Publication
Stimuli-responsive hydrogels synthesis using free radical and RAFT polymerization
| Summary: | Temperature and pH stimuli-responsive hydrogel particles were synthesized using inverse-suspension polymerization in batch stirred reactor. Different water soluble co-monomers were present in the initial mixture (e.g. N-isopropylacrylamide and acrylic acid) as well as crosslinkers with different functionalities. Different operating conditions such as polymerization temperature, monomers dilution, neutralization and the initial ratios of co-monomers and monomers/crosslinker were also tried. Hydrogel particles were produced considering classical free-radical polymerization (FRP) and also RAFT polymerization. Commercially available RAFT agents 4-cyano-4-phenylcarbonothioylthio-pentanoic acid (CPA), 2-(dodecylthiocarbonothioylthio)-2-methylpropionic acid (DDMAT) and cyanomethyl dodecyl trithiocarbonate (CDT) were alternatively used. Sampling at different polymerization times allowed the study of the kinetics of polymerization through the analysis by SEC of the soluble phase. A tetra-detector array with simultaneous detection of refractive index, light scattering, intrinsic viscosity and ultra-violet signals was used in these studies. Usefulness of in-line FTIR-ATR monitoring to study the building process of such networks was also assessed. The performance of hydrogel beads was studied through drug delivery tests triggered by changes in the environmental temperature and pH. This research aims to contribute for the elucidation of the connection between the synthesis conditions, molecular architecture and properties/performance of such advanced materials. |
|---|---|
| Main Authors: | Gonçalves, Miguel A.D. |
| Other Authors: | Pinto, Virgínia; Costa, Rita Alexandra Santos da; Dias, Rolando; Hernándes-Ortiz, Júlio; Costa, Mário Rui |
| Subject: | Crosslinking Hydrogels RAFT Stimuli-responsive polymers |
| Year: | 2013 |
| Country: | Portugal |
| Document type: | conference paper |
| Access type: | open access |
| Associated institution: | Instituto Politécnico de Bragança |
| Language: | English |
| Origin: | Biblioteca Digital do IPB |
| _version_ | 1867172805163876352 |
|---|---|
| author | Gonçalves, Miguel A.D. |
| author2 | Pinto, Virgínia Costa, Rita Alexandra Santos da Dias, Rolando Hernándes-Ortiz, Júlio Costa, Mário Rui |
| author2_role | author author author author author |
| author_facet | Gonçalves, Miguel A.D. Pinto, Virgínia Costa, Rita Alexandra Santos da Dias, Rolando Hernándes-Ortiz, Júlio Costa, Mário Rui |
| author_role | author |
| contributor_name_str_mv | Biblioteca Digital do IPB |
| country_str | PT |
| creators_json_txt | [{\"Person.name\":\"Gonçalves, Miguel A.D.\"},{\"Person.name\":\"Pinto, Virgínia\"},{\"Person.name\":\"Costa, Rita Alexandra Santos da\"},{\"Person.name\":\"Dias, Rolando\",\"Person.identifier.orcid\":\"0000-0001-7369-382X\"},{\"Person.name\":\"Hernándes-Ortiz, Júlio\"},{\"Person.name\":\"Costa, Mário Rui\"}] |
| datacite.contributors.contributor.contributorName.fl_str_mv | Biblioteca Digital do IPB |
| datacite.creators.creator.creatorName.fl_str_mv | Gonçalves, Miguel A.D. Pinto, Virgínia Costa, Rita Alexandra Santos da Dias, Rolando Hernándes-Ortiz, Júlio Costa, Mário Rui |
| datacite.date.Accepted.fl_str_mv | 2013-01-01T00:00:00Z |
| datacite.date.available.fl_str_mv | 2014-06-02T11:18:28Z |
| datacite.date.embargoed.fl_str_mv | 2014-06-02T11:18:28Z |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| datacite.subjects.subject.fl_str_mv | Crosslinking Hydrogels RAFT Stimuli-responsive polymers |
| datacite.titles.title.fl_str_mv | Stimuli-responsive hydrogels synthesis using free radical and RAFT polymerization |
| dc.contributor.none.fl_str_mv | Biblioteca Digital do IPB |
| dc.creator.none.fl_str_mv | Gonçalves, Miguel A.D. Pinto, Virgínia Costa, Rita Alexandra Santos da Dias, Rolando Hernándes-Ortiz, Júlio Costa, Mário Rui |
