Publicação
Mushroom ethanolic extracts as cosmeceuticals ingredients: Safety and ex vivo skin permeation studies
| Resumo: | Mushrooms are important sources of natural bioactive compounds that are increasingly used as cosmeceutical ingredients. In this context, ethanolic extracts were prepared from Ganoderma lucidum and Pleurotus ostreatus and tested by incorporation into base cosmetic creams. In vitro safety evaluation of the extracts and cosmetic formulations prepared therefore was carried out using the MTT and LDH assays in keratinocyte (HaCaT) and fibroblast (HFF-1) cell lines. Moreover, they were submitted to ex vivo skin permeation studies using a Franz diffusion apparatus with pig ear skin as permeation membrane. The results showed the absence of toxicity for keratinocytes and fibroblasts in a concentration dependent manner, which is indicative of the safety of these extracts for cosmeceutical ingredients purposes. Protocatechuic and syringic acids were the only compounds permeating from G. lucidum extract in the first 8 h of study, no penetration was observed for phenolic acids found in P. ostreatus extract and formulation. These results pointed out for the suitability of using mushroom extracts as skin care ingredients and may contribute for the valorisation of wastes generated by the mushroom processing industry, which can serve as raw-materials for the obtainment of the extracts. |
|---|---|
| Autores principais: | Taofiq, Oludemi |
| Outros Autores: | Rodrigues, Francisca; Barros, Lillian; Barreiro, M.F.; Ferreira, Isabel C.F.R.; Oliveira, Beatriz |
| Assunto: | Bioactive compounds Cosmeceuticals Cytotoxicity Mushrooms Skin permeation |
| Ano: | 2019 |
| País: | Portugal |
| Tipo de documento: | artigo |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Instituto Politécnico de Bragança |
| Idioma: | inglês |
| Origem: | Biblioteca Digital do IPB |
| _version_ | 1863851246778056704 |
|---|---|
| author | Taofiq, Oludemi |
| author2 | Rodrigues, Francisca Barros, Lillian Barreiro, M.F. Ferreira, Isabel C.F.R. Oliveira, Beatriz |
| author2_role | author author author author author |
| author_facet | Taofiq, Oludemi Rodrigues, Francisca Barros, Lillian Barreiro, M.F. Ferreira, Isabel C.F.R. Oliveira, Beatriz |
| author_role | author |
| contributor_name_str_mv | Biblioteca Digital do IPB |
| country_str | PT |
| creators_json_str | [{\"Person.name\":\"Taofiq, Oludemi\"},{\"Person.name\":\"Rodrigues, Francisca\"},{\"Person.name\":\"Barros, Lillian\",\"Person.identifier.orcid\":\"0000-0002-9050-5189\"},{\"Person.name\":\"Barreiro, M.F.\",\"Person.identifier.orcid\":\"0000-0002-6844-333X\"},{\"Person.name\":\"Ferreira, Isabel C.F.R.\",\"Person.identifier.orcid\":\"0000-0003-4910-4882\"},{\"Person.name\":\"Oliveira, Beatriz\"}] |
| datacite.contributors.contributor.contributorName.fl_str_mv | Biblioteca Digital do IPB |
| datacite.creators.creator.creatorName.fl_str_mv | Taofiq, Oludemi Rodrigues, Francisca Barros, Lillian Barreiro, M.F. Ferreira, Isabel C.F.R. Oliveira, Beatriz |
| datacite.date.Accepted.fl_str_mv | 2019-01-01T00:00:00Z |
| datacite.date.available.fl_str_mv | 2018-01-19T10:00:00Z |
| datacite.date.embargoed.fl_str_mv | 2018-01-19T10:00:00Z |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| datacite.subjects.subject.fl_str_mv | Bioactive compounds Cosmeceuticals Cytotoxicity Mushrooms Skin permeation |
| datacite.titles.title.fl_str_mv | Mushroom ethanolic extracts as cosmeceuticals ingredients: Safety and ex vivo skin permeation studies |
| dc.contributor.none.fl_str_mv | Biblioteca Digital do IPB |
| dc.creator.none.fl_str_mv | Taofiq, Oludemi Rodrigues, Francisca Barros, Lillian Barreiro, M.F. Ferreira, Isabel C.F.R. Oliveira, Beatriz |
| dc.date.Accepted.fl_str_mv | 2019-01-01T00:00:00Z |
| dc.date.available.fl_str_mv | 2018-01-19T10:00:00Z |
