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Cytotoxic Terphenyl Neolignans from Fungus Terana coerulea: New Natural Corticins D and E, and Revised Structure for Corticin A

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Summary:The cobalt crust fungus Terana coerulea (Phanerochaetaceae family) was selected for a bio-guided study after an ethnobotanical survey at the Irati's Forest (Navarra, Spain) for its local use as antibiotic. Six extracts of increasing polarity, from hexane to hot water, were obtained from powdered dry fungi and tested for cytotoxicity against four human tumour cell lines and one non-tumour primary cell culture. From the most cytotoxic, EtOAc extract, we isolated and identified three terphenyl neolignans: two of them new natural products, named corticins D and E, and one previously described as corticin A, whose earlier structure has been revised. Their structural elucidation and biological evaluation as cytotoxic agents are described.
Main Authors:Maisterra Udi, Maitane
Other Authors:Castro, María Ángeles; Muñoz-Centeno, Luz M.; Calhelha, Ricardo C.; Ferreira, Isabel C.F.R.; García, Pablo A.
Subject:Corticin Corticium caeruleum Cytotoxic activity Neolignans Terana caerulea Terana coerulea Terphenyls Thelephoric acid
Year:2017
Country:Portugal
Document type:article
Access type:open access
Associated institution:Instituto Politécnico de Bragança
Language:English
Origin:Biblioteca Digital do IPB

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