| dc.date.Accepted.fl_str_mv | 2013-01-01T00:00:00Z |
| dc.date.available.fl_str_mv | 2014-06-02T11:18:28Z |
| dc.date.embargoed.fl_str_mv | 2014-06-02T11:18:28Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | http://hdl.handle.net/10198/9614 |
| dc.language.none.fl_str_mv | eng |
| dc.publisher.none.fl_str_mv | WILEY-VCH |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| dc.subject.none.fl_str_mv | Crosslinking Hydrogels RAFT Stimuli-responsive polymers |
| dc.title.fl_str_mv | Stimuli-responsive hydrogels synthesis using free radical and RAFT polymerization |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_5794 |
| description | Temperature and pH stimuli-responsive hydrogel particles were synthesized using inverse-suspension polymerization in batch stirred reactor. Different water soluble co-monomers were present in the initial mixture (e.g. N-isopropylacrylamide and acrylic acid) as well as crosslinkers with different functionalities. Different operating conditions such as polymerization temperature, monomers dilution, neutralization and the initial ratios of co-monomers and monomers/crosslinker were also tried. Hydrogel particles were produced considering classical free-radical polymerization (FRP) and also RAFT polymerization. Commercially available RAFT agents 4-cyano-4-phenylcarbonothioylthio-pentanoic acid (CPA), 2-(dodecylthiocarbonothioylthio)-2-methylpropionic acid (DDMAT) and cyanomethyl dodecyl trithiocarbonate (CDT) were alternatively used. Sampling at different polymerization times allowed the study of the kinetics of polymerization through the analysis by SEC of the soluble phase. A tetra-detector array with simultaneous detection of refractive index, light scattering, intrinsic viscosity and ultra-violet signals was used in these studies. Usefulness of in-line FTIR-ATR monitoring to study the building process of such networks was also assessed. The performance of hydrogel beads was studied through drug delivery tests triggered by changes in the environmental temperature and pH. This research aims to contribute for the elucidation of the connection between the synthesis conditions, molecular architecture and properties/performance of such advanced materials. |
| dirty | 0 |
| eu_rights_str_mv | openAccess |
| format | conferencePaper |
| fulltext.url.fl_str_mv | https://bibliotecadigital.ipb.pt/bitstreams/c87e360a-a699-406e-8460-3eadb8f2e24b/download |
| funding.funder.alternateName_str_mv | FCT |
| funding.funder.identifier_str_mv | http://doi.org/10.13039/501100001871 |
| funding.funder.name_str_mv | Fundação para a Ciência e a Tecnologia |
| funding.name_str_mv | 5876-PPCDTI |
| id | ipb_4c628599db730b2ed8edca0f5cbbcc51 |
| identifier.url.fl_str_mv | http://hdl.handle.net/10198/9614 |
| instacron_str | ipb |
| institution | Instituto Politécnico de Bragança |
| instname_str | Instituto Politécnico de Bragança |
| language | eng |
| network_acronym_str | ipb |
| network_name_str | Biblioteca Digital do IPB |
| oai_identifier_str | oai:bibliotecadigital.ipb.pt:10198/9614 |
| organization_str_mv | urn:organizationAcronym:ipb |
| person_str_mv | Gonçalves, Miguel A.D. Pinto, Virgínia Costa, Rita Alexandra Santos da Dias, Rolando Dias, Rolando https://www.ciencia-id.pt/8417-4D84-973B 8417-4D84-973B http://orcid.org/0000-0001-7369-382X 0000-0001-7369-382X Hernándes-Ortiz, Júlio Costa, Mário Rui |
| publishDate | 2013 |
| publisher.none.fl_str_mv | WILEY-VCH |
| reponame_str | Biblioteca Digital do IPB |
| repository_id_str | urn:repositoryAcronym:ipb |
| service_str_mv | urn:repositoryAcronym:ipb |
