Publicação
Multifunctional graphene-based magnetic nanocarriers for combined hyperthermia and dual stimuli-responsive drug delivery
| Resumo: | The synthesis of hydrophilic graphene-based yolk-shell magnetic nanoparticles functionalized with copolymer pluronic F-127 (GYSMNP@PF127) is herein reported to achieve an efficient multifunctional biomedical system for mild hyperthermia and stimuli-responsive drug delivery. In vitro tests revealed the extraordinary ability of GYSMNP@PF127 to act as smart stimuli-responsive multifunctional nanomedicine platform for cancer therapy, exhibiting (i) an outstanding loading capacity of91% (w/w,representing 910μgmg−1) of the chemotherapeutic drug doxorubicin, (ii) a high heating efficiency under an alternating (AC) magnetic field (intrinsic power loss ranging from 2.1–2.7nHm2kg−1), and (iii) a dual pH and thermal stimuli-responsive drug controlled release (46% at acidic tumour pH vs 7% at physiological pH) under AC magnetic field, in just 30min. Additionally, GYSMNP@PF127 presents optimal hydrodynamic diameter (DH=180nm) with negative surface charge, high haemocompatibility for blood stream applications and tumour cellular uptake of drug nanocarriers. Due to its physicochemical, magnetic and biocompatibility properties, the developed graphene-based magnetic nanocarrier shows high promise as dual exogenous (AC field)/endogenous (pH) stimuli-responsive actuators for targeted thermo-chemotherapy, combining magnetic hyperthermia and controlled drug release triggered by the abnormal tumour environment. The presented strategy and findings can represent a new way to design and develop highly stable added-value graphene-based nanostructures for the combined treatment of cancer. |
|---|---|
| Autores principais: | Rodrigues, Raquel Oliveira |
| Outros Autores: | Baldi, Giovanni; Doumett, Saer; Garcia-Hevia, Lorena; Gallo, Juan; Bañobre-López, Manuel; Dražić, Goran; Calhelha, Ricardo C.; Ferreira, Isabel C.F.R.; Lima, Rui A.; Gomes, Helder; Silva, Adrián |
| Assunto: | Cancer therapy Controlled-drug release Doxorubicin Graphene magnetic nanoparticles Magnetic hyperthermia |
| Ano: | 2018 |
| País: | Portugal |
| Tipo de documento: | artigo |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Instituto Politécnico de Bragança |
| Idioma: | inglês |
| Origem: | Biblioteca Digital do IPB |
| _version_ | 1863851300693737472 |
|---|---|
| author | Rodrigues, Raquel Oliveira |
| author2 | Baldi, Giovanni Doumett, Saer Garcia-Hevia, Lorena Gallo, Juan Bañobre-López, Manuel Dražić, Goran Calhelha, Ricardo C. Ferreira, Isabel C.F.R. Lima, Rui A. Gomes, Helder Silva, Adrián |
| author2_role | author author author author author author author author author author author |
| author_facet | Rodrigues, Raquel Oliveira Baldi, Giovanni Doumett, Saer Garcia-Hevia, Lorena Gallo, Juan Bañobre-López, Manuel Dražić, Goran Calhelha, Ricardo C. Ferreira, Isabel C.F.R. Lima, Rui A. Gomes, Helder Silva, Adrián |
| author_role | author |
| contributor_name_str_mv | Biblioteca Digital do IPB |
| country_str | PT |
| creators_json_str | [{\"Person.name\":\"Rodrigues, Raquel Oliveira\"},{\"Person.name\":\"Baldi, Giovanni\"},{\"Person.name\":\"Doumett, Saer\"},{\"Person.name\":\"Garcia-Hevia, Lorena\"},{\"Person.name\":\"Gallo, Juan\"},{\"Person.name\":\"Bañobre-López, Manuel\"},{\"Person.name\":\"Dražić, Goran\"},{\"Person.name\":\"Calhelha, Ricardo C.\",\"Person.identifier.orcid\":\"0000-0002-6801-4578\"},{\"Person.name\":\"Ferreira, Isabel C.F.R.\",\"Person.identifier.orcid\":\"0000-0003-4910-4882\"},{\"Person.name\":\"Lima, Rui A.\"},{\"Person.name\":\"Gomes, Helder\",\"Person.identifier.orcid\":\"0000-0001-6898-2408\"},{\"Person.name\":\"Silva, Adrián\"}] |
