Publicação
Complete design and optimization of multicomponent separation processes: the case study of the quaternary separation of nadolol stereoisomers.
| Resumo: | Chiral liquid chromatography is based on different mutual interactions between the molecules that elute with the liquid (solvent and solutes) and the molecules that are present in the stationary phase. Therefore, optimization of a chiral separation is based on the selection of a proper combination between a CSP and a mobile phase (solvent) composition by promoting, in a favorable way, all possible mutual interactions. The optimization will be a much more challenging task if we are leading not with a traditional binary racemic mixture separation problem but if we are interested in the separation of a quaternary chiral mixture. The complexity degree will be significantly increased if we consider a preparative separation, using a technique such as the simulated moving bed technology, were high feed concentrations are normally used in order to improve the process performance. In these situations, the wanted high concentrations of the different chiral solutes inside the chromatographic columns will enhance significantly the mutual competition between solutes for adsorption with the stationary phase. |
|---|---|
| Autores principais: | Ribeiro, António E. |
| Outros Autores: | Rodrigues, Alírio; Pais, Luís S. |
| Ano: | 2014 |
| País: | Portugal |
| Tipo de documento: | póster em conferência |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Instituto Politécnico de Bragança |
| Idioma: | inglês |
| Origem: | Biblioteca Digital do IPB |
| _version_ | 1867173124985847808 |
|---|---|
| author | Ribeiro, António E. |
| author2 | Rodrigues, Alírio Pais, Luís S. |
| author2_role | author author |
| author_facet | Ribeiro, António E. Rodrigues, Alírio Pais, Luís S. |
| author_role | author |
| contributor_name_str_mv | Biblioteca Digital do IPB |
| country_str | PT |
| creators_json_txt | [{\"Person.name\":\"Ribeiro, António E.\",\"Person.identifier.orcid\":\"0000-0003-4569-7887\"},{\"Person.name\":\"Rodrigues, Alírio\"},{\"Person.name\":\"Pais, Luís S.\",\"Person.identifier.orcid\":\"0000-0002-3000-2862\"}] |
| datacite.contributors.contributor.contributorName.fl_str_mv | Biblioteca Digital do IPB |
| datacite.creators.creator.creatorName.fl_str_mv | Ribeiro, António E. Rodrigues, Alírio Pais, Luís S. |
| datacite.date.Accepted.fl_str_mv | 2014-01-01T00:00:00Z |
| datacite.date.available.fl_str_mv | 2018-04-20T13:38:47Z |
| datacite.date.embargoed.fl_str_mv | 2018-04-20T13:38:47Z |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| datacite.titles.title.fl_str_mv | Complete design and optimization of multicomponent separation processes: the case study of the quaternary separation of nadolol stereoisomers. |
| dc.contributor.none.fl_str_mv | Biblioteca Digital do IPB |
| dc.creator.none.fl_str_mv | Ribeiro, António E. Rodrigues, Alírio Pais, Luís S. |
| dc.date.Accepted.fl_str_mv | 2014-01-01T00:00:00Z |
| dc.date.available.fl_str_mv | 2018-04-20T13:38:47Z |
| dc.date.embargoed.fl_str_mv | 2018-04-20T13:38:47Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | http://hdl.handle.net/10198/17139 |
| dc.language.none.fl_str_mv | eng |
| dc.rights.cclincense.fl_str_mv | http://creativecommons.org/licenses/by/4.0/ |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| dc.title.fl_str_mv | Complete design and optimization of multicomponent separation processes: the case study of the quaternary separation of nadolol stereoisomers. |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_6670 |
| description | Chiral liquid chromatography is based on different mutual interactions between the molecules that elute with the liquid (solvent and solutes) and the molecules that are present in the stationary phase. Therefore, optimization of a chiral separation is based on the selection of a proper combination between a CSP and a mobile phase (solvent) composition by promoting, in a favorable way, all possible mutual interactions. The optimization will be a much more challenging task if we are leading not with a traditional binary racemic mixture separation problem but if we are interested in the separation of a quaternary chiral mixture. The complexity degree will be significantly increased if we consider a preparative separation, using a technique such as the simulated moving bed technology, were high feed concentrations are normally used in order to improve the process performance. In these situations, the wanted high concentrations of the different chiral solutes inside the chromatographic columns will enhance significantly the mutual competition between solutes for adsorption with the stationary phase. |
| dirty | 0 |
| eu_rights_str_mv | openAccess |
| format | conferencePoster |
