Publicação
Advances in Microfluidic Systems and Numerical Modeling in Biomedical Applications: A Review
| Resumo: | The evolution in the biomedical engineering field boosts innovative technologies, with microfluidic systems standing out as transformative tools in disease diagnosis, treatment, and monitoring. Numerical simulation has emerged as a tool of increasing importance for better understanding and predicting fluid-flow behavior in microscale devices. This review explores fabrication techniques and common materials of microfluidic devices, focusing on soft lithography and additive manufacturing. Microfluidic systems applications, including nucleic acid amplification and protein synthesis, as well as point-of-care diagnostics, DNA analysis, cell cultures, and organ-on-a-chip models (e.g., lung-, brain-, liver-, and tumor-on-a-chip), are discussed. Recent studies have applied computational tools such as ANSYS Fluent 2024 software to numerically simulate the flow behavior. Outside of the study cases, this work reports fundamental aspects of microfluidic simulations, including fluid flow, mass transport, mixing, and diffusion, and highlights the emergent field of organ-on-a-chip simulations. Additionally, it takes into account the application of geometries to improve the mixing of samples, as well as surface wettability modification. In conclusion, the present review summarizes the most relevant contributions of microfluidic systems and their numerical modeling to biomedical engineering. |
|---|---|
| Autores principais: | Ferreira, Mariana |
| Outros Autores: | Carvalho, Violeta Meneses; Ribeiro, J.E.; Lima, Rui A.; Teixeira, Senhorinha F.C.F.; Pinho, Diana |
| Assunto: | Numerical simulation Microfluidics Organ-on-a-chip Microfluidics systems Mixing |
| Ano: | 2024 |
| País: | Portugal |
| Tipo de documento: | artigo |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Instituto Politécnico de Bragança |
| Idioma: | inglês |
| Origem: | Biblioteca Digital do IPB |
| _version_ | 1867173098814439424 |
|---|---|
| author | Ferreira, Mariana |
| author2 | Carvalho, Violeta Meneses Ribeiro, J.E. Lima, Rui A. Teixeira, Senhorinha F.C.F. Pinho, Diana |
| author2_role | author author author author author |
| author_facet | Ferreira, Mariana Carvalho, Violeta Meneses Ribeiro, J.E. Lima, Rui A. Teixeira, Senhorinha F.C.F. Pinho, Diana |
| author_role | author |
| contributor_name_str_mv | Biblioteca Digital do IPB |
| country_str | PT |
| creators_json_txt | [{\"Person.name\":\"Ferreira, Mariana\"},{\"Person.name\":\"Carvalho, Violeta Meneses\"},{\"Person.name\":\"Ribeiro, J.E.\",\"Person.identifier.orcid\":\"0000-0001-6300-148X\"},{\"Person.name\":\"Lima, Rui A.\"},{\"Person.name\":\"Teixeira, Senhorinha F.C.F.\"},{\"Person.name\":\"Pinho, Diana\"}] |
| datacite.contributors.contributor.contributorName.fl_str_mv | Biblioteca Digital do IPB |
| datacite.creators.creator.creatorName.fl_str_mv | Ferreira, Mariana Carvalho, Violeta Meneses Ribeiro, J.E. Lima, Rui A. Teixeira, Senhorinha F.C.F. Pinho, Diana |
| datacite.date.Accepted.fl_str_mv | 2024-01-01T00:00:00Z |
| datacite.date.available.fl_str_mv | 2024-10-08T11:27:39Z |
| datacite.date.embargoed.fl_str_mv | 2024-10-08T11:27:39Z |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| datacite.subjects.subject.fl_str_mv | Numerical simulation Microfluidics Organ-on-a-chip Microfluidics systems Mixing |
| datacite.titles.title.fl_str_mv | Advances in Microfluidic Systems and Numerical Modeling in Biomedical Applications: A Review |
| dc.contributor.none.fl_str_mv | Biblioteca Digital do IPB |
| dc.creator.none.fl_str_mv | Ferreira, Mariana Carvalho, Violeta Meneses Ribeiro, J.E. Lima, Rui A. Teixeira, Senhorinha F.C.F. Pinho, Diana |
| dc.date.Accepted.fl_str_mv | 2024-01-01T00:00:00Z |
| dc.date.available.fl_str_mv | 2024-10-08T11:27:39Z |
| dc.date.embargoed.fl_str_mv | 2024-10-08T11:27:39Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | http://hdl.handle.net/10198/30368 |
| dc.language.none.fl_str_mv | eng |
| dc.publisher.none.fl_str_mv | MDPI |
| dc.rights.cclincense.fl_str_mv | http://creativecommons.org/licenses/by/4.0/ |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| dc.subject.none.fl_str_mv | Numerical simulation Microfluidics Organ-on-a-chip Microfluidics systems Mixing |
| dc.title.fl_str_mv | Advances in Microfluidic Systems and Numerical Modeling in Biomedical Applications: A Review |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_6501 |
