Publication
Lovage (Levisticum officinale W.D.J. Koch) roots: a source of bioactive compounds towards a circular economy
| Summary: | Lovage (Levisticum officinale W.D.J. Koch) is an aromatic plant from the Apiaceae (Umbelliferae) family used as a condiment in several regions of Europe and also described to have medicinal properties. While the aerial parts are used as foods, the roots are generally discarded. In the past, lovage roots were used in folk medicine for their diuretic, carminative, and spasmolytic properties. Therefore, the exploitation of this undervalued part of the plant can be a source of valuable bioactive compounds for food and/or pharmaceutical industries. Thus, in this study, extracts of different polarity were prepared and studied regarding their chemical composition and bioactive properties. To the best of our knowledge, the composition in phenolic compounds and the volatile profile of the n-hexane extract are reported for the first time. A total of 24 compounds were identified by GC-MS in the n-hexane extract, evidencing a high relative abundance of phthalides. A total of eight phenolic compounds were identified in lovage root extracts (decoction and hydroethanolic extract), with vanillic acid being the major compound. Regarding antioxidant activity, also reported for the first time, decoction and hydroethanolic extract exhibited a high antioxidant capacity in thiobarbituric acid reactive substances (TBARS) (179 ± 11 μg/mL) and in oxidative hemolysis (OxHLIA) assays (510 ± 6 μg/mL), respectively. n-Hexane extract showed relevant anti-proliferative activity against all tumor cell lines tested (GI50, 48-69 μg/mL), despite inhibiting also the growth of a non-tumoral hepatocyte cell line, however, presenting a significantly higher GI50 value (147 μg/mL). This study revealed that lovage root, an agri-food residue, can be a source of valuable bioactive compounds also presenting biological properties that deserve being explored, which could lead to a circular economy for food and/or the pharmaceutical industry. |
|---|---|
| Main Authors: | Sprea, Rafael M. |
| Other Authors: | Fernandes, Ângela; Finimundy, Tiane C.; Pereira, Carla; Alves, Maria José; Calhelha, Ricardo C.; Canan, Cristiane; Barros, Lillian; Amaral, Joana S.; Ferreira, Isabel C.F.R. |
| Subject: | Agri-food waste Bioactivity Circular economy Levisticum officinale roots Phenolic compounds Phthalides |
| Year: | 2020 |
| Country: | Portugal |
| Document type: | article |
| Access type: | open access |
| Associated institution: | Instituto Politécnico de Bragança |
| Language: | English |
| Origin: | Biblioteca Digital do IPB |
| _version_ | 1867172904356020224 |
|---|---|
| author | Sprea, Rafael M. |
| author2 | Fernandes, Ângela Finimundy, Tiane C. Pereira, Carla Alves, Maria José Calhelha, Ricardo C. Canan, Cristiane Barros, Lillian Amaral, Joana S. Ferreira, Isabel C.F.R. |
| author2_role | author author author author author author author author author |
| author_facet | Sprea, Rafael M. Fernandes, Ângela Finimundy, Tiane C. Pereira, Carla Alves, Maria José Calhelha, Ricardo C. Canan, Cristiane Barros, Lillian Amaral, Joana S. Ferreira, Isabel C.F.R. |
| author_role | author |
| contributor_name_str_mv | Biblioteca Digital do IPB |
| country_str | PT |
