Publicação
Antimicrobial and cytotoxic activities of short carbon chain unsaturated sucrose esters
| Resumo: | A library of C3–C5 unsaturated 6-O-sucrose esters have been investigated for their antibacterial, antifungal, and cytotoxic activities. Most of the target compounds showed good inhibitory activity against a variety of clinically and food contaminant important microbial pathogens. In particular, 6-O-methacryloyl sucrose 2 and 1′,2,3,3′,4,4′,6′-hepta-O-acetyl-6-O-methacryloyl sucrose 9 were the most active bactericides against all the tested bacteria with minimal inhibitory concentrations (MICs) ranging between 0.24 and 1.40 μM. The compound 9 showed also the highest antifungal activity with MICs from 0.28 to 1.10 μM. The synthesized compounds possessed low cytotoxicity against human breast, lung, cervical, and hepatocellular carcinoma cell lines without showing toxicity for non-tumor liver cells. Thus, this library of short carbon chain unsaturated sucrose esters represent promising leads for the development of new generation of sucrose-based antimicrobial agents. |
|---|---|
| Autores principais: | Petrova, Krasimira T. |
| Outros Autores: | Barros, M. Teresa; Calhelha, Ricardo C.; Soković, Marina; Ferreira, Isabel C.F.R. |
| Assunto: | Antibacterial activity Antifungal activity Cytotoxic activity Sucrose Unsaturated esters |
| Ano: | 2018 |
| País: | Portugal |
| Tipo de documento: | artigo |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Instituto Politécnico de Bragança |
| Idioma: | inglês |
| Origem: | Biblioteca Digital do IPB |
| _version_ | 1867172731215151104 |
|---|---|
| author | Petrova, Krasimira T. |
| author2 | Barros, M. Teresa Calhelha, Ricardo C. Soković, Marina Ferreira, Isabel C.F.R. |
| author2_role | author author author author |
| author_facet | Petrova, Krasimira T. Barros, M. Teresa Calhelha, Ricardo C. Soković, Marina Ferreira, Isabel C.F.R. |
| author_role | author |
| contributor_name_str_mv | Biblioteca Digital do IPB |
| country_str | PT |
| creators_json_txt | [{\"Person.name\":\"Petrova, Krasimira T.\"},{\"Person.name\":\"Barros, M. Teresa\"},{\"Person.name\":\"Calhelha, Ricardo C.\",\"Person.identifier.orcid\":\"0000-0002-6801-4578\"},{\"Person.name\":\"Soković, Marina\"},{\"Person.name\":\"Ferreira, Isabel C.F.R.\",\"Person.identifier.orcid\":\"0000-0003-4910-4882\"}] |
| datacite.contributors.contributor.contributorName.fl_str_mv | Biblioteca Digital do IPB |
| datacite.creators.creator.creatorName.fl_str_mv | Petrova, Krasimira T. Barros, M. Teresa Calhelha, Ricardo C. Soković, Marina Ferreira, Isabel C.F.R. |
| datacite.date.Accepted.fl_str_mv | 2018-01-01T00:00:00Z |
| datacite.date.available.fl_str_mv | 2018-01-19T10:00:00Z |
| datacite.date.embargoed.fl_str_mv | 2018-01-19T10:00:00Z |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| datacite.subjects.subject.fl_str_mv | Antibacterial activity Antifungal activity Cytotoxic activity Sucrose Unsaturated esters |
| datacite.titles.title.fl_str_mv | Antimicrobial and cytotoxic activities of short carbon chain unsaturated sucrose esters |
| dc.contributor.none.fl_str_mv | Biblioteca Digital do IPB |
| dc.creator.none.fl_str_mv | Petrova, Krasimira T. Barros, M. Teresa Calhelha, Ricardo C. Soković, Marina Ferreira, Isabel C.F.R. |
| dc.date.Accepted.fl_str_mv | 2018-01-01T00:00:00Z |
| dc.date.available.fl_str_mv | 2018-01-19T10:00:00Z |
| dc.date.embargoed.fl_str_mv | 2018-01-19T10:00:00Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | http://hdl.handle.net/10198/18549 |
| dc.language.none.fl_str_mv | eng |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| dc.subject.none.fl_str_mv | Antibacterial activity Antifungal activity Cytotoxic activity Sucrose Unsaturated esters |
| dc.title.fl_str_mv | Antimicrobial and cytotoxic activities of short carbon chain unsaturated sucrose esters |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_6501 |
| description | A library of C3–C5 unsaturated 6-O-sucrose esters have been investigated for their antibacterial, antifungal, and cytotoxic activities. Most of the target compounds showed good inhibitory activity against a variety of clinically and food contaminant important microbial pathogens. In particular, 6-O-methacryloyl sucrose 2 and 1′,2,3,3′,4,4′,6′-hepta-O-acetyl-6-O-methacryloyl sucrose 9 were the most active bactericides against all the tested bacteria with minimal inhibitory concentrations (MICs) ranging between 0.24 and 1.40 μM. The compound 9 showed also the highest antifungal activity with MICs from 0.28 to 1.10 μM. The synthesized compounds possessed low cytotoxicity against human breast, lung, cervical, and hepatocellular carcinoma cell lines without showing toxicity for non-tumor liver cells. Thus, this library of short carbon chain unsaturated sucrose esters represent promising leads for the development of new generation of sucrose-based antimicrobial agents. |
| dirty | 0 |