| description | The evolution in the biomedical engineering field boosts innovative technologies, with microfluidic systems standing out as transformative tools in disease diagnosis, treatment, and monitoring. Numerical simulation has emerged as a tool of increasing importance for better understanding and predicting fluid-flow behavior in microscale devices. This review explores fabrication techniques and common materials of microfluidic devices, focusing on soft lithography and additive manufacturing. Microfluidic systems applications, including nucleic acid amplification and protein synthesis, as well as point-of-care diagnostics, DNA analysis, cell cultures, and organ-on-a-chip models (e.g., lung-, brain-, liver-, and tumor-on-a-chip), are discussed. Recent studies have applied computational tools such as ANSYS Fluent 2024 software to numerically simulate the flow behavior. Outside of the study cases, this work reports fundamental aspects of microfluidic simulations, including fluid flow, mass transport, mixing, and diffusion, and highlights the emergent field of organ-on-a-chip simulations. Additionally, it takes into account the application of geometries to improve the mixing of samples, as well as surface wettability modification. In conclusion, the present review summarizes the most relevant contributions of microfluidic systems and their numerical modeling to biomedical engineering. |
| dirty | 0 |
| eu_rights_str_mv | openAccess |
| format | article |
| fulltext.url.fl_str_mv | https://bibliotecadigital.ipb.pt/bitstreams/0b0b2e07-8ac7-4176-8193-542ede5b1acc/download |
| funding.funder.alternateName_str_mv | FCT FCT FCT FCT FCT FCT FCT FCT FCT FCT FCT |
| funding.funder.identifier_str_mv | http://doi.org/10.13039/501100001871 http://doi.org/10.13039/501100001871 http://doi.org/10.13039/501100001871 http://doi.org/10.13039/501100001871 http://doi.org/10.13039/501100001871 http://doi.org/10.13039/501100001871 http://doi.org/10.13039/501100001871 http://doi.org/10.13039/501100001871 http://doi.org/10.13039/501100001871 http://doi.org/10.13039/501100001871 http://doi.org/10.13039/501100001871 |
| funding.funder.name_str_mv | Fundação para a Ciência e a Tecnologia Fundação para a Ciência e a Tecnologia Fundação para a Ciência e a Tecnologia Fundação para a Ciência e a Tecnologia Fundação para a Ciência e a Tecnologia Fundação para a Ciência e a Tecnologia Fundação para a Ciência e a Tecnologia Fundação para a Ciência e a Tecnologia Fundação para a Ciência e a Tecnologia Fundação para a Ciência e a Tecnologia Fundação para a Ciência e a Tecnologia |
| funding.name_str_mv | Concurso de Projetos de I&D em Todos os Domínios Científicos - 2022 3599-PPCDT 6817 - DCRRNI ID 6817 - DCRRNI ID 6817 - DCRRNI ID 6817 - DCRRNI ID 6817 - DCRRNI ID 6817 - DCRRNI ID 6817 - DCRRNI ID 6817 - DCRRNI ID CEEC IND4ed |
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| identifier.url.fl_str_mv | http://hdl.handle.net/10198/30368 |
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| institution | Instituto Politécnico de Bragança |
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| language | eng |
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| network_name_str | Biblioteca Digital do IPB |
| oai_identifier_str | oai:bibliotecadigital.ipb.pt:10198/30368 |
| organization_str_mv | urn:organizationAcronym:ipb |
| person_str_mv | Ferreira, Mariana Carvalho, Violeta Meneses Ribeiro, J.E. Ribeiro, J.E. https://www.ciencia-id.pt/0F15-FB62-29DB 0F15-FB62-29DB http://orcid.org/0000-0001-6300-148X 0000-0001-6300-148X Lima, Rui A. Teixeira, Senhorinha F.C.F. Pinho, Diana |
| publishDate | 2024 |
| publisher.none.fl_str_mv | MDPI |
| reponame_str | Biblioteca Digital do IPB |
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| spelling | engMDPIpt_PTThe evolution in the biomedical engineering field boosts innovative technologies, with microfluidic systems standing out as transformative tools in disease diagnosis, treatment, and monitoring. Numerical simulation has emerged as a tool of increasing importance for better understanding and predicting fluid-flow behavior in microscale devices. This review explores fabrication techniques and common materials of microfluidic devices, focusing on soft lithography and additive manufacturing. Microfluidic systems applications, including nucleic acid amplification and protein synthesis, as well as point-of-care diagnostics, DNA analysis, cell cultures, and organ-on-a-chip models (e.g., lung-, brain-, liver-, and tumor-on-a-chip), are discussed. Recent studies have applied computational tools such as ANSYS Fluent 2024 software to numerically simulate the flow behavior. Outside of the study cases, this work reports fundamental aspects of microfluidic simulations, including fluid flow, mass transport, mixing, and diffusion, and highlights the emergent field of organ-on-a-chip