Publicação
Co-ingestion of amatoxins and isoxazoles-containing mushrooms and successful treatment: A case report
| Resumo: | Mushroom poisonings occur when ingestion of wild mushrooms containing toxins takes place, placing the consumers at life-threatening risk. In the present case report, an unusual multiple poisoning with isoxazoles- and amatoxins-containing mushrooms in a context of altered mental state and poorly controlled hypertension is presented. A 68-year-old female was presented to São João hospital (Portugal) with complaints of extreme dizziness, hallucinations, vertigo and imbalance, 3 h after consuming a stew of wild mushrooms. The first observations revealed altered mental state and elevated blood pressure. The examination of cooked mushroom fragments allowed a preliminary identification of Amanita pantherina. Gas chromatography-mass spectrometry (GC-MS) showed the presence of muscimol in urine. Moreover, through high-performance liquid chromatography-ultraviolet detection (HPLC-UV) analysis of the gastric juice, the presence of α-amanitin was found, showing that amatoxins-containing mushrooms were also included in the stew. After 4 days of supportive treatment, activated charcoal, silybin and N-acetylcysteine, the patient recovered being discharged 10 days post-ingestion with no organ complications. The prompt and appropriate therapy protocol for life-threatening amatoxins toxicity probably saved the patient's life as oral absorption was decreased and also supportive care was immediately started. |
|---|---|
| Autores principais: | Garcia, Juliana |
| Outros Autores: | Costa, Vera M.; Costa, Ana Elisa; Andrade, Sérgio; Carneiro, Ana Cristina; Conceição, Filipe; Paiva, José Artur; Pinho, P. Guedes de; Baptista, Paula; Bastos, Maria de Lourdes; Carvalho, Félix |
| Assunto: | Amanita pantherina Amanita phalloides Amatoxins Intoxication Isoxazoles Wild mushrooms |
| Ano: | 2015 |
| País: | Portugal |
| Tipo de documento: | artigo |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Instituto Politécnico de Bragança |
| Idioma: | inglês |
| Origem: | Biblioteca Digital do IPB |
| _version_ | 1863850656284016640 |
|---|---|
| author | Garcia, Juliana |
| author2 | Costa, Vera M. Costa, Ana Elisa Andrade, Sérgio Carneiro, Ana Cristina Conceição, Filipe Paiva, José Artur Pinho, P. Guedes de Baptista, Paula Bastos, Maria de Lourdes Carvalho, Félix |
| author2_role | author author author author author author author author author author |
| author_facet | Garcia, Juliana Costa, Vera M. Costa, Ana Elisa Andrade, Sérgio Carneiro, Ana Cristina Conceição, Filipe Paiva, José Artur Pinho, P. Guedes de Baptista, Paula Bastos, Maria de Lourdes Carvalho, Félix |
| author_role | author |
| contributor_name_str_mv | Biblioteca Digital do IPB |
| country_str | PT |
| creators_json_str | [{\"Person.name\":\"Garcia, Juliana\"},{\"Person.name\":\"Costa, Vera M.\"},{\"Person.name\":\"Costa, Ana Elisa\"},{\"Person.name\":\"Andrade, Sérgio\"},{\"Person.name\":\"Carneiro, Ana Cristina\"},{\"Person.name\":\"Conceição, Filipe\"},{\"Person.name\":\"Paiva, José Artur\"},{\"Person.name\":\"Pinho, P. Guedes de\"},{\"Person.name\":\"Baptista, Paula\",\"Person.identifier.orcid\":\"0000-0001-6331-3731\"},{\"Person.name\":\"Bastos, Maria de Lourdes\"},{\"Person.name\":\"Carvalho, Félix\"}] |
| datacite.contributors.contributor.contributorName.fl_str_mv | Biblioteca Digital do IPB |
| datacite.creators.creator.creatorName.fl_str_mv | Garcia, Juliana Costa, Vera M. Costa, Ana Elisa Andrade, Sérgio Carneiro, Ana Cristina Conceição, Filipe Paiva, José Artur Pinho, P. Guedes de Baptista, Paula Bastos, Maria de Lourdes Carvalho, Félix |
| datacite.date.Accepted.fl_str_mv | 2015-01-01T00:00:00Z |
| datacite.date.available.fl_str_mv | 2018-01-19T10:00:00Z |
