Publicação
Phytochemicals in Rubus ulmifolius Schott metanol/water extracts and its antifungal properties against Candida species
| Resumo: | The use of medicinal plants is an ancient practice, in part due to the evidenced richness in phytotherapeutic properties [l]. Currently, a wide variety of studies have been carried out, towards the investigation of these natural matrices, clarifying effects, health benefits and even mechanism of action of some of their bioactive compounds, namely phenolic compounds [2,3]. In parallel with these advances, an increasing incidence of opportunistic fungal infections has been observed, associated with development of antimicrobial drugs-resistant by the microorganisms [ 4]. In this sense, alternatives to the current antifungal drugs are necessary. In this work, the antifungal potential of Rubus ulmifolius Schott (Rosaceae) methanol! water (80:20, v!v) extract, prepared from flower buds, was evaluated against nineteen Candida strains, belonging to the species C. albicans, C. glabrata, C. parapsilosis and C. tropicalis, by using the disc diffusion halo assay. The obtained results were expressed as inhibition zones (mm). R. ulmifolius extract was effective against eleven Candida strains, maintaining the inhibitory effect at 24h, 48h and even 72h. At the tested concentration (SO mg/mL), the inhibition zones ranged between 9-15 mm for C. albicans, 16-19 mm for C. glabrata (16-19 mm) and 9-10 mm for C. parapsilosis. Regarding C. tropicalis, only impairment on the cellular growth was observed. The most abundant compounds found in the extract were ellagitannin derivatives, such as a sanguiin H -10 isomer and lambertianin C. Besides ellagitannins, flavonoids such as quercetin and kaempferol based flavonol conjugates were also found, being quercetin 3-0-glucuronide and quercetin 3-0-glucoside the most abundant [5]. |
|---|---|
| Autores principais: | Martins, Natália |
| Outros Autores: | Barros, Lillian; Oliveira, Sónia; Carvalho, Ana Maria; Henriques, Mariana; Ferreira, Isabel C.F.R. |
| Ano: | 2014 |
| País: | Portugal |
| Tipo de documento: | documento de conferência |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Instituto Politécnico de Bragança |
| Idioma: | inglês |
| Origem: | Biblioteca Digital do IPB |
| _version_ | 1867172805027561472 |
|---|---|
| author | Martins, Natália |
| author2 | Barros, Lillian Oliveira, Sónia Carvalho, Ana Maria Henriques, Mariana Ferreira, Isabel C.F.R. |
| author2_role | author author author author author |
| author_facet | Martins, Natália Barros, Lillian Oliveira, Sónia Carvalho, Ana Maria Henriques, Mariana Ferreira, Isabel C.F.R. |
| author_role | author |
| contributor_name_str_mv | Biblioteca Digital do IPB |
| country_str | PT |
| creators_json_txt | [{\"Person.name\":\"Martins, Natália\"},{\"Person.name\":\"Barros, Lillian\",\"Person.identifier.orcid\":\"0000-0002-9050-5189\"},{\"Person.name\":\"Oliveira, Sónia\"},{\"Person.name\":\"Carvalho, Ana Maria\",\"Person.identifier.orcid\":\"0000-0001-5508-5935\"},{\"Person.name\":\"Henriques, Mariana\"},{\"Person.name\":\"Ferreira, Isabel C.F.R.\",\"Person.identifier.orcid\":\"0000-0003-4910-4882\"}] |
| datacite.contributors.contributor.contributorName.fl_str_mv | Biblioteca Digital do IPB |
| datacite.creators.creator.creatorName.fl_str_mv | Martins, Natália Barros, Lillian Oliveira, Sónia Carvalho, Ana Maria Henriques, Mariana Ferreira, Isabel C.F.R. |
| datacite.date.Accepted.fl_str_mv | 2014-01-01T00:00:00Z |
| datacite.date.available.fl_str_mv | 2015-11-04T11:47:22Z |
| datacite.date.embargoed.fl_str_mv | 2015-11-04T11:47:22Z |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| datacite.titles.title.fl_str_mv | Phytochemicals in Rubus ulmifolius Schott metanol/water extracts and its antifungal properties against Candida species |
| dc.contributor.none.fl_str_mv | Biblioteca Digital do IPB |
| dc.creator.none.fl_str_mv | Martins, Natália Barros, Lillian Oliveira, Sónia Carvalho, Ana Maria Henriques, Mariana Ferreira, Isabel C.F.R. |
| dc.date.Accepted.fl_str_mv | 2014-01-01T00:00:00Z |
| dc.date.available.fl_str_mv | 2015-11-04T11:47:22Z |
| dc.date.embargoed.fl_str_mv | 2015-11-04T11:47:22Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | http://hdl.handle.net/10198/12265 |
