Publicação
A Tailor-made protocol to synthesize yolk-shell graphene-based magnetic nanoparticles for nanomedicine
| Resumo: | A simple tailor-made protocol to synthesize graphene-based magnetic nanoparticles (GbMNPs) for nanomedicine is herein reported. Different GbMNPs with very distinctive physicochemical and toxicological properties were synthesized by adjusting the number of carbon precursors in the coating of superparamagnetic iron oxide nanoparticles. In vitro tests show the ability to use these GbMNPs as intelligent and on-demand drug nanocarrier systems for drug delivery, exhibiting the following features: good colloidal stability, good loading capacity of the chemotherapeutic drug doxorubicin, high pH-controlled release of the encapsulated drug (targeting tumour acidic pH conditions), superparamagnetic behaviour and biocompatibility. Due to their combined properties (i.e., physicochemical, magnetic, and biocompatibility), GbMNPs show high potentiality to be combined with other biomedical techniques, such as magnetic hyperthermia, which can represent an enhancement in the treatment of cancer. |
|---|---|
| Autores principais: | Rodrigues, Raquel Oliveira |
| Outros Autores: | Baldi, Giovanni; Doumett, Saer; Gallo, Juan; Bañobre-López, Manuel; Dražić, Goran; Calhelha, Ricardo C.; Ferreira, Isabel C.F.R.; Lima, Rui A.; Silva, Adrián; Gomes, Helder |
| Assunto: | Graphene magnetic nanocomposites Drug delivery DOX cancer |
| Ano: | 2018 |
| País: | Portugal |
| Tipo de documento: | artigo |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Instituto Politécnico de Bragança |
| Idioma: | inglês |
| Origem: | Biblioteca Digital do IPB |
| _version_ | 1863851134206083072 |
|---|---|
| author | Rodrigues, Raquel Oliveira |
| author2 | Baldi, Giovanni Doumett, Saer Gallo, Juan Bañobre-López, Manuel Dražić, Goran Calhelha, Ricardo C. Ferreira, Isabel C.F.R. Lima, Rui A. Silva, Adrián Gomes, Helder |
| author2_role | author author author author author author author author author author |
| author_facet | Rodrigues, Raquel Oliveira Baldi, Giovanni Doumett, Saer Gallo, Juan Bañobre-López, Manuel Dražić, Goran Calhelha, Ricardo C. Ferreira, Isabel C.F.R. Lima, Rui A. Silva, Adrián Gomes, Helder |
| author_role | author |
| contributor_name_str_mv | Biblioteca Digital do IPB |
| country_str | PT |
| creators_json_str | [{\"Person.name\":\"Rodrigues, Raquel Oliveira\"},{\"Person.name\":\"Baldi, Giovanni\"},{\"Person.name\":\"Doumett, Saer\"},{\"Person.name\":\"Gallo, Juan\"},{\"Person.name\":\"Bañobre-López, Manuel\"},{\"Person.name\":\"Dražić, Goran\"},{\"Person.name\":\"Calhelha, Ricardo C.\",\"Person.identifier.orcid\":\"0000-0002-6801-4578\"},{\"Person.name\":\"Ferreira, Isabel C.F.R.\",\"Person.identifier.orcid\":\"0000-0003-4910-4882\"},{\"Person.name\":\"Lima, Rui A.\"},{\"Person.name\":\"Silva, Adrián\"},{\"Person.name\":\"Gomes, Helder\",\"Person.identifier.orcid\":\"0000-0001-6898-2408\"}] |
| datacite.contributors.contributor.contributorName.fl_str_mv | Biblioteca Digital do IPB |
| datacite.creators.creator.creatorName.fl_str_mv | Rodrigues, Raquel Oliveira Baldi, Giovanni Doumett, Saer Gallo, Juan Bañobre-López, Manuel Dražić, Goran Calhelha, Ricardo C. Ferreira, Isabel C.F.R. Lima, Rui A. Silva, Adrián Gomes, Helder |
| datacite.date.Accepted.fl_str_mv | 2018-01-01T00:00:00Z |
| datacite.date.available.fl_str_mv | 2020-01-03T12:04:26Z |
| datacite.date.embargoed.fl_str_mv | 2020-01-03T12:04:26Z |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| datacite.subjects.subject.fl_str_mv | Graphene magnetic nanocomposites Drug delivery DOX cancer |
| datacite.titles.title.fl_str_mv | A Tailor-made protocol to synthesize yolk-shell graphene-based magnetic nanoparticles for nanomedicine |
| dc.contributor.none.fl_str_mv | Biblioteca Digital do IPB |