| fulltext.url.fl_str_mv | https://bibliotecadigital.ipb.pt/bitstreams/5b3e6e4c-6eb4-4091-b6d7-bdd342c3feb3/download |
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| identifier.url.fl_str_mv | http://hdl.handle.net/10198/17139 |
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| institution | Instituto Politécnico de Bragança |
| instname_str | Instituto Politécnico de Bragança |
| language | eng |
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| organization_str_mv | urn:organizationAcronym:ipb |
| person_str_mv | Ribeiro, António E. Ribeiro, António E. https://www.ciencia-id.pt/3211-D5B0-870D 3211-D5B0-870D http://orcid.org/0000-0003-4569-7887 0000-0003-4569-7887 Rodrigues, Alírio Pais, Luís S. Pais, Luís S. https://www.ciencia-id.pt/421E-0CCD-A84F 421E-0CCD-A84F http://orcid.org/0000-0002-3000-2862 0000-0002-3000-2862 |
| publishDate | 2014 |
| reponame_str | Biblioteca Digital do IPB |
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| spelling | engpt_PTChiral liquid chromatography is based on different mutual interactions between the molecules that elute with the liquid (solvent and solutes) and the molecules that are present in the stationary phase. Therefore, optimization of a chiral separation is based on the selection of a proper combination between a CSP and a mobile phase (solvent) composition by promoting, in a favorable way, all possible mutual interactions. The optimization will be a much more challenging task if we are leading not with a traditional binary racemic mixture separation problem but if we are interested in the separation of a quaternary chiral mixture. The complexity degree will be significantly increased if we consider a preparative separation, using a technique such as the simulated moving bed technology, were high feed concentrations are normally used in order to improve the process performance. In these situations, the wanted high concentrations of the different chiral solutes inside the chromatographic columns will enhance significantly the mutual competition between solutes for adsorption with the stationary phase.application/pdfpt_PTComplete design and optimization of multicomponent separation processes: the case study of the quaternary separation of nadolol stereoisomers.PersonalRibeiro, António E.DSpacehttp://dspace.org/items/52666376-f100-4407-87ef-dc5df3613761DSpacehttp://dspace.org/items/52666376-f100-4407-87ef-dc5df3613761RibeiroAntónio E.Ciência IDhttps://www.ciencia-id.pt3211-D5B0-870DORCIDhttp://orcid.org0000-0003-4569-7887Scopus Author IDhttps://www.scopus.com23390701300Scopus Author IDhttps://www.scopus.com57202082018Rodrigues, AlírioPersonalPais, Luís S.DSpacehttp://dspace.org/items/c6d25534-8487-45b1-90af-d350f4e3ac55DSpacehttp://dspace.org/items/c6d25534-8487-45b1-90af-d350f4e3ac55PaisLuís S.Ciência IDhttps://www.ciencia-id.pt421E-0CCD-A84FORCIDhttp://orcid.org0000-0002-3000-2862Scopus Author IDhttps://www.scopus.com6603930478HostingInstitutionOrganizationalBiblioteca Digital do IPBe-mailmailto:dspace@ipb.ptdspace@ipb.pt2018-04-20T13:38:47Z20142014-01-01T00:00:00ZHandlehttp://hdl.handle.net/10198/17139http://purl.org/coar/access_right/c_abf2open access2260459 bytesother research producthttp://purl.org/coar/resource_type/c_6670conference poster2014http://creativecommons.org/licenses/by/4.0/http://purl.org/coar/access_right/c_abf2application/pdffulltexthttps://bibliotecadigital.ipb.pt/bitstreams/5b3e6e4c-6eb4-4091-b6d7-bdd342c3feb3/download15th International Symposium on Preparative and Industrial Chromatography and Allied Techniques - SPICA 2014 - Basel, SwitzerlandBasel, Switzerland |
| spellingShingle | Complete design and optimization of multicomponent separation processes: the case study of the quaternary separation of nadolol stereoisomers. Ribeiro, António E. |
| status | SINGLETON |
| title | Complete design and optimization of multicomponent separation processes: the case study of the quaternary separation of nadolol stereoisomers. |
| title_full | Complete design and optimization of multicomponent separation processes: the case study of the quaternary separation of nadolol stereoisomers. |
| title_fullStr | Complete design and optimization of multicomponent separation processes: the case study of the quaternary separation of nadolol stereoisomers. |
| title_full_unstemmed | Complete design and optimization of multicomponent separation processes: the case study of the quaternary separation of nadolol stereoisomers. |
| title_short | Complete design and optimization of multicomponent separation processes: the case study of the quaternary separation of nadolol stereoisomers. |
| title_sort | Complete design and optimization of multicomponent separation processes: the case study of the quaternary separation of nadolol stereoisomers. |
| url | http://hdl.handle.net/10198/17139 |
| visible | 1 |