Publicação
1-Aryl-3-[ 4-( thieno[3,2-d]pyrimidin-4-yloxy )phenyl]ureas as VEG FR2 inhibitors: synthesis, docking enzymatic and cellular assays
| Resumo: | A number of thienopyrimidines derivatives have shown potent VEGFR2 (Vascular Endothelium Growth Factor Receptor2) tyrosine kinase inhibition activity.[ll VEGF is a sun·ogate marker of angiogenesis that activates VEGFR2 in endothelial cells. Here we present the synthesis of new 1-aryl-3-[ 4-(thieno[3,2-d]pyrimidin-4- yloxy)phenyl]ureas from the aminodi(hetero)arylether 1, also prepared by us, which was reacted with arylisocyanates to give the corresponding 1,3-diarylureas 2a-c. |
|---|---|
| Autores principais: | Peixoto, Daniela |
| Outros Autores: | Calhelha, Ricardo C.; Soares, Pedro; Abreu, Rui M.V.; Froufe, Hugo J.C.; Ferreira, Isabel C.F.R.; Costa, Raquel; Soares, Raquel; Queiroz, Maria João R.P. |
| Ano: | 2012 |
| País: | Portugal |
| Tipo de documento: | documento de conferência |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Instituto Politécnico de Bragança |
| Idioma: | inglês |
| Origem: | Biblioteca Digital do IPB |
| _version_ | 1867172805969182720 |
|---|---|
| author | Peixoto, Daniela |
| author2 | Calhelha, Ricardo C. Soares, Pedro Abreu, Rui M.V. Froufe, Hugo J.C. Ferreira, Isabel C.F.R. Costa, Raquel Soares, Raquel Queiroz, Maria João R.P. |
| author2_role | author author author author author author author author |
| author_facet | Peixoto, Daniela Calhelha, Ricardo C. Soares, Pedro Abreu, Rui M.V. Froufe, Hugo J.C. Ferreira, Isabel C.F.R. Costa, Raquel Soares, Raquel Queiroz, Maria João R.P. |
| author_role | author |
| contributor_name_str_mv | Biblioteca Digital do IPB |
| country_str | PT |
| creators_json_txt | [{\"Person.name\":\"Peixoto, Daniela\"},{\"Person.name\":\"Calhelha, Ricardo C.\",\"Person.identifier.orcid\":\"0000-0002-6801-4578\"},{\"Person.name\":\"Soares, Pedro\"},{\"Person.name\":\"Abreu, Rui M.V.\",\"Person.identifier.orcid\":\"0000-0002-7745-8015\"},{\"Person.name\":\"Froufe, Hugo J.C.\"},{\"Person.name\":\"Ferreira, Isabel C.F.R.\",\"Person.identifier.orcid\":\"0000-0003-4910-4882\"},{\"Person.name\":\"Costa, Raquel\"},{\"Person.name\":\"Soares, Raquel\"},{\"Person.name\":\"Queiroz, Maria João R.P.\"}] |
| datacite.contributors.contributor.contributorName.fl_str_mv | Biblioteca Digital do IPB |
| datacite.creators.creator.creatorName.fl_str_mv | Peixoto, Daniela Calhelha, Ricardo C. Soares, Pedro Abreu, Rui M.V. Froufe, Hugo J.C. Ferreira, Isabel C.F.R. Costa, Raquel Soares, Raquel Queiroz, Maria João R.P. |
| datacite.date.Accepted.fl_str_mv | 2012-01-01T00:00:00Z |
| datacite.date.available.fl_str_mv | 2014-05-09T09:56:53Z |
| datacite.date.embargoed.fl_str_mv | 2014-05-09T09:56:53Z |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| datacite.titles.title.fl_str_mv | 1-Aryl-3-[ 4-( thieno[3,2-d]pyrimidin-4-yloxy )phenyl]ureas as VEG FR2 inhibitors: synthesis, docking enzymatic and cellular assays |
| dc.contributor.none.fl_str_mv | Biblioteca Digital do IPB |
| dc.creator.none.fl_str_mv | Peixoto, Daniela Calhelha, Ricardo C. Soares, Pedro Abreu, Rui M.V. Froufe, Hugo J.C. Ferreira, Isabel C.F.R. Costa, Raquel Soares, Raquel Queiroz, Maria João R.P. |
