Publicação
Bioactivity evaluation of four technical lignins: Alcell, Indulin-AT, Sarkanda and Curan 27-11P
| Resumo: | In what concerns bioactive properties, and due to its phenolic character, lignin is mostly studied for their antioxidant activity. In this work four technical lignins (Alcell, Indulin-AT, Sarkanda and Curan 27-11P) have been evaluated for their antioxidant activity (DPPH radical scavenging activity, reducing power and inhibition of β-carotene bleaching) and antitumor potential against MCF-7, NCI-H460, HCT-15, HeLa and HepG2 cell lines. Additionally, the toxicity for non-tumour cells (PLP2) was also evaluated. The obtained results were correlated with the chemical and structural features of the studied lignins. Based on the achieved results, lignins of GS type, i.e. lignins rich in syringyl phenol units and poor in p-hydroxyphenyl ones result in better antitumor potential. |
|---|---|
| Autores principais: | Marques, A. |
| Outros Autores: | Cateto, Carolina; Calhelha, Ricardo C.; Barros, Lillian; Queiroz, Maria João R.P.; Belgacem, Mohamed Naceur; Rodrigues, Alírio; Ferreira, Isabel C.F.R.; Barreiro, M.F. |
| Ano: | 2014 |
| País: | Portugal |
| Tipo de documento: | comunicação em conferência |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Instituto Politécnico de Bragança |
| Idioma: | inglês |
| Origem: | Biblioteca Digital do IPB |
| _version_ | 1867173000606908416 |
|---|---|
| author | Marques, A. |
| author2 | Cateto, Carolina Calhelha, Ricardo C. Barros, Lillian Queiroz, Maria João R.P. Belgacem, Mohamed Naceur Rodrigues, Alírio Ferreira, Isabel C.F.R. Barreiro, M.F. |
| author2_role | author author author author author author author author |
| author_facet | Marques, A. Cateto, Carolina Calhelha, Ricardo C. Barros, Lillian Queiroz, Maria João R.P. Belgacem, Mohamed Naceur Rodrigues, Alírio Ferreira, Isabel C.F.R. Barreiro, M.F. |
| author_role | author |
| contributor_name_str_mv | Biblioteca Digital do IPB |
| country_str | PT |
| creators_json_txt | [{\"Person.name\":\"Marques, A.\"},{\"Person.name\":\"Cateto, Carolina\"},{\"Person.name\":\"Calhelha, Ricardo C.\",\"Person.identifier.orcid\":\"0000-0002-6801-4578\"},{\"Person.name\":\"Barros, Lillian\",\"Person.identifier.orcid\":\"0000-0002-9050-5189\"},{\"Person.name\":\"Queiroz, Maria João R.P.\"},{\"Person.name\":\"Belgacem, Mohamed Naceur\"},{\"Person.name\":\"Rodrigues, Alírio\"},{\"Person.name\":\"Ferreira, Isabel C.F.R.\",\"Person.identifier.orcid\":\"0000-0003-4910-4882\"},{\"Person.name\":\"Barreiro, M.F.\",\"Person.identifier.orcid\":\"0000-0002-6844-333X\"}] |
| datacite.contributors.contributor.contributorName.fl_str_mv | Biblioteca Digital do IPB |
| datacite.creators.creator.creatorName.fl_str_mv | Marques, A. Cateto, Carolina Calhelha, Ricardo C. Barros, Lillian Queiroz, Maria João R.P. Belgacem, Mohamed Naceur Rodrigues, Alírio Ferreira, Isabel C.F.R. Barreiro, M.F. |
| datacite.date.Accepted.fl_str_mv | 2014-01-01T00:00:00Z |
| datacite.date.available.fl_str_mv | 2015-10-22T15:11:43Z |
| datacite.date.embargoed.fl_str_mv | 2015-10-22T15:11:43Z |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| datacite.titles.title.fl_str_mv | Bioactivity evaluation of four technical lignins: Alcell, Indulin-AT, Sarkanda and Curan 27-11P |
| dc.contributor.none.fl_str_mv | Biblioteca Digital do IPB |
| dc.creator.none.fl_str_mv | Marques, A. Cateto, Carolina Calhelha, Ricardo C. Barros, Lillian Queiroz, Maria João R.P. Belgacem, Mohamed Naceur Rodrigues, Alírio Ferreira, Isabel C.F.R. Barreiro, M.F. |
| dc.date.Accepted.fl_str_mv | 2014-01-01T00:00:00Z |
| dc.date.available.fl_str_mv | 2015-10-22T15:11:43Z |
| dc.date.embargoed.fl_str_mv | 2015-10-22T15:11:43Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | http://hdl.handle.net/10198/12182 |