| datacite.contributors.contributor.contributorName.fl_str_mv | Biblioteca Digital do IPB |
| datacite.creators.creator.creatorName.fl_str_mv | Rodrigues, Raquel Oliveira Baldi, Giovanni Doumett, Saer Garcia-Hevia, Lorena Gallo, Juan Bañobre-López, Manuel Dražić, Goran Calhelha, Ricardo C. Ferreira, Isabel C.F.R. Lima, Rui A. Gomes, Helder Silva, Adrián |
| datacite.date.Accepted.fl_str_mv | 2018-01-01T00:00:00Z |
| datacite.date.available.fl_str_mv | 2018-01-19T10:00:00Z |
| datacite.date.embargoed.fl_str_mv | 2018-01-19T10:00:00Z |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| datacite.subjects.subject.fl_str_mv | Cancer therapy Controlled-drug release Doxorubicin Graphene magnetic nanoparticles Magnetic hyperthermia |
| datacite.titles.title.fl_str_mv | Multifunctional graphene-based magnetic nanocarriers for combined hyperthermia and dual stimuli-responsive drug delivery |
| dc.contributor.none.fl_str_mv | Biblioteca Digital do IPB |
| dc.creator.none.fl_str_mv | Rodrigues, Raquel Oliveira Baldi, Giovanni Doumett, Saer Garcia-Hevia, Lorena Gallo, Juan Bañobre-López, Manuel Dražić, Goran Calhelha, Ricardo C. Ferreira, Isabel C.F.R. Lima, Rui A. Gomes, Helder Silva, Adrián |
| dc.date.Accepted.fl_str_mv | 2018-01-01T00:00:00Z |
| dc.date.available.fl_str_mv | 2018-01-19T10:00:00Z |
| dc.date.embargoed.fl_str_mv | 2018-01-19T10:00:00Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | http://hdl.handle.net/10198/18658 |
| dc.language.none.fl_str_mv | eng |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| dc.subject.none.fl_str_mv | Cancer therapy Controlled-drug release Doxorubicin Graphene magnetic nanoparticles Magnetic hyperthermia |
| dc.title.fl_str_mv | Multifunctional graphene-based magnetic nanocarriers for combined hyperthermia and dual stimuli-responsive drug delivery |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_6501 |
| description | The synthesis of hydrophilic graphene-based yolk-shell magnetic nanoparticles functionalized with copolymer pluronic F-127 (GYSMNP@PF127) is herein reported to achieve an efficient multifunctional biomedical system for mild hyperthermia and stimuli-responsive drug delivery. In vitro tests revealed the extraordinary ability of GYSMNP@PF127 to act as smart stimuli-responsive multifunctional nanomedicine platform for cancer therapy, exhibiting (i) an outstanding loading capacity of91% (w/w,representing 910μgmg−1) of the chemotherapeutic drug doxorubicin, (ii) a high heating efficiency under an alternating (AC) magnetic field (intrinsic power loss ranging from 2.1–2.7nHm2kg−1), and (iii) a dual pH and thermal stimuli-responsive drug controlled release (46% at acidic tumour pH vs 7% at physiological pH) under AC magnetic field, in just 30min. Additionally, GYSMNP@PF127 presents optimal hydrodynamic diameter (DH=180nm) with negative surface charge, high haemocompatibility for blood stream applications and tumour cellular uptake of drug nanocarriers. Due to its physicochemical, magnetic and biocompatibility properties, the developed graphene-based magnetic nanocarrier shows high promise as dual exogenous (AC field)/endogenous (pH) stimuli-responsive actuators for targeted thermo-chemotherapy, combining magnetic hyperthermia and controlled drug release triggered by the abnormal tumour environment. The presented strategy and findings can represent a new way to design and develop highly stable added-value graphene-based nanostructures for the combined treatment of cancer. |
