Publicação
Inherited and acquired risk factors and their combined effects in pediatric stroke
| Resumo: | The aim of this study was to identify hereditary and acquired risk-factors as they are related to the occurrence of stroke in children. We identified 21 children with stroke. A search of the Factor V Leiden mutation, the Factor II G20210A variant, and the thermolabile variant of methylenetetrahydrofolate reductase was performed in patients and in a control group (n = 115).We identified risk factors of acquired and/or hereditary nature for stroke in 19 of 21 children. Eleven children had three or more risk factors, seven had two risk factors, and one child had only one risk factor. We found three carriers (14.3%) of the Factor V Leiden mutation, two carriers (9.5%) of the Factor II G20210A variant, eleven (52.4%) thermolabile variant of methylenetetrahydrofolate reductase heterozygote carriers, and one (4.8%) homozygotes for this variant.Frequencies of the Factor V Leiden mutation and the Factor II variant were higher in patients than in controls, suggesting that these variants are associated with an increased risk of stroke in childhood. Homozygosity for the thermolabile variant of methylenetetrahydrofolate reductase was equally frequent amongst patients and controls.Our study confirms that stroke in children is commonly associated with a combination of multiple risk factors, both genetic and acquired, and that the Factor V Leiden mutation and the Factor II G20210A variant are predisposing factors for this situation. |
|---|---|
| Autores principais: | Barreirinho, Maria Sameiro |
| Outros Autores: | Ferro, Anabela; Santos, Manuela; Costa, Elísio; Pinto-Bastos, Jorge; Sousa, Alda; Sequeiros, Jorge; Maciel, Patricia; Barbot, Clara; Barbot, José |
| Assunto: | Childhood stroke Risk factors FV Leiden FII variant Thrombophilia |
| Ano: | 2003 |
| País: | Portugal |
| Tipo de documento: | artigo |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Instituto Politécnico de Bragança |
| Idioma: | inglês |
| Origem: | Biblioteca Digital do IPB |
| _version_ | 1867173075553878016 |
|---|---|
| author | Barreirinho, Maria Sameiro |
| author2 | Ferro, Anabela Santos, Manuela Costa, Elísio Pinto-Bastos, Jorge Sousa, Alda Sequeiros, Jorge Maciel, Patricia Barbot, Clara Barbot, José |
| author2_role | author author author author author author author author author |
| author_facet | Barreirinho, Maria Sameiro Ferro, Anabela Santos, Manuela Costa, Elísio Pinto-Bastos, Jorge Sousa, Alda Sequeiros, Jorge Maciel, Patricia Barbot, Clara Barbot, José |
| author_role | author |
| contributor_name_str_mv | Biblioteca Digital do IPB |
| country_str | PT |
| creators_json_txt | [{\"Person.name\":\"Barreirinho, Maria Sameiro\"},{\"Person.name\":\"Ferro, Anabela\"},{\"Person.name\":\"Santos, Manuela\"},{\"Person.name\":\"Costa, Elísio\"},{\"Person.name\":\"Pinto-Bastos, Jorge\"},{\"Person.name\":\"Sousa, Alda\"},{\"Person.name\":\"Sequeiros, Jorge\"},{\"Person.name\":\"Maciel, Patricia\"},{\"Person.name\":\"Barbot, Clara\"},{\"Person.name\":\"Barbot, José\"}] |
| datacite.contributors.contributor.contributorName.fl_str_mv | Biblioteca Digital do IPB |
| datacite.creators.creator.creatorName.fl_str_mv | Barreirinho, Maria Sameiro Ferro, Anabela Santos, Manuela Costa, Elísio Pinto-Bastos, Jorge Sousa, Alda Sequeiros, Jorge Maciel, Patricia Barbot, Clara Barbot, José |
| datacite.date.Accepted.fl_str_mv | 2003-01-01T00:00:00Z |
| datacite.date.available.fl_str_mv | 2008-02-19T15:17:46Z |
| datacite.date.embargoed.fl_str_mv | 2008-02-19T15:17:46Z |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| datacite.subjects.subject.fl_str_mv | Childhood stroke Risk factors FV Leiden FII variant Thrombophilia |
| datacite.titles.title.fl_str_mv | Inherited and acquired risk factors and their combined effects in pediatric stroke |
| dc.contributor.none.fl_str_mv | Biblioteca Digital do IPB |
| dc.creator.none.fl_str_mv | Barreirinho, Maria Sameiro Ferro, Anabela Santos, Manuela Costa, Elísio Pinto-Bastos, Jorge Sousa, Alda Sequeiros, Jorge Maciel, Patricia Barbot, Clara Barbot, José |
| dc.date.Accepted.fl_str_mv | 2003-01-01T00:00:00Z |
| dc.date.available.fl_str_mv | 2008-02-19T15:17:46Z |
| dc.date.embargoed.fl_str_mv | 2008-02-19T15:17:46Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | http://hdl.handle.net/10198/496 |
| dc.language.none.fl_str_mv | eng |
| dc.publisher.none.fl_str_mv | Elsevier |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| dc.subject.none.fl_str_mv | Childhood stroke Risk factors FV Leiden FII variant Thrombophilia |
| dc.title.fl_str_mv | Inherited and acquired risk factors and their combined effects in pediatric stroke |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_6501 |