simulations. Additionally, it takes into account the application of geometries to improve the mixing of samples, as well as surface wettability modification. In conclusion, the present review summarizes the most relevant contributions of microfluidic systems and their numerical modeling to biomedical engineering.application/pdfpt_PTAdvances in Microfluidic Systems and Numerical Modeling in Biomedical Applications: A ReviewFerreira, MarianaCarvalho, Violeta MenesesPersonalRibeiro, J.E.DSpacehttp://dspace.org/items/c90169e6-7889-4270-a096-35b98c75f9f9DSpacehttp://dspace.org/items/c90169e6-7889-4270-a096-35b98c75f9f9RibeiroJ.E.Ciência IDhttps://www.ciencia-id.pt0F15-FB62-29DBORCIDhttp://orcid.org0000-0001-6300-148XResearcher IDhttps://www.researcherid.comG-3839-2018Scopus Author IDhttps://www.scopus.com25638652400Lima, Rui A.Teixeira, Senhorinha F.C.F.Pinho, DianaHostingInstitutionOrganizationalBiblioteca Digital do IPBe-mailmailto:dspace@ipb.ptdspace@ipb.ptISSNIsPartOf2072-666XDOIIsPartOf10.3390/mi150708732024-10-08T11:27:39Z20242024-01-01T00:00:00ZHandlehttp://hdl.handle.net/10198/30368http://purl.org/coar/access_right/c_abf2open accessNumerical simulationMicrofluidicsOrgan-on-a-chipMicrofluidics systemsMixing3657439 bytesFundação para a Ciência e a TecnologiaPortable Microfluidic system for fast molecular diagnostics of StrokeConcurso de Projetos de I&D em Todos os Domínios Científicos - 2022Crossref Funder IDhttp://doi.org/10.13039/501100001871Fundação para a Ciência e a TecnologiaMultiplexed micro(bio)sensors array integrated into an organ-on-a-chip device for assessing cancer NANOtherapy3599-PPCDTCrossref Funder IDhttp://doi.org/10.13039/501100001871Fundação para a Ciência e a TecnologiaMicroelectromechanical Systems Research Unit6817 - DCRRNI IDCrossref Funder IDhttp://doi.org/10.13039/501100001871Fundação para a Ciência e a TecnologiaMicroelectromechanical Systems Research Unit6817 - DCRRNI IDCrossref Funder IDhttp://doi.org/10.13039/501100001871Fundação para a Ciência e a TecnologiaMechanical Engineering and Resource Sustainability Center6817 - DCRRNI IDCrossref Funder IDhttp://doi.org/10.13039/501100001871Fundação para a Ciência e a TecnologiaMechanical Engineering and Resource Sustainability Center6817 - DCRRNI IDCrossref Funder IDhttp://doi.org/10.13039/501100001871Fundação para a Ciência e a TecnologiaTransport Phenomena Research Center6817 - DCRRNI IDCrossref Funder IDhttp://doi.org/10.13039/501100001871Fundação para a Ciência e a TecnologiaMountain Research Center6817 - DCRRNI IDCrossref Funder IDhttp://doi.org/10.13039/501100001871Fundação para a Ciência e a TecnologiaPhysics Center of Minho and Porto Universities6817 - DCRRNI IDCrossref Funder IDhttp://doi.org/10.13039/501100001871Fundação para a Ciência e a TecnologiaALICE - Associate Laboratory in Chemical Engineering6817 - DCRRNI IDCrossref Funder IDhttp://doi.org/10.13039/501100001871Fundação para a Ciência e a TecnologiaNEXTGENmOCp: Next generation of a microfluidic Organ-on-a-Chip platform (mOCp) to assess and diagnosis therapeutic effects of innovative nanomedicinesCEEC IND4edCrossref Funder IDhttp://doi.org/10.13039/501100001871literaturehttp://purl.org/coar/resource_type/c_6501journal article2024http://creativecommons.org/licenses/by/4.0/http://purl.org/coar/access_right/c_abf2application/pdffulltexthttps://bibliotecadigital.ipb.pt/bitstreams/0b0b2e07-8ac7-4176-8193-542ede5b1acc/downloadMicromachines157873 |
| spellingShingle | Advances in Microfluidic Systems and Numerical Modeling in Biomedical Applications: A Review Ferreira, Mariana Numerical simulation Microfluidics Organ-on-a-chip Microfluidics systems Mixing |
| status | SINGLETON |
| subject.fl_str_mv | Numerical simulation Microfluidics Organ-on-a-chip Microfluidics systems Mixing |
| title | Advances in Microfluidic Systems and Numerical Modeling in Biomedical Applications: A Review |
| title_full | Advances in Microfluidic Systems and Numerical Modeling in Biomedical Applications: A Review |
| title_fullStr | Advances in Microfluidic Systems and Numerical Modeling in Biomedical Applications: A Review |
| title_full_unstemmed | Advances in Microfluidic Systems and Numerical Modeling in Biomedical Applications: A Review |
| title_short | Advances in Microfluidic Systems and Numerical Modeling in Biomedical Applications: A Review |
| title_sort | Advances in Microfluidic Systems and Numerical Modeling in Biomedical Applications: A Review |
| topic | Numerical simulation Microfluidics Organ-on-a-chip Microfluidics systems Mixing |
| topic_facet | Numerical simulation Microfluidics Organ-on-a-chip Microfluidics systems Mixing |
| url | http://hdl.handle.net/10198/30368 |
| visible | 1 |