Publicação
The health-benefits and phytochemical profile of Salvia apiana and Salvia farinacea var. Victoria blue decoctions
| Resumo: | Salvia apiana and Salvia farinacea var. Victoria Blue decoctions were screened for diverse bioactivities, including the ability to counteract oxidative and inflammatory events, as well as to act as cytotoxic and antimicrobial agents. Both extracts showed good activities and that of S. apiana origin was particularly effective regarding the ability to prevent lipid peroxidation and to prevent nitric oxide (NO ) production in lipopolysaccharide (LPS)-activated murine macrophage RAW 264.7 cell line (EC50 = 50 µg/mL). Moreover, it displayed high cytotoxic capacity against hepatocellular carcinoma HepG2, cervical carcinoma HeLa, and breast carcinoma cells MCF-7, but comparatively low effects in porcine liver primary cells, which highlights its selectivity (GI50 = 41–60 µg/mL vs. 362 µg/mL, respectively). Further, it exhibited inhibitory and lethal potential against a panel of Gram-positive and Gram-negative bacteria. It is possible that the bioactive properties of the two Salvia extracts are associated to their phenolic components and, in the particular case of S. apiana, to its richness in phenolic terpenes, namely in rosmanol, hydroxycarnosic acid and a derivative of sageone, which were found in the extract. |
|---|---|
| Autores principais: | Afonso, Andrea Luísa Fernandes |
| Outros Autores: | Pereira, Olívia R.; Fernandes, Ângela; Calhelha, Ricardo C.; Silva, Artur; Ferreira, Isabel C.F.R.; Cardoso, Susana M. |
| Assunto: | Sage Bioactivity Antioxidants Anti-inflammatory Cytotoxicity Antibacterial Phenolic compounds Terpenes |
| Ano: | 2019 |
| País: | Portugal |
| Tipo de documento: | artigo |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Instituto Politécnico de Bragança |
| Idioma: | inglês |
| Origem: | Biblioteca Digital do IPB |
| _version_ | 1863851379364200448 |
|---|---|
| author | Afonso, Andrea Luísa Fernandes |
| author2 | Pereira, Olívia R. Fernandes, Ângela Calhelha, Ricardo C. Silva, Artur Ferreira, Isabel C.F.R. Cardoso, Susana M. |
| author2_role | author author author author author author |
| author_facet | Afonso, Andrea Luísa Fernandes Pereira, Olívia R. Fernandes, Ângela Calhelha, Ricardo C. Silva, Artur Ferreira, Isabel C.F.R. Cardoso, Susana M. |
| author_role | author |
| contributor_name_str_mv | Biblioteca Digital do IPB |
| country_str | PT |
| creators_json_str | [{\"Person.name\":\"Afonso, Andrea Luísa Fernandes\",\"Person.identifier.orcid\":\"0000-0002-8858-1617\"},{\"Person.name\":\"Pereira, Olívia R.\",\"Person.identifier.orcid\":\"0000-0002-6275-3134\"},{\"Person.name\":\"Fernandes, Ângela\",\"Person.identifier.orcid\":\"0000-0002-0157-9873\"},{\"Person.name\":\"Calhelha, Ricardo C.\",\"Person.identifier.orcid\":\"0000-0002-6801-4578\"},{\"Person.name\":\"Silva, Artur\"},{\"Person.name\":\"Ferreira, Isabel C.F.R.\",\"Person.identifier.orcid\":\"0000-0003-4910-4882\"},{\"Person.name\":\"Cardoso, Susana M.\"}] |
| datacite.contributors.contributor.contributorName.fl_str_mv | Biblioteca Digital do IPB |
| datacite.creators.creator.creatorName.fl_str_mv | Afonso, Andrea Luísa Fernandes Pereira, Olívia R. Fernandes, Ângela Calhelha, Ricardo C. Silva, Artur Ferreira, Isabel C.F.R. Cardoso, Susana M. |
| datacite.date.Accepted.fl_str_mv | 2019-01-01T00:00:00Z |