| description | The aim of this study was to identify hereditary and acquired risk-factors as they are related to the occurrence of stroke in children. We identified 21 children with stroke. A search of the Factor V Leiden mutation, the Factor II G20210A variant, and the thermolabile variant of methylenetetrahydrofolate reductase was performed in patients and in a control group (n = 115).We identified risk factors of acquired and/or hereditary nature for stroke in 19 of 21 children. Eleven children had three or more risk factors, seven had two risk factors, and one child had only one risk factor. We found three carriers (14.3%) of the Factor V Leiden mutation, two carriers (9.5%) of the Factor II G20210A variant, eleven (52.4%) thermolabile variant of methylenetetrahydrofolate reductase heterozygote carriers, and one (4.8%) homozygotes for this variant.Frequencies of the Factor V Leiden mutation and the Factor II variant were higher in patients than in controls, suggesting that these variants are associated with an increased risk of stroke in childhood. Homozygosity for the thermolabile variant of methylenetetrahydrofolate reductase was equally frequent amongst patients and controls.Our study confirms that stroke in children is commonly associated with a combination of multiple risk factors, both genetic and acquired, and that the Factor V Leiden mutation and the Factor II G20210A variant are predisposing factors for this situation. |
| dirty | 0 |
| eu_rights_str_mv | openAccess |
| format | article |
| fulltext.url.fl_str_mv | https://bibliotecadigital.ipb.pt/bitstreams/99964ba3-d536-4f97-a7ae-7455c1e5de1e/download |
| id | ipb_7ae5b3cfdfc5aa7dc4a67acd2d0709b8 |
| identifier.url.fl_str_mv | http://hdl.handle.net/10198/496 |
| instacron_str | ipb |
| institution | Instituto Politécnico de Bragança |
| instname_str | Instituto Politécnico de Bragança |
| language | eng |
| network_acronym_str | ipb |
| network_name_str | Biblioteca Digital do IPB |
| oai_identifier_str | oai:bibliotecadigital.ipb.pt:10198/496 |
| organization_str_mv | urn:organizationAcronym:ipb |
| person_str_mv | Barreirinho, Maria Sameiro Ferro, Anabela Santos, Manuela Costa, Elísio Pinto-Bastos, Jorge Sousa, Alda Sequeiros, Jorge Maciel, Patricia Barbot, Clara Barbot, José |
| publishDate | 2003 |
| publisher.none.fl_str_mv | Elsevier |
| reponame_str | Biblioteca Digital do IPB |
| repository_id_str | urn:repositoryAcronym:ipb |
| service_str_mv | urn:repositoryAcronym:ipb |
| spelling | engElsevierenThe aim of this study was to identify hereditary and acquired risk-factors as they are related to the occurrence of stroke in children. We identified 21 children with stroke. A search of the Factor V Leiden mutation, the Factor II G20210A variant, and the thermolabile variant of methylenetetrahydrofolate reductase was performed in patients and in a control group (n = 115).We identified risk factors of acquired and/or hereditary nature for stroke in 19 of 21 children. Eleven children had three or more risk factors, seven had two risk factors, and one child had only one risk factor. We found three carriers (14.3%) of the Factor V Leiden mutation, two carriers (9.5%) of the Factor II G20210A variant, eleven (52.4%) thermolabile variant of methylenetetrahydrofolate reductase heterozygote carriers, and one (4.8%) homozygotes for this variant.Frequencies of the Factor V Leiden mutation and the Factor II variant were higher in patients than in controls, suggesting that these variants are associated with an increased risk of stroke in childhood. Homozygosity for the thermolabile variant of methylenetetrahydrofolate reductase was equally frequent amongst patients and controls.Our study confirms that stroke in children is commonly associated with a combination of multiple risk factors, both genetic and acquired, and that the Factor V Leiden mutation and the Factor II G20210A variant are predisposing factors for this situation.application/pdfenInherited and acquired risk factors and their combined effects in pediatric strokeBarreirinho, Maria SameiroFerro, AnabelaSantos, ManuelaCosta, ElísioPinto-Bastos, JorgeSousa, AldaSequeiros, JorgeMaciel, PatriciaBarbot, ClaraBarbot, JoséHostingInstitutionOrganizationalBiblioteca Digital do IPBe-mailmailto:dspace@ipb.ptdspace@ipb.ptISSNIsPartOf0887-89942008-02-19T15:17:46Z20032003-01-01T00:00:00ZHandlehttp://hdl.handle.net/10198/496http://purl.org/coar/access_right/c_abf2open accessChildhood strokeRisk factorsFV LeidenFII variantThrombophilia49422 bytesliteraturehttp://purl.org/coar/resource_type/c_6501journal articlehttp://purl.org/coar/access_right/c_abf2application/pdffulltexthttps://bibliotecadigital.ipb.pt/bitstreams/99964ba3-d536-4f97-a7ae-7455c1e5de1e/download |
| spellingShingle | Inherited and acquired risk factors and their combined effects in pediatric stroke Barreirinho, Maria Sameiro Childhood stroke Risk factors FV Leiden FII variant Thrombophilia |
| status | SINGLETON |
| subject.fl_str_mv | Childhood stroke Risk factors FV Leiden FII variant Thrombophilia |
| title | Inherited and acquired risk factors and their combined effects in pediatric stroke |
| title_full | Inherited and acquired risk factors and their combined effects in pediatric stroke |
| title_fullStr | Inherited and acquired risk factors and their combined effects in pediatric stroke |
| title_full_unstemmed | Inherited and acquired risk factors and their combined effects in pediatric stroke |
| title_short | Inherited and acquired risk factors and their combined effects in pediatric stroke |
| title_sort | Inherited and acquired risk factors and their combined effects in pediatric stroke |
| topic | Childhood stroke Risk factors FV Leiden FII variant Thrombophilia |
| topic_facet | Childhood stroke Risk factors FV Leiden FII variant Thrombophilia |
| url | http://hdl.handle.net/10198/496 |
| visible | 1 |