Publicação
Bioactive properties of medicinal plants from the Algerian flora: selecting the species with the highest potential in view of application purposes
| Resumo: | The Algerian flora contains a wide variety of plant species with potential to be used in medicinal applications. Herein, the bioactive properties of medicinal plants from Algeria were evaluated to select the species with highest suitability to be used under specific purposes, while scientifically validating their health claims. The antioxidant activity of the infusions was screened by using several tests and cytotoxic properties were evaluated against human tumor cell lines (as also against non-tumor cells). Different hydrophilic bioactive compounds were also quantified. The results were analyzed considering individual variations in each parameter (ANOVA), but also in an aggregated approach by applying principal component analysis to acquire a comprehensive knowledge regarding the overall bioactive potential of the studied species. Limoniastrum guyonianum and Thymus pallescens showed the highest antioxidant activity (EC50 values ranging from 29 to 229 μg/mL and 54 to 240 μg/mL, respectively), whilst Asteriscus graveolens and L. guyonianum gave the best cytotoxicity against human tumor cell lines (GI50 values ranging from 11 to 29 μg/mL and 22 to 70 μg/mL, respectively). T. pallescens stood out as the species with highest bioactive compounds contents (phenols: 463 mg GAE, flavonoids: 194 mg CE, esters; 186 mg CAE; flavonols: 85 mg QE, considering g of lyophilized infusion basis). From a global point of view, T. pallescens, Saccocalyx satureioides and Ptychotis verticillata proved to be the preferable choices as high potential sources of bioactive compounds, while Haloxylon scoparium, L. guyonianum and A. graveolens would be the most suitable matrices considering the bioactivity (especially cytotoxicity) criterion, as inferred from the PCA outputs. |
|---|---|
| Autores principais: | Ziani, Borhane E.C. |
| Outros Autores: | Calhelha, Ricardo C.; Barreira, João C.M.; Barros, Lillian; Hazzit, Mohamed; Ferreira, Isabel C.F.R. |
| Assunto: | Algerian flora Hydrophilic extracts Antioxidant activity Antitumor activity Bioactive compounds |
| Ano: | 2015 |
| País: | Portugal |
| Tipo de documento: | artigo |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Instituto Politécnico de Bragança |
| Idioma: | inglês |
| Origem: | Biblioteca Digital do IPB |
| _version_ | 1867173344652034048 |
|---|---|
| author | Ziani, Borhane E.C. |
| author2 | Calhelha, Ricardo C. Barreira, João C.M. Barros, Lillian Hazzit, Mohamed Ferreira, Isabel C.F.R. |
| author2_role | author author author author author |
| author_facet | Ziani, Borhane E.C. Calhelha, Ricardo C. Barreira, João C.M. Barros, Lillian Hazzit, Mohamed Ferreira, Isabel C.F.R. |
| author_role | author |
| contributor_name_str_mv | Biblioteca Digital do IPB |
| country_str | PT |
| creators_json_txt | [{\"Person.name\":\"Ziani, Borhane E.C.\"},{\"Person.name\":\"Calhelha, Ricardo C.\",\"Person.identifier.orcid\":\"0000-0002-6801-4578\"},{\"Person.name\":\"Barreira, João C.M.\",\"Person.identifier.orcid\":\"0000-0003-1233-0990\"},{\"Person.name\":\"Barros, Lillian\",\"Person.identifier.orcid\":\"0000-0002-9050-5189\"},{\"Person.name\":\"Hazzit, Mohamed\"},{\"Person.name\":\"Ferreira, Isabel C.F.R.\",\"Person.identifier.orcid\":\"0000-0003-4910-4882\"}] |
| datacite.contributors.contributor.contributorName.fl_str_mv | Biblioteca Digital do IPB |
| datacite.creators.creator.creatorName.fl_str_mv | Ziani, Borhane E.C. Calhelha, Ricardo C. Barreira, João C.M. Barros, Lillian Hazzit, Mohamed Ferreira, Isabel C.F.R. |
| datacite.date.Accepted.fl_str_mv | 2015-01-01T00:00:00Z |
| datacite.date.available.fl_str_mv | 2015-12-01T11:03:07Z |
