Publicação
Combined action of dietary-based approaches and therapeutic agents on cholesterol metabolism and main related diseases
| Resumo: | Dyslipidaemia is among the major causes of severe diseases and, despite being wellestablished, the hypocholesterolaemic therapies still face significant concerns about potential side effects (such as myopathy, myalgia, liver injury digestive problems, or mental fuzziness in some people taking statins), interaction with other drugs or specific foods. Accordingly, this review describes the latest developments in the most effective therapies to control and regulate dyslipidaemia. Scope and approach: Herein, the metabolic dynamics of cholesterol and their integration with the current therapies: statins, bile acid sequestrants, fibrates, niacin, proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors, reconstituted high-density lipoprotein (rHDL), or anti-inflammatory and immunemodulating therapies), were compared focusing their effectiveness, patients’ adhesion and typical side-effects. Likewise, the interaction of these therapies with recommended dietary habits, focusing functional foods and nutraceuticals uptake were also considered. Key findings and conclusions: Since none of the current therapeutic alternatives represent an ideal solution (mainly due to side-effects or patients’ tolerance), the potential adjuvant action of selected diets (and other healthy habits) was proposed as a way to improve the cholesterol-lowering effectiveness, while reducing the adverse effects caused by dose-increase or continuous uptake of alternating therapeutic agents. In general, the relevance of well-adapted diets must be acknowledged and their potential effects must be exhorted among patients, who need to be aware of the associated multifactorial advantages. |
|---|---|
| Autores principais: | Baptista, Eugénia |
| Outros Autores: | Pereira, Cláudia S.G.P.; García, Pablo A.; Ferreira, Isabel C.F.R.; Barreira, João C.M. |
| Assunto: | Cholesterol biosynthesis and homeostasis Metabolic disorders Dyslipidaemia Atherosclerosis Healthy lifestyles Functional foods and nutraceuticals |
| Ano: | 2025 |
| País: | Portugal |
| Tipo de documento: | artigo |
| Tipo de acesso: | acesso restrito |
| Instituição associada: | Instituto Politécnico de Bragança |
| Idioma: | inglês |
| Origem: | Biblioteca Digital do IPB |
| _version_ | 1867173245932797952 |
|---|---|
| author | Baptista, Eugénia |
| author2 | Pereira, Cláudia S.G.P. García, Pablo A. Ferreira, Isabel C.F.R. Barreira, João C.M. |
| author2_role | author author author author |
| author_facet | Baptista, Eugénia Pereira, Cláudia S.G.P. García, Pablo A. Ferreira, Isabel C.F.R. Barreira, João C.M. |
| author_role | author |
| contributor_name_str_mv | Biblioteca Digital do IPB |
| country_str | PT |
| creators_json_txt | [{\"Person.name\":\"Baptista, Eugénia\"},{\"Person.name\":\"Pereira, Cláudia S.G.P.\"},{\"Person.name\":\"García, Pablo A.\"},{\"Person.name\":\"Ferreira, Isabel C.F.R.\",\"Person.identifier.orcid\":\"0000-0003-4910-4882\"},{\"Person.name\":\"Barreira, João C.M.\",\"Person.identifier.orcid\":\"0000-0003-1233-0990\"}] |
| datacite.contributors.contributor.contributorName.fl_str_mv | Biblioteca Digital do IPB |
| datacite.creators.creator.creatorName.fl_str_mv | Baptista, Eugénia Pereira, Cláudia S.G.P. García, Pablo A. Ferreira, Isabel C.F.R. Barreira, João C.M. |
| datacite.date.Accepted.fl_str_mv | 2025-01-01T00:00:00Z |
| datacite.date.available.fl_str_mv | 2025-01-30T11:43:20Z |
| datacite.date.embargoed.fl_str_mv | 2025-01-30T11:43:20Z |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_16ec |
| datacite.subjects.subject.fl_str_mv | Cholesterol biosynthesis and homeostasis Metabolic disorders Dyslipidaemia Atherosclerosis Healthy lifestyles Functional foods and nutraceuticals |
| datacite.titles.title.fl_str_mv | Combined action of dietary-based approaches and therapeutic agents on cholesterol metabolism and main related diseases |
| dc.contributor.none.fl_str_mv | Biblioteca Digital do IPB |
| dc.creator.none.fl_str_mv | Baptista, Eugénia Pereira, Cláudia S.G.P. García, Pablo A. Ferreira, Isabel C.F.R. Barreira, João C.M. |
| dc.date.Accepted.fl_str_mv | 2025-01-01T00:00:00Z |
| dc.date.available.fl_str_mv | 2025-01-30T11:43:20Z |
| dc.date.embargoed.fl_str_mv | 2025-01-30T11:43:20Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | http://hdl.handle.net/10198/31100 |
| dc.language.none.fl_str_mv | eng |
| dc.publisher.none.fl_str_mv | Elsevier |
| dc.rights.cclincense.fl_str_mv | http://creativecommons.org/licenses/by/4.0/ |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_16ec |
