Publicação
Intersubject variability of blood analysis reference values: assessment of age and locality influence by means of a linear discriminant analysis model
| Resumo: | Glycemic and lipidic profiles might be influenced by several factors. The fact that the age group might alter the most extensively evaluated lipidic and glycemic parameters is a more or less well accepted fact. To verify this empirical notion, 996 human subjects aged between 21 and 90 years from different localities were characterized according to age. To assess lipid profile, total cholesterol and cholesterol associated with lipoprotein fractions (c-LDL and c-HDL) and triglycerides were determined. Regarding glycemic profile, glucose and glycated hemoglobin were measured. The majority of the population had values of lipidic parameters fit into the reference values, presenting low or moderate risk for developing cardiovascular disease. Blood glucose was often far above the desirable, but this can be devalued due to the HbA1c values, which were overwhelmingly located in the normal range. The categorization of data in different age groups did not allow defining statistically significant differences. Despite the discriminant linear model was presented, the results indicate that age group did not act as a strong discriminant factor. Somehow unexpectedly, the most significant differences were found among the different localities, which tended to show a similarity according with their latitude. Furthermore, there were no significant correlations in the parameters associated with lipidic profile, but there was a direct correlation between glucose levels and HbA1c (glycemic parameters). |
|---|---|
| Autores principais: | Barreira, João C.M. |
| Outros Autores: | Costa, Roberto Germano; Pombo, Graça; Ferreira, Isabel C.F.R. |
| Assunto: | LDL-C HDL-C Triglycerides Glycated hemoglobin Biostatistics |
| Ano: | 2013 |
| País: | Portugal |
| Tipo de documento: | artigo |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Instituto Politécnico de Bragança |
| Idioma: | inglês |
| Origem: | Biblioteca Digital do IPB |
| _version_ | 1867173000251441152 |
|---|---|
| author | Barreira, João C.M. |
| author2 | Costa, Roberto Germano Pombo, Graça Ferreira, Isabel C.F.R. |
| author2_role | author author author |
| author_facet | Barreira, João C.M. Costa, Roberto Germano Pombo, Graça Ferreira, Isabel C.F.R. |
| author_role | author |
| contributor_name_str_mv | Biblioteca Digital do IPB |
| country_str | PT |
| creators_json_txt | [{\"Person.name\":\"Barreira, João C.M.\",\"Person.identifier.orcid\":\"0000-0003-1233-0990\"},{\"Person.name\":\"Costa, Roberto Germano\"},{\"Person.name\":\"Pombo, Graça\"},{\"Person.name\":\"Ferreira, Isabel C.F.R.\",\"Person.identifier.orcid\":\"0000-0003-4910-4882\"}] |
| datacite.contributors.contributor.contributorName.fl_str_mv | Biblioteca Digital do IPB |
| datacite.creators.creator.creatorName.fl_str_mv | Barreira, João C.M. Costa, Roberto Germano Pombo, Graça Ferreira, Isabel C.F.R. |
| datacite.date.Accepted.fl_str_mv | 2013-01-01T00:00:00Z |
| datacite.date.available.fl_str_mv | 2014-05-13T14:34:08Z |
| datacite.date.embargoed.fl_str_mv | 2014-05-13T14:34:08Z |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| datacite.subjects.subject.fl_str_mv | LDL-C HDL-C Triglycerides Glycated hemoglobin Biostatistics |
| datacite.titles.title.fl_str_mv | Intersubject variability of blood analysis reference values: assessment of age and locality influence by means of a linear discriminant analysis model |
| dc.contributor.none.fl_str_mv | Biblioteca Digital do IPB |
| dc.creator.none.fl_str_mv | Barreira, João C.M. Costa, Roberto Germano Pombo, Graça Ferreira, Isabel C.F.R. |
| dc.date.Accepted.fl_str_mv | 2013-01-01T00:00:00Z |
| dc.date.available.fl_str_mv | 2014-05-13T14:34:08Z |
| dc.date.embargoed.fl_str_mv | 2014-05-13T14:34:08Z |
| dc.format.none.fl_str_mv | application/pdf application/pdf |
