Publication
Insights on the extraction performance of Alkanediols and Glycerol: ssing Juglans regia L. Leaves as a source of bioactive compounds
| Summary: | Glycerol and alkanediols are being studied as alternative solvents to extract phytochemicals from plant material, often as hydrogen bond donors in deep eutectic solvents (DESs). Many of those alcohols are liquid at room temperature, yet studies of their use as extraction solvents are scarce. In this work, glycerol and a series of alkanediols (1,2-ethanediol, 1,2-propanediol, 1,3-propanediol, 1,3-butanediol, 1,2-pentanediol, 1,5-pentanediol, and 1,2-hexanediol) were studied for the extraction of phenolic compounds from Juglans regia L. leaves, a rich source of this class of bioactive compounds. The extraction yield was quantified, and the bioactivity of both extracts and pure solvents was evaluated by measuring the anti-inflammatory and cytotoxic activities. The solvents showing the best combined results were 1,2 and 1,3-propanediol, as their extracts presented a high amount of phenolic compounds, close to the results of ethanol, and similar cytotoxicity against cervical carcinoma cells, with no impact on non-tumor porcine liver cells in the studied concentration range. On the other hand, none of the extracts (and solvents) presented anti-inflammatory activity. Overall, the results obtained in this work contribute to the study of alternative solvents that could potentially be used also as formulation media, highlighting the importance of walnut leaves as a source of bioactive compounds. |
|---|---|
| Main Authors: | Vieira, Vanessa |
| Other Authors: | Calhelha, Ricardo C.; Barros, Lillian; Coutinho, João A.P.; Ferreira, Isabel C.F.R.; Ferreira, Olga |
| Subject: | Alkanediols Anti-inflammatory activity Cytotoxicity Glycerol Juglans regia L. Phenolic compounds Solvents |
| Year: | 2020 |
| Country: | Portugal |
| Document type: | article |
| Access type: | open access |
| Associated institution: | Instituto Politécnico de Bragança |
| Language: | English |
| Origin: | Biblioteca Digital do IPB |
| _version_ | 1863851163805286400 |
|---|---|
| author | Vieira, Vanessa |
| author2 | Calhelha, Ricardo C. Barros, Lillian Coutinho, João A.P. Ferreira, Isabel C.F.R. Ferreira, Olga |
| author2_role | author author author author author |
| author_facet | Vieira, Vanessa Calhelha, Ricardo C. Barros, Lillian Coutinho, João A.P. Ferreira, Isabel C.F.R. Ferreira, Olga |
| author_role | author |
| contributor_name_str_mv | Biblioteca Digital do IPB |
| country_str | PT |
| creators_json_str | [{\"Person.name\":\"Vieira, Vanessa\"},{\"Person.name\":\"Calhelha, Ricardo C.\",\"Person.identifier.orcid\":\"0000-0002-6801-4578\"},{\"Person.name\":\"Barros, Lillian\",\"Person.identifier.orcid\":\"0000-0002-9050-5189\"},{\"Person.name\":\"Coutinho, João A.P.\"},{\"Person.name\":\"Ferreira, Isabel C.F.R.\",\"Person.identifier.orcid\":\"0000-0003-4910-4882\"},{\"Person.name\":\"Ferreira, Olga\",\"Person.identifier.orcid\":\"0000-0001-8414-3479\"}] |
| datacite.contributors.contributor.contributorName.fl_str_mv | Biblioteca Digital do IPB |
| datacite.creators.creator.creatorName.fl_str_mv | Vieira, Vanessa Calhelha, Ricardo C. Barros, Lillian Coutinho, João A.P. Ferreira, Isabel C.F.R. Ferreira, Olga |
| datacite.date.Accepted.fl_str_mv | 2020-01-01T00:00:00Z |
| datacite.date.available.fl_str_mv | 2018-01-19T10:00:00Z |
| datacite.date.embargoed.fl_str_mv | 2018-01-19T10:00:00Z |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| datacite.subjects.subject.fl_str_mv | Alkanediols Anti-inflammatory activity Cytotoxicity Glycerol Juglans regia L. Phenolic compounds Solvents |
| datacite.titles.title.fl_str_mv | Insights on the extraction performance of Alkanediols and Glycerol: ssing Juglans regia L. Leaves as a source of bioactive compounds |
| dc.contributor.none.fl_str_mv | Biblioteca Digital do IPB |
| dc.creator.none.fl_str_mv | Vieira, Vanessa Calhelha, Ricardo C. Barros, Lillian Coutinho, João A.P. Ferreira, Isabel C.F.R. Ferreira, Olga |
| dc.date.Accepted.fl_str_mv | 2020-01-01T00:00:00Z |
| dc.date.available.fl_str_mv | 2018-01-19T10:00:00Z |
| dc.date.embargoed.fl_str_mv | 2018-01-19T10:00:00Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | http://hdl.handle.net/10198/22293 |
