Publicação
Development of hydrosoluble gels with Crataegus monogyna extracts for topical application: evaluation of antioxidant activity of the final formulations
| Resumo: | Crataegus monogyna, commonly known as hawthorn, is notorious for having different ethnopharmacological applications. The antioxidant activity of methanolic extracts from its flowers and fruits in several stages of development was formerly reported by us. Therefore it is believable that the extracts of its botanical parts might have great potential to be incorporated in innovative pharmaceutical formulations. Accordingly, several paraben free, carbopol 940 based semisolid formulations were prepared with different hawthorn parts extracts. The antioxidant properties of ethanolic and aqueous hawthorn extracts, as well as their corresponding hydrosoluble gels, were screened. Ethanolic extracts proved to be more effective, while flowers and unripe fruits were the most bioactive hawthorn parts. The prepared hydrosoluble gels, that presented an adequate consistency, a pleasant colour and a non greasy texture, kept almost entirely the antioxidant activity exhibited by the extracts from which they were prepared. In addition, the hydrosoluble gels were tested and promptly absorbed by the skin and did not show significant pH alterations during the 90 days of observation. Despite the need of further tests (viscosity, extrudability, spreadability or transepidermal water loss), the prepared formulations demonstrate interesting attributes to be explored as potential dermopharmaceutical products. |
|---|---|
| Autores principais: | Barreira, João C.M. |
| Outros Autores: | Rodrigues, Sandra; Carvalho, Ana Maria; Ferreira, Isabel C.F.R. |
| Assunto: | Hydrosoluble gels Hawthorn Ethnopharmacology Antioxidant activity Bioactive compounds |
| Ano: | 2013 |
| País: | Portugal |
| Tipo de documento: | artigo |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Instituto Politécnico de Bragança |
| Idioma: | inglês |
| Origem: | Biblioteca Digital do IPB |
| _version_ | 1867173222400655360 |
|---|---|
| author | Barreira, João C.M. |
| author2 | Rodrigues, Sandra Carvalho, Ana Maria Ferreira, Isabel C.F.R. |
| author2_role | author author author |
| author_facet | Barreira, João C.M. Rodrigues, Sandra Carvalho, Ana Maria Ferreira, Isabel C.F.R. |
| author_role | author |
| contributor_name_str_mv | Biblioteca Digital do IPB |
| country_str | PT |
| creators_json_txt | [{\"Person.name\":\"Barreira, João C.M.\",\"Person.identifier.orcid\":\"0000-0003-1233-0990\"},{\"Person.name\":\"Rodrigues, Sandra\",\"Person.identifier.orcid\":\"0000-0003-3301-1729\"},{\"Person.name\":\"Carvalho, Ana Maria\",\"Person.identifier.orcid\":\"0000-0001-5508-5935\"},{\"Person.name\":\"Ferreira, Isabel C.F.R.\",\"Person.identifier.orcid\":\"0000-0003-4910-4882\"}] |
| datacite.contributors.contributor.contributorName.fl_str_mv | Biblioteca Digital do IPB |
| datacite.creators.creator.creatorName.fl_str_mv | Barreira, João C.M. Rodrigues, Sandra Carvalho, Ana Maria Ferreira, Isabel C.F.R. |
| datacite.date.Accepted.fl_str_mv | 2013-01-01T00:00:00Z |
| datacite.date.available.fl_str_mv | 2012-11-05T15:44:08Z |
| datacite.date.embargoed.fl_str_mv | 2012-11-05T15:44:08Z |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| datacite.subjects.subject.fl_str_mv | Hydrosoluble gels Hawthorn Ethnopharmacology Antioxidant activity Bioactive compounds |
| datacite.titles.title.fl_str_mv | Development of hydrosoluble gels with Crataegus monogyna extracts for topical application: evaluation of antioxidant activity of the final formulations |
| dc.contributor.none.fl_str_mv | Biblioteca Digital do IPB |
| dc.creator.none.fl_str_mv | Barreira, João C.M. Rodrigues, Sandra Carvalho, Ana Maria Ferreira, Isabel C.F.R. |
| dc.date.Accepted.fl_str_mv | 2013-01-01T00:00:00Z |
| dc.date.available.fl_str_mv | 2012-11-05T15:44:08Z |
| dc.date.embargoed.fl_str_mv | 2012-11-05T15:44:08Z |
| dc.format.none.fl_str_mv | application/pdf application/pdf |
| dc.identifier.none.fl_str_mv | http://hdl.handle.net/10198/7715 |
| dc.language.none.fl_str_mv | eng |
| dc.publisher.none.fl_str_mv | Elsevier |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| dc.subject.none.fl_str_mv | Hydrosoluble gels Hawthorn Ethnopharmacology Antioxidant activity Bioactive compounds |
| dc.title.fl_str_mv | Development of hydrosoluble gels with Crataegus monogyna extracts for topical application: evaluation of antioxidant activity of the final formulations |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_6501 |