| datacite.date.embargoed.fl_str_mv | 2018-01-19T10:00:00Z |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| datacite.subjects.subject.fl_str_mv | Amanita pantherina Amanita phalloides Amatoxins Intoxication Isoxazoles Wild mushrooms |
| datacite.titles.title.fl_str_mv | Co-ingestion of amatoxins and isoxazoles-containing mushrooms and successful treatment: A case report |
| dc.contributor.none.fl_str_mv | Biblioteca Digital do IPB |
| dc.creator.none.fl_str_mv | Garcia, Juliana Costa, Vera M. Costa, Ana Elisa Andrade, Sérgio Carneiro, Ana Cristina Conceição, Filipe Paiva, José Artur Pinho, P. Guedes de Baptista, Paula Bastos, Maria de Lourdes Carvalho, Félix |
| dc.date.Accepted.fl_str_mv | 2015-01-01T00:00:00Z |
| dc.date.available.fl_str_mv | 2018-01-19T10:00:00Z |
| dc.date.embargoed.fl_str_mv | 2018-01-19T10:00:00Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | http://hdl.handle.net/10198/16113 |
| dc.language.none.fl_str_mv | eng |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| dc.subject.none.fl_str_mv | Amanita pantherina Amanita phalloides Amatoxins Intoxication Isoxazoles Wild mushrooms |
| dc.title.fl_str_mv | Co-ingestion of amatoxins and isoxazoles-containing mushrooms and successful treatment: A case report |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_6501 |
| description | Mushroom poisonings occur when ingestion of wild mushrooms containing toxins takes place, placing the consumers at life-threatening risk. In the present case report, an unusual multiple poisoning with isoxazoles- and amatoxins-containing mushrooms in a context of altered mental state and poorly controlled hypertension is presented. A 68-year-old female was presented to São João hospital (Portugal) with complaints of extreme dizziness, hallucinations, vertigo and imbalance, 3 h after consuming a stew of wild mushrooms. The first observations revealed altered mental state and elevated blood pressure. The examination of cooked mushroom fragments allowed a preliminary identification of Amanita pantherina. Gas chromatography-mass spectrometry (GC-MS) showed the presence of muscimol in urine. Moreover, through high-performance liquid chromatography-ultraviolet detection (HPLC-UV) analysis of the gastric juice, the presence of α-amanitin was found, showing that amatoxins-containing mushrooms were also included in the stew. After 4 days of supportive treatment, activated charcoal, silybin and N-acetylcysteine, the patient recovered being discharged 10 days post-ingestion with no organ complications. The prompt and appropriate therapy protocol for life-threatening amatoxins toxicity probably saved the patient's life as oral absorption was decreased and also supportive care was immediately started. |
| dirty | 0 |
| eu_rights_str_mv | openAccess |
| format | article |
| fulltext.url.fl_str_mv | https://bibliotecadigital.ipb.pt/bitstreams/5a6f37af-ddf0-4fb0-9609-8795b6d59269/download |
| id | ipb_ac57eff9bc8d8ec2f4121c7ecd9f9739 |
| identifier.url.fl_str_mv | http://hdl.handle.net/10198/16113 |
| instacron_str | ipb |
| institution | Instituto Politécnico de Bragança |
| instname_str | Instituto Politécnico de Bragança |
| language | eng |
| network_acronym_str | ipb |
| network_name_str | Biblioteca Digital do IPB |
| oai_identifier_str | oai:bibliotecadigital.ipb.pt:10198/16113 |
| organization_str_mv | urn:organizationAcronym:ipb |
| person_str_mv | Garcia, Juliana Costa, Vera M. Costa, Ana Elisa Andrade, Sérgio Carneiro, Ana Cristina Conceição, Filipe Paiva, José Artur Pinho, P. Guedes de Baptista, Paula Baptista, Paula https://www.ciencia-id.pt/7D11-FE1E-CD0F 7D11-FE1E-CD0F http://orcid.org/0000-0001-6331-3731 0000-0001-6331-3731 Bastos, Maria de Lourdes Carvalho, Félix |
| publishDate | 2015 |
| reponame_str | Biblioteca Digital do IPB |
| repository_id_str | urn:repositoryAcronym:ipb |
| service_str_mv | urn:repositoryAcronym:ipb |
