Publicação

Antioxidant activity of aminodiarylamines in the thieno[3,2-b]pyridine series: radical scavenging activity, lipid peroxidation inhibition and redox profile

Detalhes bibliográficos
Resumo:	The antioxidant activity of the aminodi(hetero)arylamines, prepared by C-N coupling of the methyl 3-aminothieno[3,2-b]pyridine-2-carboxylate with bromonitrobenzenes and further reduction of the obtained nitro compounds, was evaluated by chemical, biochemical and electrochemical assays. The aminodi(hetero) arylamine with the amino group ortho to the NH and a methoxy group in para, was the most efficient in radical scavenging activity (RSA, 63 mu M) and reducing power (RP, 33 mu M), while the aminodiarylamine with the amino group in para to the NH, gave the best results in beta-carotene-linoleate system (41 mu M) and inhibition of formation of thiobarbituric acid reactive substances in porcine brain cells homogenates (7 mu M), with EC50 values even lower than those obtained for the standard trolox. This diarylamine also presented the lowest oxidation potential, lower than the one of trolox, and the highest antioxidant power in the electrochemical assays. The para substitution with an amino group enables higher antioxidant potential.
Autores principais:	Calhelha, Ricardo C.
Outros Autores:	Peixoto, Daniela; Vilas-Boas, Miguel; Queiroz, Maria João R.P.; Ferreira, Isabel C.F.R.
Assunto:	Antioxidant activity Di(hetero)arylamine EElectrochemical assays Tthieno[3,2-b]pyridine
Ano:	2014
País:	Portugal
Tipo de documento:	artigo
Tipo de acesso:	acesso aberto
Instituição associada:	Instituto Politécnico de Bragança
Idioma:	inglês
Origem:	Biblioteca Digital do IPB

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