| creators_json_txt | [{\"Person.name\":\"Sprea, Rafael M.\"},{\"Person.name\":\"Fernandes, Ângela\",\"Person.identifier.orcid\":\"0000-0002-0157-9873\"},{\"Person.name\":\"Finimundy, Tiane C.\",\"Person.identifier.orcid\":\"0000-0003-3516-0795\"},{\"Person.name\":\"Pereira, Carla\",\"Person.identifier.orcid\":\"0000-0003-0093-771X\"},{\"Person.name\":\"Alves, Maria José\",\"Person.identifier.orcid\":\"0000-0001-8506-4393\"},{\"Person.name\":\"Calhelha, Ricardo C.\",\"Person.identifier.orcid\":\"0000-0002-6801-4578\"},{\"Person.name\":\"Canan, Cristiane\"},{\"Person.name\":\"Barros, Lillian\",\"Person.identifier.orcid\":\"0000-0002-9050-5189\"},{\"Person.name\":\"Amaral, Joana S.\",\"Person.identifier.orcid\":\"0000-0002-3648-7303\"},{\"Person.name\":\"Ferreira, Isabel C.F.R.\",\"Person.identifier.orcid\":\"0000-0003-4910-4882\"}] |
| datacite.contributors.contributor.contributorName.fl_str_mv | Biblioteca Digital do IPB |
| datacite.creators.creator.creatorName.fl_str_mv | Sprea, Rafael M. Fernandes, Ângela Finimundy, Tiane C. Pereira, Carla Alves, Maria José Calhelha, Ricardo C. Canan, Cristiane Barros, Lillian Amaral, Joana S. Ferreira, Isabel C.F.R. |
| datacite.date.Accepted.fl_str_mv | 2020-01-01T00:00:00Z |
| datacite.date.available.fl_str_mv | 2018-01-19T10:00:00Z |
| datacite.date.embargoed.fl_str_mv | 2018-01-19T10:00:00Z |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| datacite.subjects.subject.fl_str_mv | Agri-food waste Bioactivity Circular economy Levisticum officinale roots Phenolic compounds Phthalides |
| datacite.titles.title.fl_str_mv | Lovage (Levisticum officinale W.D.J. Koch) roots: a source of bioactive compounds towards a circular economy |
| dc.contributor.none.fl_str_mv | Biblioteca Digital do IPB |
| dc.creator.none.fl_str_mv | Sprea, Rafael M. Fernandes, Ângela Finimundy, Tiane C. Pereira, Carla Alves, Maria José Calhelha, Ricardo C. Canan, Cristiane Barros, Lillian Amaral, Joana S. Ferreira, Isabel C.F.R. |
| dc.date.Accepted.fl_str_mv | 2020-01-01T00:00:00Z |
| dc.date.available.fl_str_mv | 2018-01-19T10:00:00Z |
| dc.date.embargoed.fl_str_mv | 2018-01-19T10:00:00Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | http://hdl.handle.net/10198/23404 |
| dc.language.none.fl_str_mv | eng |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| dc.subject.none.fl_str_mv | Agri-food waste Bioactivity Circular economy Levisticum officinale roots Phenolic compounds Phthalides |
| dc.title.fl_str_mv | Lovage (Levisticum officinale W.D.J. Koch) roots: a source of bioactive compounds towards a circular economy |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_6501 |
| description | Lovage (Levisticum officinale W.D.J. Koch) is an aromatic plant from the Apiaceae (Umbelliferae) family used as a condiment in several regions of Europe and also described to have medicinal properties. While the aerial parts are used as foods, the roots are generally discarded. In the past, lovage roots were used in folk medicine for their diuretic, carminative, and spasmolytic properties. Therefore, the exploitation of this undervalued part of the plant can be a source of valuable bioactive compounds for food and/or pharmaceutical industries. Thus, in this study, extracts of different polarity were prepared and studied regarding their chemical composition and bioactive properties. To the best of our knowledge, the composition in phenolic compounds and the volatile profile of the n-hexane extract are reported for the first time. A total of 24 compounds were identified