Publicação
Brazilian berry waste as a source of bioactive compounds: grumixama (Eugenia brasiliensis Lam.) as a case study
| Resumo: | Grumixama, Eugenia brasiliensis Lam., is a Brazilian berry little explored commercially and scientifically. However, local small producers market this fruit in the form of frozen pulp, which generates bioresidues, composed of seeds and peels. With the view to propose strategies for valuing grumixama, this study aimed to determine the chemical composition and assess the bioactivities of the hydroethanolic extracts of the whole residue (GR), seed (GS) and peel (GP) fractions of E. brasiliensis. From the results, GP had the highest concentration of organic acids (oxalic, malic, ascorbic and citric acids), total tocopherols, condensed tannins, anthocyanins, and other flavonoids. On the other hand, GS showed the highest content of monounsaturated fatty acids and hydrolysable tannins, whereas GR displayed a mixture of compounds detected in each of its parts. Regarding the bioactivities, low extract concentrations were required in two in vitro antioxidant assays, namely TBARS (EC50 = 0.90-1.34 mu g mL(-1)) and OxHLIA (IC50 = 21-65 mu g mL(-1)). Furthermore, GP had the highest inhibition activity of cellular oxidation in the CAA assay (80 +/- 0.6%), while GS showed the highest anti-inflammatory activity via nitric oxide production inhibition (EC50 = 98.0 +/- 0.5 mu g mL(-1)). All samples induced cell growth inhibition of the tested tumor cells (GI(50) = 14.7-186 mu g mL(-1)) besides antibacterial and antifungal effects at low concentrations, but all samples were harmful to normal cells at moderate concentrations (GI(50) = 145-268 mu g mL(-1)d). Therefore, E. brasiliensis residue could be a good source of bioactive compounds to be used in several areas. However, additional studies are needed to confirm its safety as well as to unravel the mechanisms behind its biological activities. |
|---|---|
| Autores principais: | Albuquerque, Bianca R. |
| Outros Autores: | Finimundy, Tiane C.; Pinela, José; Pires, Tânia C.S.P.; Mandim, Filipa; Vaz, Josiana A.; Corrêa, Rúbia C.G.; Oliveira, Beatriz; Barros, Lillian |
| Assunto: | Polyphenol-rich juice Hydroalcoholic extract Phenolic profile Essential oil Native fruit Antioxidant Acid Ellagitannins Anthocyanins Leaves |
| Ano: | 2023 |
| País: | Portugal |
| Tipo de documento: | artigo |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Instituto Politécnico de Bragança |
| Idioma: | inglês |
| Origem: | Biblioteca Digital do IPB |
| _version_ | 1863850921883074560 |
|---|---|
| author | Albuquerque, Bianca R. |
| author2 | Finimundy, Tiane C. Pinela, José Pires, Tânia C.S.P. Mandim, Filipa Vaz, Josiana A. Corrêa, Rúbia C.G. Oliveira, Beatriz Barros, Lillian |
| author2_role | author author author author author author author author |
| author_facet | Albuquerque, Bianca R. Finimundy, Tiane C. Pinela, José Pires, Tânia C.S.P. Mandim, Filipa Vaz, Josiana A. Corrêa, Rúbia C.G. Oliveira, Beatriz Barros, Lillian |
| author_role | author |
| contributor_name_str_mv | Biblioteca Digital do IPB |
| country_str | PT |