| datacite.date.available.fl_str_mv | 2019-07-30T11:17:46Z |
| datacite.date.embargoed.fl_str_mv | 2019-07-30T11:17:46Z |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| datacite.subjects.subject.fl_str_mv | Sage Bioactivity Antioxidants Anti-inflammatory Cytotoxicity Antibacterial Phenolic compounds Terpenes |
| datacite.titles.title.fl_str_mv | The health-benefits and phytochemical profile of Salvia apiana and Salvia farinacea var. Victoria blue decoctions |
| dc.contributor.none.fl_str_mv | Biblioteca Digital do IPB |
| dc.creator.none.fl_str_mv | Afonso, Andrea Luísa Fernandes Pereira, Olívia R. Fernandes, Ângela Calhelha, Ricardo C. Silva, Artur Ferreira, Isabel C.F.R. Cardoso, Susana M. |
| dc.date.Accepted.fl_str_mv | 2019-01-01T00:00:00Z |
| dc.date.available.fl_str_mv | 2019-07-30T11:17:46Z |
| dc.date.embargoed.fl_str_mv | 2019-07-30T11:17:46Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | http://hdl.handle.net/10198/19458 |
| dc.language.none.fl_str_mv | eng |
| dc.publisher.none.fl_str_mv | MDPI |
| dc.rights.cclincense.fl_str_mv | http://creativecommons.org/licenses/by/4.0/ |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| dc.subject.none.fl_str_mv | Sage Bioactivity Antioxidants Anti-inflammatory Cytotoxicity Antibacterial Phenolic compounds Terpenes |
| dc.title.fl_str_mv | The health-benefits and phytochemical profile of Salvia apiana and Salvia farinacea var. Victoria blue decoctions |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_6501 |
| description | Salvia apiana and Salvia farinacea var. Victoria Blue decoctions were screened for diverse bioactivities, including the ability to counteract oxidative and inflammatory events, as well as to act as cytotoxic and antimicrobial agents. Both extracts showed good activities and that of S. apiana origin was particularly effective regarding the ability to prevent lipid peroxidation and to prevent nitric oxide (NO ) production in lipopolysaccharide (LPS)-activated murine macrophage RAW 264.7 cell line (EC50 = 50 µg/mL). Moreover, it displayed high cytotoxic capacity against hepatocellular carcinoma HepG2, cervical carcinoma HeLa, and breast carcinoma cells MCF-7, but comparatively low effects in porcine liver primary cells, which highlights its selectivity (GI50 = 41–60 µg/mL vs. 362 µg/mL, respectively). Further, it exhibited inhibitory and lethal potential against a panel of Gram-positive and Gram-negative bacteria. It is possible that the bioactive properties of the two Salvia extracts are associated to their phenolic components and, in the particular case of S. apiana, to its richness in phenolic terpenes, namely in rosmanol, hydroxycarnosic acid and a derivative of sageone, which were found in the extract. |
| dirty | 0 |
| eu_rights_str_mv | openAccess |
| format | article |
| fulltext.url.fl_str_mv | https://bibliotecadigital.ipb.pt/bitstreams/0f5553b0-fa3c-45cf-997c-0aacd50c7ea5/download |
| funding.funder.alternateName_str_mv | FCT |
| funding.funder.identifier_str_mv | http://doi.org/10.13039/501100001871 |
| funding.funder.name_str_mv | Fundação para a Ciência e a Tecnologia |
| funding.name_str_mv | 6817 - DCRRNI ID |
| id | ipb_0db09b36df54f8a1384bb82ebb7934a2 |
| identifier.url.fl_str_mv | http://hdl.handle.net/10198/19458 |
| instacron_str | ipb |
| institution | Instituto Politécnico de Bragança |