by GC-MS in the n-hexane extract, evidencing a high relative abundance of phthalides. A total of eight phenolic compounds were identified in lovage root extracts (decoction and hydroethanolic extract), with vanillic acid being the major compound. Regarding antioxidant activity, also reported for the first time, decoction and hydroethanolic extract exhibited a high antioxidant capacity in thiobarbituric acid reactive substances (TBARS) (179 ± 11 μg/mL) and in oxidative hemolysis (OxHLIA) assays (510 ± 6 μg/mL), respectively. n-Hexane extract showed relevant anti-proliferative activity against all tumor cell lines tested (GI50, 48-69 μg/mL), despite inhibiting also the growth of a non-tumoral hepatocyte cell line, however, presenting a significantly higher GI50 value (147 μg/mL). This study revealed that lovage root, an agri-food residue, can be a source of valuable bioactive compounds also presenting biological properties that deserve being explored, which could lead to a circular economy for food and/or the pharmaceutical industry. |
| dirty | 0 |
| eu_rights_str_mv | openAccess |
| format | article |
| fulltext.url.fl_str_mv | https://bibliotecadigital.ipb.pt/bitstreams/084f3da8-b630-43ba-b8c7-dc46826ea8e4/download |
| id | ipb_98e3a31d3d741cb9993b8a4e287c34c9 |
| identifier.url.fl_str_mv | http://hdl.handle.net/10198/23404 |
| instacron_str | ipb |
| institution | Instituto Politécnico de Bragança |
| instname_str | Instituto Politécnico de Bragança |
| language | eng |
| network_acronym_str | ipb |
| network_name_str | Biblioteca Digital do IPB |
| oai_identifier_str | oai:bibliotecadigital.ipb.pt:10198/23404 |
| organization_str_mv | urn:organizationAcronym:ipb |
| person_str_mv | Sprea, Rafael M. Sprea, Rafael M. https://www.ciencia-id.pt/001F-273E-3A67 001F-273E-3A67 Fernandes, Ângela Fernandes, Ângela https://www.ciencia-id.pt/2015-0434-AE7C 2015-0434-AE7C http://orcid.org/0000-0002-0157-9873 0000-0002-0157-9873 Finimundy, Tiane C. Finimundy, Tiane C. https://www.ciencia-id.pt/2F18-67B1-776A 2F18-67B1-776A http://orcid.org/0000-0003-3516-0795 0000-0003-3516-0795 Pereira, Carla Pereira, Carla https://www.ciencia-id.pt/EF10-2739-2B70 EF10-2739-2B70 http://orcid.org/0000-0003-0093-771X 0000-0003-0093-771X Alves, Maria José Alves, Maria José https://www.ciencia-id.pt/D618-B3A9-D312 D618-B3A9-D312 http://orcid.org/0000-0001-8506-4393 0000-0001-8506-4393 Calhelha, Ricardo C. Calhelha, Ricardo C. https://www.ciencia-id.pt/F313-E3CE-554E F313-E3CE-554E http://orcid.org/0000-0002-6801-4578 0000-0002-6801-4578 Canan, Cristiane Barros, Lillian Barros, Lillian https://www.ciencia-id.pt/9616-35CB-D001 9616-35CB-D001 http://orcid.org/0000-0002-9050-5189 0000-0002-9050-5189 Amaral, Joana S. Amaral, Joana S. https://www.ciencia-id.pt/5319-7DE8-BEDA 5319-7DE8-BEDA http://orcid.org/0000-0002-3648-7303 0000-0002-3648-7303 Ferreira, Isabel C.F.R. Ferreira, Isabel C.F.R. https://www.ciencia-id.pt/9418-CF95-9919 9418-CF95-9919 http://orcid.org/0000-0003-4910-4882 0000-0003-4910-4882 |
| publishDate | 2020 |
| reponame_str | Biblioteca Digital do IPB |
| repository_id_str | urn:repositoryAcronym:ipb |
| service_str_mv | urn:repositoryAcronym:ipb |