| description | Crataegus monogyna, commonly known as hawthorn, is notorious for having different ethnopharmacological applications. The antioxidant activity of methanolic extracts from its flowers and fruits in several stages of development was formerly reported by us. Therefore it is believable that the extracts of its botanical parts might have great potential to be incorporated in innovative pharmaceutical formulations. Accordingly, several paraben free, carbopol 940 based semisolid formulations were prepared with different hawthorn parts extracts. The antioxidant properties of ethanolic and aqueous hawthorn extracts, as well as their corresponding hydrosoluble gels, were screened. Ethanolic extracts proved to be more effective, while flowers and unripe fruits were the most bioactive hawthorn parts. The prepared hydrosoluble gels, that presented an adequate consistency, a pleasant colour and a non greasy texture, kept almost entirely the antioxidant activity exhibited by the extracts from which they were prepared. In addition, the hydrosoluble gels were tested and promptly absorbed by the skin and did not show significant pH alterations during the 90 days of observation. Despite the need of further tests (viscosity, extrudability, spreadability or transepidermal water loss), the prepared formulations demonstrate interesting attributes to be explored as potential dermopharmaceutical products. |
| dirty | 0 |
| eu_rights_str_mv | openAccess |
| format | article |
| fulltext.url.fl_str_mv | https://bibliotecadigital.ipb.pt/bitstreams/1e42c7e0-6941-4d44-b4ab-6378836dcc7c/download |
| funding.funder.alternateName_str_mv | FCT FCT |
| funding.funder.identifier_str_mv | http://doi.org/10.13039/501100001871 http://doi.org/10.13039/501100001871 |
| funding.funder.name_str_mv | Fundação para a Ciência e a Tecnologia Fundação para a Ciência e a Tecnologia |
| funding.name_str_mv | 6817 - DCRRNI ID |
| id | ipb_9898a7f4857d85fb36f683096b07b014 |
| identifier.url.fl_str_mv | http://hdl.handle.net/10198/7715 |
| instacron_str | ipb |
| institution | Instituto Politécnico de Bragança |
| instname_str | Instituto Politécnico de Bragança |
| language | eng |
| network_acronym_str | ipb |
| network_name_str | Biblioteca Digital do IPB |
| oai_identifier_str | oai:bibliotecadigital.ipb.pt:10198/7715 |
| organization_str_mv | urn:organizationAcronym:ipb |
| person_str_mv | Barreira, João C.M. Barreira, João C.M. http://orcid.org/0000-0003-1233-0990 0000-0003-1233-0990 Rodrigues, Sandra Rodrigues, Sandra https://www.ciencia-id.pt/651F-D964-32E1 651F-D964-32E1 http://orcid.org/0000-0003-3301-1729 0000-0003-3301-1729 Carvalho, Ana Maria Carvalho, Ana Maria https://www.ciencia-id.pt/D31A-35AF-E2A9 D31A-35AF-E2A9 http://orcid.org/0000-0001-5508-5935 0000-0001-5508-5935 Ferreira, Isabel C.F.R. Ferreira, Isabel C.F.R. https://www.ciencia-id.pt/9418-CF95-9919 9418-CF95-9919 http://orcid.org/0000-0003-4910-4882 0000-0003-4910-4882 |
| publishDate | 2013 |
| publisher.none.fl_str_mv | Elsevier |
| reponame_str | Biblioteca Digital do IPB |
| repository_id_str | urn:repositoryAcronym:ipb |
| service_str_mv | urn:repositoryAcronym:ipb |
| spelling | engElsevierCrataegus monogyna, commonly known as hawthorn, is notorious for having different ethnopharmacological applications. The antioxidant activity of methanolic extracts from its flowers and fruits in several stages of development was formerly reported by us. Therefore it is believable that the extracts of its botanical parts might have great potential to be incorporated in innovative pharmaceutical formulations. Accordingly, several paraben free, carbopol 940 based semisolid formulations were prepared with different hawthorn parts extracts. The antioxidant properties of ethanolic and aqueous hawthorn extracts, as well as their corresponding hydrosoluble gels, were screened. Ethanolic extracts proved to be more effective, while flowers and unripe fruits were the most bioactive hawthorn parts. The prepared hydrosoluble gels, that presented an adequate consistency, a pleasant colour and a non greasy texture, kept almost entirely the antioxidant activity exhibited by the extracts from which they were prepared. In addition, the hydrosoluble gels were tested and promptly absorbed by the skin and did not show significant pH alterations during the 90 days of observation. Despite the need of further tests (viscosity, extrudability, spreadability or transepidermal water loss), the prepared formulations demonstrate interesting