| dc.language.none.fl_str_mv | eng |
| dc.rights.cclincense.fl_str_mv | http://creativecommons.org/licenses/by/4.0/ |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| dc.title.fl_str_mv | Bioactivity evaluation of four technical lignins: Alcell, Indulin-AT, Sarkanda and Curan 27-11P |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_5794 |
| description | In what concerns bioactive properties, and due to its phenolic character, lignin is mostly studied for their antioxidant activity. In this work four technical lignins (Alcell, Indulin-AT, Sarkanda and Curan 27-11P) have been evaluated for their antioxidant activity (DPPH radical scavenging activity, reducing power and inhibition of β-carotene bleaching) and antitumor potential against MCF-7, NCI-H460, HCT-15, HeLa and HepG2 cell lines. Additionally, the toxicity for non-tumour cells (PLP2) was also evaluated. The obtained results were correlated with the chemical and structural features of the studied lignins. Based on the achieved results, lignins of GS type, i.e. lignins rich in syringyl phenol units and poor in p-hydroxyphenyl ones result in better antitumor potential. |
| dirty | 0 |
| eu_rights_str_mv | openAccess |
| format | conferencePaper |
| fulltext.url.fl_str_mv | https://bibliotecadigital.ipb.pt/bitstreams/8be4cba5-c8cb-4d23-b58c-461f2907f96d/download |
| funding.funder.alternateName_str_mv | FCT FCT |
| funding.funder.identifier_str_mv | http://doi.org/10.13039/501100001871 http://doi.org/10.13039/501100001871 |
| funding.funder.name_str_mv | Fundação para a Ciência e a Tecnologia Fundação para a Ciência e a Tecnologia |
| funding.name_str_mv | 6817 - DCRRNI ID |
| id | ipb_1c96e7c99c5fec4e846f50c0f6fa8acf |
| identifier.url.fl_str_mv | http://hdl.handle.net/10198/12182 |
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| institution | Instituto Politécnico de Bragança |
| instname_str | Instituto Politécnico de Bragança |
| language | eng |
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| network_name_str | Biblioteca Digital do IPB |
| oai_identifier_str | oai:bibliotecadigital.ipb.pt:10198/12182 |
| organization_str_mv | urn:organizationAcronym:ipb |
| person_str_mv | Marques, A. Cateto, Carolina Calhelha, Ricardo C. Calhelha, Ricardo C. https://www.ciencia-id.pt/F313-E3CE-554E F313-E3CE-554E http://orcid.org/0000-0002-6801-4578 0000-0002-6801-4578 Barros, Lillian Barros, Lillian https://www.ciencia-id.pt/9616-35CB-D001 9616-35CB-D001 http://orcid.org/0000-0002-9050-5189 0000-0002-9050-5189 Queiroz, Maria João R.P. Belgacem, Mohamed Naceur Rodrigues, Alírio Ferreira, Isabel C.F.R. Ferreira, Isabel C.F.R. https://www.ciencia-id.pt/9418-CF95-9919 9418-CF95-9919 http://orcid.org/0000-0003-4910-4882 0000-0003-4910-4882 Barreiro, M.F. Barreiro, M.F. https://www.ciencia-id.pt/3418-47D5-5746 3418-47D5-5746 http://orcid.org/0000-0002-6844-333X 0000-0002-6844-333X |
| publishDate | 2014 |
| reponame_str | Biblioteca Digital do IPB |
| repository_id_str | urn:repositoryAcronym:ipb |
| service_str_mv | urn:repositoryAcronym:ipb |
| spelling | engpt_PTIn what concerns bioactive properties, and due to its phenolic character, lignin is mostly studied for their antioxidant activity. In this work four technical lignins (Alcell, Indulin-AT, Sarkanda and Curan 27-11P) have been evaluated for their antioxidant activity (DPPH radical scavenging activity, reducing power and inhibition of β-carotene bleaching) and antitumor potential against MCF-7, NCI-H460, HCT-15, HeLa and HepG2 cell lines. Additionally, the toxicity for non-tumour cells (PLP2) was also evaluated. The obtained results were correlated with the chemical and structural features of the studied lignins. Based on the