Publicação
Antimalarial and cytotoxic activity of native plants used in cabo verde traditional medicine
| Resumo: | Medicinal plants have historically been a source of drugs in multiple applications, including the treatment of malaria infections. The Cabo Verde archipelago harbors a rich diversity of native plants, most of which are used for medicinal purposes. The present study investigated the in vitro antiplasmodial activities of four native plants from Cabo Verde (i.e., Artemisia gorgonum, Lavandula rotundifolia, Sideroxylon marginatum, and Tamarix senegalensis). Traditional preparations of these medicinal plants, namely aqueous extracts (infusions) and ethanolic extracts, were tested against both chloroquine-sensitive (3D7) and chloroquine-resistant (Dd2) Plasmodium falciparum strains using the SYBR Green detection method. The in vitro cytotoxicity was evaluated in Caco-2 and PLP2 cells using a sulforhodamine B colorimetric assay. An ethanolic extract of A. gorgonum and infusions of T. senegalensis exhibited high antiplasmodial activities (EC50 < 5 g/mL) without cytotoxicity (GI50 > 400 g/mL). Extracts of L. rotundifolia and S. marginatum exhibited moderate activities, with EC50 values ranging from 10–30 g/mL. The A. gorgonum ethanolic extract showed activity toward early ring stages, and parasites treated with the T. senegalensis infusions progressed to the early trophozoite stage, although did not develop further to the late trophozoite or schizont stages. Antimalarial activities and the lack of cytotoxicity of the extracts are reported in the present study and support previous claims by traditional practitioners for the use of these plants against malaria while suggesting their ethnopharmacological usefulness as future antimalarials. |
|---|---|
| Autores principais: | Essoh, Anyse P. |
| Outros Autores: | Cassiano, Gustavo Capatti; Mandim, Filipa; Barros, Lillian; Gomes, Isildo; Medeiros, Márcia Melo; Moura, Monica B.M.V.; Cravo, Pedro V.L.; Romeiras, Maria M. |
| Assunto: | Tropical plants Traditional medicine Malaria Ethnopharmacology West Africa |
| Ano: | 2023 |
| País: | Portugal |
| Tipo de documento: | artigo |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Instituto Politécnico de Bragança |
| Idioma: | inglês |
| Origem: | Biblioteca Digital do IPB |
| _version_ | 1867172852880375808 |
|---|---|
| author | Essoh, Anyse P. |
| author2 | Cassiano, Gustavo Capatti Mandim, Filipa Barros, Lillian Gomes, Isildo Medeiros, Márcia Melo Moura, Monica B.M.V. Cravo, Pedro V.L. Romeiras, Maria M. |
| author2_role | author author author author author author author author |
| author_facet | Essoh, Anyse P. Cassiano, Gustavo Capatti Mandim, Filipa Barros, Lillian Gomes, Isildo Medeiros, Márcia Melo Moura, Monica B.M.V. Cravo, Pedro V.L. Romeiras, Maria M. |
| author_role | author |
| contributor_name_str_mv | Biblioteca Digital do IPB |
| country_str | PT |
| creators_json_txt | [{\"Person.name\":\"Essoh, Anyse P.\"},{\"Person.name\":\"Cassiano, Gustavo Capatti\"},{\"Person.name\":\"Mandim, Filipa\",\"Person.identifier.orcid\":\"0000-0002-6494-2326\"},{\"Person.name\":\"Barros, Lillian\",\"Person.identifier.orcid\":\"0000-0002-9050-5189\"},{\"Person.name\":\"Gomes, Isildo\"},{\"Person.name\":\"Medeiros, Márcia Melo\"},{\"Person.name\":\"Moura, Monica B.M.V.\"},{\"Person.name\":\"Cravo, Pedro V.L.\"},{\"Person.name\":\"Romeiras, Maria M.\"}] |
| datacite.contributors.contributor.contributorName.fl_str_mv | Biblioteca Digital do IPB |
| datacite.creators.creator.creatorName.fl_str_mv | Essoh, Anyse P. Cassiano, Gustavo Capatti Mandim, Filipa Barros, Lillian Gomes, Isildo Medeiros, Márcia Melo Moura, Monica B.M.V. Cravo, Pedro V.L. Romeiras, Maria M. |
| datacite.date.Accepted.fl_str_mv | 2023-01-01T00:00:00Z |
| datacite.date.available.fl_str_mv | 2024-01-03T11:08:11Z |
| datacite.date.embargoed.fl_str_mv | 2024-01-03T11:08:11Z |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| datacite.subjects.subject.fl_str_mv | Tropical plants Traditional medicine Malaria Ethnopharmacology West Africa |
| datacite.titles.title.fl_str_mv | Antimalarial and cytotoxic activity of native plants used in cabo verde traditional medicine |
