Publicação
Virgin olive oil as a source of anti-inflammatory agents
| Resumo: | Virgin olive oil (VOO) has many potential health benefits, including the amelioration of inflammatory processes. In part, this is known to occur through the modification of the endothelial function, leading to a decrease of the levels of cell-adhesion molecules (CAMs), including the inter-cellular adhesion molecule 1 (ICAM-1) and the vascular cell adhesion molecule 1 (VCAM-1). Importantly, virgin olive oil is able to inhibit the tumor necrosis factor-alpha (TNF-α), that is a key cytokine in controlling distinct types of cell functions and a particular therapeutic target for inflammatory diseases. Moreover, in vitro and in vivo assays with virgin olive oil or its main components clearly indicate a marked modulation of signaling pathways regulating the activation of pro-inflammatory mediators, including the nuclear transcriptional factor NF-κβ, the cytokines interleukin-1 (IL-1), and interleukin-6 (IL-6), and the enzymes cyclooxygenase-2 (COX-2), 5-lipoxygenase (5-LOX) and inducible nitric oxide synthase (iNOS). So far, the cellular and molecular anti-inflammatory mechanisms of virgin olive oil have been particular associated with its high amounts of phenolic compounds, as well as to its composition in mono and polyunsaturated fatty acids. Still, the available data is disperse and needs consolidation, in order to allow solid conclusions on this issue. The present chapter summarizes the epidemiological data and intervention trials focusing the effects of virgin olive oil in inflammatory processes and/or inflammatory related-diseases, as well as the main virgin olive oil constituents associated to the protection process and their underlying mechanisms of action. |
|---|---|
| Autores principais: | Cardoso, Susana M. |
| Outros Autores: | Catarino, Marcelo D.; Semião, Marta S.; Pereira, Olívia R. |
| Assunto: | Virgin olive oil IIflammation Atherosclerosis Bowel diseases Cancer |
| Ano: | 2014 |
| País: | Portugal |
| Tipo de documento: | capítulo de livro |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Instituto Politécnico de Bragança |
| Idioma: | inglês |
| Origem: | Biblioteca Digital do IPB |
| _version_ | 1867173320336605184 |
|---|---|
| author | Cardoso, Susana M. |
| author2 | Catarino, Marcelo D. Semião, Marta S. Pereira, Olívia R. |
| author2_role | author author author |
| author_facet | Cardoso, Susana M. Catarino, Marcelo D. Semião, Marta S. Pereira, Olívia R. |
| author_role | author |
| contributor_name_str_mv | Biblioteca Digital do IPB |
| country_str | PT |
| creators_json_txt | [{\"Person.name\":\"Cardoso, Susana M.\"},{\"Person.name\":\"Catarino, Marcelo D.\"},{\"Person.name\":\"Semião, Marta S.\"},{\"Person.name\":\"Pereira, Olívia R.\",\"Person.identifier.orcid\":\"0000-0002-6275-3134\"}] |
| datacite.contributors.contributor.contributorName.fl_str_mv | Biblioteca Digital do IPB |
| datacite.creators.creator.creatorName.fl_str_mv | Cardoso, Susana M. Catarino, Marcelo D. Semião, Marta S. Pereira, Olívia R. |
| datacite.date.Accepted.fl_str_mv | 2014-01-01T00:00:00Z |
| datacite.date.available.fl_str_mv | 2014-08-04T10:32:38Z |
| datacite.date.embargoed.fl_str_mv | 2014-08-04T10:32:38Z |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| datacite.subjects.subject.fl_str_mv | Virgin olive oil IIflammation Atherosclerosis Bowel diseases Cancer |
| datacite.titles.title.fl_str_mv | Virgin olive oil as a source of anti-inflammatory agents |
| dc.contributor.none.fl_str_mv | Biblioteca Digital do IPB |
| dc.creator.none.fl_str_mv | Cardoso, Susana M. Catarino, Marcelo D. Semião, Marta S. Pereira, Olívia R. |