| dc.date.embargoed.fl_str_mv | 2018-01-19T10:00:00Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | http://hdl.handle.net/10198/19982 |
| dc.language.none.fl_str_mv | eng |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| dc.subject.none.fl_str_mv | Bioactive compounds Cosmeceuticals Cytotoxicity Mushrooms Skin permeation |
| dc.title.fl_str_mv | Mushroom ethanolic extracts as cosmeceuticals ingredients: Safety and ex vivo skin permeation studies |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_6501 |
| description | Mushrooms are important sources of natural bioactive compounds that are increasingly used as cosmeceutical ingredients. In this context, ethanolic extracts were prepared from Ganoderma lucidum and Pleurotus ostreatus and tested by incorporation into base cosmetic creams. In vitro safety evaluation of the extracts and cosmetic formulations prepared therefore was carried out using the MTT and LDH assays in keratinocyte (HaCaT) and fibroblast (HFF-1) cell lines. Moreover, they were submitted to ex vivo skin permeation studies using a Franz diffusion apparatus with pig ear skin as permeation membrane. The results showed the absence of toxicity for keratinocytes and fibroblasts in a concentration dependent manner, which is indicative of the safety of these extracts for cosmeceutical ingredients purposes. Protocatechuic and syringic acids were the only compounds permeating from G. lucidum extract in the first 8 h of study, no penetration was observed for phenolic acids found in P. ostreatus extract and formulation. These results pointed out for the suitability of using mushroom extracts as skin care ingredients and may contribute for the valorisation of wastes generated by the mushroom processing industry, which can serve as raw-materials for the obtainment of the extracts. |
| dirty | 0 |
| eu_rights_str_mv | openAccess |
| format | article |
| fulltext.url.fl_str_mv | https://bibliotecadigital.ipb.pt/bitstreams/f49180ea-2665-4785-8b1b-0f0b53bca7cb/download |
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| identifier.url.fl_str_mv | http://hdl.handle.net/10198/19982 |
| instacron_str | ipb |
| institution | Instituto Politécnico de Bragança |
| instname_str | Instituto Politécnico de Bragança |
| language | eng |
| network_acronym_str | ipb |
| network_name_str | Biblioteca Digital do IPB |
| oai_identifier_str | oai:bibliotecadigital.ipb.pt:10198/19982 |
| organization_str_mv | urn:organizationAcronym:ipb |
| person_str_mv | Taofiq, Oludemi Rodrigues, Francisca Barros, Lillian Barros, Lillian https://www.ciencia-id.pt/9616-35CB-D001 9616-35CB-D001 http://orcid.org/0000-0002-9050-5189 0000-0002-9050-5189 Barreiro, M.F. Barreiro, M.F. https://www.ciencia-id.pt/3418-47D5-5746 3418-47D5-5746 http://orcid.org/0000-0002-6844-333X 0000-0002-6844-333X Ferreira, Isabel C.F.R. Ferreira, Isabel C.F.R. https://www.ciencia-id.pt/9418-CF95-9919 9418-CF95-9919 http://orcid.org/0000-0003-4910-4882 0000-0003-4910-4882 Oliveira, Beatriz |
| publishDate | 2019 |
| reponame_str | Biblioteca Digital do IPB |
| repository_id_str | urn:repositoryAcronym:ipb |
| service_str_mv | urn:repositoryAcronym:ipb |
| spelling | engMushrooms are important sources of natural bioactive compounds that are increasingly used as cosmeceutical ingredients. In this context, ethanolic extracts were prepared from Ganoderma lucidum and Pleurotus ostreatus and tested by incorporation into base cosmetic creams. In vitro safety evaluation of the extracts and cosmetic formulations prepared therefore was carried out using the MTT and LDH assays in keratinocyte (HaCaT) and fibroblast (HFF-1) cell lines. Moreover, they were submitted to ex vivo skin permeation studies using a Franz diffusion apparatus with pig ear skin as permeation membrane. The results showed the absence of toxicity for keratinocytes