| dc.contributor.none.fl_str_mv | Biblioteca Digital do IPB |
| dc.creator.none.fl_str_mv | Essoh, Anyse P. Cassiano, Gustavo Capatti Mandim, Filipa Barros, Lillian Gomes, Isildo Medeiros, Márcia Melo Moura, Monica B.M.V. Cravo, Pedro V.L. Romeiras, Maria M. |
| dc.date.Accepted.fl_str_mv | 2023-01-01T00:00:00Z |
| dc.date.available.fl_str_mv | 2024-01-03T11:08:11Z |
| dc.date.embargoed.fl_str_mv | 2024-01-03T11:08:11Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | http://hdl.handle.net/10198/29048 |
| dc.language.none.fl_str_mv | eng |
| dc.publisher.none.fl_str_mv | MDPI |
| dc.rights.cclincense.fl_str_mv | http://creativecommons.org/licenses/by/4.0/ |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| dc.subject.none.fl_str_mv | Tropical plants Traditional medicine Malaria Ethnopharmacology West Africa |
| dc.title.fl_str_mv | Antimalarial and cytotoxic activity of native plants used in cabo verde traditional medicine |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_6501 |
| description | Medicinal plants have historically been a source of drugs in multiple applications, including the treatment of malaria infections. The Cabo Verde archipelago harbors a rich diversity of native plants, most of which are used for medicinal purposes. The present study investigated the in vitro antiplasmodial activities of four native plants from Cabo Verde (i.e., Artemisia gorgonum, Lavandula rotundifolia, Sideroxylon marginatum, and Tamarix senegalensis). Traditional preparations of these medicinal plants, namely aqueous extracts (infusions) and ethanolic extracts, were tested against both chloroquine-sensitive (3D7) and chloroquine-resistant (Dd2) Plasmodium falciparum strains using the SYBR Green detection method. The in vitro cytotoxicity was evaluated in Caco-2 and PLP2 cells using a sulforhodamine B colorimetric assay. An ethanolic extract of A. gorgonum and infusions of T. senegalensis exhibited high antiplasmodial activities (EC50 < 5 g/mL) without cytotoxicity (GI50 > 400 g/mL). Extracts of L. rotundifolia and S. marginatum exhibited moderate activities, with EC50 values ranging from 10–30 g/mL. The A. gorgonum ethanolic extract showed activity toward early ring stages, and parasites treated with the T. senegalensis infusions progressed to the early trophozoite stage, although did not develop further to the late trophozoite or schizont stages. Antimalarial activities and the lack of cytotoxicity of the extracts are reported in the present study and support previous claims by traditional practitioners for the use of these plants against malaria while suggesting their ethnopharmacological usefulness as future antimalarials. |
| dirty | 0 |
| eu_rights_str_mv | openAccess |
| format | article |
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| identifier.url.fl_str_mv | http://hdl.handle.net/10198/29048 |
| instacron_str | ipb |
| institution | Instituto Politécnico de Bragança |
| instname_str | Instituto Politécnico de Bragança |
| language | eng |
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| network_name_str | Biblioteca Digital do IPB |
| oai_identifier_str | oai:bibliotecadigital.ipb.pt:10198/29048 |
| organization_str_mv | urn:organizationAcronym:ipb |
| person_str_mv | Essoh, Anyse P. Cassiano, Gustavo Capatti Mandim, Filipa Mandim, Filipa https://www.ciencia-id.pt/F318-9049-EB99 F318-9049-EB99 http://orcid.org/0000-0002-6494-2326 0000-0002-6494-2326 Barros, Lillian Barros, Lillian https://www.ciencia-id.pt/9616-35CB-D001 9616-35CB-D001 http://orcid.org/0000-0002-9050-5189 0000-0002-9050-5189 Gomes, Isildo Medeiros, Márcia Melo Moura, Monica B.M.V. Cravo, Pedro V.L. Romeiras, Maria M. |
| publishDate | 2023 |
| publisher.none.fl_str_mv | MDPI |
| reponame_str | Biblioteca Digital do IPB |
| repository_id_str | urn:repositoryAcronym:ipb |