| dc.creator.none.fl_str_mv | Rodrigues, Raquel Oliveira Baldi, Giovanni Doumett, Saer Gallo, Juan Bañobre-López, Manuel Dražić, Goran Calhelha, Ricardo C. Ferreira, Isabel C.F.R. Lima, Rui A. Silva, Adrián Gomes, Helder |
| dc.date.Accepted.fl_str_mv | 2018-01-01T00:00:00Z |
| dc.date.available.fl_str_mv | 2020-01-03T12:04:26Z |
| dc.date.embargoed.fl_str_mv | 2020-01-03T12:04:26Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | http://hdl.handle.net/10198/20005 |
| dc.language.none.fl_str_mv | eng |
| dc.rights.cclincense.fl_str_mv | http://creativecommons.org/licenses/by-nc/4.0/ |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| dc.subject.none.fl_str_mv | Graphene magnetic nanocomposites Drug delivery DOX cancer |
| dc.title.fl_str_mv | A Tailor-made protocol to synthesize yolk-shell graphene-based magnetic nanoparticles for nanomedicine |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_6501 |
| description | A simple tailor-made protocol to synthesize graphene-based magnetic nanoparticles (GbMNPs) for nanomedicine is herein reported. Different GbMNPs with very distinctive physicochemical and toxicological properties were synthesized by adjusting the number of carbon precursors in the coating of superparamagnetic iron oxide nanoparticles. In vitro tests show the ability to use these GbMNPs as intelligent and on-demand drug nanocarrier systems for drug delivery, exhibiting the following features: good colloidal stability, good loading capacity of the chemotherapeutic drug doxorubicin, high pH-controlled release of the encapsulated drug (targeting tumour acidic pH conditions), superparamagnetic behaviour and biocompatibility. Due to their combined properties (i.e., physicochemical, magnetic, and biocompatibility), GbMNPs show high potentiality to be combined with other biomedical techniques, such as magnetic hyperthermia, which can represent an enhancement in the treatment of cancer. |
| dirty | 0 |
| eu_rights_str_mv | openAccess |
| format | article |
| fulltext.url.fl_str_mv | https://bibliotecadigital.ipb.pt/bitstreams/c975a6ea-e9d8-4956-94fe-b7dff00b4af3/download |
| funding.funder.alternateName_str_mv | FCT |
| funding.funder.identifier_str_mv | http://doi.org/10.13039/501100001871 |
| funding.funder.name_str_mv | Fundação para a Ciência e a Tecnologia |
| id | ipb_eecfdd20a3752dd09aacaf5374538542 |
| identifier.url.fl_str_mv | http://hdl.handle.net/10198/20005 |
| instacron_str | ipb |
| institution | Instituto Politécnico de Bragança |
| instname_str | Instituto Politécnico de Bragança |
| language | eng |
| network_acronym_str | ipb |
| network_name_str | Biblioteca Digital do IPB |
| oai_identifier_str | oai:bibliotecadigital.ipb.pt:10198/20005 |
| organization_str_mv | urn:organizationAcronym:ipb |
| person_str_mv | Rodrigues, Raquel Oliveira Baldi, Giovanni Doumett, Saer Gallo, Juan Bañobre-López, Manuel Dražić, Goran Calhelha, Ricardo C. Calhelha, Ricardo C. https://www.ciencia-id.pt/F313-E3CE-554E F313-E3CE-554E http://orcid.org/0000-0002-6801-4578 0000-0002-6801-4578 Ferreira, Isabel C.F.R. Ferreira, Isabel C.F.R. https://www.ciencia-id.pt/9418-CF95-9919 9418-CF95-9919 http://orcid.org/0000-0003-4910-4882 0000-0003-4910-4882 Lima, Rui A. Silva, Adrián Gomes, Helder Gomes, Helder https://www.ciencia-id.pt/6218-1E19-13EE 6218-1E19-13EE http://orcid.org/0000-0001-6898-2408 0000-0001-6898-2408 |
| publishDate | 2018 |
| reponame_str | Biblioteca Digital do IPB |
| repository_id_str | urn:repositoryAcronym:ipb |
| service_str_mv | urn:repositoryAcronym:ipb |
