
| dc.title.fl_str_mv | Inhibitory Effects of Aqueous and Hydroalcoholic Extracts from Jatobá Coat (Hymenaea courbaril L.) on Pancreatic Amylase and Starch Absorption |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_6501 |
| description | Jatobá (Hymenaea courbaril) is a native tree abundant in Brazil. The fruit coat is an industrial by-product of jatobá flour processing, typically discarded. Presently, within the circular bioeconomy concept, there are efforts underway that aim at finding economically viable applications for the bio-residues of jatobá. Within this context, the present work attempts to find possible applications for the jatobá coat in glycemic control through inhibition of α-amylase activity. Aqueous and hydroethanolic extracts were used. In vitro experiments included detailed kinetic studies with an α-amylase catalyzed reaction. Starch absorption in vivo was assessed by means of a starch tolerance test in mice. Both extracts inhibited α-amylase. The IC50 values for the aqueous and hydroalcoholic extracts were 81.98 ± 3.53 µg/mL and 51.06 ± 0.42 µg/mL, respectively. The inhibition was of the non-competitive type. Both extracts reduced hyperglycemia caused by starch administration in mice, the aqueous extract being effective over a larger dose range. This action can be attributed to the α-amylase inhibition. In silico studies suggested that procyanidin dimers, taxifolin 7-O-rhamnoside, and quercetin 7-rhamnoside contribute, but several other not-yet-identified substances may be involved. The findings suggest that aqueous and hydroalcoholic extracts from jatobá coat warrant further investigations as potential modulators of glycemia following starch ingestion. |
| dirty | 0 |
| eu_rights_str_mv | openAccess |
| format | article |
| fulltext.url.fl_str_mv | https://bibliotecadigital.ipb.pt/bitstreams/7e04f2cd-681c-4aee-b41d-b69f58a0abad/download |
| id | ipb_0da7cf87e0b00a3ccce3bc08969e7650 |
| identifier.url.fl_str_mv | http://hdl.handle.net/10198/34518 |
| instacron_str | ipb |
| institution | Instituto Politécnico de Bragança |
| instname_str | Instituto Politécnico de Bragança |
| language | eng |
| network_acronym_str | ipb |
| network_name_str | Biblioteca Digital do IPB |
| oai_identifier_str | oai:bibliotecadigital.ipb.pt:10198/34518 |
| organization_str_mv | urn:organizationAcronym:ipb |
| person_str_mv | Polo, Ana Caroline Uber, Thaís Marques Souza, Gustavo Henrique Corrêa, Rúbia C.G. Corrêa, Rúbia C.G. https://www.ciencia-id.pt/6C1F-2818-CBB5 6C1F-2818-CBB5 http://orcid.org/0000-0003-0269-4344 0000-0003-0269-4344 Santos Filho, José Rivaldo dos Sá-Nakanishi, Anacharis Babeto de Seixas, Flávio Augusto Vicente Bracht, Adelar Peralta, Rosane Marina |
| publishDate | 2025 |
| publisher.none.fl_str_mv | MDPI |
| reponame_str | Biblioteca Digital do IPB |
| repository_id_str | urn:repositoryAcronym:ipb |
| service_str_mv | urn:repositoryAcronym:ipb |
| spelling | engMDPIengJatobá (Hymenaea courbaril) is a native tree abundant in Brazil. The fruit coat is an industrial by-product of jatobá flour processing, typically discarded. Presently, within the circular bioeconomy concept, there are efforts underway that aim at finding economically viable applications for the bio-residues of jatobá. Within this context, the present work attempts to find possible applications for the jatobá coat in glycemic control through inhibition of α-amylase activity. Aqueous and hydroethanolic extracts were used. In vitro experiments included detailed kinetic studies with an α-amylase catalyzed reaction. Starch absorption in vivo was assessed by means of a starch