| creators_json_str | [{\"Person.name\":\"Albuquerque, Bianca R.\",\"Person.identifier.orcid\":\"0000-0003-4109-7921\"},{\"Person.name\":\"Finimundy, Tiane C.\",\"Person.identifier.orcid\":\"0000-0003-3516-0795\"},{\"Person.name\":\"Pinela, José\",\"Person.identifier.orcid\":\"0000-0001-7523-1637\"},{\"Person.name\":\"Pires, Tânia C.S.P.\",\"Person.identifier.orcid\":\"0000-0002-3954-3833\"},{\"Person.name\":\"Mandim, Filipa\",\"Person.identifier.orcid\":\"0000-0002-6494-2326\"},{\"Person.name\":\"Vaz, Josiana A.\",\"Person.identifier.orcid\":\"0000-0002-6989-1169\"},{\"Person.name\":\"Corrêa, Rúbia C.G.\",\"Person.identifier.orcid\":\"0000-0003-0269-4344\"},{\"Person.name\":\"Oliveira, Beatriz\"},{\"Person.name\":\"Barros, Lillian\",\"Person.identifier.orcid\":\"0000-0002-9050-5189\"}] |
| datacite.contributors.contributor.contributorName.fl_str_mv | Biblioteca Digital do IPB |
| datacite.creators.creator.creatorName.fl_str_mv | Albuquerque, Bianca R. Finimundy, Tiane C. Pinela, José Pires, Tânia C.S.P. Mandim, Filipa Vaz, Josiana A. Corrêa, Rúbia C.G. Oliveira, Beatriz Barros, Lillian |
| datacite.date.Accepted.fl_str_mv | 2023-01-01T00:00:00Z |
| datacite.date.available.fl_str_mv | 2023-02-24T09:58:05Z |
| datacite.date.embargoed.fl_str_mv | 2023-02-24T09:58:05Z |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| datacite.subjects.subject.fl_str_mv | Polyphenol-rich juice Hydroalcoholic extract Phenolic profile Essential oil Native fruit Antioxidant Acid Ellagitannins Anthocyanins Leaves |
| datacite.titles.title.fl_str_mv | Brazilian berry waste as a source of bioactive compounds: grumixama (Eugenia brasiliensis Lam.) as a case study |
| dc.contributor.none.fl_str_mv | Biblioteca Digital do IPB |
| dc.creator.none.fl_str_mv | Albuquerque, Bianca R. Finimundy, Tiane C. Pinela, José Pires, Tânia C.S.P. Mandim, Filipa Vaz, Josiana A. Corrêa, Rúbia C.G. Oliveira, Beatriz Barros, Lillian |
| dc.date.Accepted.fl_str_mv | 2023-01-01T00:00:00Z |
| dc.date.available.fl_str_mv | 2023-02-24T09:58:05Z |
| dc.date.embargoed.fl_str_mv | 2023-02-24T09:58:05Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | http://hdl.handle.net/10198/27167 |
| dc.language.none.fl_str_mv | eng |
| dc.publisher.none.fl_str_mv | The Royal Society of Chemistry |
| dc.rights.cclincense.fl_str_mv | http://creativecommons.org/licenses/by/4.0/ |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| dc.subject.none.fl_str_mv | Polyphenol-rich juice Hydroalcoholic extract Phenolic profile Essential oil Native fruit Antioxidant Acid Ellagitannins Anthocyanins Leaves |
| dc.title.fl_str_mv | Brazilian berry waste as a source of bioactive compounds: grumixama (Eugenia brasiliensis Lam.) as a case study |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_6501 |
| description | Grumixama, Eugenia brasiliensis Lam., is a Brazilian berry little explored commercially and scientifically. However, local small producers market this fruit in the form of frozen pulp, which generates bioresidues, composed of seeds and peels. With the view to propose strategies for valuing grumixama, this study aimed to determine the chemical composition and assess the bioactivities of the hydroethanolic extracts of the whole residue (GR), seed (GS) and peel (GP) fractions of E. brasiliensis. From the results, GP had the highest concentration of organic acids (oxalic, malic, ascorbic and citric acids), total tocopherols, condensed tannins, anthocyanins, and other flavonoids. On the other hand, GS showed the highest content of monounsaturated fatty acids and hydrolysable