| instname_str | Instituto Politécnico de Bragança |
| language | eng |
| network_acronym_str | ipb |
| network_name_str | Biblioteca Digital do IPB |
| oai_identifier_str | oai:bibliotecadigital.ipb.pt:10198/19458 |
| organization_str_mv | urn:organizationAcronym:ipb |
| person_str_mv | Afonso, Andrea Luísa Fernandes Afonso, Andrea Luísa Fernandes https://www.ciencia-id.pt/9C1D-41E7-9BBF 9C1D-41E7-9BBF http://orcid.org/0000-0002-8858-1617 0000-0002-8858-1617 Pereira, Olívia R. Pereira, Olívia R. https://www.ciencia-id.pt/B312-AF21-D2FA B312-AF21-D2FA http://orcid.org/0000-0002-6275-3134 0000-0002-6275-3134 Fernandes, Ângela Fernandes, Ângela https://www.ciencia-id.pt/2015-0434-AE7C 2015-0434-AE7C http://orcid.org/0000-0002-0157-9873 0000-0002-0157-9873 Calhelha, Ricardo C. Calhelha, Ricardo C. https://www.ciencia-id.pt/F313-E3CE-554E F313-E3CE-554E http://orcid.org/0000-0002-6801-4578 0000-0002-6801-4578 Silva, Artur Ferreira, Isabel C.F.R. Ferreira, Isabel C.F.R. https://www.ciencia-id.pt/9418-CF95-9919 9418-CF95-9919 http://orcid.org/0000-0003-4910-4882 0000-0003-4910-4882 Cardoso, Susana M. |
| publishDate | 2019 |
| publisher.none.fl_str_mv | MDPI |
| reponame_str | Biblioteca Digital do IPB |
| repository_id_str | urn:repositoryAcronym:ipb |
| service_str_mv | urn:repositoryAcronym:ipb |
| spelling | engMDPIpt_PTSalvia apiana and Salvia farinacea var. Victoria Blue decoctions were screened for diverse bioactivities, including the ability to counteract oxidative and inflammatory events, as well as to act as cytotoxic and antimicrobial agents. Both extracts showed good activities and that of S. apiana origin was particularly effective regarding the ability to prevent lipid peroxidation and to prevent nitric oxide (NO ) production in lipopolysaccharide (LPS)-activated murine macrophage RAW 264.7 cell line (EC50 = 50 µg/mL). Moreover, it displayed high cytotoxic capacity against hepatocellular carcinoma HepG2, cervical carcinoma HeLa, and breast carcinoma cells MCF-7, but comparatively low effects in porcine liver primary cells, which highlights its selectivity (GI50 = 41–60 µg/mL vs. 362 µg/mL, respectively). Further, it exhibited inhibitory and lethal potential against a panel of Gram-positive and Gram-negative bacteria. It is possible that the bioactive properties of the two Salvia extracts are associated to their phenolic components and, in the particular case of S. apiana, to its richness in phenolic terpenes, namely in rosmanol, hydroxycarnosic acid and a derivative of sageone, which were found in the extract.application/pdfpt_PTThe health-benefits and phytochemical profile of Salvia apiana and Salvia farinacea var. Victoria blue decoctionsPersonalAfonso, Andrea Luísa FernandesDSpacehttp://dspace.org/items/af7d647c-f5a6-48f7-afcf-6307c3677b1dDSpacehttp://dspace.org/items/af7d647c-f5a6-48f7-afcf-6307c3677b1dAfonsoAndrea Luísa FernandesCiência IDhttps://www.ciencia-id.pt9C1D-41E7-9BBFORCIDhttp://orcid.org0000-0002-8858-1617Scopus Author IDhttps://www.scopus.com36766901000PersonalPereira, Olívia R.DSpacehttp://dspace.org/items/e8fdab9a-3ad6-47e6-b90c-7a37aabcb453DSpacehttp://dspace.org/items/e8fdab9a-3ad6-47e6-b90c-7a37aabcb453PereiraOlívia R.Ciência IDhttps://www.ciencia-id.ptB312-AF21-D2FAORCIDhttp://orcid.org0000-0002-6275-3134Researcher IDhttps://www.researcherid.comH-1049-2014Scopus Author