| dc.language.none.fl_str_mv | eng |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| dc.subject.none.fl_str_mv | Alkanediols Anti-inflammatory activity Cytotoxicity Glycerol Juglans regia L. Phenolic compounds Solvents |
| dc.title.fl_str_mv | Insights on the extraction performance of Alkanediols and Glycerol: ssing Juglans regia L. Leaves as a source of bioactive compounds |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_6501 |
| description | Glycerol and alkanediols are being studied as alternative solvents to extract phytochemicals from plant material, often as hydrogen bond donors in deep eutectic solvents (DESs). Many of those alcohols are liquid at room temperature, yet studies of their use as extraction solvents are scarce. In this work, glycerol and a series of alkanediols (1,2-ethanediol, 1,2-propanediol, 1,3-propanediol, 1,3-butanediol, 1,2-pentanediol, 1,5-pentanediol, and 1,2-hexanediol) were studied for the extraction of phenolic compounds from Juglans regia L. leaves, a rich source of this class of bioactive compounds. The extraction yield was quantified, and the bioactivity of both extracts and pure solvents was evaluated by measuring the anti-inflammatory and cytotoxic activities. The solvents showing the best combined results were 1,2 and 1,3-propanediol, as their extracts presented a high amount of phenolic compounds, close to the results of ethanol, and similar cytotoxicity against cervical carcinoma cells, with no impact on non-tumor porcine liver cells in the studied concentration range. On the other hand, none of the extracts (and solvents) presented anti-inflammatory activity. Overall, the results obtained in this work contribute to the study of alternative solvents that could potentially be used also as formulation media, highlighting the importance of walnut leaves as a source of bioactive compounds. |
| dirty | 0 |
| eu_rights_str_mv | openAccess |
| format | article |
| fulltext.url.fl_str_mv | https://bibliotecadigital.ipb.pt/bitstreams/a6082cfb-48cf-4718-aa7a-72e4ea2670db/download |
| id | ipb_4ed6772fa27f4e310b38ac28fa12c340 |
| identifier.url.fl_str_mv | http://hdl.handle.net/10198/22293 |
| instacron_str | ipb |
| institution | Instituto Politécnico de Bragança |
| instname_str | Instituto Politécnico de Bragança |
| language | eng |
| network_acronym_str | ipb |
| network_name_str | Biblioteca Digital do IPB |
| oai_identifier_str | oai:bibliotecadigital.ipb.pt:10198/22293 |
| organization_str_mv | urn:organizationAcronym:ipb |
| person_str_mv | Vieira, Vanessa Calhelha, Ricardo C. Calhelha, Ricardo C. https://www.ciencia-id.pt/F313-E3CE-554E F313-E3CE-554E http://orcid.org/0000-0002-6801-4578 0000-0002-6801-4578 Barros, Lillian Barros, Lillian https://www.ciencia-id.pt/9616-35CB-D001 9616-35CB-D001 http://orcid.org/0000-0002-9050-5189 0000-0002-9050-5189 Coutinho, João A.P. Ferreira, Isabel C.F.R. Ferreira, Isabel C.F.R. https://www.ciencia-id.pt/9418-CF95-9919 9418-CF95-9919 http://orcid.org/0000-0003-4910-4882 0000-0003-4910-4882 Ferreira, Olga Ferreira, Olga https://www.ciencia-id.pt/9F1D-C75A-4A54 9F1D-C75A-4A54 http://orcid.org/0000-0001-8414-3479 0000-0001-8414-3479 |
| publishDate | 2020 |
| reponame_str | Biblioteca Digital do IPB |
| repository_id_str | urn:repositoryAcronym:ipb |
| service_str_mv | urn:repositoryAcronym:ipb |
| spelling | engGlycerol and alkanediols are being studied as alternative solvents to extract phytochemicals from plant material, often as hydrogen bond donors in deep eutectic solvents (DESs). Many of those alcohols are liquid at room temperature, yet studies of their use as extraction solvents are scarce. In this work, glycerol and a series of alkanediols (1,2-ethanediol, 1,2-propanediol, 1,3-propanediol, 1,3-butanediol, 1,2-pentanediol, 1,5-pentanediol, and 1,2-hexanediol) were studied for the extraction of phenolic compounds from Juglans regia L. leaves, a rich source of this class of bioactive compounds. The extraction yield was quantified, and the bioactivity of both extracts and pure solvents was evaluated by measuring the anti-inflammatory and cytotoxic activities. The solvents showing the best combined results were 1,2 and 1,3-propanediol, as their extracts presented a high amount of phenolic compounds, close to the results of ethanol, and similar cytotoxicity against cervical carcinoma cells, with no impact on