| dc.identifier.none.fl_str_mv | http://hdl.handle.net/10198/9506 |
| dc.language.none.fl_str_mv | eng |
| dc.publisher.none.fl_str_mv | Wiley |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| dc.subject.none.fl_str_mv | LDL-C HDL-C Triglycerides Glycated hemoglobin Biostatistics |
| dc.title.fl_str_mv | Intersubject variability of blood analysis reference values: assessment of age and locality influence by means of a linear discriminant analysis model |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_6501 |
| description | Glycemic and lipidic profiles might be influenced by several factors. The fact that the age group might alter the most extensively evaluated lipidic and glycemic parameters is a more or less well accepted fact. To verify this empirical notion, 996 human subjects aged between 21 and 90 years from different localities were characterized according to age. To assess lipid profile, total cholesterol and cholesterol associated with lipoprotein fractions (c-LDL and c-HDL) and triglycerides were determined. Regarding glycemic profile, glucose and glycated hemoglobin were measured. The majority of the population had values of lipidic parameters fit into the reference values, presenting low or moderate risk for developing cardiovascular disease. Blood glucose was often far above the desirable, but this can be devalued due to the HbA1c values, which were overwhelmingly located in the normal range. The categorization of data in different age groups did not allow defining statistically significant differences. Despite the discriminant linear model was presented, the results indicate that age group did not act as a strong discriminant factor. Somehow unexpectedly, the most significant differences were found among the different localities, which tended to show a similarity according with their latitude. Furthermore, there were no significant correlations in the parameters associated with lipidic profile, but there was a direct correlation between glucose levels and HbA1c (glycemic parameters). |
| dirty | 0 |
| eu_rights_str_mv | openAccess |
| format | article |
| fulltext.url.fl_str_mv | https://bibliotecadigital.ipb.pt/bitstreams/9c5398ff-ff58-476c-901a-4ce20793630b/download |
| id | ipb_bbc61d6a44b4e601deee36e0d5df349b |
| identifier.url.fl_str_mv | http://hdl.handle.net/10198/9506 |
| instacron_str | ipb |
| institution | Instituto Politécnico de Bragança |
| instname_str | Instituto Politécnico de Bragança |
| language | eng |
| network_acronym_str | ipb |
| network_name_str | Biblioteca Digital do IPB |
| oai_identifier_str | oai:bibliotecadigital.ipb.pt:10198/9506 |
| organization_str_mv | urn:organizationAcronym:ipb |
| person_str_mv | Barreira, João C.M. Barreira, João C.M. http://orcid.org/0000-0003-1233-0990 0000-0003-1233-0990 Costa, Roberto Germano Pombo, Graça Ferreira, Isabel C.F.R. Ferreira, Isabel C.F.R. https://www.ciencia-id.pt/9418-CF95-9919 9418-CF95-9919 http://orcid.org/0000-0003-4910-4882 0000-0003-4910-4882 |
| publishDate | 2013 |
| publisher.none.fl_str_mv | Wiley |
| reponame_str | Biblioteca Digital do IPB |
| repository_id_str | urn:repositoryAcronym:ipb |
| service_str_mv | urn:repositoryAcronym:ipb |
| spelling | engWileyporGlycemic and lipidic profiles might be influenced by several factors. The fact that the age group might alter the most extensively evaluated lipidic and glycemic parameters is a more or less well accepted fact. To verify this empirical notion, 996 human subjects aged between 21 and 90 years from different localities were characterized according to age. To assess lipid profile, total cholesterol and cholesterol associated with lipoprotein fractions (c-LDL and c-HDL) and triglycerides were determined. Regarding glycemic profile, glucose and glycated hemoglobin were measured. The majority of the population had values of lipidic parameters fit into the reference values, presenting low or moderate risk for developing cardiovascular disease. Blood glucose was often far above the