Publicação

Rational design of thieno[3,2-b]pyridines as potential new VEGFR-2 inhibitors based on improved docking scores.

Detalhes bibliográficos
Resumo:	Angiogenesis is the process of new blood vessel formation from pre-existing vascular networks by capillary sprouting, and plays an important role in the pathogenesis of several disorders including cancer, proliferative retinopathies and rheumatoid arthritis. A key regulatory pathway of angiogenesis is mediated by the vascular endothelial growth factor (VEGF) and its cell membrane tyrosine kinase receptor VEGFR-2 (also know as KDR kinase) [1]. Several VEGFR-2 inhibitors have emerged as promising anti-angiogenic agents for possible treatment against a wide variety of cancers including: sorafenib, sunitinib, and pazopanib, that have been approved for the treatment of advanced renal cell carcinoma. Several scaffolds have been studied for anti-VEGFR-2 activity as thieno[3,2-b]pyridines [2].
Autores principais:	Abreu, Rui M.V.
Outros Autores:	Froufe, Hugo J.C.; Ferreira, Isabel C.F.R.; Queiroz, Maria João R.P.
Ano:	2011
País:	Portugal
Tipo de documento:	documento de conferência
Tipo de acesso:	acesso aberto
Instituição associada:	Instituto Politécnico de Bragança
Idioma:	inglês
Origem:	Biblioteca Digital do IPB

Registos relacionados

Synthesis, docking, enzymatic and cellular assays of thieno[3,2-b]pyridine-thioether-1,3-diarylureas as VEGFR2 inhibitors
por: Queiroz, Maria João R.P.
Publicado em: (2012)

Synthesis, docking, enzymatic and cellular assays of thieno[3,2-b]pyridine-thioether-1,3-diarylureas as VEGFR2 inhibitors
por: Queiroz, Maria João R. P.
Publicado em: (2013)

Synthesis of new N-[3-(thieno[3,2-b]pyridine-7-ylthio)phenyl]benzamides as potential inhibitors of VEGFR2 using rational design
por: Queiroz, Maria João R.P.
Publicado em: (2013)

Virtual screening of thieno[3,2-b]pyridine arylthioether (hetero)aryltriazole derivatives as potential tyrosine kinase VEGFR2 inhibitors.
por: Calhelha, Ricardo C.
Publicado em: (2013)

New di(heteroaryl)thioethers 1,3-diarylureas in the thieno[3,2-b]pyridine series as VEGFR2 tyrosine kinase inhibitors: docking, synthesis, enzymatic and cellular assays
por: Machado, Vera A.
Publicado em: (2013)

Selective flexibility of side-chain residues improves VEGFR-2 docking score using AutoDock Vina
por: Abreu, Rui M.V.
Publicado em: (2012)

Synthesis, molecular Docking and biological evaluation of new 1-Aryl-3-[3-(thieno[3,2-b]pyridin-7-ylthio)phenylureas as Potent Type II VEGFR-2 Tyrosine Kinase inhibitors
por: Machado, Vera A.
Publicado em: (2014)

Synthesis of new N-[3-(thieno[3,2-b]pyridine-7-ylthio)phenyl]benzamides as potential inhibitors the tyrosine kinase domain of VEGFR2
por: Campos, Joana F.
Publicado em: (2013)

Methyl 3-[4-(3-arylureido)phenylamino]thieno[3,2-b]pyridine-2-carboxylates as potential inhibitors of VEGFR-2: synthesis and molecular modelling studies
por: Peixoto, Daniela
Publicado em: (2011)

Anti-proliferative activity of thieno[3,2-b]pyridine derivatives in tumoral and primary hepatic cell lines.
por: Abreu, Rui M.V.
Publicado em: (2010)

Synthesis of novel 1-aryl-3-[2,3- or 4-(thieno[3,2-b]pyridin-7-ylthio)phenyl]ureas and evaluation as VEGFR2 tyrosine kinase inhibitors
por: Peixoto, Daniela
Publicado em: (2012)

Synthesis of novel 1-Aryl-3-[2-,3- Or 4-(Thieno[3,2-b]Pyridin-7-Ylthio)Phenyl]Ureas and evaluation as VEGFR2 Tyrosine kinase inhibitors
por: Peixoto, Daniela
Publicado em: (2012)

Synthesis, antiangiogenesis evaluation and molecular docking studies of 1-aryl-3-[(thieno[3,2-b]pyridin-7-ylthio)phenyl]ureas: Discovery of a new substitution pattern for type II VEGFR-2 Tyr kinase inhibitors
por: Machado, Vera A.
Publicado em: (2015)

Synthesis, antiangiogenesis evaluation and molecular docking studies of 1-Aryl-3-[(thieno[3,2-b]pyridin-7-ylthio)phenyl]ureas: Discovery of a new substitution pattern for type II VEGFR-2 Tyr kinase inhibitors
por: Machado, Vera A.
Publicado em: (2015)

Heteroarylether 1,3-diarylureas in the thieno[3,2-d]pyrimidine series as VEGFR2 tyrosine Kinase inhibitors: synthesis, docking studies, enzymatic and cellular assays
por: Queiroz, Maria João R.P.
Publicado em: (2012)

Heteroarylether 1,3-diarylureas in the thieno[3,2-d]pyrimidine series as VEGFR2 tyrosine kinase inhibitors: synthesis, docking studies, enzymatic and cellular assays
por: Queiroz, Maria João R. P.
Publicado em: (2013)