| eu_rights_str_mv | openAccess |
| format | article |
| fulltext.url.fl_str_mv | https://bibliotecadigital.ipb.pt/bitstreams/1bcee419-b652-4394-afd0-472b8c5ac3ee/download |
| id | ipb_7290661237a5385d83388b3b3e4ab577 |
| identifier.url.fl_str_mv | http://hdl.handle.net/10198/18549 |
| instacron_str | ipb |
| institution | Instituto Politécnico de Bragança |
| instname_str | Instituto Politécnico de Bragança |
| language | eng |
| network_acronym_str | ipb |
| network_name_str | Biblioteca Digital do IPB |
| oai_identifier_str | oai:bibliotecadigital.ipb.pt:10198/18549 |
| organization_str_mv | urn:organizationAcronym:ipb |
| person_str_mv | Petrova, Krasimira T. Barros, M. Teresa Calhelha, Ricardo C. Calhelha, Ricardo C. https://www.ciencia-id.pt/F313-E3CE-554E F313-E3CE-554E http://orcid.org/0000-0002-6801-4578 0000-0002-6801-4578 Soković, Marina Ferreira, Isabel C.F.R. Ferreira, Isabel C.F.R. https://www.ciencia-id.pt/9418-CF95-9919 9418-CF95-9919 http://orcid.org/0000-0003-4910-4882 0000-0003-4910-4882 |
| publishDate | 2018 |
| reponame_str | Biblioteca Digital do IPB |
| repository_id_str | urn:repositoryAcronym:ipb |
| service_str_mv | urn:repositoryAcronym:ipb |
| spelling | engA library of C3–C5 unsaturated 6-O-sucrose esters have been investigated for their antibacterial, antifungal, and cytotoxic activities. Most of the target compounds showed good inhibitory activity against a variety of clinically and food contaminant important microbial pathogens. In particular, 6-O-methacryloyl sucrose 2 and 1′,2,3,3′,4,4′,6′-hepta-O-acetyl-6-O-methacryloyl sucrose 9 were the most active bactericides against all the tested bacteria with minimal inhibitory concentrations (MICs) ranging between 0.24 and 1.40 μM. The compound 9 showed also the highest antifungal activity with MICs from 0.28 to 1.10 μM. The synthesized compounds possessed low cytotoxicity against human breast, lung, cervical, and hepatocellular carcinoma cell lines without showing toxicity for non-tumor liver cells. Thus, this library of short carbon chain unsaturated sucrose esters represent promising leads for the development of new generation of sucrose-based antimicrobial agents.application/pdfen_ENAntimicrobial and cytotoxic activities of short carbon chain unsaturated sucrose estersPetrova, Krasimira T.Barros, M. TeresaPersonalCalhelha, Ricardo C.DSpacehttp://dspace.org/items/2d5d1a41-7561-4a01-871c-b4c97da35053DSpacehttp://dspace.org/items/2d5d1a41-7561-4a01-871c-b4c97da35053CalhelhaRicardo C.Ciência IDhttps://www.ciencia-id.ptF313-E3CE-554EORCIDhttp://orcid.org0000-0002-6801-4578Researcher IDhttps://www.researcherid.comJ-2172-2014Scopus Author IDhttps://www.scopus.com6507978333Soković, MarinaPersonalFerreira, Isabel C.F.R.DSpacehttp://dspace.org/items/bd0d1537-2e03-41fb-b27a-140af9c35db8DSpacehttp://dspace.org/items/bd0d1537-2e03-41fb-b27a-140af9c35db8FerreiraIsabel C.F.R.Ciência IDhttps://www.ciencia-id.pt9418-CF95-9919ORCIDhttp://orcid.org0000-0003-4910-4882Researcher IDhttps://www.researcherid.comE-8500-2013Scopus Author IDhttps://www.scopus.com36868826600HostingInstitutionOrganizationalBiblioteca Digital do IPBe-mailmailto:dspace@ipb.ptdspace@ipb.ptISSNIsPartOf1054-2523DOIIsPartOf10.1007/s00044-017-2121-52018-01-19T10:00:00Z20182018-01-01T00:00:00ZHandlehttp://hdl.handle.net/10198/18549http://purl.org/coar/access_right/c_abf2open accessAntibacterial activityAntifungal activityCytotoxic activitySucroseUnsaturated esters562710 bytesliteraturehttp://purl.org/coar/resource_type/c_6501journal articlehttp://purl.org/coar/access_right/c_abf2application/pdffulltexthttps://bibliotecadigital.ipb.pt/bitstreams/1bcee419-b652-4394-afd0-472b8c5ac3ee/download |
| spellingShingle | Antimicrobial and cytotoxic activities of short carbon chain unsaturated sucrose esters Petrova, Krasimira T. Antibacterial activity Antifungal activity Cytotoxic activity Sucrose Unsaturated esters |
| status | SINGLETON |
| subject.fl_str_mv | Antibacterial activity Antifungal activity Cytotoxic activity Sucrose Unsaturated esters |
| title | Antimicrobial and cytotoxic activities of short carbon chain unsaturated sucrose esters |
| title_full | Antimicrobial and cytotoxic activities of short carbon chain unsaturated sucrose esters |
| title_fullStr | Antimicrobial and cytotoxic activities of short carbon chain unsaturated sucrose esters |
| title_full_unstemmed | Antimicrobial and cytotoxic activities of short carbon chain unsaturated sucrose esters |
| title_short | Antimicrobial and cytotoxic activities of short carbon chain unsaturated sucrose esters |
| title_sort | Antimicrobial and cytotoxic activities of short carbon chain unsaturated sucrose esters |
| topic | Antibacterial activity Antifungal activity Cytotoxic activity Sucrose Unsaturated esters |
| topic_facet | Antibacterial activity Antifungal activity Cytotoxic activity Sucrose Unsaturated esters |
| url | http://hdl.handle.net/10198/18549 |
| visible | 1 |