| dc.language.none.fl_str_mv | eng |
| dc.rights.cclincense.fl_str_mv | http://creativecommons.org/licenses/by/4.0/ |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| dc.title.fl_str_mv | Phytochemicals in Rubus ulmifolius Schott metanol/water extracts and its antifungal properties against Candida species |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_c94f |
| description | The use of medicinal plants is an ancient practice, in part due to the evidenced richness in phytotherapeutic properties [l]. Currently, a wide variety of studies have been carried out, towards the investigation of these natural matrices, clarifying effects, health benefits and even mechanism of action of some of their bioactive compounds, namely phenolic compounds [2,3]. In parallel with these advances, an increasing incidence of opportunistic fungal infections has been observed, associated with development of antimicrobial drugs-resistant by the microorganisms [ 4]. In this sense, alternatives to the current antifungal drugs are necessary. In this work, the antifungal potential of Rubus ulmifolius Schott (Rosaceae) methanol! water (80:20, v!v) extract, prepared from flower buds, was evaluated against nineteen Candida strains, belonging to the species C. albicans, C. glabrata, C. parapsilosis and C. tropicalis, by using the disc diffusion halo assay. The obtained results were expressed as inhibition zones (mm). R. ulmifolius extract was effective against eleven Candida strains, maintaining the inhibitory effect at 24h, 48h and even 72h. At the tested concentration (SO mg/mL), the inhibition zones ranged between 9-15 mm for C. albicans, 16-19 mm for C. glabrata (16-19 mm) and 9-10 mm for C. parapsilosis. Regarding C. tropicalis, only impairment on the cellular growth was observed. The most abundant compounds found in the extract were ellagitannin derivatives, such as a sanguiin H -10 isomer and lambertianin C. Besides ellagitannins, flavonoids such as quercetin and kaempferol based flavonol conjugates were also found, being quercetin 3-0-glucuronide and quercetin 3-0-glucoside the most abundant [5]. |
| dirty | 0 |
| eu_rights_str_mv | openAccess |
| format | conferenceObject |
| fulltext.url.fl_str_mv | https://bibliotecadigital.ipb.pt/bitstreams/1811703e-4072-4c08-a50f-4cc2f3f6c139/download |
| funding.funder.alternateName_str_mv | FCT |
| funding.funder.identifier_str_mv | http://doi.org/10.13039/501100001871 |
| funding.funder.name_str_mv | Fundação para a Ciência e a Tecnologia |
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| identifier.url.fl_str_mv | http://hdl.handle.net/10198/12265 |
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| institution | Instituto Politécnico de Bragança |
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| language | eng |
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| person_str_mv | Martins, Natália Barros, Lillian Barros, Lillian https://www.ciencia-id.pt/9616-35CB-D001 9616-35CB-D001 http://orcid.org/0000-0002-9050-5189 0000-0002-9050-5189 Oliveira, Sónia Carvalho, Ana Maria Carvalho, Ana Maria https://www.ciencia-id.pt/D31A-35AF-E2A9 D31A-35AF-E2A9 http://orcid.org/0000-0001-5508-5935 0000-0001-5508-5935 Henriques, Mariana Ferreira, Isabel C.F.R. Ferreira, Isabel C.F.R. https://www.ciencia-id.pt/9418-CF95-9919 9418-CF95-9919 http://orcid.org/0000-0003-4910-4882 0000-0003-4910-4882 |
| publishDate | 2014 |
| reponame_str | Biblioteca Digital do IPB |
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| spelling | engpt_PTThe use of medicinal plants is an ancient practice, in part due to the evidenced richness in phytotherapeutic properties [l]. Currently, a wide variety of studies have been carried out, towards the investigation of these natural matrices, clarifying effects, health benefits and even mechanism of action of some of their bioactive compounds, namely phenolic compounds [2,3]. In parallel with these advances, an increasing incidence of opportunistic fungal infections has been observed, associated with development of antimicrobial drugs-resistant by the microorganisms [ 4]. In this sense, alternatives to the current antifungal drugs are necessary. In this work, the antifungal potential of Rubus ulmifolius