| datacite.date.embargoed.fl_str_mv | 2015-12-01T11:03:07Z |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| datacite.subjects.subject.fl_str_mv | Algerian flora Hydrophilic extracts Antioxidant activity Antitumor activity Bioactive compounds |
| datacite.titles.title.fl_str_mv | Bioactive properties of medicinal plants from the Algerian flora: selecting the species with the highest potential in view of application purposes |
| dc.contributor.none.fl_str_mv | Biblioteca Digital do IPB |
| dc.creator.none.fl_str_mv | Ziani, Borhane E.C. Calhelha, Ricardo C. Barreira, João C.M. Barros, Lillian Hazzit, Mohamed Ferreira, Isabel C.F.R. |
| dc.date.Accepted.fl_str_mv | 2015-01-01T00:00:00Z |
| dc.date.available.fl_str_mv | 2015-12-01T11:03:07Z |
| dc.date.embargoed.fl_str_mv | 2015-12-01T11:03:07Z |
| dc.format.none.fl_str_mv | application/pdf application/pdf |
| dc.identifier.none.fl_str_mv | http://hdl.handle.net/10198/12464 |
| dc.language.none.fl_str_mv | eng |
| dc.publisher.none.fl_str_mv | Elsevier |
| dc.rights.cclincense.fl_str_mv | http://creativecommons.org/licenses/by/4.0/ |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| dc.subject.none.fl_str_mv | Algerian flora Hydrophilic extracts Antioxidant activity Antitumor activity Bioactive compounds |
| dc.title.fl_str_mv | Bioactive properties of medicinal plants from the Algerian flora: selecting the species with the highest potential in view of application purposes |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_6501 |
| description | The Algerian flora contains a wide variety of plant species with potential to be used in medicinal applications. Herein, the bioactive properties of medicinal plants from Algeria were evaluated to select the species with highest suitability to be used under specific purposes, while scientifically validating their health claims. The antioxidant activity of the infusions was screened by using several tests and cytotoxic properties were evaluated against human tumor cell lines (as also against non-tumor cells). Different hydrophilic bioactive compounds were also quantified. The results were analyzed considering individual variations in each parameter (ANOVA), but also in an aggregated approach by applying principal component analysis to acquire a comprehensive knowledge regarding the overall bioactive potential of the studied species. Limoniastrum guyonianum and Thymus pallescens showed the highest antioxidant activity (EC50 values ranging from 29 to 229 μg/mL and 54 to 240 μg/mL, respectively), whilst Asteriscus graveolens and L. guyonianum gave the best cytotoxicity against human tumor cell lines (GI50 values ranging from 11 to 29 μg/mL and 22 to 70 μg/mL, respectively). T. pallescens stood out as the species with highest bioactive compounds contents (phenols: 463 mg GAE, flavonoids: 194 mg CE, esters; 186 mg CAE; flavonols: 85 mg QE, considering g of lyophilized infusion basis). From a global point of view, T. pallescens, Saccocalyx satureioides and Ptychotis verticillata proved to be the preferable choices as high potential sources of bioactive compounds, while Haloxylon scoparium, L. guyonianum and A. graveolens would be the most suitable matrices considering the bioactivity (especially cytotoxicity) criterion, as inferred from the PCA outputs. |
| dirty | 0 |
| eu_rights_str_mv | openAccess |
| format | article |
| fulltext.url.fl_str_mv | https://bibliotecadigital.ipb.pt/bitstreams/1cd15d91-d02f-40cf-b2e7-ef7faef59613/download |
| funding.funder.alternateName_str_mv | FCT |
| funding.funder.identifier_str_mv | http://doi.org/10.13039/501100001871 |
| funding.funder.name_str_mv | Fundação para a Ciência e a Tecnologia |
| id | ipb_6e0eae2a69f627c5ce903da08ea9cd4f |
| identifier.url.fl_str_mv | http://hdl.handle.net/10198/12464 |