| spelling | engWILEY-VCHporTemperature and pH stimuli-responsive hydrogel particles were synthesized using inverse-suspension polymerization in batch stirred reactor. Different water soluble co-monomers were present in the initial mixture (e.g. N-isopropylacrylamide and acrylic acid) as well as crosslinkers with different functionalities. Different operating conditions such as polymerization temperature, monomers dilution, neutralization and the initial ratios of co-monomers and monomers/crosslinker were also tried. Hydrogel particles were produced considering classical free-radical polymerization (FRP) and also RAFT polymerization. Commercially available RAFT agents 4-cyano-4-phenylcarbonothioylthio-pentanoic acid (CPA), 2-(dodecylthiocarbonothioylthio)-2-methylpropionic acid (DDMAT) and cyanomethyl dodecyl trithiocarbonate (CDT) were alternatively used. Sampling at different polymerization times allowed the study of the kinetics of polymerization through the analysis by SEC of the soluble phase. A tetra-detector array with simultaneous detection of refractive index, light scattering, intrinsic viscosity and ultra-violet signals was used in these studies. Usefulness of in-line FTIR-ATR monitoring to study the building process of such networks was also assessed. The performance of hydrogel beads was studied through drug delivery tests triggered by changes in the environmental temperature and pH. This research aims to contribute for the elucidation of the connection between the synthesis conditions, molecular architecture and properties/performance of such advanced materials.application/pdfporStimuli-responsive hydrogels synthesis using free radical and RAFT polymerizationGonçalves, Miguel A.D.Pinto, VirgíniaCosta, Rita Alexandra Santos daPersonalDias, RolandoDSpacehttp://dspace.org/items/d7109687-6adf-4268-a462-8d1a2e2c01cbDSpacehttp://dspace.org/items/d7109687-6adf-4268-a462-8d1a2e2c01cbDiasRolandoCiência IDhttps://www.ciencia-id.pt8417-4D84-973BORCIDhttp://orcid.org0000-0001-7369-382XResearcher IDhttps://www.researcherid.comM-8552-2013Scopus Author IDhttps://www.scopus.com7102885104Hernándes-Ortiz, JúlioCosta, Mário RuiHostingInstitutionOrganizationalBiblioteca Digital do IPBe-mailmailto:dspace@ipb.ptdspace@ipb.ptDOIIsPartOf10.1002/masy.2013000452014-06-02T11:18:28Z20132013-01-01T00:00:00ZHandlehttp://hdl.handle.net/10198/9614http://purl.org/coar/access_right/c_abf2open accessCrosslinkingHydrogelsRAFTStimuli-responsive polymers1250497 bytesFundação para a Ciência e a TecnologiaMolecular Engineering, Synthesis and Testing of Water Compatible Smart Polymers5876-PPCDTICrossref Funder IDhttp://doi.org/10.13039/501100001871other research producthttp://purl.org/coar/resource_type/c_5794conference paperhttp://purl.org/coar/access_right/c_abf2application/pdffulltexthttps://bibliotecadigital.ipb.pt/bitstreams/c87e360a-a699-406e-8460-3eadb8f2e24b/downloadMacromolecular Symposia - Special Issue: Polymer Reaction Engineering3334154Hamburg |
| spellingShingle | Stimuli-responsive hydrogels synthesis using free radical and RAFT polymerization Gonçalves, Miguel A.D. Crosslinking Hydrogels RAFT Stimuli-responsive polymers |
| status | SINGLETON |
| subject.fl_str_mv | Crosslinking Hydrogels RAFT Stimuli-responsive polymers |
| title | Stimuli-responsive hydrogels synthesis using free radical and RAFT polymerization |
| title_full | Stimuli-responsive hydrogels synthesis using free radical and RAFT polymerization |
| title_fullStr | Stimuli-responsive hydrogels synthesis using free radical and RAFT polymerization |
| title_full_unstemmed | Stimuli-responsive hydrogels synthesis using free radical and RAFT polymerization |
| title_short | Stimuli-responsive hydrogels synthesis using free radical and RAFT polymerization |
| title_sort | Stimuli-responsive hydrogels synthesis using free radical and RAFT polymerization |
| topic | Crosslinking Hydrogels RAFT Stimuli-responsive polymers |
| topic_facet | Crosslinking Hydrogels RAFT Stimuli-responsive polymers |
| url | http://hdl.handle.net/10198/9614 |
| visible | 1 |