Publicação

Development of semi-solid formulations containing Juglans regia L. leaves extracts for topical application

Ver documento

Detalhes bibliográficos
Resumo:The leaves of walnut trees (Juglans regia L.) stand out as a rich source of phenolic compounds and other phytochemicals. Because of that, their extracts find application as traditional herbal medicinal products and can also be valorized as potential bioactive ingredients in the cosmeceutical and food areas, among others. In this context, the main objective of this thesis is to develop a semi-solid formulation for topical use containing Juglans regia extracts and, then, to characterize and analyze the bioactive properties and stability of the final formulation. After obtaining the extract using both hydroethanolic and 1,2-propanediol mixtures, a series of bioactivity studies such as antioxidant, cytotoxic, anti-inflammatory, antimicrobial, anti-tyrosinase and photostability were carried out. The hydroethanolic extracts were more efficient than the propanediol extract in the anti-tyrosinase, antioxidant, and anti-inflammatory assays. In the antimicrobial assay both extracts showed similar microbial properties. Both extracts were found to be rich sources of phenolic compounds, being 3-O-caffeoylquinic acid, quercetin-O-pentoside, taxifolin O-pentoside isomer, quercetin 3-O-glucoside, and 3-p-coumaroylquinic acid, the most abundant compounds. The propanediol and hydroethanolic extracts were incorporated in a base cream to have the final formulation for topical application. The stability of the final formulation was studied according to the following parameters: pH, color, phenolic compounds, and antioxidant activity. After incorporation into the base cream, the hydroethanolic extract preserved its phenolic compounds content over time at different storage conditions. Regarding the formulation containing propanediol extract, quercetin 3-O-glucoside and traces of other compounds were identified due to the small amount of incorporated extract. Both final formulations also presented antioxidant activity and a pH ranging from 3.8 and 4.7 which is compatible within the range of normal skin. These preliminary results suggest the potential use of J. regia extracts as a source of bioactive compounds for further incorporation into skin care products. Further work should be carried out to assess a longer term stability, safety and toxicity of these extracts.
Autores principais:Besrour, Nermine
Assunto:Walnut leaves Extraction solvents Bioactivity Cosmeceutical formulations
Ano:2020
País:Portugal
Tipo de documento:dissertação de mestrado
Tipo de acesso:acesso restrito
Instituição associada:Instituto Politécnico de Bragança
Idioma:inglês
Origem:Biblioteca Digital do IPB

Registos relacionados

Registos relacionados