| instacron_str | ipb |
| institution | Instituto Politécnico de Bragança |
| instname_str | Instituto Politécnico de Bragança |
| language | eng |
| network_acronym_str | ipb |
| network_name_str | Biblioteca Digital do IPB |
| oai_identifier_str | oai:bibliotecadigital.ipb.pt:10198/12464 |
| organization_str_mv | urn:organizationAcronym:ipb |
| person_str_mv | Ziani, Borhane E.C. Calhelha, Ricardo C. Calhelha, Ricardo C. https://www.ciencia-id.pt/F313-E3CE-554E F313-E3CE-554E http://orcid.org/0000-0002-6801-4578 0000-0002-6801-4578 Barreira, João C.M. Barreira, João C.M. http://orcid.org/0000-0003-1233-0990 0000-0003-1233-0990 Barros, Lillian Barros, Lillian https://www.ciencia-id.pt/9616-35CB-D001 9616-35CB-D001 http://orcid.org/0000-0002-9050-5189 0000-0002-9050-5189 Hazzit, Mohamed Ferreira, Isabel C.F.R. Ferreira, Isabel C.F.R. https://www.ciencia-id.pt/9418-CF95-9919 9418-CF95-9919 http://orcid.org/0000-0003-4910-4882 0000-0003-4910-4882 |
| publishDate | 2015 |
| publisher.none.fl_str_mv | Elsevier |
| reponame_str | Biblioteca Digital do IPB |
| repository_id_str | urn:repositoryAcronym:ipb |
| service_str_mv | urn:repositoryAcronym:ipb |
| spelling | engElsevierpt_PTThe Algerian flora contains a wide variety of plant species with potential to be used in medicinal applications. Herein, the bioactive properties of medicinal plants from Algeria were evaluated to select the species with highest suitability to be used under specific purposes, while scientifically validating their health claims. The antioxidant activity of the infusions was screened by using several tests and cytotoxic properties were evaluated against human tumor cell lines (as also against non-tumor cells). Different hydrophilic bioactive compounds were also quantified. The results were analyzed considering individual variations in each parameter (ANOVA), but also in an aggregated approach by applying principal component analysis to acquire a comprehensive knowledge regarding the overall bioactive potential of the studied species. Limoniastrum guyonianum and Thymus pallescens showed the highest antioxidant activity (EC50 values ranging from 29 to 229 μg/mL and 54 to 240 μg/mL, respectively), whilst Asteriscus graveolens and L. guyonianum gave the best cytotoxicity against human tumor cell lines (GI50 values ranging from 11 to 29 μg/mL and 22 to 70 μg/mL, respectively). T. pallescens stood out as the species with highest bioactive compounds contents (phenols: 463 mg GAE, flavonoids: 194 mg CE, esters; 186 mg CAE; flavonols: 85 mg QE, considering g of lyophilized infusion basis). From a global point of view, T. pallescens, Saccocalyx satureioides and Ptychotis verticillata proved to be the preferable choices as high potential sources of bioactive compounds, while Haloxylon scoparium, L. guyonianum and A. graveolens would be the most suitable matrices considering the bioactivity (especially cytotoxicity) criterion, as inferred from the PCA outputs.application/pdfapplication/pdfpt_PTBioactive properties of medicinal plants from the Algerian flora: selecting the species with the highest potential in view of application purposesZiani, Borhane E.C.PersonalCalhelha, Ricardo C.DSpacehttp://dspace.org/items/2d5d1a41-7561-4a01-871c-b4c97da35053DSpacehttp://dspace.org/items/2d5d1a41-7561-4a01-871c-b4c97da35053CalhelhaRicardo C.Ciência IDhttps://www.ciencia-id.ptF313-E3CE-554EORCIDhttp://orcid.org0000-0002-6801-4578Researcher IDhttps://www.researcherid.comJ-2172-2014Scopus Author IDhttps://www.scopus.com6507978333PersonalBarreira, João C.M.DSpacehttp://dspace.org/items/4629b12c-39b0-4da8-8b8d-6efba5cf2d81DSpacehttp://dspace.org/items/4629b12c-39b0-4da8-8b8d-6efba5cf2d81BarreiraJoão C.M.ORCIDhttp://orcid.org0000-0003-1233-0990Researcher