1-Aryl-3-[4-(thieno[3,2-d]pyrimidin-4-yloxy)phenyl]ureas as VEGFR2 inhibitors: synthesis, docking enzymatic and cellular assays
por: Peixoto, Daniela
Publicado em: (2012)

VEGFR2 selective residue flexibility enriches AutoDock Vina docking results
por: Abreu, Rui M.V.
Publicado em: (2011)

Selective flexibility of side-chain residues improves VEGFR-2 docking score using autodock vina
por: Abreu, Rui M. V.
Publicado em: (2012)

Methyl 3-amino-6-[4 or 3 or 2-(3-arylureido)phenyl]thieno[3,2-b]pyridine-2-carboxylates: synthesis and molecular modelling studies using VEGFR-2
por: Peixoto, Daniela
Publicado em: (2011)

1-Aryl-3-[4-(thieno[3,2-d]pyrimidin-4-yloxy)phenyl]ureas as VEGFR2 tyrosine kinase inhibitors: synthesis, docking studies, enzymatic and cellular assays
por: Queiroz, Maria João R.P.
Publicado em: (2012)

1-Aryl-3-[4-(thieno[3,2-d]pyrimidin-4-yloxy)phenyl]ureas as VEGFR2 tyrosine kinase inhibitors: synthesis, docking, studies, enzymatic and cellular assays
por: Queiroz, Maria João R. P.
Publicado em: (2012)

Synthesis, molecular docking and biological Evaluation of New 1-Aryl-3-[3-(thieno[3,2-b]pyridin-7-ylthio)phenyl]ureas as Potent Type II CEGFR-2 Tyrosine Kinase Inhibitors
por: Machado, Vera Alexandra Pereira
Publicado em: (2014)

Thieno[3,2-b]pyridine arylethers: synthesis and growth inhibitory activity on human tumor cell lines
por: Calhelha, Ricardo C.
Publicado em: (2012)

Magnetoliposomes as carriers for promising antitumor thieno[3,2-b]pyridin-7-arylamines: photophysical and biological studies
por: Rodrigues, Ana Rita O.
Publicado em: (2017)

Synthesis and antioxidant activity of new methoxylated di(hetero)arylamines derivatives of thieno[3,2-b]pyridines,
por: Queiroz, Maria João R.P.
Publicado em: (2008)

Synthesis of Di(Hetero)Arylamines and Ethers in the Thieno[3,2-b]Pyridine series by Metal-Catalyzed couplings
por: Peixoto, Daniela
Publicado em: (2012)

Synthesis of 1,3-diarylureas from different (thieno3,2-b]pyridin-7-ylthio)anilines
por: Queiroz, Maria João R. P.
Publicado em: (2011)

Thieno[3,2-b]pyridine arylethers: synthesis and growth inhibitory activity on human tumor cell lines
por: Calhelha, Ricardo C.
Publicado em: (2013)

Magnetoliposomes as carriers for promising antitumor thieno[3,2-b]pyridin-7-arylamines: photophysical and biological studies
por: Rodrigues, Ana Rita O.
Publicado em: (2017)

Radical scavenging activity, lipid peroxidation inhibition and redox profile of aminodiarylamines in the thieno[3,2-b]pyridine series
por: Calhelha, Ricardo C.
Publicado em: (2013)

New potential antitumoral fluorescent tetracyclic thieno[3,2-b]pyridine derivatives: interaction with DNA and encapsulation in nanoliposomes
por: Castanheira, Elisabete M. S.
Publicado em: (2010)

Synthesis of Tetracyclic systems and (Thio)Ureas from Aminodi(Hetero)Arylamines in the Thieno[3,2-b]Pyridine series
por: Queiroz, Maria João R. P.
Publicado em: (2012)

New potential antitumoral fluorescent tetracyclic thieno[3,2-b]pyridine derivatives: interaction with DNA and nanosized liposomes
por: Castanheira, Elisabete M. S.
Publicado em: (2011)

1-Aryl-3-[4-(thieno[3,2-d]pyrimidin-4-yloxy)phenyl]ureas as potential inhibitors of VEGFR-2: synthesis and molecular modelling studies
por: Soares, Pedro
Publicado em: (2011)

Synthesis of aminodiarylamines in the thieno[3,2-b]pyridine series and effects on tumor cell growth inhibition, cell cycle and apoptosis
por: Calhelha, Ricardo C.
Publicado em: (2011)

Chemical, biochemical and electrochemical assays to evaluate antioxidant properties of three new diarylamines in the thieno[3,2-b]pyridine series.
por: Calhelha, Ricardo C.
Publicado em: (2011)

Synthesis and evaluation of the antitumor potential of new aminated or methoxylated di(hetero)arylthioethers in the thieno[3,2-b]pyridine series
por: Calhelha, Ricardo C.
Publicado em: (2013)

Fluorescence studies on new potential antitumoral 1,3-diarylurea derivatives of thieno[3,2-b]pyridines in solution and in nanoliposomes
por: Castanheira, Elisabete M. S.
Publicado em: (2011)

Encapsulation of a new antitumoral fluorescent 6-(benzo[d]thiazo-2-ylamino)thieno[3,2-b]pyridine derivative in nanoliposomes
por: Oliveira, Andreia D. S.
Publicado em: (2010)