| dc.date.Accepted.fl_str_mv | 2012-01-01T00:00:00Z |
| dc.date.available.fl_str_mv | 2014-05-09T09:56:53Z |
| dc.date.embargoed.fl_str_mv | 2014-05-09T09:56:53Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | http://hdl.handle.net/10198/9474 |
| dc.language.none.fl_str_mv | eng |
| dc.publisher.none.fl_str_mv | Universidade de Aveiro |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| dc.title.fl_str_mv | 1-Aryl-3-[ 4-( thieno[3,2-d]pyrimidin-4-yloxy )phenyl]ureas as VEG FR2 inhibitors: synthesis, docking enzymatic and cellular assays |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_c94f |
| description | A number of thienopyrimidines derivatives have shown potent VEGFR2 (Vascular Endothelium Growth Factor Receptor2) tyrosine kinase inhibition activity.[ll VEGF is a sun·ogate marker of angiogenesis that activates VEGFR2 in endothelial cells. Here we present the synthesis of new 1-aryl-3-[ 4-(thieno[3,2-d]pyrimidin-4- yloxy)phenyl]ureas from the aminodi(hetero)arylether 1, also prepared by us, which was reacted with arylisocyanates to give the corresponding 1,3-diarylureas 2a-c. |
| dirty | 0 |
| eu_rights_str_mv | openAccess |
| format | conferenceObject |
| fulltext.url.fl_str_mv | https://bibliotecadigital.ipb.pt/bitstreams/219a0616-c163-4531-9219-ab260b432a20/download |
| id | ipb_c430704dedb4d55fb80ff0e9cd79bc6d |
| identifier.url.fl_str_mv | http://hdl.handle.net/10198/9474 |
| instacron_str | ipb |
| institution | Instituto Politécnico de Bragança |
| instname_str | Instituto Politécnico de Bragança |
| language | eng |
| network_acronym_str | ipb |
| network_name_str | Biblioteca Digital do IPB |
| oai_identifier_str | oai:bibliotecadigital.ipb.pt:10198/9474 |
| organization_str_mv | urn:organizationAcronym:ipb |
| person_str_mv | Peixoto, Daniela Calhelha, Ricardo C. Calhelha, Ricardo C. https://www.ciencia-id.pt/F313-E3CE-554E F313-E3CE-554E http://orcid.org/0000-0002-6801-4578 0000-0002-6801-4578 Soares, Pedro Abreu, Rui M.V. Abreu, Rui M.V. https://www.ciencia-id.pt/0F19-0DE2-12A2 0F19-0DE2-12A2 http://orcid.org/0000-0002-7745-8015 0000-0002-7745-8015 Froufe, Hugo J.C. Ferreira, Isabel C.F.R. Ferreira, Isabel C.F.R. https://www.ciencia-id.pt/9418-CF95-9919 9418-CF95-9919 http://orcid.org/0000-0003-4910-4882 0000-0003-4910-4882 Costa, Raquel Soares, Raquel Queiroz, Maria João R.P. |
| publishDate | 2012 |
| publisher.none.fl_str_mv | Universidade de Aveiro |
| reponame_str | Biblioteca Digital do IPB |
| repository_id_str | urn:repositoryAcronym:ipb |
| service_str_mv | urn:repositoryAcronym:ipb |