IDhttps://www.researcherid.comD-8269-2013Scopus Author IDhttps://www.scopus.com54895546900PersonalBarros, LillianDSpacehttp://dspace.org/items/3af07ffe-f914-48ba-a5d5-efcf70fdce01DSpacehttp://dspace.org/items/3af07ffe-f914-48ba-a5d5-efcf70fdce01BarrosLillianCiência IDhttps://www.ciencia-id.pt9616-35CB-D001ORCIDhttp://orcid.org0000-0002-9050-5189Researcher IDhttps://www.researcherid.comJ-3600-2013Researcher IDhttps://www.researcherid.comJ-3600-2013Scopus Author IDhttps://www.scopus.com35236343600Scopus Author IDhttps://www.scopus.com57194900801Hazzit, MohamedPersonalFerreira, Isabel C.F.R.DSpacehttp://dspace.org/items/bd0d1537-2e03-41fb-b27a-140af9c35db8DSpacehttp://dspace.org/items/bd0d1537-2e03-41fb-b27a-140af9c35db8FerreiraIsabel C.F.R.Ciência IDhttps://www.ciencia-id.pt9418-CF95-9919ORCIDhttp://orcid.org0000-0003-4910-4882Researcher IDhttps://www.researcherid.comE-8500-2013Scopus Author IDhttps://www.scopus.com36868826600HostingInstitutionOrganizationalBiblioteca Digital do IPBe-mailmailto:dspace@ipb.ptdspace@ipb.ptISSNIsPartOf0926-6690DOIIsPartOf10.1016/j.indcrop.2015.09.0342015-12-01T11:03:07Z20152015-01-01T00:00:00ZHandlehttp://hdl.handle.net/10198/12464http://purl.org/coar/access_right/c_abf2open accessAlgerian floraHydrophilic extractsAntioxidant activityAntitumor activityBioactive compounds1032685 bytes842333 bytesFundação para a Ciência e a TecnologiaBIOACTIVE PROPERTIES & CYTOPROTECTIVE POTENTIAL OF NATURAL EXTRACTS/INDIVIDUAL COMPOUNDS: APPLICATION OF SINGLE CELL GEL ELECTROPHORESIS AND OTHER BIOCHEMICAL, CHEMICAL AND ELECTROCHEMICAL ASSAYSCrossref Funder IDhttp://doi.org/10.13039/501100001871literaturehttp://purl.org/coar/resource_type/c_6501journal article2015http://creativecommons.org/licenses/by/4.0/http://purl.org/coar/access_right/c_abf2application/pdffulltexthttps://bibliotecadigital.ipb.pt/bitstreams/1cd15d91-d02f-40cf-b2e7-ef7faef59613/downloadhttp://purl.org/coar/access_right/c_abf2application/pdffulltexthttps://bibliotecadigital.ipb.pt/bitstreams/7d5d32af-72b1-431b-8276-89aa29f61adb/downloadIndustrial Crops and Products77582589 |
| spellingShingle | Bioactive properties of medicinal plants from the Algerian flora: selecting the species with the highest potential in view of application purposes Ziani, Borhane E.C. Algerian flora Hydrophilic extracts Antioxidant activity Antitumor activity Bioactive compounds |
| status | SINGLETON |
| subject.fl_str_mv | Algerian flora Hydrophilic extracts Antioxidant activity Antitumor activity Bioactive compounds |
| title | Bioactive properties of medicinal plants from the Algerian flora: selecting the species with the highest potential in view of application purposes |
| title_full | Bioactive properties of medicinal plants from the Algerian flora: selecting the species with the highest potential in view of application purposes |
| title_fullStr | Bioactive properties of medicinal plants from the Algerian flora: selecting the species with the highest potential in view of application purposes |
| title_full_unstemmed | Bioactive properties of medicinal plants from the Algerian flora: selecting the species with the highest potential in view of application purposes |
| title_short | Bioactive properties of medicinal plants from the Algerian flora: selecting the species with the highest potential in view of application purposes |
| title_sort | Bioactive properties of medicinal plants from the Algerian flora: selecting the species with the highest potential in view of application purposes |
| topic | Algerian flora Hydrophilic extracts Antioxidant activity Antitumor activity Bioactive compounds |
| topic_facet | Algerian flora Hydrophilic extracts Antioxidant activity Antitumor activity Bioactive compounds |
| url | http://hdl.handle.net/10198/12464 |
| visible | 1 |