tolerance test in mice. Both extracts inhibited α-amylase. The IC50 values for the aqueous and hydroalcoholic extracts were 81.98 ± 3.53 µg/mL and 51.06 ± 0.42 µg/mL, respectively. The inhibition was of the non-competitive type. Both extracts reduced hyperglycemia caused by starch administration in mice, the aqueous extract being effective over a larger dose range. This action can be attributed to the α-amylase inhibition. In silico studies suggested that procyanidin dimers, taxifolin 7-O-rhamnoside, and quercetin 7-rhamnoside contribute, but several other not-yet-identified substances may be involved. The findings suggest that aqueous and hydroalcoholic extracts from jatobá coat warrant further investigations as potential modulators of glycemia following starch ingestion.application/pdfengInhibitory Effects of Aqueous and Hydroalcoholic Extracts from Jatobá Coat (Hymenaea courbaril L.) on Pancreatic Amylase and Starch AbsorptionPolo, Ana CarolineUber, Thaís MarquesSouza, Gustavo HenriquePersonalCorrêa, Rúbia C.G.DSpacehttp://dspace.org/items/35cf5f0f-d5bc-49ad-9704-e6613e60f0fcDSpacehttp://dspace.org/items/35cf5f0f-d5bc-49ad-9704-e6613e60f0fcCorrêaRúbia C.G.Ciência IDhttps://www.ciencia-id.pt6C1F-2818-CBB5ORCIDhttp://orcid.org0000-0003-0269-4344Scopus Author IDhttps://www.scopus.com37661286600Santos Filho, José Rivaldo dosSá-Nakanishi, Anacharis Babeto deSeixas, Flávio Augusto VicenteBracht, AdelarPeralta, Rosane MarinaHostingInstitutionOrganizationalBiblioteca Digital do IPBe-mailmailto:dspace@ipb.ptdspace@ipb.ptISSNIsPartOf2223-7747DOIIsPartOf10.3390/plants140711332025-05-30T08:20:49Z20252025-01-01T00:00:00ZHandlehttp://hdl.handle.net/10198/34518http://purl.org/coar/access_right/c_abf2open accessDiabetesα-amylase inhibitionStarch absorptionGlycemiaTannins3707286 bytesliteraturehttp://purl.org/coar/resource_type/c_6501journal article2025http://creativecommons.org/licenses/by/4.0/http://purl.org/coar/access_right/c_abf2application/pdffulltexthttps://bibliotecadigital.ipb.pt/bitstreams/7e04f2cd-681c-4aee-b41d-b69f58a0abad/downloadPlants147119 |
| spellingShingle | Inhibitory Effects of Aqueous and Hydroalcoholic Extracts from Jatobá Coat (Hymenaea courbaril L.) on Pancreatic Amylase and Starch Absorption Polo, Ana Caroline Diabetes α-amylase inhibition Starch absorption Glycemia Tannins |
| status | SINGLETON |
| subject.fl_str_mv | Diabetes α-amylase inhibition Starch absorption Glycemia Tannins |
| title | Inhibitory Effects of Aqueous and Hydroalcoholic Extracts from Jatobá Coat (Hymenaea courbaril L.) on Pancreatic Amylase and Starch Absorption |
| title_full | Inhibitory Effects of Aqueous and Hydroalcoholic Extracts from Jatobá Coat (Hymenaea courbaril L.) on Pancreatic Amylase and Starch Absorption |
| title_fullStr | Inhibitory Effects of Aqueous and Hydroalcoholic Extracts from Jatobá Coat (Hymenaea courbaril L.) on Pancreatic Amylase and Starch Absorption |
| title_full_unstemmed | Inhibitory Effects of Aqueous and Hydroalcoholic Extracts from Jatobá Coat (Hymenaea courbaril L.) on Pancreatic Amylase and Starch Absorption |
| title_short | Inhibitory Effects of Aqueous and Hydroalcoholic Extracts from Jatobá Coat (Hymenaea courbaril L.) on Pancreatic Amylase and Starch Absorption |
| title_sort | Inhibitory Effects of Aqueous and Hydroalcoholic Extracts from Jatobá Coat (Hymenaea courbaril L.) on Pancreatic Amylase and Starch Absorption |
| topic | Diabetes α-amylase inhibition Starch absorption Glycemia Tannins |
| topic_facet | Diabetes α-amylase inhibition Starch absorption Glycemia Tannins |
| url | http://hdl.handle.net/10198/34518 |
| visible | 1 |