| dirty | 0 |
| eu_rights_str_mv | openAccess |
| format | article |
| fulltext.url.fl_str_mv | https://bibliotecadigital.ipb.pt/bitstreams/b2c97e2a-f690-413d-89ee-b8ee89c9364c/download |
| funding.funder.alternateName_str_mv | FCT |
| funding.funder.identifier_str_mv | http://doi.org/10.13039/501100001871 |
| funding.funder.name_str_mv | Fundação para a Ciência e a Tecnologia |
| id | ipb_b4eeaedbbc1df42f9f52213b05ffb3a3 |
| identifier.url.fl_str_mv | http://hdl.handle.net/10198/18658 |
| instacron_str | ipb |
| institution | Instituto Politécnico de Bragança |
| instname_str | Instituto Politécnico de Bragança |
| language | eng |
| network_acronym_str | ipb |
| network_name_str | Biblioteca Digital do IPB |
| oai_identifier_str | oai:bibliotecadigital.ipb.pt:10198/18658 |
| organization_str_mv | urn:organizationAcronym:ipb |
| person_str_mv | Rodrigues, Raquel Oliveira Baldi, Giovanni Doumett, Saer Garcia-Hevia, Lorena Gallo, Juan Bañobre-López, Manuel Dražić, Goran Calhelha, Ricardo C. Calhelha, Ricardo C. https://www.ciencia-id.pt/F313-E3CE-554E F313-E3CE-554E http://orcid.org/0000-0002-6801-4578 0000-0002-6801-4578 Ferreira, Isabel C.F.R. Ferreira, Isabel C.F.R. https://www.ciencia-id.pt/9418-CF95-9919 9418-CF95-9919 http://orcid.org/0000-0003-4910-4882 0000-0003-4910-4882 Lima, Rui A. Gomes, Helder Gomes, Helder https://www.ciencia-id.pt/6218-1E19-13EE 6218-1E19-13EE http://orcid.org/0000-0001-6898-2408 0000-0001-6898-2408 Silva, Adrián |
| publishDate | 2018 |
| reponame_str | Biblioteca Digital do IPB |
| repository_id_str | urn:repositoryAcronym:ipb |
| service_str_mv | urn:repositoryAcronym:ipb |
| spelling | engen_ENThe synthesis of hydrophilic graphene-based yolk-shell magnetic nanoparticles functionalized with copolymer pluronic F-127 (GYSMNP@PF127) is herein reported to achieve an efficient multifunctional biomedical system for mild hyperthermia and stimuli-responsive drug delivery. In vitro tests revealed the extraordinary ability of GYSMNP@PF127 to act as smart stimuli-responsive multifunctional nanomedicine platform for cancer therapy, exhibiting (i) an outstanding loading capacity of91% (w/w,representing 910μgmg−1) of the chemotherapeutic drug doxorubicin, (ii) a high heating efficiency under an alternating (AC) magnetic field (intrinsic power loss ranging from 2.1–2.7nHm2kg−1), and (iii) a dual pH and thermal stimuli-responsive drug controlled release (46% at acidic tumour pH vs 7% at physiological pH) under AC magnetic field, in just 30min. Additionally, GYSMNP@PF127 presents optimal hydrodynamic diameter (DH=180nm) with negative surface charge, high haemocompatibility for blood stream applications and tumour cellular uptake of drug nanocarriers. Due to its physicochemical, magnetic and biocompatibility properties, the developed graphene-based magnetic nanocarrier shows high promise as dual exogenous (AC field)/endogenous (pH) stimuli-responsive actuators for targeted thermo-chemotherapy, combining magnetic hyperthermia and controlled drug release triggered by the abnormal tumour environment. The presented strategy and findings can represent a new way to design and develop highly stable added-value graphene-based nanostructures for the combined treatment of cancer.application/pdfen_ENMultifunctional graphene-based magnetic nanocarriers for combined hyperthermia and dual