| spelling | engpt_PTA simple tailor-made protocol to synthesize graphene-based magnetic nanoparticles (GbMNPs) for nanomedicine is herein reported. Different GbMNPs with very distinctive physicochemical and toxicological properties were synthesized by adjusting the number of carbon precursors in the coating of superparamagnetic iron oxide nanoparticles. In vitro tests show the ability to use these GbMNPs as intelligent and on-demand drug nanocarrier systems for drug delivery, exhibiting the following features: good colloidal stability, good loading capacity of the chemotherapeutic drug doxorubicin, high pH-controlled release of the encapsulated drug (targeting tumour acidic pH conditions), superparamagnetic behaviour and biocompatibility. Due to their combined properties (i.e., physicochemical, magnetic, and biocompatibility), GbMNPs show high potentiality to be combined with other biomedical techniques, such as magnetic hyperthermia, which can represent an enhancement in the treatment of cancer.application/pdfpt_PTA Tailor-made protocol to synthesize yolk-shell graphene-based magnetic nanoparticles for nanomedicineRodrigues, Raquel OliveiraBaldi, GiovanniDoumett, SaerGallo, JuanBañobre-López, ManuelDražić, GoranPersonalCalhelha, Ricardo C.DSpacehttp://dspace.org/items/2d5d1a41-7561-4a01-871c-b4c97da35053DSpacehttp://dspace.org/items/2d5d1a41-7561-4a01-871c-b4c97da35053CalhelhaRicardo C.Ciência IDhttps://www.ciencia-id.ptF313-E3CE-554EORCIDhttp://orcid.org0000-0002-6801-4578Researcher IDhttps://www.researcherid.comJ-2172-2014Scopus Author IDhttps://www.scopus.com6507978333PersonalFerreira, Isabel C.F.R.DSpacehttp://dspace.org/items/bd0d1537-2e03-41fb-b27a-140af9c35db8DSpacehttp://dspace.org/items/bd0d1537-2e03-41fb-b27a-140af9c35db8FerreiraIsabel C.F.R.Ciência IDhttps://www.ciencia-id.pt9418-CF95-9919ORCIDhttp://orcid.org0000-0003-4910-4882Researcher IDhttps://www.researcherid.comE-8500-2013Scopus Author IDhttps://www.scopus.com36868826600Lima, Rui A.Silva, AdriánPersonalGomes, HelderDSpacehttp://dspace.org/items/0eb96337-224a-4339-9918-334436fbbb99DSpacehttp://dspace.org/items/0eb96337-224a-4339-9918-334436fbbb99GomesHelder T.Ciência IDhttps://www.ciencia-id.pt6218-1E19-13EEORCIDhttp://orcid.org0000-0001-6898-2408HostingInstitutionOrganizationalBiblioteca Digital do IPBe-mailmailto:dspace@ipb.ptdspace@ipb.ptISSNIsPartOf2311-5629DOIIsPartOf10.3390/c40400552020-01-03T12:04:26Z20182018-01-01T00:00:00ZHandlehttp://hdl.handle.net/10198/20005http://purl.org/coar/access_right/c_abf2open accessGraphene magnetic nanocompositesDrug deliveryDOX cancer3419343 bytesFundação para a Ciência e a TecnologiaMAGNETIC CARBON NANOSTRUCTURES AND STUDY OF THEIR TRANSPORT IN MICROFLUIDIC DEVICES FOR HYPERTHERMIACrossref Funder IDhttp://doi.org/10.13039/501100001871literaturehttp://purl.org/coar/resource_type/c_6501journal article2018http://creativecommons.org/licenses/by-nc/4.0/http://purl.org/coar/access_right/c_abf2application/pdffulltexthttps://bibliotecadigital.ipb.pt/bitstreams/c975a6ea-e9d8-4956-94fe-b7dff00b4af3/downloadC - Journal of Carbon Research44 |
| spellingShingle | A Tailor-made protocol to synthesize yolk-shell graphene-based magnetic nanoparticles for nanomedicine Rodrigues, Raquel Oliveira Graphene magnetic nanocomposites Drug delivery DOX cancer |
| subject.fl_str_mv | Graphene magnetic nanocomposites Drug delivery DOX cancer |
| title | A Tailor-made protocol to synthesize yolk-shell graphene-based magnetic nanoparticles for nanomedicine |
| title_full | A Tailor-made protocol to synthesize yolk-shell graphene-based magnetic nanoparticles for nanomedicine |
| title_fullStr | A Tailor-made protocol to synthesize yolk-shell graphene-based magnetic nanoparticles for nanomedicine |
| title_full_unstemmed | A Tailor-made protocol to synthesize yolk-shell graphene-based magnetic nanoparticles for nanomedicine |
| title_short | A Tailor-made protocol to synthesize yolk-shell graphene-based magnetic nanoparticles for nanomedicine |
| title_sort | A Tailor-made protocol to synthesize yolk-shell graphene-based magnetic nanoparticles for nanomedicine |
| topic | Graphene magnetic nanocomposites Drug delivery DOX cancer |
| topic_facet | Graphene magnetic nanocomposites Drug delivery DOX cancer |
| url | http://hdl.handle.net/10198/20005 |
| visible | 1 |