Publicação
Modeling, simulation and operation of a simulated moving bed for continuous chromatographic separation of 1,1'-bi-2-naphthol enantiomers
| Resumo: | The objective of this paper is to study the separation of enantiomers of 1,1′-bi-2-naphthol in 3,5-dinitrobenzoyl phenylglycine bonded to silica gel, using heptane–isopropanol (72:28) as eluent by simulated moving bed chromatography (SMB). A model for the prediction of the cyclic steady state performance of the SMB, based on the analogy with the true moving bed, is developed assuming axial dispersion flow, linear driving force approximation for intraparticle mass transfer and multicomponent adsorption equilibria. The SMB package allows the simulation of the pilot unit. The effect of several operating parameters on the SMB performance is analyzed. The performance is characterized by purity, recovery, solvent consumption and adsorbent productivity. The package is an important tool for learning and training operators, allowing the choice of best operating conditions. The operation of the SMB pilot unit was carried out for the separation of racemic mixtures using a 8-column configuration. Purities and recoveries higher than 95% in the extract and raffinate were obtained. Model and experimental results are compared and the package is also used to predict the steady state internal profiles for the SMB operation in good agreement with experimental results. |
|---|---|
| Autores principais: | Pais, Luís S. |
| Outros Autores: | Loureiro, José M.; Rodrigues, Alírio |
| Assunto: | Simulated moving bed chromatography Enantiomer separation Computer simulation Binaphthol |
| Ano: | 1997 |
| País: | Portugal |
| Tipo de documento: | artigo |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Instituto Politécnico de Bragança |
| Idioma: | inglês |
| Origem: | Biblioteca Digital do IPB |
| _version_ | 1867173100650496000 |
|---|---|
| author | Pais, Luís S. |
| author2 | Loureiro, José M. Rodrigues, Alírio |
| author2_role | author author |
| author_facet | Pais, Luís S. Loureiro, José M. Rodrigues, Alírio |
| author_role | author |
| contributor_name_str_mv | Biblioteca Digital do IPB |
| country_str | PT |
| creators_json_txt | [{\"Person.name\":\"Pais, Luís S.\",\"Person.identifier.orcid\":\"0000-0002-3000-2862\"},{\"Person.name\":\"Loureiro, José M.\"},{\"Person.name\":\"Rodrigues, Alírio\"}] |
| datacite.contributors.contributor.contributorName.fl_str_mv | Biblioteca Digital do IPB |
| datacite.creators.creator.creatorName.fl_str_mv | Pais, Luís S. Loureiro, José M. Rodrigues, Alírio |
| datacite.date.Accepted.fl_str_mv | 1997-01-01T00:00:00Z |
| datacite.date.available.fl_str_mv | 2009-04-17T15:22:13Z |
| datacite.date.embargoed.fl_str_mv | 2009-04-17T15:22:13Z |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| datacite.subjects.subject.fl_str_mv | Simulated moving bed chromatography Enantiomer separation Computer simulation Binaphthol |
| datacite.titles.title.fl_str_mv | Modeling, simulation and operation of a simulated moving bed for continuous chromatographic separation of 1,1'-bi-2-naphthol enantiomers |
| dc.contributor.none.fl_str_mv | Biblioteca Digital do IPB |
| dc.creator.none.fl_str_mv | Pais, Luís S. Loureiro, José M. Rodrigues, Alírio |
| dc.date.Accepted.fl_str_mv | 1997-01-01T00:00:00Z |
| dc.date.available.fl_str_mv | 2009-04-17T15:22:13Z |
| dc.date.embargoed.fl_str_mv | 2009-04-17T15:22:13Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | http://hdl.handle.net/10198/1148 |
| dc.language.none.fl_str_mv | eng |
| dc.publisher.none.fl_str_mv | Elsevier |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| dc.subject.none.fl_str_mv | Simulated moving bed chromatography Enantiomer separation Computer simulation Binaphthol |
| dc.title.fl_str_mv | Modeling, simulation and operation of a simulated moving bed for continuous chromatographic separation of 1,1'-bi-2-naphthol enantiomers |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_6501 |
| description | The objective of this paper is to study the separation of enantiomers of 1,1′-bi-2-naphthol in 3,5-dinitrobenzoyl phenylglycine bonded to silica gel, using heptane–isopropanol (72:28) as eluent by simulated moving bed chromatography (SMB). A model for the prediction of the cyclic steady state performance of the SMB, based on the analogy with the true moving bed, is developed assuming axial dispersion flow, linear driving force approximation for intraparticle mass transfer and multicomponent adsorption equilibria. The SMB package allows the simulation of the pilot unit. The effect of several operating parameters on the SMB performance is analyzed. The performance is characterized by purity, recovery, solvent consumption and adsorbent productivity. The package is an important tool for learning and training operators, allowing the choice of best operating conditions. The operation of the SMB pilot unit was carried out for the separation of racemic mixtures using a 8-column configuration. Purities and recoveries higher than 95% in the extract and raffinate were obtained. Model and experimental results are compared and the package is also used to predict the steady state internal profiles for the SMB operation in good agreement with experimental results. |
