Publicação
Phase equilibria of phenolic compounds in aqueous, organic and supercritical solvents
| Resumo: | Phenolic compounds are relevant chemicals in industrial and biological processes. Their production, either by synthesis or extraction from biological media, requires the knowledge of phase equilibrium data that is lacking considerably in the open literature. For this reason, we have been performing at our laboratory a series of experimental measurements of solubility in water (1,2] and organic solvents, focused on two important families of phenolics: hydroxybenzoic and phenylpropenoic acids. The analytical shake flask method was employed for generating the saturated solutions, followed by quantitative analysis by Uv-vis spectrophotometry and/or gravimetry [1,2]. Alternatively, a synthetic method using DSC is being implemented, as this is faster and requires smaller amounts of solid. For a better understanding of the solubilization process, the corresponding melting properties were determined by DSC, with the exception of those phenolics that decompose upon melting, such as Do-coumaric, gallic and caffeic acids. For these, the Marrero and Gani group-contribution procedure [3] was used to generate estimates of the melting properties [1]. Since the studied molecules are organic acids, dissociation constants were also determined by potentiometric titratpon. As these compounds represent a class of associating molecules containing different associating groups such as hydroxyl and carboxyl (in many cases with, multiple substitutions), a new methodology for modeling these multifunctional compounds with the cubic-plus-association (CM) equation of state was developed. In this, the three cubic term parameters (a0, ci and b) are obtained from correlations involving the critical temperature and pressure, and van der Waals volumes, while the association term parameters depend on the nature and positron of each associating group (1,2]. Results showed that this methodology for the pure component parameters can lead to a good description of the aqueous solubility of phenolics using a single, small and temperature independent binary interaction parameter in the physical contribution of CPA. Further results for organic and supercritical solvents using the same methodology will be presented during the meeting. |
|---|---|
| Autores principais: | Queimada, António |
| Outros Autores: | Direito, Filipe; Mota, Fátima L.; Pinho, Simão; Macedo, Eugénia A. |
| Assunto: | Phenolic compounds Organic solvents Supercritical solvents Solubility CPA |
| Ano: | 2009 |
| País: | Portugal |
| Tipo de documento: | documento de conferência |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Instituto Politécnico de Bragança |
| Idioma: | inglês |
| Origem: | Biblioteca Digital do IPB |
| _version_ | 1863850750579310592 |
|---|---|
| author | Queimada, António |
| author2 | Direito, Filipe Mota, Fátima L. Pinho, Simão Macedo, Eugénia A. |
| author2_role | author author author author |
| author_facet | Queimada, António Direito, Filipe Mota, Fátima L. Pinho, Simão Macedo, Eugénia A. |
| author_role | author |
| contributor_name_str_mv | Biblioteca Digital do IPB |
| country_str | PT |
| creators_json_str | [{\"Person.name\":\"Queimada, António\"},{\"Person.name\":\"Direito, Filipe\"},{\"Person.name\":\"Mota, Fátima L.\"},{\"Person.name\":\"Pinho, Simão\",\"Person.identifier.orcid\":\"0000-0002-9211-857X\"},{\"Person.name\":\"Macedo, Eugénia A.\"}] |
| datacite.contributors.contributor.contributorName.fl_str_mv | Biblioteca Digital do IPB |
| datacite.creators.creator.creatorName.fl_str_mv | Queimada, António Direito, Filipe Mota, Fátima L. Pinho, Simão Macedo, Eugénia A. |
| datacite.date.Accepted.fl_str_mv | 2009-01-01T00:00:00Z |
| datacite.date.available.fl_str_mv | 2010-08-04T10:32:20Z |
| datacite.date.embargoed.fl_str_mv | 2010-08-04T10:32:20Z |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| datacite.subjects.subject.fl_str_mv | Phenolic compounds Organic solvents Supercritical solvents Solubility CPA |
| datacite.titles.title.fl_str_mv | Phase equilibria of phenolic compounds in aqueous, organic and supercritical solvents |
| dc.contributor.none.fl_str_mv | Biblioteca Digital do IPB |
| dc.creator.none.fl_str_mv | Queimada, António Direito, Filipe Mota, Fátima L. Pinho, Simão Macedo, Eugénia A. |