| dc.subject.none.fl_str_mv | Cholesterol biosynthesis and homeostasis Metabolic disorders Dyslipidaemia Atherosclerosis Healthy lifestyles Functional foods and nutraceuticals |
| dc.title.fl_str_mv | Combined action of dietary-based approaches and therapeutic agents on cholesterol metabolism and main related diseases |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_6501 |
| description | Dyslipidaemia is among the major causes of severe diseases and, despite being wellestablished, the hypocholesterolaemic therapies still face significant concerns about potential side effects (such as myopathy, myalgia, liver injury digestive problems, or mental fuzziness in some people taking statins), interaction with other drugs or specific foods. Accordingly, this review describes the latest developments in the most effective therapies to control and regulate dyslipidaemia. Scope and approach: Herein, the metabolic dynamics of cholesterol and their integration with the current therapies: statins, bile acid sequestrants, fibrates, niacin, proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors, reconstituted high-density lipoprotein (rHDL), or anti-inflammatory and immunemodulating therapies), were compared focusing their effectiveness, patients’ adhesion and typical side-effects. Likewise, the interaction of these therapies with recommended dietary habits, focusing functional foods and nutraceuticals uptake were also considered. Key findings and conclusions: Since none of the current therapeutic alternatives represent an ideal solution (mainly due to side-effects or patients’ tolerance), the potential adjuvant action of selected diets (and other healthy habits) was proposed as a way to improve the cholesterol-lowering effectiveness, while reducing the adverse effects caused by dose-increase or continuous uptake of alternating therapeutic agents. In general, the relevance of well-adapted diets must be acknowledged and their potential effects must be exhorted among patients, who need to be aware of the associated multifactorial advantages. |
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| eu_rights_str_mv | restrictedAccess |
| format | article |
| fulltext.url.fl_str_mv | https://bibliotecadigital.ipb.pt/bitstreams/f5ed6868-d07e-455f-a076-542f8f6825a5/download |
| funding.funder.alternateName_str_mv | FCT FCT FCT |
| funding.funder.identifier_str_mv | http://doi.org/10.13039/501100001871 http://doi.org/10.13039/501100001871 http://doi.org/10.13039/501100001871 |
| funding.funder.name_str_mv | Fundação para a Ciência e a Tecnologia Fundação para a Ciência e a Tecnologia Fundação para a Ciência e a Tecnologia |
| funding.name_str_mv | 6817 - DCRRNI ID CEEC IND 2017 POR_NORTE |
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| identifier.url.fl_str_mv | http://hdl.handle.net/10198/31100 |
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| institution | Instituto Politécnico de Bragança |
| instname_str | Instituto Politécnico de Bragança |
| language | eng |
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| network_name_str | Biblioteca Digital do IPB |
| oai_identifier_str | oai:bibliotecadigital.ipb.pt:10198/31100 |
| organization_str_mv | urn:organizationAcronym:ipb |
| person_str_mv | Baptista, Eugénia Pereira, Cláudia S.G.P. García, Pablo A. Ferreira, Isabel C.F.R. Ferreira, Isabel C.F.R. https://www.ciencia-id.pt/9418-CF95-9919 9418-CF95-9919 http://orcid.org/0000-0003-4910-4882 0000-0003-4910-4882 Barreira, João C.M. Barreira, João C.M. http://orcid.org/0000-0003-1233-0990 0000-0003-1233-0990 |
| publishDate | 2025 |
| publisher.none.fl_str_mv | Elsevier |
| reponame_str | Biblioteca Digital do IPB |
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| spelling | engElsevierpt_PTDyslipidaemia is among the major causes of severe diseases and, despite being wellestablished, the hypocholesterolaemic therapies still face significant concerns about potential side effects (such as myopathy, myalgia, liver injury digestive problems, or mental fuzziness in some people taking statins), interaction with other drugs or specific foods. Accordingly, this review describes the latest developments in the most effective therapies to control and regulate dyslipidaemia. Scope and approach: Herein, the metabolic dynamics of cholesterol and their integration with the current therapies: statins, bile acid sequestrants, fibrates, niacin, proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors, reconstituted high-density lipoprotein (rHDL), or anti-inflammatory and immunemodulating therapies), were compared focusing their effectiveness, patients’ adhesion and typical side-effects. Likewise, the