| spelling | engen_ENLovage (Levisticum officinale W.D.J. Koch) is an aromatic plant from the Apiaceae (Umbelliferae) family used as a condiment in several regions of Europe and also described to have medicinal properties. While the aerial parts are used as foods, the roots are generally discarded. In the past, lovage roots were used in folk medicine for their diuretic, carminative, and spasmolytic properties. Therefore, the exploitation of this undervalued part of the plant can be a source of valuable bioactive compounds for food and/or pharmaceutical industries. Thus, in this study, extracts of different polarity were prepared and studied regarding their chemical composition and bioactive properties. To the best of our knowledge, the composition in phenolic compounds and the volatile profile of the n-hexane extract are reported for the first time. A total of 24 compounds were identified by GC-MS in the n-hexane extract, evidencing a high relative abundance of phthalides. A total of eight phenolic compounds were identified in lovage root extracts (decoction and hydroethanolic extract), with vanillic acid being the major compound. Regarding antioxidant activity, also reported for the first time, decoction and hydroethanolic extract exhibited a high antioxidant capacity in thiobarbituric acid reactive substances (TBARS) (179 ± 11 μg/mL) and in oxidative hemolysis (OxHLIA) assays (510 ± 6 μg/mL), respectively. n-Hexane extract showed relevant anti-proliferative activity against all tumor cell lines tested (GI50, 48-69 μg/mL), despite inhibiting also the growth of a non-tumoral hepatocyte cell line, however, presenting a significantly higher GI50 value (147 μg/mL). This study revealed that lovage root, an agri-food residue, can be a source of valuable bioactive compounds also presenting biological properties that deserve being explored, which could lead to a circular economy for food and/or the pharmaceutical industry.application/pdfen_ENLovage (Levisticum officinale W.D.J. Koch) roots: a source of bioactive compounds towards a circular economyPersonalSprea, Rafael M.DSpacehttp://dspace.org/items/7779265b-4054-4822-9a2a-03b1482c81e0DSpacehttp://dspace.org/items/7779265b-4054-4822-9a2a-03b1482c81e0SpreaRafael M.Ciência IDhttps://www.ciencia-id.pt001F-273E-3A67PersonalFernandes, ÂngelaDSpacehttp://dspace.org/items/6233e657-3885-40a3-885e-0d51cf4dbaadDSpacehttp://dspace.org/items/6233e657-3885-40a3-885e-0d51cf4dbaadFernandesÂngelaCiência IDhttps://www.ciencia-id.pt2015-0434-AE7CORCIDhttp://orcid.org0000-0002-0157-9873PersonalFinimundy, Tiane C.DSpacehttp://dspace.org/items/4f8767d4-4e62-4550-9b35-740cb2f672daDSpacehttp://dspace.org/items/4f8767d4-4e62-4550-9b35-740cb2f672daFinimundyTiane C.Ciência IDhttps://www.ciencia-id.pt2F18-67B1-776AORCIDhttp://orcid.org0000-0003-3516-0795PersonalPereira, CarlaDSpacehttp://dspace.org/items/e07a8e12-52bb-47c5-bae7-41a5f648213bDSpacehttp://dspace.org/items/e07a8e12-52bb-47c5-bae7-41a5f648213bPereiraCarlaCiência IDhttps://www.ciencia-id.ptEF10-2739-2B70ORCIDhttp://orcid.org0000-0003-0093-771XResearcher IDhttps://www.researcherid.comK-1629-2016Scopus Author IDhttps://www.scopus.com55627876424PersonalAlves, Maria JoséDSpacehttp://dspace.org/items/7850f8c2-8834-4d5a-b4a7-df482abd76d3DSpacehttp://dspace.org/items/7850f8c2-8834-4d5a-b4a7-df482abd76d3AlvesMaria JoséCiência IDhttps://www.ciencia-id.ptD618-B3A9-D312ORCIDhttp://orcid.org0000-0001-8506-4393Researcher IDhttps://www.researcherid.comM-6624-2016Scopus Author IDhttps://www.scopus.com16400584800PersonalCalhelha, Ricardo C.DSpacehttp://dspace.org/items/2d5d1a41-7561-4a01-871c-b4c97da35053DSpacehttp://dspace.org/items/2d5d1a41-7561-4a01-871c-b4c97da35053CalhelhaRicardo