desirable, but this can be devalued due to the HbA1c values, which were overwhelmingly located in the normal range. The categorization of data in different age groups did not allow defining statistically significant differences. Despite the discriminant linear model was presented, the results indicate that age group did not act as a strong discriminant factor. Somehow unexpectedly, the most significant differences were found among the different localities, which tended to show a similarity according with their latitude. Furthermore, there were no significant correlations in the parameters associated with lipidic profile, but there was a direct correlation between glucose levels and HbA1c (glycemic parameters).application/pdfapplication/pdfporIntersubject variability of blood analysis reference values: assessment of age and locality influence by means of a linear discriminant analysis modelPersonalBarreira, João C.M.DSpacehttp://dspace.org/items/4629b12c-39b0-4da8-8b8d-6efba5cf2d81DSpacehttp://dspace.org/items/4629b12c-39b0-4da8-8b8d-6efba5cf2d81BarreiraJoão C.M.ORCIDhttp://orcid.org0000-0003-1233-0990Researcher IDhttps://www.researcherid.comD-8269-2013Scopus Author IDhttps://www.scopus.com54895546900Costa, Roberto GermanoPombo, GraçaPersonalFerreira, Isabel C.F.R.DSpacehttp://dspace.org/items/bd0d1537-2e03-41fb-b27a-140af9c35db8DSpacehttp://dspace.org/items/bd0d1537-2e03-41fb-b27a-140af9c35db8FerreiraIsabel C.F.R.Ciência IDhttps://www.ciencia-id.pt9418-CF95-9919ORCIDhttp://orcid.org0000-0003-4910-4882Researcher IDhttps://www.researcherid.comE-8500-2013Scopus Author IDhttps://www.scopus.com36868826600HostingInstitutionOrganizationalBiblioteca Digital do IPBe-mailmailto:dspace@ipb.ptdspace@ipb.ptISSNIsPartOf1098-2825DOIIsPartOf10.1002/jcla.215902014-05-13T14:34:08Z20132013-01-01T00:00:00ZHandlehttp://hdl.handle.net/10198/9506http://purl.org/coar/access_right/c_abf2open accessLDL-CHDL-CTriglyceridesGlycated hemoglobinBiostatistics2257066 bytes609010 bytesliteraturehttp://purl.org/coar/resource_type/c_6501journal articlehttp://purl.org/coar/access_right/c_abf2application/pdffulltexthttps://bibliotecadigital.ipb.pt/bitstreams/9c5398ff-ff58-476c-901a-4ce20793630b/downloadhttp://purl.org/coar/access_right/c_abf2application/pdffulltexthttps://bibliotecadigital.ipb.pt/bitstreams/fb821175-b89a-4fd5-bd32-b0775dcfc05e/downloadJournal of Clinical Laboratory Analysis27237244 |
| spellingShingle | Intersubject variability of blood analysis reference values: assessment of age and locality influence by means of a linear discriminant analysis model Barreira, João C.M. LDL-C HDL-C Triglycerides Glycated hemoglobin Biostatistics |
| status | SINGLETON |
| subject.fl_str_mv | LDL-C HDL-C Triglycerides Glycated hemoglobin Biostatistics |
| title | Intersubject variability of blood analysis reference values: assessment of age and locality influence by means of a linear discriminant analysis model |
| title_full | Intersubject variability of blood analysis reference values: assessment of age and locality influence by means of a linear discriminant analysis model |
| title_fullStr | Intersubject variability of blood analysis reference values: assessment of age and locality influence by means of a linear discriminant analysis model |
| title_full_unstemmed | Intersubject variability of blood analysis reference values: assessment of age and locality influence by means of a linear discriminant analysis model |
| title_short | Intersubject variability of blood analysis reference values: assessment of age and locality influence by means of a linear discriminant analysis model |
| title_sort | Intersubject variability of blood analysis reference values: assessment of age and locality influence by means of a linear discriminant analysis model |
| topic | LDL-C HDL-C Triglycerides Glycated hemoglobin Biostatistics |
| topic_facet | LDL-C HDL-C Triglycerides Glycated hemoglobin Biostatistics |
| url | http://hdl.handle.net/10198/9506 |
| visible | 1 |