| spelling | engUniversidade de AveiroporA number of thienopyrimidines derivatives have shown potent VEGFR2 (Vascular Endothelium Growth Factor Receptor2) tyrosine kinase inhibition activity.[ll VEGF is a sun·ogate marker of angiogenesis that activates VEGFR2 in endothelial cells. Here we present the synthesis of new 1-aryl-3-[ 4-(thieno[3,2-d]pyrimidin-4- yloxy)phenyl]ureas from the aminodi(hetero)arylether 1, also prepared by us, which was reacted with arylisocyanates to give the corresponding 1,3-diarylureas 2a-c.application/pdfpor1-Aryl-3-[ 4-( thieno[3,2-d]pyrimidin-4-yloxy )phenyl]ureas as VEG FR2 inhibitors: synthesis, docking enzymatic and cellular assaysPeixoto, DanielaPersonalCalhelha, Ricardo C.DSpacehttp://dspace.org/items/2d5d1a41-7561-4a01-871c-b4c97da35053DSpacehttp://dspace.org/items/2d5d1a41-7561-4a01-871c-b4c97da35053CalhelhaRicardo C.Ciência IDhttps://www.ciencia-id.ptF313-E3CE-554EORCIDhttp://orcid.org0000-0002-6801-4578Researcher IDhttps://www.researcherid.comJ-2172-2014Scopus Author IDhttps://www.scopus.com6507978333Soares, PedroPersonalAbreu, Rui M.V.DSpacehttp://dspace.org/items/cadb03a4-5e60-4745-b35f-fc3a97c071bcDSpacehttp://dspace.org/items/cadb03a4-5e60-4745-b35f-fc3a97c071bcAbreuRui M.V.Ciência IDhttps://www.ciencia-id.pt0F19-0DE2-12A2ORCIDhttp://orcid.org0000-0002-7745-8015Scopus Author IDhttps://www.scopus.com7003290613Froufe, Hugo J.C.PersonalFerreira, Isabel C.F.R.DSpacehttp://dspace.org/items/bd0d1537-2e03-41fb-b27a-140af9c35db8DSpacehttp://dspace.org/items/bd0d1537-2e03-41fb-b27a-140af9c35db8FerreiraIsabel C.F.R.Ciência IDhttps://www.ciencia-id.pt9418-CF95-9919ORCIDhttp://orcid.org0000-0003-4910-4882Researcher IDhttps://www.researcherid.comE-8500-2013Scopus Author IDhttps://www.scopus.com36868826600Costa, RaquelSoares, RaquelQueiroz, Maria João R.P.HostingInstitutionOrganizationalBiblioteca Digital do IPBe-mailmailto:dspace@ipb.ptdspace@ipb.pt2014-05-09T09:56:53Z20122012-01-01T00:00:00ZHandlehttp://hdl.handle.net/10198/9474http://purl.org/coar/access_right/c_abf2open access1756325 bytesother research producthttp://purl.org/coar/resource_type/c_c94fconference objecthttp://purl.org/coar/access_right/c_abf2application/pdffulltexthttps://bibliotecadigital.ipb.pt/bitstreams/219a0616-c163-4531-9219-ab260b432a20/download3º Encontro Nacional de Química Terapêutica e 1st Portuguese-Spanish-Brazilian Meeting on Medicinal Chemistry, 28 a 30 de NovembroAveiro |
| spellingShingle | 1-Aryl-3-[ 4-( thieno[3,2-d]pyrimidin-4-yloxy )phenyl]ureas as VEG FR2 inhibitors: synthesis, docking enzymatic and cellular assays Peixoto, Daniela |
| status | SINGLETON |
| title | 1-Aryl-3-[ 4-( thieno[3,2-d]pyrimidin-4-yloxy )phenyl]ureas as VEG FR2 inhibitors: synthesis, docking enzymatic and cellular assays |
| title_full | 1-Aryl-3-[ 4-( thieno[3,2-d]pyrimidin-4-yloxy )phenyl]ureas as VEG FR2 inhibitors: synthesis, docking enzymatic and cellular assays |
| title_fullStr | 1-Aryl-3-[ 4-( thieno[3,2-d]pyrimidin-4-yloxy )phenyl]ureas as VEG FR2 inhibitors: synthesis, docking enzymatic and cellular assays |
| title_full_unstemmed | 1-Aryl-3-[ 4-( thieno[3,2-d]pyrimidin-4-yloxy )phenyl]ureas as VEG FR2 inhibitors: synthesis, docking enzymatic and cellular assays |
| title_short | 1-Aryl-3-[ 4-( thieno[3,2-d]pyrimidin-4-yloxy )phenyl]ureas as VEG FR2 inhibitors: synthesis, docking enzymatic and cellular assays |
| title_sort | 1-Aryl-3-[ 4-( thieno[3,2-d]pyrimidin-4-yloxy )phenyl]ureas as VEG FR2 inhibitors: synthesis, docking enzymatic and cellular assays |
| url | http://hdl.handle.net/10198/9474 |
| visible | 1 |