Schott (Rosaceae) methanol! water (80:20, v!v) extract, prepared from flower buds, was evaluated against nineteen Candida strains, belonging to the species C. albicans, C. glabrata, C. parapsilosis and C. tropicalis, by using the disc diffusion halo assay. The obtained results were expressed as inhibition zones (mm). R. ulmifolius extract was effective against eleven Candida strains, maintaining the inhibitory effect at 24h, 48h and even 72h. At the tested concentration (SO mg/mL), the inhibition zones ranged between 9-15 mm for C. albicans, 16-19 mm for C. glabrata (16-19 mm) and 9-10 mm for C. parapsilosis. Regarding C. tropicalis, only impairment on the cellular growth was observed. The most abundant compounds found in the extract were ellagitannin derivatives, such as a sanguiin H -10 isomer and lambertianin C. Besides ellagitannins, flavonoids such as quercetin and kaempferol based flavonol conjugates were also found, being quercetin 3-0-glucuronide and quercetin 3-0-glucoside the most abundant [5].application/pdfpt_PTPhytochemicals in Rubus ulmifolius Schott metanol/water extracts and its antifungal properties against Candida speciesMartins, NatáliaPersonalBarros, LillianDSpacehttp://dspace.org/items/3af07ffe-f914-48ba-a5d5-efcf70fdce01DSpacehttp://dspace.org/items/3af07ffe-f914-48ba-a5d5-efcf70fdce01BarrosLillianCiência IDhttps://www.ciencia-id.pt9616-35CB-D001ORCIDhttp://orcid.org0000-0002-9050-5189Researcher IDhttps://www.researcherid.comJ-3600-2013Researcher IDhttps://www.researcherid.comJ-3600-2013Scopus Author IDhttps://www.scopus.com35236343600Scopus Author IDhttps://www.scopus.com57194900801Oliveira, SóniaPersonalCarvalho, Ana MariaDSpacehttp://dspace.org/items/977f5254-f7c5-4c91-873f-2700ecd4692fDSpacehttp://dspace.org/items/977f5254-f7c5-4c91-873f-2700ecd4692fCarvalhoAna MariaCiência IDhttps://www.ciencia-id.ptD31A-35AF-E2A9ORCIDhttp://orcid.org0000-0001-5508-5935Scopus Author IDhttps://www.scopus.com20336503900Henriques, MarianaPersonalFerreira, Isabel C.F.R.DSpacehttp://dspace.org/items/bd0d1537-2e03-41fb-b27a-140af9c35db8DSpacehttp://dspace.org/items/bd0d1537-2e03-41fb-b27a-140af9c35db8FerreiraIsabel C.F.R.Ciência IDhttps://www.ciencia-id.pt9418-CF95-9919ORCIDhttp://orcid.org0000-0003-4910-4882Researcher IDhttps://www.researcherid.comE-8500-2013Scopus Author IDhttps://www.scopus.com36868826600HostingInstitutionOrganizationalBiblioteca Digital do IPBe-mailmailto:dspace@ipb.ptdspace@ipb.ptISBNIsPartOf978-989-98541-7-82015-11-04T11:47:22Z20142014-01-01T00:00:00ZHandlehttp://hdl.handle.net/10198/12265http://purl.org/coar/access_right/c_abf2open access809361 bytesFundação para a Ciência e a TecnologiaPLANTAS MEDICINAIS A UTILIZAR EM FITOTERAPIA COMO ANTI-FÚNGICOS: EFEITO DE COMPOSTOS FENÓLICOS NO CRESCIMENTO DE ESPÉCIES DE CANDIDA EM SUSPENSÃO E EM BIOFILMESCrossref Funder IDhttp://doi.org/10.13039/501100001871other research producthttp://purl.org/coar/resource_type/c_c94fconference object2014http://creativecommons.org/licenses/by/4.0/http://purl.org/coar/access_right/c_abf2application/pdffulltexthttps://bibliotecadigital.ipb.pt/bitstreams/1811703e-4072-4c08-a50f-4cc2f3f6c139/downloadXX Encontro Luso-Galego de Química |
| spellingShingle | Phytochemicals in Rubus ulmifolius Schott metanol/water extracts and its antifungal properties against Candida species Martins, Natália |
| status | SINGLETON |
| title | Phytochemicals in Rubus ulmifolius Schott metanol/water extracts and its antifungal properties against Candida species |
| title_full | Phytochemicals in Rubus ulmifolius Schott metanol/water extracts and its antifungal properties against Candida species |
| title_fullStr | Phytochemicals in Rubus ulmifolius Schott metanol/water extracts and its antifungal properties against Candida species |
| title_full_unstemmed | Phytochemicals in Rubus ulmifolius Schott metanol/water extracts and its antifungal properties against Candida species |
| title_short | Phytochemicals in Rubus ulmifolius Schott metanol/water extracts and its antifungal properties against Candida species |
| title_sort | Phytochemicals in Rubus ulmifolius Schott metanol/water extracts and its antifungal properties against Candida species |
| url | http://hdl.handle.net/10198/12265 |
| visible | 1 |