tannins, whereas GR displayed a mixture of compounds detected in each of its parts. Regarding the bioactivities, low extract concentrations were required in two in vitro antioxidant assays, namely TBARS (EC50 = 0.90-1.34 mu g mL(-1)) and OxHLIA (IC50 = 21-65 mu g mL(-1)). Furthermore, GP had the highest inhibition activity of cellular oxidation in the CAA assay (80 +/- 0.6%), while GS showed the highest anti-inflammatory activity via nitric oxide production inhibition (EC50 = 98.0 +/- 0.5 mu g mL(-1)). All samples induced cell growth inhibition of the tested tumor cells (GI(50) = 14.7-186 mu g mL(-1)) besides antibacterial and antifungal effects at low concentrations, but all samples were harmful to normal cells at moderate concentrations (GI(50) = 145-268 mu g mL(-1)d). Therefore, E. brasiliensis residue could be a good source of bioactive compounds to be used in several areas. However, additional studies are needed to confirm its safety as well as to unravel the mechanisms behind its biological activities. |
| dirty | 0 |
| eu_rights_str_mv | openAccess |
| format | article |
| fulltext.url.fl_str_mv | https://bibliotecadigital.ipb.pt/bitstreams/fb2aa606-8f2d-4563-9266-4a3322f73260/download |
| id | ipb_ea3eb8ad939da0eb8948d48cdbcc4d85 |
| identifier.url.fl_str_mv | http://hdl.handle.net/10198/27167 |
| instacron_str | ipb |
| institution | Instituto Politécnico de Bragança |
| instname_str | Instituto Politécnico de Bragança |
| language | eng |
| network_acronym_str | ipb |
| network_name_str | Biblioteca Digital do IPB |
| oai_identifier_str | oai:bibliotecadigital.ipb.pt:10198/27167 |
| organization_str_mv | urn:organizationAcronym:ipb |
| person_str_mv | Albuquerque, Bianca R. Albuquerque, Bianca R. https://www.ciencia-id.pt/621C-B603-7519 621C-B603-7519 http://orcid.org/0000-0003-4109-7921 0000-0003-4109-7921 Finimundy, Tiane C. Finimundy, Tiane C. https://www.ciencia-id.pt/2F18-67B1-776A 2F18-67B1-776A http://orcid.org/0000-0003-3516-0795 0000-0003-3516-0795 Pinela, José Pinela, José https://www.ciencia-id.pt/771C-2B43-B108 771C-2B43-B108 http://orcid.org/0000-0001-7523-1637 0000-0001-7523-1637 Pires, Tânia C.S.P. Pires, Tânia C.S.P. https://www.ciencia-id.pt/321E-2D96-00CA 321E-2D96-00CA http://orcid.org/0000-0002-3954-3833 0000-0002-3954-3833 Mandim, Filipa Mandim, Filipa https://www.ciencia-id.pt/F318-9049-EB99 F318-9049-EB99 http://orcid.org/0000-0002-6494-2326 0000-0002-6494-2326 Vaz, Josiana A. Vaz, Josiana A. https://www.ciencia-id.pt/171B-88BA-64F5 171B-88BA-64F5 http://orcid.org/0000-0002-6989-1169 0000-0002-6989-1169 Corrêa, Rúbia C.G. Corrêa, Rúbia C.G. https://www.ciencia-id.pt/6C1F-2818-CBB5 6C1F-2818-CBB5 http://orcid.org/0000-0003-0269-4344 0000-0003-0269-4344 Oliveira, Beatriz Barros, Lillian Barros, Lillian https://www.ciencia-id.pt/9616-35CB-D001 9616-35CB-D001 http://orcid.org/0000-0002-9050-5189 0000-0002-9050-5189 |
| publishDate | 2023 |
| publisher.none.fl_str_mv | The Royal Society of Chemistry |
| reponame_str | Biblioteca Digital do IPB |
| repository_id_str | urn:repositoryAcronym:ipb |
| service_str_mv | urn:repositoryAcronym:ipb |