IDhttps://www.scopus.com52264387000PersonalFernandes, ÂngelaDSpacehttp://dspace.org/items/6233e657-3885-40a3-885e-0d51cf4dbaadDSpacehttp://dspace.org/items/6233e657-3885-40a3-885e-0d51cf4dbaadFernandesÂngelaCiência IDhttps://www.ciencia-id.pt2015-0434-AE7CORCIDhttp://orcid.org0000-0002-0157-9873PersonalCalhelha, Ricardo C.DSpacehttp://dspace.org/items/2d5d1a41-7561-4a01-871c-b4c97da35053DSpacehttp://dspace.org/items/2d5d1a41-7561-4a01-871c-b4c97da35053CalhelhaRicardo C.Ciência IDhttps://www.ciencia-id.ptF313-E3CE-554EORCIDhttp://orcid.org0000-0002-6801-4578Researcher IDhttps://www.researcherid.comJ-2172-2014Scopus Author IDhttps://www.scopus.com6507978333Silva, ArturPersonalFerreira, Isabel C.F.R.DSpacehttp://dspace.org/items/bd0d1537-2e03-41fb-b27a-140af9c35db8DSpacehttp://dspace.org/items/bd0d1537-2e03-41fb-b27a-140af9c35db8FerreiraIsabel C.F.R.Ciência IDhttps://www.ciencia-id.pt9418-CF95-9919ORCIDhttp://orcid.org0000-0003-4910-4882Researcher IDhttps://www.researcherid.comE-8500-2013Scopus Author IDhttps://www.scopus.com36868826600Cardoso, Susana M.HostingInstitutionOrganizationalBiblioteca Digital do IPBe-mailmailto:dspace@ipb.ptdspace@ipb.ptISSNIsPartOf2076-3921DOIIsPartOf10.3390/antiox80802412019-07-30T11:17:46Z20192019-01-01T00:00:00ZHandlehttp://hdl.handle.net/10198/19458http://purl.org/coar/access_right/c_abf2open accessSageBioactivityAntioxidantsAnti-inflammatoryCytotoxicityAntibacterialPhenolic compoundsTerpenes599062 bytesFundação para a Ciência e a TecnologiaOrganic Chemistry, Natural Products and Food Stuffs6817 - DCRRNI IDCrossref Funder IDhttp://doi.org/10.13039/501100001871literaturehttp://purl.org/coar/resource_type/c_6501journal article2019http://creativecommons.org/licenses/by/4.0/http://purl.org/coar/access_right/c_abf2application/pdffulltexthttps://bibliotecadigital.ipb.pt/bitstreams/0f5553b0-fa3c-45cf-997c-0aacd50c7ea5/downloadAntioxidants88114Basel, Switzerland |
| spellingShingle | The health-benefits and phytochemical profile of Salvia apiana and Salvia farinacea var. Victoria blue decoctions Afonso, Andrea Luísa Fernandes Sage Bioactivity Antioxidants Anti-inflammatory Cytotoxicity Antibacterial Phenolic compounds Terpenes |
| subject.fl_str_mv | Sage Bioactivity Antioxidants Anti-inflammatory Cytotoxicity Antibacterial Phenolic compounds Terpenes |
| title | The health-benefits and phytochemical profile of Salvia apiana and Salvia farinacea var. Victoria blue decoctions |
| title_full | The health-benefits and phytochemical profile of Salvia apiana and Salvia farinacea var. Victoria blue decoctions |
| title_fullStr | The health-benefits and phytochemical profile of Salvia apiana and Salvia farinacea var. Victoria blue decoctions |
| title_full_unstemmed | The health-benefits and phytochemical profile of Salvia apiana and Salvia farinacea var. Victoria blue decoctions |
| title_short | The health-benefits and phytochemical profile of Salvia apiana and Salvia farinacea var. Victoria blue decoctions |
| title_sort | The health-benefits and phytochemical profile of Salvia apiana and Salvia farinacea var. Victoria blue decoctions |
| topic | Sage Bioactivity Antioxidants Anti-inflammatory Cytotoxicity Antibacterial Phenolic compounds Terpenes |
| topic_facet | Sage Bioactivity Antioxidants Anti-inflammatory Cytotoxicity Antibacterial Phenolic compounds Terpenes |
| url | http://hdl.handle.net/10198/19458 |
| visible | 1 |