non-tumor porcine liver cells in the studied concentration range. On the other hand, none of the extracts (and solvents) presented anti-inflammatory activity. Overall, the results obtained in this work contribute to the study of alternative solvents that could potentially be used also as formulation media, highlighting the importance of walnut leaves as a source of bioactive compounds.application/pdfen_ENInsights on the extraction performance of Alkanediols and Glycerol: ssing Juglans regia L. Leaves as a source of bioactive compoundsVieira, VanessaPersonalCalhelha, Ricardo C.DSpacehttp://dspace.org/items/2d5d1a41-7561-4a01-871c-b4c97da35053DSpacehttp://dspace.org/items/2d5d1a41-7561-4a01-871c-b4c97da35053CalhelhaRicardo C.Ciência IDhttps://www.ciencia-id.ptF313-E3CE-554EORCIDhttp://orcid.org0000-0002-6801-4578Researcher IDhttps://www.researcherid.comJ-2172-2014Scopus Author IDhttps://www.scopus.com6507978333PersonalBarros, LillianDSpacehttp://dspace.org/items/3af07ffe-f914-48ba-a5d5-efcf70fdce01DSpacehttp://dspace.org/items/3af07ffe-f914-48ba-a5d5-efcf70fdce01BarrosLillianCiência IDhttps://www.ciencia-id.pt9616-35CB-D001ORCIDhttp://orcid.org0000-0002-9050-5189Researcher IDhttps://www.researcherid.comJ-3600-2013Researcher IDhttps://www.researcherid.comJ-3600-2013Scopus Author IDhttps://www.scopus.com35236343600Scopus Author IDhttps://www.scopus.com57194900801Coutinho, João A.P.PersonalFerreira, Isabel C.F.R.DSpacehttp://dspace.org/items/bd0d1537-2e03-41fb-b27a-140af9c35db8DSpacehttp://dspace.org/items/bd0d1537-2e03-41fb-b27a-140af9c35db8FerreiraIsabel C.F.R.Ciência IDhttps://www.ciencia-id.pt9418-CF95-9919ORCIDhttp://orcid.org0000-0003-4910-4882Researcher IDhttps://www.researcherid.comE-8500-2013Scopus Author IDhttps://www.scopus.com36868826600PersonalFerreira, OlgaDSpacehttp://dspace.org/items/59e0c608-0c21-4191-af5e-529d21970399DSpacehttp://dspace.org/items/59e0c608-0c21-4191-af5e-529d21970399FerreiraOlgaCiência IDhttps://www.ciencia-id.pt9F1D-C75A-4A54ORCIDhttp://orcid.org0000-0001-8414-3479Researcher IDhttps://www.researcherid.comM-4567-2013Scopus Author IDhttps://www.scopus.com57203083219HostingInstitutionOrganizationalBiblioteca Digital do IPBe-mailmailto:dspace@ipb.ptdspace@ipb.ptDOIIsPartOf10.3390/molecules251124972018-01-19T10:00:00Z20202020-01-01T00:00:00ZHandlehttp://hdl.handle.net/10198/22293http://purl.org/coar/access_right/c_abf2open accessAlkanediolsAnti-inflammatory activityCytotoxicityGlycerolJuglans regia L.Phenolic compoundsSolvents317173 bytesliteraturehttp://purl.org/coar/resource_type/c_6501journal articlehttp://purl.org/coar/access_right/c_abf2application/pdffulltexthttps://bibliotecadigital.ipb.pt/bitstreams/a6082cfb-48cf-4718-aa7a-72e4ea2670db/download |
| spellingShingle | Insights on the extraction performance of Alkanediols and Glycerol: ssing Juglans regia L. Leaves as a source of bioactive compounds Vieira, Vanessa Alkanediols Anti-inflammatory activity Cytotoxicity Glycerol Juglans regia L. Phenolic compounds Solvents |
| subject.fl_str_mv | Alkanediols Anti-inflammatory activity Cytotoxicity Glycerol Juglans regia L. Phenolic compounds Solvents |
| title | Insights on the extraction performance of Alkanediols and Glycerol: ssing Juglans regia L. Leaves as a source of bioactive compounds |
| title_full | Insights on the extraction performance of Alkanediols and Glycerol: ssing Juglans regia L. Leaves as a source of bioactive compounds |
| title_fullStr | Insights on the extraction performance of Alkanediols and Glycerol: ssing Juglans regia L. Leaves as a source of bioactive compounds |
| title_full_unstemmed | Insights on the extraction performance of Alkanediols and Glycerol: ssing Juglans regia L. Leaves as a source of bioactive compounds |
| title_short | Insights on the extraction performance of Alkanediols and Glycerol: ssing Juglans regia L. Leaves as a source of bioactive compounds |
| title_sort | Insights on the extraction performance of Alkanediols and Glycerol: ssing Juglans regia L. Leaves as a source of bioactive compounds |
| topic | Alkanediols Anti-inflammatory activity Cytotoxicity Glycerol Juglans regia L. Phenolic compounds Solvents |
| topic_facet | Alkanediols Anti-inflammatory activity Cytotoxicity Glycerol Juglans regia L. Phenolic compounds Solvents |
| url | http://hdl.handle.net/10198/22293 |
| visible | 1 |