| spelling | engThe Royal Society of Chemistrypt_PTGrumixama, Eugenia brasiliensis Lam., is a Brazilian berry little explored commercially and scientifically. However, local small producers market this fruit in the form of frozen pulp, which generates bioresidues, composed of seeds and peels. With the view to propose strategies for valuing grumixama, this study aimed to determine the chemical composition and assess the bioactivities of the hydroethanolic extracts of the whole residue (GR), seed (GS) and peel (GP) fractions of E. brasiliensis. From the results, GP had the highest concentration of organic acids (oxalic, malic, ascorbic and citric acids), total tocopherols, condensed tannins, anthocyanins, and other flavonoids. On the other hand, GS showed the highest content of monounsaturated fatty acids and hydrolysable tannins, whereas GR displayed a mixture of compounds detected in each of its parts. Regarding the bioactivities, low extract concentrations were required in two in vitro antioxidant assays, namely TBARS (EC50 = 0.90-1.34 mu g mL(-1)) and OxHLIA (IC50 = 21-65 mu g mL(-1)). Furthermore, GP had the highest inhibition activity of cellular oxidation in the CAA assay (80 +/- 0.6%), while GS showed the highest anti-inflammatory activity via nitric oxide production inhibition (EC50 = 98.0 +/- 0.5 mu g mL(-1)). All samples induced cell growth inhibition of the tested tumor cells (GI(50) = 14.7-186 mu g mL(-1)) besides antibacterial and antifungal effects at low concentrations, but all samples were harmful to normal cells at moderate concentrations (GI(50) = 145-268 mu g mL(-1)d). Therefore, E. brasiliensis residue could be a good source of bioactive compounds to be used in several areas. However, additional studies are needed to confirm its safety as well as to unravel the mechanisms behind its biological activities.application/pdfpt_PTBrazilian berry waste as a source of bioactive compounds: grumixama (Eugenia brasiliensis Lam.) as a case studyPersonalAlbuquerque, Bianca R.DSpacehttp://dspace.org/items/c74e6f34-eab8-47bc-906b-dafb96b9f473DSpacehttp://dspace.org/items/c74e6f34-eab8-47bc-906b-dafb96b9f473AlbuquerqueBianca R.Ciência IDhttps://www.ciencia-id.pt621C-B603-7519ORCIDhttp://orcid.org0000-0003-4109-7921Scopus Author IDhttps://www.scopus.com57192311941PersonalFinimundy, Tiane C.DSpacehttp://dspace.org/items/4f8767d4-4e62-4550-9b35-740cb2f672daDSpacehttp://dspace.org/items/4f8767d4-4e62-4550-9b35-740cb2f672daFinimundyTiane C.Ciência IDhttps://www.ciencia-id.pt2F18-67B1-776AORCIDhttp://orcid.org0000-0003-3516-0795PersonalPinela, JoséDSpacehttp://dspace.org/items/706cd9ff-065b-4c98-98a7-5c0a9e45adc4DSpacehttp://dspace.org/items/706cd9ff-065b-4c98-98a7-5c0a9e45adc4PinelaJoséCiência IDhttps://www.ciencia-id.pt771C-2B43-B108ORCIDhttp://orcid.org0000-0001-7523-1637Researcher IDhttps://www.researcherid.comB-4466-2014Scopus Author IDhttps://www.scopus.com54392272800PersonalPires, Tânia C.S.P.DSpacehttp://dspace.org/items/34af4d18-b8ae-4329-9450-69dc35ed448fDSpacehttp://dspace.org/items/34af4d18-b8ae-4329-9450-69dc35ed448fPiresTânia C.S.P.Ciência IDhttps://www.ciencia-id.pt321E-2D96-00CAORCIDhttp://orcid.org0000-0002-3954-3833Researcher IDhttps://www.researcherid.comQ-2842-2018Scopus Author IDhttps://www.scopus.com57057440000PersonalMandim, FilipaDSpacehttp://dspace.org/items/bcc274d4-7e6c-46a8-8e49-2752f9dbfbcdDSpacehttp://dspace.org/items/bcc274d4-7e6c-46a8-8e49-2752f9dbfbcdMandimFilipaCiência IDhttps://www.ciencia-id.ptF318-9049-EB99ORCIDhttp://orcid.org0000-0002-6494-2326PersonalVaz, Josiana