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| spelling | engMDPIpt_PTMedicinal plants have historically been a source of drugs in multiple applications, including the treatment of malaria infections. The Cabo Verde archipelago harbors a rich diversity of native plants, most of which are used for medicinal purposes. The present study investigated the in vitro antiplasmodial activities of four native plants from Cabo Verde (i.e., Artemisia gorgonum, Lavandula rotundifolia, Sideroxylon marginatum, and Tamarix senegalensis). Traditional preparations of these medicinal plants, namely aqueous extracts (infusions) and ethanolic extracts, were tested against both chloroquine-sensitive (3D7) and chloroquine-resistant (Dd2) Plasmodium falciparum strains using the SYBR Green detection method. The in vitro cytotoxicity was evaluated in Caco-2 and PLP2 cells using a sulforhodamine B colorimetric assay. An ethanolic extract of A. gorgonum and infusions of T. senegalensis exhibited high antiplasmodial activities (EC50 < 5 g/mL) without cytotoxicity (GI50 > 400 g/mL). Extracts of L. rotundifolia and S. marginatum exhibited moderate activities, with EC50 values ranging from 10–30 g/mL. The A. gorgonum ethanolic extract showed activity toward early ring stages, and parasites treated with the T. senegalensis infusions progressed to the early trophozoite stage, although did not develop further to the late trophozoite or schizont stages. Antimalarial activities and the lack of cytotoxicity of the extracts are reported in the present study and support previous claims by traditional practitioners for the use of these plants against malaria while suggesting their ethnopharmacological usefulness as future antimalarials.application/pdfpt_PTAntimalarial and cytotoxic activity of native plants used in cabo verde traditional medicineEssoh, Anyse P.Cassiano, Gustavo CapattiPersonalMandim, FilipaDSpacehttp://dspace.org/items/bcc274d4-7e6c-46a8-8e49-2752f9dbfbcdDSpacehttp://dspace.org/items/bcc274d4-7e6c-46a8-8e49-2752f9dbfbcdMandimFilipaCiência IDhttps://www.ciencia-id.ptF318-9049-EB99ORCIDhttp://orcid.org0000-0002-6494-2326PersonalBarros, LillianDSpacehttp://dspace.org/items/3af07ffe-f914-48ba-a5d5-efcf70fdce01DSpacehttp://dspace.org/items/3af07ffe-f914-48ba-a5d5-efcf70fdce01BarrosLillianCiência IDhttps://www.ciencia-id.pt9616-35CB-D001ORCIDhttp://orcid.org0000-0002-9050-5189Researcher IDhttps://www.researcherid.comJ-3600-2013Researcher IDhttps://www.researcherid.comJ-3600-2013Scopus Author IDhttps://www.scopus.com35236343600Scopus Author IDhttps://www.scopus.com57194900801Gomes, IsildoMedeiros, Márcia MeloMoura, Monica B.M.V.Cravo, Pedro V.L.Romeiras, Maria M.HostingInstitutionOrganizationalBiblioteca Digital do IPBe-mailmailto:dspace@ipb.ptdspace@ipb.ptDOIIsPartOf10.3390/plants120409632024-01-03T11:08:11Z20232023-01-01T00:00:00ZHandlehttp://hdl.handle.net/10198/29048http://purl.org/coar/access_right/c_abf2open accessTropical plantsTraditional medicineMalariaEthnopharmacologyWest Africa1285252 bytesliteraturehttp://purl.org/coar/resource_type/c_6501journal article2023http://creativecommons.org/licenses/by/4.0/http://purl.org/coar/access_right/c_abf2application/pdffulltexthttps://bibliotecadigital.ipb.pt/bitstreams/ba75e3b2-859d-4879-9038-a2a238d36f82/downloadPlants124112 |
| spellingShingle | Antimalarial and cytotoxic activity of native plants used in cabo verde traditional medicine Essoh, Anyse P. Tropical plants Traditional medicine Malaria Ethnopharmacology West Africa |
| status | SINGLETON |
| subject.fl_str_mv | Tropical plants Traditional medicine Malaria Ethnopharmacology West Africa |
| title | Antimalarial and cytotoxic activity of native plants used in cabo verde traditional medicine |
| title_full | Antimalarial and cytotoxic activity of native plants used in cabo verde traditional medicine |
| title_fullStr | Antimalarial and cytotoxic activity of native plants used in cabo verde traditional medicine |
| title_full_unstemmed | Antimalarial and cytotoxic activity of native plants used in cabo verde traditional medicine |
| title_short | Antimalarial and cytotoxic activity of native plants used in cabo verde traditional medicine |
| title_sort | Antimalarial and cytotoxic activity of native plants used in cabo verde traditional medicine |
| topic | Tropical plants Traditional medicine Malaria Ethnopharmacology West Africa |
| topic_facet | Tropical plants Traditional medicine Malaria Ethnopharmacology West Africa |
| url | http://hdl.handle.net/10198/29048 |
| visible | 1 |