and fibroblasts in a concentration dependent manner, which is indicative of the safety of these extracts for cosmeceutical ingredients purposes. Protocatechuic and syringic acids were the only compounds permeating from G. lucidum extract in the first 8 h of study, no penetration was observed for phenolic acids found in P. ostreatus extract and formulation. These results pointed out for the suitability of using mushroom extracts as skin care ingredients and may contribute for the valorisation of wastes generated by the mushroom processing industry, which can serve as raw-materials for the obtainment of the extracts.application/pdfen_ENMushroom ethanolic extracts as cosmeceuticals ingredients: Safety and ex vivo skin permeation studiesTaofiq, OludemiRodrigues, FranciscaPersonalBarros, LillianDSpacehttp://dspace.org/items/3af07ffe-f914-48ba-a5d5-efcf70fdce01DSpacehttp://dspace.org/items/3af07ffe-f914-48ba-a5d5-efcf70fdce01BarrosLillianCiência IDhttps://www.ciencia-id.pt9616-35CB-D001ORCIDhttp://orcid.org0000-0002-9050-5189Researcher IDhttps://www.researcherid.comJ-3600-2013Researcher IDhttps://www.researcherid.comJ-3600-2013Scopus Author IDhttps://www.scopus.com35236343600Scopus Author IDhttps://www.scopus.com57194900801PersonalBarreiro, M.F.DSpacehttp://dspace.org/items/0391987c-ba90-488b-839a-153447ce1f0fDSpacehttp://dspace.org/items/0391987c-ba90-488b-839a-153447ce1f0fBarreiroFilomenaCiência IDhttps://www.ciencia-id.pt3418-47D5-5746ORCIDhttp://orcid.org0000-0002-6844-333XResearcher IDhttps://www.researcherid.comL-9802-2014Scopus Author IDhttps://www.scopus.com57188719717PersonalFerreira, Isabel C.F.R.DSpacehttp://dspace.org/items/bd0d1537-2e03-41fb-b27a-140af9c35db8DSpacehttp://dspace.org/items/bd0d1537-2e03-41fb-b27a-140af9c35db8FerreiraIsabel C.F.R.Ciência IDhttps://www.ciencia-id.pt9418-CF95-9919ORCIDhttp://orcid.org0000-0003-4910-4882Researcher IDhttps://www.researcherid.comE-8500-2013Scopus Author IDhttps://www.scopus.com36868826600Oliveira, BeatrizHostingInstitutionOrganizationalBiblioteca Digital do IPBe-mailmailto:dspace@ipb.ptdspace@ipb.ptISSNIsPartOf0278-6915DOIIsPartOf10.1016/j.fct.2019.03.0452018-01-19T10:00:00Z20192019-01-01T00:00:00ZHandlehttp://hdl.handle.net/10198/19982http://purl.org/coar/access_right/c_abf2open accessBioactive compoundsCosmeceuticalsCytotoxicityMushroomsSkin permeation748073 bytesliteraturehttp://purl.org/coar/resource_type/c_6501journal articlehttp://purl.org/coar/access_right/c_abf2application/pdffulltexthttps://bibliotecadigital.ipb.pt/bitstreams/f49180ea-2665-4785-8b1b-0f0b53bca7cb/download |
| spellingShingle | Mushroom ethanolic extracts as cosmeceuticals ingredients: Safety and ex vivo skin permeation studies Taofiq, Oludemi Bioactive compounds Cosmeceuticals Cytotoxicity Mushrooms Skin permeation |
| subject.fl_str_mv | Bioactive compounds Cosmeceuticals Cytotoxicity Mushrooms Skin permeation |
| title | Mushroom ethanolic extracts as cosmeceuticals ingredients: Safety and ex vivo skin permeation studies |
| title_full | Mushroom ethanolic extracts as cosmeceuticals ingredients: Safety and ex vivo skin permeation studies |
| title_fullStr | Mushroom ethanolic extracts as cosmeceuticals ingredients: Safety and ex vivo skin permeation studies |
| title_full_unstemmed | Mushroom ethanolic extracts as cosmeceuticals ingredients: Safety and ex vivo skin permeation studies |
| title_short | Mushroom ethanolic extracts as cosmeceuticals ingredients: Safety and ex vivo skin permeation studies |
| title_sort | Mushroom ethanolic extracts as cosmeceuticals ingredients: Safety and ex vivo skin permeation studies |
| topic | Bioactive compounds Cosmeceuticals Cytotoxicity Mushrooms Skin permeation |
| topic_facet | Bioactive compounds Cosmeceuticals Cytotoxicity Mushrooms Skin permeation |
| url | http://hdl.handle.net/10198/19982 |
| visible | 1 |