stimuli-responsive drug deliveryRodrigues, Raquel OliveiraBaldi, GiovanniDoumett, SaerGarcia-Hevia, LorenaGallo, JuanBañobre-López, ManuelDražić, GoranPersonalCalhelha, Ricardo C.DSpacehttp://dspace.org/items/2d5d1a41-7561-4a01-871c-b4c97da35053DSpacehttp://dspace.org/items/2d5d1a41-7561-4a01-871c-b4c97da35053CalhelhaRicardo C.Ciência IDhttps://www.ciencia-id.ptF313-E3CE-554EORCIDhttp://orcid.org0000-0002-6801-4578Researcher IDhttps://www.researcherid.comJ-2172-2014Scopus Author IDhttps://www.scopus.com6507978333PersonalFerreira, Isabel C.F.R.DSpacehttp://dspace.org/items/bd0d1537-2e03-41fb-b27a-140af9c35db8DSpacehttp://dspace.org/items/bd0d1537-2e03-41fb-b27a-140af9c35db8FerreiraIsabel C.F.R.Ciência IDhttps://www.ciencia-id.pt9418-CF95-9919ORCIDhttp://orcid.org0000-0003-4910-4882Researcher IDhttps://www.researcherid.comE-8500-2013Scopus Author IDhttps://www.scopus.com36868826600Lima, Rui A.PersonalGomes, HelderDSpacehttp://dspace.org/items/0eb96337-224a-4339-9918-334436fbbb99DSpacehttp://dspace.org/items/0eb96337-224a-4339-9918-334436fbbb99GomesHelder T.Ciência IDhttps://www.ciencia-id.pt6218-1E19-13EEORCIDhttp://orcid.org0000-0001-6898-2408Silva, AdriánHostingInstitutionOrganizationalBiblioteca Digital do IPBe-mailmailto:dspace@ipb.ptdspace@ipb.ptISSNIsPartOf0928-4931DOIIsPartOf10.1016/j.msec.2018.07.0602018-01-19T10:00:00Z20182018-01-01T00:00:00ZHandlehttp://hdl.handle.net/10198/18658http://purl.org/coar/access_right/c_abf2open accessCancer therapyControlled-drug releaseDoxorubicinGraphene magnetic nanoparticlesMagnetic hyperthermia2549663 bytesFundação para a Ciência e a TecnologiaMAGNETIC CARBON NANOSTRUCTURES AND STUDY OF THEIR TRANSPORT IN MICROFLUIDIC DEVICES FOR HYPERTHERMIACrossref Funder IDhttp://doi.org/10.13039/501100001871literaturehttp://purl.org/coar/resource_type/c_6501journal articlehttp://purl.org/coar/access_right/c_abf2application/pdffulltexthttps://bibliotecadigital.ipb.pt/bitstreams/b2c97e2a-f690-413d-89ee-b8ee89c9364c/download |
| spellingShingle | Multifunctional graphene-based magnetic nanocarriers for combined hyperthermia and dual stimuli-responsive drug delivery Rodrigues, Raquel Oliveira Cancer therapy Controlled-drug release Doxorubicin Graphene magnetic nanoparticles Magnetic hyperthermia |
| subject.fl_str_mv | Cancer therapy Controlled-drug release Doxorubicin Graphene magnetic nanoparticles Magnetic hyperthermia |
| title | Multifunctional graphene-based magnetic nanocarriers for combined hyperthermia and dual stimuli-responsive drug delivery |
| title_full | Multifunctional graphene-based magnetic nanocarriers for combined hyperthermia and dual stimuli-responsive drug delivery |
| title_fullStr | Multifunctional graphene-based magnetic nanocarriers for combined hyperthermia and dual stimuli-responsive drug delivery |
| title_full_unstemmed | Multifunctional graphene-based magnetic nanocarriers for combined hyperthermia and dual stimuli-responsive drug delivery |
| title_short | Multifunctional graphene-based magnetic nanocarriers for combined hyperthermia and dual stimuli-responsive drug delivery |
| title_sort | Multifunctional graphene-based magnetic nanocarriers for combined hyperthermia and dual stimuli-responsive drug delivery |
| topic | Cancer therapy Controlled-drug release Doxorubicin Graphene magnetic nanoparticles Magnetic hyperthermia |
| topic_facet | Cancer therapy Controlled-drug release Doxorubicin Graphene magnetic nanoparticles Magnetic hyperthermia |
| url | http://hdl.handle.net/10198/18658 |
| visible | 1 |