C.Ciência IDhttps://www.ciencia-id.ptF313-E3CE-554EORCIDhttp://orcid.org0000-0002-6801-4578Researcher IDhttps://www.researcherid.comJ-2172-2014Scopus Author IDhttps://www.scopus.com6507978333Canan, CristianePersonalBarros, LillianDSpacehttp://dspace.org/items/3af07ffe-f914-48ba-a5d5-efcf70fdce01DSpacehttp://dspace.org/items/3af07ffe-f914-48ba-a5d5-efcf70fdce01BarrosLillianCiência IDhttps://www.ciencia-id.pt9616-35CB-D001ORCIDhttp://orcid.org0000-0002-9050-5189Researcher IDhttps://www.researcherid.comJ-3600-2013Researcher IDhttps://www.researcherid.comJ-3600-2013Scopus Author IDhttps://www.scopus.com35236343600Scopus Author IDhttps://www.scopus.com57194900801PersonalAmaral, Joana S.DSpacehttp://dspace.org/items/42be2cf4-adc4-4e7f-ac60-7aab515b38cdDSpacehttp://dspace.org/items/42be2cf4-adc4-4e7f-ac60-7aab515b38cdAmaralJoana S.Ciência IDhttps://www.ciencia-id.pt5319-7DE8-BEDAORCIDhttp://orcid.org0000-0002-3648-7303PersonalFerreira, Isabel C.F.R.DSpacehttp://dspace.org/items/bd0d1537-2e03-41fb-b27a-140af9c35db8DSpacehttp://dspace.org/items/bd0d1537-2e03-41fb-b27a-140af9c35db8FerreiraIsabel C.F.R.Ciência IDhttps://www.ciencia-id.pt9418-CF95-9919ORCIDhttp://orcid.org0000-0003-4910-4882Researcher IDhttps://www.researcherid.comE-8500-2013Scopus Author IDhttps://www.scopus.com36868826600HostingInstitutionOrganizationalBiblioteca Digital do IPBe-mailmailto:dspace@ipb.ptdspace@ipb.ptDOIIsPartOf10.3390/RESOURCES90700812018-01-19T10:00:00Z20202020-01-01T00:00:00ZHandlehttp://hdl.handle.net/10198/23404http://purl.org/coar/access_right/c_abf2open accessAgri-food wasteBioactivityCircular economyLevisticum officinale rootsPhenolic compoundsPhthalides1162210 bytesliteraturehttp://purl.org/coar/resource_type/c_6501journal articlehttp://purl.org/coar/access_right/c_abf2application/pdffulltexthttps://bibliotecadigital.ipb.pt/bitstreams/084f3da8-b630-43ba-b8c7-dc46826ea8e4/download |
| spellingShingle | Lovage (Levisticum officinale W.D.J. Koch) roots: a source of bioactive compounds towards a circular economy Sprea, Rafael M. Agri-food waste Bioactivity Circular economy Levisticum officinale roots Phenolic compounds Phthalides |
| status | SINGLETON |
| subject.fl_str_mv | Agri-food waste Bioactivity Circular economy Levisticum officinale roots Phenolic compounds Phthalides |
| title | Lovage (Levisticum officinale W.D.J. Koch) roots: a source of bioactive compounds towards a circular economy |
| title_full | Lovage (Levisticum officinale W.D.J. Koch) roots: a source of bioactive compounds towards a circular economy |
| title_fullStr | Lovage (Levisticum officinale W.D.J. Koch) roots: a source of bioactive compounds towards a circular economy |
| title_full_unstemmed | Lovage (Levisticum officinale W.D.J. Koch) roots: a source of bioactive compounds towards a circular economy |
| title_short | Lovage (Levisticum officinale W.D.J. Koch) roots: a source of bioactive compounds towards a circular economy |
| title_sort | Lovage (Levisticum officinale W.D.J. Koch) roots: a source of bioactive compounds towards a circular economy |
| topic | Agri-food waste Bioactivity Circular economy Levisticum officinale roots Phenolic compounds Phthalides |
| topic_facet | Agri-food waste Bioactivity Circular economy Levisticum officinale roots Phenolic compounds Phthalides |
| url | http://hdl.handle.net/10198/23404 |
| visible | 1 |