| dirty | 0 |
| eu_rights_str_mv | openAccess |
| format | article |
| fulltext.url.fl_str_mv | https://bibliotecadigital.ipb.pt/bitstreams/eb37b9da-2e13-4745-a972-e65f94c6349f/download |
| id | ipb_cfd0a41dcab7c08d9de7d3971e6a409d |
| identifier.url.fl_str_mv | http://hdl.handle.net/10198/1148 |
| instacron_str | ipb |
| institution | Instituto Politécnico de Bragança |
| instname_str | Instituto Politécnico de Bragança |
| language | eng |
| network_acronym_str | ipb |
| network_name_str | Biblioteca Digital do IPB |
| oai_identifier_str | oai:bibliotecadigital.ipb.pt:10198/1148 |
| organization_str_mv | urn:organizationAcronym:ipb |
| person_str_mv | Pais, Luís S. Pais, Luís S. https://www.ciencia-id.pt/421E-0CCD-A84F 421E-0CCD-A84F http://orcid.org/0000-0002-3000-2862 0000-0002-3000-2862 Loureiro, José M. Rodrigues, Alírio |
| publishDate | 1997 |
| publisher.none.fl_str_mv | Elsevier |
| reponame_str | Biblioteca Digital do IPB |
| repository_id_str | urn:repositoryAcronym:ipb |
| service_str_mv | urn:repositoryAcronym:ipb |
| spelling | engElsevierenThe objective of this paper is to study the separation of enantiomers of 1,1′-bi-2-naphthol in 3,5-dinitrobenzoyl phenylglycine bonded to silica gel, using heptane–isopropanol (72:28) as eluent by simulated moving bed chromatography (SMB). A model for the prediction of the cyclic steady state performance of the SMB, based on the analogy with the true moving bed, is developed assuming axial dispersion flow, linear driving force approximation for intraparticle mass transfer and multicomponent adsorption equilibria. The SMB package allows the simulation of the pilot unit. The effect of several operating parameters on the SMB performance is analyzed. The performance is characterized by purity, recovery, solvent consumption and adsorbent productivity. The package is an important tool for learning and training operators, allowing the choice of best operating conditions. The operation of the SMB pilot unit was carried out for the separation of racemic mixtures using a 8-column configuration. Purities and recoveries higher than 95% in the extract and raffinate were obtained. Model and experimental results are compared and the package is also used to predict the steady state internal profiles for the SMB operation in good agreement with experimental results.application/pdfenModeling, simulation and operation of a simulated moving bed for continuous chromatographic separation of 1,1'-bi-2-naphthol enantiomersPersonalPais, Luís S.DSpacehttp://dspace.org/items/c6d25534-8487-45b1-90af-d350f4e3ac55DSpacehttp://dspace.org/items/c6d25534-8487-45b1-90af-d350f4e3ac55PaisLuís S.Ciência IDhttps://www.ciencia-id.pt421E-0CCD-A84FORCIDhttp://orcid.org0000-0002-3000-2862Scopus Author IDhttps://www.scopus.com6603930478Loureiro, José M.Rodrigues, AlírioHostingInstitutionOrganizationalBiblioteca Digital do IPBe-mailmailto:dspace@ipb.ptdspace@ipb.ptISSNIsPartOf0021-9673DOIIsPartOf10.1016/S0021-9673(96)01076-X2009-04-17T15:22:13Z199719971997-01-01T00:00:00ZHandlehttp://hdl.handle.net/10198/1148http://purl.org/coar/access_right/c_abf2open accessSimulated moving bed chromatographyEnantiomer separationComputer simulationBinaphthol554122 bytesliteraturehttp://purl.org/coar/resource_type/c_6501journal articlehttp://purl.org/coar/access_right/c_abf2application/pdffulltexthttps://bibliotecadigital.ipb.pt/bitstreams/eb37b9da-2e13-4745-a972-e65f94c6349f/download |
| spellingShingle | Modeling, simulation and operation of a simulated moving bed for continuous chromatographic separation of 1,1'-bi-2-naphthol enantiomers Pais, Luís S. Simulated moving bed chromatography Enantiomer separation Computer simulation Binaphthol |
| status | SINGLETON |
| subject.fl_str_mv | Simulated moving bed chromatography Enantiomer separation Computer simulation Binaphthol |
| title | Modeling, simulation and operation of a simulated moving bed for continuous chromatographic separation of 1,1'-bi-2-naphthol enantiomers |
| title_full | Modeling, simulation and operation of a simulated moving bed for continuous chromatographic separation of 1,1'-bi-2-naphthol enantiomers |
| title_fullStr | Modeling, simulation and operation of a simulated moving bed for continuous chromatographic separation of 1,1'-bi-2-naphthol enantiomers |
| title_full_unstemmed | Modeling, simulation and operation of a simulated moving bed for continuous chromatographic separation of 1,1'-bi-2-naphthol enantiomers |
| title_short | Modeling, simulation and operation of a simulated moving bed for continuous chromatographic separation of 1,1'-bi-2-naphthol enantiomers |
| title_sort | Modeling, simulation and operation of a simulated moving bed for continuous chromatographic separation of 1,1'-bi-2-naphthol enantiomers |
| topic | Simulated moving bed chromatography Enantiomer separation Computer simulation Binaphthol |
| topic_facet | Simulated moving bed chromatography Enantiomer separation Computer simulation Binaphthol |
| url | http://hdl.handle.net/10198/1148 |
| visible | 1 |