A.DSpacehttp://dspace.org/items/1c1a2cb9-5a36-47ba-bca0-ffcbef28df18DSpacehttp://dspace.org/items/1c1a2cb9-5a36-47ba-bca0-ffcbef28df18VazJosiana A.Ciência IDhttps://www.ciencia-id.pt171B-88BA-64F5ORCIDhttp://orcid.org0000-0002-6989-1169Scopus Author IDhttps://www.scopus.com16305323200PersonalCorrêa, Rúbia C.G.DSpacehttp://dspace.org/items/35cf5f0f-d5bc-49ad-9704-e6613e60f0fcDSpacehttp://dspace.org/items/35cf5f0f-d5bc-49ad-9704-e6613e60f0fcCorrêaRúbia C.G.Ciência IDhttps://www.ciencia-id.pt6C1F-2818-CBB5ORCIDhttp://orcid.org0000-0003-0269-4344Scopus Author IDhttps://www.scopus.com37661286600Oliveira, BeatrizPersonalBarros, LillianDSpacehttp://dspace.org/items/3af07ffe-f914-48ba-a5d5-efcf70fdce01DSpacehttp://dspace.org/items/3af07ffe-f914-48ba-a5d5-efcf70fdce01BarrosLillianCiência IDhttps://www.ciencia-id.pt9616-35CB-D001ORCIDhttp://orcid.org0000-0002-9050-5189Researcher IDhttps://www.researcherid.comJ-3600-2013Researcher IDhttps://www.researcherid.comJ-3600-2013Scopus Author IDhttps://www.scopus.com35236343600Scopus Author IDhttps://www.scopus.com57194900801HostingInstitutionOrganizationalBiblioteca Digital do IPBe-mailmailto:dspace@ipb.ptdspace@ipb.ptISSNIsPartOf2042-6496DOIIsPartOf10.1039/d2fo04107c2023-02-24T09:58:05Z20232023-01-01T00:00:00ZHandlehttp://hdl.handle.net/10198/27167http://purl.org/coar/access_right/c_abf2open accessPolyphenol-rich juiceHydroalcoholic extractPhenolic profileEssential oilNative fruitAntioxidantAcidEllagitanninsAnthocyaninsLeaves786878 bytesliteraturehttp://purl.org/coar/resource_type/c_6501journal article2023http://creativecommons.org/licenses/by/4.0/http://purl.org/coar/access_right/c_abf2application/pdffulltexthttps://bibliotecadigital.ipb.pt/bitstreams/fb2aa606-8f2d-4563-9266-4a3322f73260/downloadFood & Function |
| spellingShingle | Brazilian berry waste as a source of bioactive compounds: grumixama (Eugenia brasiliensis Lam.) as a case study Albuquerque, Bianca R. Polyphenol-rich juice Hydroalcoholic extract Phenolic profile Essential oil Native fruit Antioxidant Acid Ellagitannins Anthocyanins Leaves |
| subject.fl_str_mv | Polyphenol-rich juice Hydroalcoholic extract Phenolic profile Essential oil Native fruit Antioxidant Acid Ellagitannins Anthocyanins Leaves |
| title | Brazilian berry waste as a source of bioactive compounds: grumixama (Eugenia brasiliensis Lam.) as a case study |
| title_full | Brazilian berry waste as a source of bioactive compounds: grumixama (Eugenia brasiliensis Lam.) as a case study |
| title_fullStr | Brazilian berry waste as a source of bioactive compounds: grumixama (Eugenia brasiliensis Lam.) as a case study |
| title_full_unstemmed | Brazilian berry waste as a source of bioactive compounds: grumixama (Eugenia brasiliensis Lam.) as a case study |
| title_short | Brazilian berry waste as a source of bioactive compounds: grumixama (Eugenia brasiliensis Lam.) as a case study |
| title_sort | Brazilian berry waste as a source of bioactive compounds: grumixama (Eugenia brasiliensis Lam.) as a case study |
| topic | Polyphenol-rich juice Hydroalcoholic extract Phenolic profile Essential oil Native fruit Antioxidant Acid Ellagitannins Anthocyanins Leaves |
| topic_facet | Polyphenol-rich juice Hydroalcoholic extract Phenolic profile Essential oil Native fruit Antioxidant Acid Ellagitannins Anthocyanins Leaves |
| url | http://hdl.handle.net/10198/27167 |
| visible | 1 |