| dc.date.Accepted.fl_str_mv | 2014-01-01T00:00:00Z |
| dc.date.available.fl_str_mv | 2014-08-04T10:32:38Z |
| dc.date.embargoed.fl_str_mv | 2014-08-04T10:32:38Z |
| dc.format.none.fl_str_mv | application/pdf application/pdf |
| dc.identifier.none.fl_str_mv | http://hdl.handle.net/10198/10017 |
| dc.language.none.fl_str_mv | eng |
| dc.publisher.none.fl_str_mv | Nova Science Publishers |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| dc.subject.none.fl_str_mv | Virgin olive oil IIflammation Atherosclerosis Bowel diseases Cancer |
| dc.title.fl_str_mv | Virgin olive oil as a source of anti-inflammatory agents |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_3248 |
| description | Virgin olive oil (VOO) has many potential health benefits, including the amelioration of inflammatory processes. In part, this is known to occur through the modification of the endothelial function, leading to a decrease of the levels of cell-adhesion molecules (CAMs), including the inter-cellular adhesion molecule 1 (ICAM-1) and the vascular cell adhesion molecule 1 (VCAM-1). Importantly, virgin olive oil is able to inhibit the tumor necrosis factor-alpha (TNF-α), that is a key cytokine in controlling distinct types of cell functions and a particular therapeutic target for inflammatory diseases. Moreover, in vitro and in vivo assays with virgin olive oil or its main components clearly indicate a marked modulation of signaling pathways regulating the activation of pro-inflammatory mediators, including the nuclear transcriptional factor NF-κβ, the cytokines interleukin-1 (IL-1), and interleukin-6 (IL-6), and the enzymes cyclooxygenase-2 (COX-2), 5-lipoxygenase (5-LOX) and inducible nitric oxide synthase (iNOS). So far, the cellular and molecular anti-inflammatory mechanisms of virgin olive oil have been particular associated with its high amounts of phenolic compounds, as well as to its composition in mono and polyunsaturated fatty acids. Still, the available data is disperse and needs consolidation, in order to allow solid conclusions on this issue. The present chapter summarizes the epidemiological data and intervention trials focusing the effects of virgin olive oil in inflammatory processes and/or inflammatory related-diseases, as well as the main virgin olive oil constituents associated to the protection process and their underlying mechanisms of action. |
| dirty | 0 |
| eu_rights_str_mv | openAccess |
| format | bookPart |
| fulltext.url.fl_str_mv | https://bibliotecadigital.ipb.pt/bitstreams/57bef31d-07d5-45bb-8724-17f1c91bc776/download |
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| identifier.url.fl_str_mv | http://hdl.handle.net/10198/10017 |
| instacron_str | ipb |
| institution | Instituto Politécnico de Bragança |
| instname_str | Instituto Politécnico de Bragança |
| language | eng |
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| oai_identifier_str | oai:bibliotecadigital.ipb.pt:10198/10017 |
| organization_str_mv | urn:organizationAcronym:ipb |
| person_str_mv | Cardoso, Susana M. Catarino, Marcelo D. Semião, Marta S. Pereira, Olívia R. Pereira, Olívia R. https://www.ciencia-id.pt/B312-AF21-D2FA B312-AF21-D2FA http://orcid.org/0000-0002-6275-3134 0000-0002-6275-3134 |
| publishDate | 2014 |
| publisher.none.fl_str_mv | Nova Science Publishers |
| reponame_str | Biblioteca Digital do IPB |