achieved results, lignins of GS type, i.e. lignins rich in syringyl phenol units and poor in p-hydroxyphenyl ones result in better antitumor potential.application/pdfpt_PTBioactivity evaluation of four technical lignins: Alcell, Indulin-AT, Sarkanda and Curan 27-11PMarques, A.Cateto, CarolinaPersonalCalhelha, Ricardo C.DSpacehttp://dspace.org/items/2d5d1a41-7561-4a01-871c-b4c97da35053DSpacehttp://dspace.org/items/2d5d1a41-7561-4a01-871c-b4c97da35053CalhelhaRicardo C.Ciência IDhttps://www.ciencia-id.ptF313-E3CE-554EORCIDhttp://orcid.org0000-0002-6801-4578Researcher IDhttps://www.researcherid.comJ-2172-2014Scopus Author IDhttps://www.scopus.com6507978333PersonalBarros, LillianDSpacehttp://dspace.org/items/3af07ffe-f914-48ba-a5d5-efcf70fdce01DSpacehttp://dspace.org/items/3af07ffe-f914-48ba-a5d5-efcf70fdce01BarrosLillianCiência IDhttps://www.ciencia-id.pt9616-35CB-D001ORCIDhttp://orcid.org0000-0002-9050-5189Researcher IDhttps://www.researcherid.comJ-3600-2013Researcher IDhttps://www.researcherid.comJ-3600-2013Scopus Author IDhttps://www.scopus.com35236343600Scopus Author IDhttps://www.scopus.com57194900801Queiroz, Maria João R.P.Belgacem, Mohamed NaceurRodrigues, AlírioPersonalFerreira, Isabel C.F.R.DSpacehttp://dspace.org/items/bd0d1537-2e03-41fb-b27a-140af9c35db8DSpacehttp://dspace.org/items/bd0d1537-2e03-41fb-b27a-140af9c35db8FerreiraIsabel C.F.R.Ciência IDhttps://www.ciencia-id.pt9418-CF95-9919ORCIDhttp://orcid.org0000-0003-4910-4882Researcher IDhttps://www.researcherid.comE-8500-2013Scopus Author IDhttps://www.scopus.com36868826600PersonalBarreiro, M.F.DSpacehttp://dspace.org/items/0391987c-ba90-488b-839a-153447ce1f0fDSpacehttp://dspace.org/items/0391987c-ba90-488b-839a-153447ce1f0fBarreiroFilomenaCiência IDhttps://www.ciencia-id.pt3418-47D5-5746ORCIDhttp://orcid.org0000-0002-6844-333XResearcher IDhttps://www.researcherid.comL-9802-2014Scopus Author IDhttps://www.scopus.com57188719717HostingInstitutionOrganizationalBiblioteca Digital do IPBe-mailmailto:dspace@ipb.ptdspace@ipb.ptISBNIsPartOf978-972-752-170-82015-10-22T15:11:43Z20142014-01-01T00:00:00ZHandlehttp://hdl.handle.net/10198/12182http://purl.org/coar/access_right/c_abf2open access1467878 bytesFundação para a Ciência e a TecnologiaStrategic Project - UI 690 - 2011-20126817 - DCRRNI IDCrossref Funder IDhttp://doi.org/10.13039/501100001871Fundação para a Ciência e a TecnologiaPOLIURETANOS DERIVADOS DA LENHINA: FORMAÇÃO, CARACTERIZAÇÃO E APLICAÇÕESCrossref Funder IDhttp://doi.org/10.13039/501100001871other research producthttp://purl.org/coar/resource_type/c_5794conference paper2014http://creativecommons.org/licenses/by/4.0/http://purl.org/coar/access_right/c_abf2application/pdffulltexthttps://bibliotecadigital.ipb.pt/bitstreams/8be4cba5-c8cb-4d23-b58c-461f2907f96d/download12th International Chemical and Biological Engineering Conference (CHEMPOR 2014)8991 |
| spellingShingle | Bioactivity evaluation of four technical lignins: Alcell, Indulin-AT, Sarkanda and Curan 27-11P Marques, A. |
| status | SINGLETON |
| title | Bioactivity evaluation of four technical lignins: Alcell, Indulin-AT, Sarkanda and Curan 27-11P |
| title_full | Bioactivity evaluation of four technical lignins: Alcell, Indulin-AT, Sarkanda and Curan 27-11P |
| title_fullStr | Bioactivity evaluation of four technical lignins: Alcell, Indulin-AT, Sarkanda and Curan 27-11P |
| title_full_unstemmed | Bioactivity evaluation of four technical lignins: Alcell, Indulin-AT, Sarkanda and Curan 27-11P |
| title_short | Bioactivity evaluation of four technical lignins: Alcell, Indulin-AT, Sarkanda and Curan 27-11P |
| title_sort | Bioactivity evaluation of four technical lignins: Alcell, Indulin-AT, Sarkanda and Curan 27-11P |
| url | http://hdl.handle.net/10198/12182 |
| visible | 1 |