interaction of these therapies with recommended dietary habits, focusing functional foods and nutraceuticals uptake were also considered. Key findings and conclusions: Since none of the current therapeutic alternatives represent an ideal solution (mainly due to side-effects or patients’ tolerance), the potential adjuvant action of selected diets (and other healthy habits) was proposed as a way to improve the cholesterol-lowering effectiveness, while reducing the adverse effects caused by dose-increase or continuous uptake of alternating therapeutic agents. In general, the relevance of well-adapted diets must be acknowledged and their potential effects must be exhorted among patients, who need to be aware of the associated multifactorial advantages.application/pdfpt_PTCombined action of dietary-based approaches and therapeutic agents on cholesterol metabolism and main related diseasesBaptista, EugéniaPereira, Cláudia S.G.P.García, Pablo A.PersonalFerreira, Isabel C.F.R.DSpacehttp://dspace.org/items/bd0d1537-2e03-41fb-b27a-140af9c35db8DSpacehttp://dspace.org/items/bd0d1537-2e03-41fb-b27a-140af9c35db8FerreiraIsabel C.F.R.Ciência IDhttps://www.ciencia-id.pt9418-CF95-9919ORCIDhttp://orcid.org0000-0003-4910-4882Researcher IDhttps://www.researcherid.comE-8500-2013Scopus Author IDhttps://www.scopus.com36868826600PersonalBarreira, João C.M.DSpacehttp://dspace.org/items/4629b12c-39b0-4da8-8b8d-6efba5cf2d81DSpacehttp://dspace.org/items/4629b12c-39b0-4da8-8b8d-6efba5cf2d81BarreiraJoão C.M.ORCIDhttp://orcid.org0000-0003-1233-0990Researcher IDhttps://www.researcherid.comD-8269-2013Scopus Author IDhttps://www.scopus.com54895546900HostingInstitutionOrganizationalBiblioteca Digital do IPBe-mailmailto:dspace@ipb.ptdspace@ipb.ptISSNIsPartOf2405-4577DOIIsPartOf10.1016/j.clnesp.2025.01.0262025-01-30T11:43:20Z20252025-01-01T00:00:00ZHandlehttp://hdl.handle.net/10198/31100http://purl.org/coar/access_right/c_16ecrestricted accessCholesterol biosynthesis and homeostasisMetabolic disordersDyslipidaemiaAtherosclerosisHealthy lifestylesFunctional foods and nutraceuticals779580 bytesFundação para a Ciência e a TecnologiaAssociated Laboratory for Green Chemistry - Clean Technologies and Processes6817 - DCRRNI IDCrossref Funder IDhttp://doi.org/10.13039/501100001871Fundação para a Ciência e a TecnologiaNot AvailableCEEC IND 2017Crossref Funder IDhttp://doi.org/10.13039/501100001871Fundação para a Ciência e a TecnologiaBoosting immunity against viral infections with bioactive food constituents: validating differentiated leading trends through scholarly publications clustering mapsPOR_NORTECrossref Funder IDhttp://doi.org/10.13039/501100001871literaturehttp://purl.org/coar/resource_type/c_6501journal article2025http://creativecommons.org/licenses/by/4.0/http://purl.org/coar/access_right/c_16ecapplication/pdffulltexthttps://bibliotecadigital.ipb.pt/bitstreams/f5ed6868-d07e-455f-a076-542f8f6825a5/downloadClinical Nutrition ESPEN665168 |
| spellingShingle | Combined action of dietary-based approaches and therapeutic agents on cholesterol metabolism and main related diseases Baptista, Eugénia Cholesterol biosynthesis and homeostasis Metabolic disorders Dyslipidaemia Atherosclerosis Healthy lifestyles Functional foods and nutraceuticals |
| status | SINGLETON |
| subject.fl_str_mv | Cholesterol biosynthesis and homeostasis Metabolic disorders Dyslipidaemia Atherosclerosis Healthy lifestyles Functional foods and nutraceuticals |
| title | Combined action of dietary-based approaches and therapeutic agents on cholesterol metabolism and main related diseases |
| title_full | Combined action of dietary-based approaches and therapeutic agents on cholesterol metabolism and main related diseases |
| title_fullStr | Combined action of dietary-based approaches and therapeutic agents on cholesterol metabolism and main related diseases |
| title_full_unstemmed | Combined action of dietary-based approaches and therapeutic agents on cholesterol metabolism and main related diseases |
| title_short | Combined action of dietary-based approaches and therapeutic agents on cholesterol metabolism and main related diseases |
| title_sort | Combined action of dietary-based approaches and therapeutic agents on cholesterol metabolism and main related diseases |
| topic | Cholesterol biosynthesis and homeostasis Metabolic disorders Dyslipidaemia Atherosclerosis Healthy lifestyles Functional foods and nutraceuticals |
| topic_facet | Cholesterol biosynthesis and homeostasis Metabolic disorders Dyslipidaemia Atherosclerosis Healthy lifestyles Functional foods and nutraceuticals |
| url | http://hdl.handle.net/10198/31100 |
| visible | 1 |