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| spelling | engNova Science PublishersporVirgin olive oil (VOO) has many potential health benefits, including the amelioration of inflammatory processes. In part, this is known to occur through the modification of the endothelial function, leading to a decrease of the levels of cell-adhesion molecules (CAMs), including the inter-cellular adhesion molecule 1 (ICAM-1) and the vascular cell adhesion molecule 1 (VCAM-1). Importantly, virgin olive oil is able to inhibit the tumor necrosis factor-alpha (TNF-α), that is a key cytokine in controlling distinct types of cell functions and a particular therapeutic target for inflammatory diseases. Moreover, in vitro and in vivo assays with virgin olive oil or its main components clearly indicate a marked modulation of signaling pathways regulating the activation of pro-inflammatory mediators, including the nuclear transcriptional factor NF-κβ, the cytokines interleukin-1 (IL-1), and interleukin-6 (IL-6), and the enzymes cyclooxygenase-2 (COX-2), 5-lipoxygenase (5-LOX) and inducible nitric oxide synthase (iNOS). So far, the cellular and molecular anti-inflammatory mechanisms of virgin olive oil have been particular associated with its high amounts of phenolic compounds, as well as to its composition in mono and polyunsaturated fatty acids. Still, the available data is disperse and needs consolidation, in order to allow solid conclusions on this issue. The present chapter summarizes the epidemiological data and intervention trials focusing the effects of virgin olive oil in inflammatory processes and/or inflammatory related-diseases, as well as the main virgin olive oil constituents associated to the protection process and their underlying mechanisms of action.application/pdfapplication/pdfporVirgin olive oil as a source of anti-inflammatory agentsCardoso, Susana M.Catarino, Marcelo D.Semião, Marta S.PersonalPereira, Olívia R.DSpacehttp://dspace.org/items/e8fdab9a-3ad6-47e6-b90c-7a37aabcb453DSpacehttp://dspace.org/items/e8fdab9a-3ad6-47e6-b90c-7a37aabcb453PereiraOlívia R.Ciência IDhttps://www.ciencia-id.ptB312-AF21-D2FAORCIDhttp://orcid.org0000-0002-6275-3134Researcher IDhttps://www.researcherid.comH-1049-2014Scopus Author IDhttps://www.scopus.com52264387000HostingInstitutionOrganizationalBiblioteca Digital do IPBe-mailmailto:dspace@ipb.ptdspace@ipb.ptISBNIsPartOf978-1-63117-662-32014-08-04T10:32:38Z20142014-01-01T00:00:00ZHandlehttp://hdl.handle.net/10198/10017http://purl.org/coar/access_right/c_abf2open accessVirgin olive oilIIflammationAtherosclerosisBowel diseasesCancer801155 bytes1785928 bytesliteraturehttp://purl.org/coar/resource_type/c_3248book parthttp://purl.org/coar/access_right/c_abf2application/pdffulltexthttps://bibliotecadigital.ipb.pt/bitstreams/57bef31d-07d5-45bb-8724-17f1c91bc776/downloadhttp://purl.org/coar/access_right/c_abf2application/pdffulltexthttps://bibliotecadigital.ipb.pt/bitstreams/319f0a9c-1b10-4f7c-9a89-d23076b634a3/downloadVirgin olive oil, production, composition, uses and benefits for man187209New York |
| spellingShingle | Virgin olive oil as a source of anti-inflammatory agents Cardoso, Susana M. Virgin olive oil IIflammation Atherosclerosis Bowel diseases Cancer |
| status | SINGLETON |
| subject.fl_str_mv | Virgin olive oil IIflammation Atherosclerosis Bowel diseases Cancer |
| title | Virgin olive oil as a source of anti-inflammatory agents |
| title_full | Virgin olive oil as a source of anti-inflammatory agents |
| title_fullStr | Virgin olive oil as a source of anti-inflammatory agents |
| title_full_unstemmed | Virgin olive oil as a source of anti-inflammatory agents |
| title_short | Virgin olive oil as a source of anti-inflammatory agents |
| title_sort | Virgin olive oil as a source of anti-inflammatory agents |
| topic | Virgin olive oil IIflammation Atherosclerosis Bowel diseases Cancer |
| topic_facet | Virgin olive oil IIflammation Atherosclerosis Bowel diseases Cancer |
| url | http://hdl.handle.net/10198/10017 |
| visible | 1 |