| spelling | engen_ENMushroom poisonings occur when ingestion of wild mushrooms containing toxins takes place, placing the consumers at life-threatening risk. In the present case report, an unusual multiple poisoning with isoxazoles- and amatoxins-containing mushrooms in a context of altered mental state and poorly controlled hypertension is presented. A 68-year-old female was presented to São João hospital (Portugal) with complaints of extreme dizziness, hallucinations, vertigo and imbalance, 3 h after consuming a stew of wild mushrooms. The first observations revealed altered mental state and elevated blood pressure. The examination of cooked mushroom fragments allowed a preliminary identification of Amanita pantherina. Gas chromatography-mass spectrometry (GC-MS) showed the presence of muscimol in urine. Moreover, through high-performance liquid chromatography-ultraviolet detection (HPLC-UV) analysis of the gastric juice, the presence of α-amanitin was found, showing that amatoxins-containing mushrooms were also included in the stew. After 4 days of supportive treatment, activated charcoal, silybin and N-acetylcysteine, the patient recovered being discharged 10 days post-ingestion with no organ complications. The prompt and appropriate therapy protocol for life-threatening amatoxins toxicity probably saved the patient's life as oral absorption was decreased and also supportive care was immediately started.application/pdfen_ENCo-ingestion of amatoxins and isoxazoles-containing mushrooms and successful treatment: A case reportGarcia, JulianaCosta, Vera M.Costa, Ana ElisaAndrade, SérgioCarneiro, Ana CristinaConceição, FilipePaiva, José ArturPinho, P. Guedes dePersonalBaptista, PaulaDSpacehttp://dspace.org/items/3f35226a-b17a-4f7d-8da1-3297105cbfe9DSpacehttp://dspace.org/items/3f35226a-b17a-4f7d-8da1-3297105cbfe9BaptistaPaulaCiência IDhttps://www.ciencia-id.pt7D11-FE1E-CD0FORCIDhttp://orcid.org0000-0001-6331-3731Scopus Author IDhttps://www.scopus.com14051688000Scopus Author IDhttps://www.scopus.com57394839600Bastos, Maria de LourdesCarvalho, FélixHostingInstitutionOrganizationalBiblioteca Digital do IPBe-mailmailto:dspace@ipb.ptdspace@ipb.ptISSNIsPartOf0041-0101DOIIsPartOf10.1016/j.toxicon.2015.06.0122018-01-19T10:00:00Z20152015-01-01T00:00:00ZHandlehttp://hdl.handle.net/10198/16113http://purl.org/coar/access_right/c_abf2open accessAmanita pantherinaAmanita phalloidesAmatoxinsIntoxicationIsoxazolesWild mushrooms746070 bytesliteraturehttp://purl.org/coar/resource_type/c_6501journal articlehttp://purl.org/coar/access_right/c_abf2application/pdffulltexthttps://bibliotecadigital.ipb.pt/bitstreams/5a6f37af-ddf0-4fb0-9609-8795b6d59269/download |
| spellingShingle | Co-ingestion of amatoxins and isoxazoles-containing mushrooms and successful treatment: A case report Garcia, Juliana Amanita pantherina Amanita phalloides Amatoxins Intoxication Isoxazoles Wild mushrooms |
| subject.fl_str_mv | Amanita pantherina Amanita phalloides Amatoxins Intoxication Isoxazoles Wild mushrooms |
| title | Co-ingestion of amatoxins and isoxazoles-containing mushrooms and successful treatment: A case report |
| title_full | Co-ingestion of amatoxins and isoxazoles-containing mushrooms and successful treatment: A case report |
| title_fullStr | Co-ingestion of amatoxins and isoxazoles-containing mushrooms and successful treatment: A case report |
| title_full_unstemmed | Co-ingestion of amatoxins and isoxazoles-containing mushrooms and successful treatment: A case report |
| title_short | Co-ingestion of amatoxins and isoxazoles-containing mushrooms and successful treatment: A case report |
| title_sort | Co-ingestion of amatoxins and isoxazoles-containing mushrooms and successful treatment: A case report |
| topic | Amanita pantherina Amanita phalloides Amatoxins Intoxication Isoxazoles Wild mushrooms |
| topic_facet | Amanita pantherina Amanita phalloides Amatoxins Intoxication Isoxazoles Wild mushrooms |
| url | http://hdl.handle.net/10198/16113 |
| visible | 1 |