attributes to be explored as potential dermopharmaceutical products.application/pdfapplication/pdfporDevelopment of hydrosoluble gels with Crataegus monogyna extracts for topical application: evaluation of antioxidant activity of the final formulationsPersonalBarreira, João C.M.DSpacehttp://dspace.org/items/4629b12c-39b0-4da8-8b8d-6efba5cf2d81DSpacehttp://dspace.org/items/4629b12c-39b0-4da8-8b8d-6efba5cf2d81BarreiraJoão C.M.ORCIDhttp://orcid.org0000-0003-1233-0990Researcher IDhttps://www.researcherid.comD-8269-2013Scopus Author IDhttps://www.scopus.com54895546900PersonalRodrigues, SandraDSpacehttp://dspace.org/items/684ab6a0-e3ea-4b6e-9874-d20d71e2a3f5DSpacehttp://dspace.org/items/684ab6a0-e3ea-4b6e-9874-d20d71e2a3f5RodriguesSandraCiência IDhttps://www.ciencia-id.pt651F-D964-32E1ORCIDhttp://orcid.org0000-0003-3301-1729Researcher IDhttps://www.researcherid.comC-6486-2008Scopus Author IDhttps://www.scopus.com14048942500PersonalCarvalho, Ana MariaDSpacehttp://dspace.org/items/977f5254-f7c5-4c91-873f-2700ecd4692fDSpacehttp://dspace.org/items/977f5254-f7c5-4c91-873f-2700ecd4692fCarvalhoAna MariaCiência IDhttps://www.ciencia-id.ptD31A-35AF-E2A9ORCIDhttp://orcid.org0000-0001-5508-5935Scopus Author IDhttps://www.scopus.com20336503900PersonalFerreira, Isabel C.F.R.DSpacehttp://dspace.org/items/bd0d1537-2e03-41fb-b27a-140af9c35db8DSpacehttp://dspace.org/items/bd0d1537-2e03-41fb-b27a-140af9c35db8FerreiraIsabel C.F.R.Ciência IDhttps://www.ciencia-id.pt9418-CF95-9919ORCIDhttp://orcid.org0000-0003-4910-4882Researcher IDhttps://www.researcherid.comE-8500-2013Scopus Author IDhttps://www.scopus.com36868826600HostingInstitutionOrganizationalBiblioteca Digital do IPBe-mailmailto:dspace@ipb.ptdspace@ipb.ptISSNIsPartOf0926-6690DOIIsPartOf10.1016/j.indcrop.2012.05.0342012-11-05T15:44:08Z20132013-01-01T00:00:00ZHandlehttp://hdl.handle.net/10198/7715http://purl.org/coar/access_right/c_abf2open accessHydrosoluble gelsHawthornEthnopharmacologyAntioxidant activityBioactive compounds736811 bytes361574 bytesFundação para a Ciência e a TecnologiaStrategic Project - UI 690 - 2011-20126817 - DCRRNI IDCrossref Funder IDhttp://doi.org/10.13039/501100001871Fundação para a Ciência e a TecnologiaBIOACTIVE PROPERTIES & CYTOPROTECTIVE POTENTIAL OF NATURAL EXTRACTS/INDIVIDUAL COMPOUNDS: APPLICATION OF SINGLE CELL GEL ELECTROPHORESIS AND OTHER BIOCHEMICAL, CHEMICAL AND ELECTROCHEMICAL ASSAYSCrossref Funder IDhttp://doi.org/10.13039/501100001871literaturehttp://purl.org/coar/resource_type/c_6501journal articlehttp://purl.org/coar/access_right/c_abf2application/pdffulltexthttps://bibliotecadigital.ipb.pt/bitstreams/1e42c7e0-6941-4d44-b4ab-6378836dcc7c/downloadhttp://purl.org/coar/access_right/c_abf2application/pdffulltexthttps://bibliotecadigital.ipb.pt/bitstreams/ec6f0f51-317a-4a72-aa81-23c6a9fcfe44/downloadIndustrial Crops and Products42175180 |
| spellingShingle | Development of hydrosoluble gels with Crataegus monogyna extracts for topical application: evaluation of antioxidant activity of the final formulations Barreira, João C.M. Hydrosoluble gels Hawthorn Ethnopharmacology Antioxidant activity Bioactive compounds |
| status | SINGLETON |
| subject.fl_str_mv | Hydrosoluble gels Hawthorn Ethnopharmacology Antioxidant activity Bioactive compounds |
| title | Development of hydrosoluble gels with Crataegus monogyna extracts for topical application: evaluation of antioxidant activity of the final formulations |
| title_full | Development of hydrosoluble gels with Crataegus monogyna extracts for topical application: evaluation of antioxidant activity of the final formulations |
| title_fullStr | Development of hydrosoluble gels with Crataegus monogyna extracts for topical application: evaluation of antioxidant activity of the final formulations |
| title_full_unstemmed | Development of hydrosoluble gels with Crataegus monogyna extracts for topical application: evaluation of antioxidant activity of the final formulations |
| title_short | Development of hydrosoluble gels with Crataegus monogyna extracts for topical application: evaluation of antioxidant activity of the final formulations |
| title_sort | Development of hydrosoluble gels with Crataegus monogyna extracts for topical application: evaluation of antioxidant activity of the final formulations |
| topic | Hydrosoluble gels Hawthorn Ethnopharmacology Antioxidant activity Bioactive compounds |
| topic_facet | Hydrosoluble gels Hawthorn Ethnopharmacology Antioxidant activity Bioactive compounds |
| url | http://hdl.handle.net/10198/7715 |
| visible | 1 |