| dc.date.Accepted.fl_str_mv | 2009-01-01T00:00:00Z |
| dc.date.available.fl_str_mv | 2010-08-04T10:32:20Z |
| dc.date.embargoed.fl_str_mv | 2010-08-04T10:32:20Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | http://hdl.handle.net/10198/2549 |
| dc.language.none.fl_str_mv | eng |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| dc.subject.none.fl_str_mv | Phenolic compounds Organic solvents Supercritical solvents Solubility CPA |
| dc.title.fl_str_mv | Phase equilibria of phenolic compounds in aqueous, organic and supercritical solvents |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_c94f |
| description | Phenolic compounds are relevant chemicals in industrial and biological processes. Their production, either by synthesis or extraction from biological media, requires the knowledge of phase equilibrium data that is lacking considerably in the open literature. For this reason, we have been performing at our laboratory a series of experimental measurements of solubility in water (1,2] and organic solvents, focused on two important families of phenolics: hydroxybenzoic and phenylpropenoic acids. The analytical shake flask method was employed for generating the saturated solutions, followed by quantitative analysis by Uv-vis spectrophotometry and/or gravimetry [1,2]. Alternatively, a synthetic method using DSC is being implemented, as this is faster and requires smaller amounts of solid. For a better understanding of the solubilization process, the corresponding melting properties were determined by DSC, with the exception of those phenolics that decompose upon melting, such as Do-coumaric, gallic and caffeic acids. For these, the Marrero and Gani group-contribution procedure [3] was used to generate estimates of the melting properties [1]. Since the studied molecules are organic acids, dissociation constants were also determined by potentiometric titratpon. As these compounds represent a class of associating molecules containing different associating groups such as hydroxyl and carboxyl (in many cases with, multiple substitutions), a new methodology for modeling these multifunctional compounds with the cubic-plus-association (CM) equation of state was developed. In this, the three cubic term parameters (a0, ci and b) are obtained from correlations involving the critical temperature and pressure, and van der Waals volumes, while the association term parameters depend on the nature and positron of each associating group (1,2]. Results showed that this methodology for the pure component parameters can lead to a good description of the aqueous solubility of phenolics using a single, small and temperature independent binary interaction parameter in the physical contribution of CPA. Further results for organic and supercritical solvents using the same methodology will be presented during the meeting. |
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| eu_rights_str_mv | openAccess |
| format | conferenceObject |
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| identifier.url.fl_str_mv | http://hdl.handle.net/10198/2549 |
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| institution | Instituto Politécnico de Bragança |
| instname_str | Instituto Politécnico de Bragança |
| language | eng |
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| organization_str_mv | urn:organizationAcronym:ipb |
| person_str_mv | Queimada, António Direito, Filipe Mota, Fátima L. Pinho, Simão Pinho, Simão https://www.ciencia-id.pt/481D-73AD-8D0F 481D-73AD-8D0F http://orcid.org/0000-0002-9211-857X 0000-0002-9211-857X Macedo, Eugénia A. |
| publishDate | 2009 |
| reponame_str | Biblioteca Digital do IPB |
| repository_id_str | urn:repositoryAcronym:ipb |
| service_str_mv | urn:repositoryAcronym:ipb |
| spelling | engptPhenolic compounds are relevant chemicals in industrial and biological processes. Their production, either by synthesis or extraction from biological media, requires the knowledge of phase equilibrium data that is lacking considerably in the open literature. For this reason, we have been performing at our laboratory a series of experimental measurements of solubility in water (1,2] and organic solvents, focused on two important families of phenolics: hydroxybenzoic and phenylpropenoic acids. The analytical shake flask method was employed for generating the saturated solutions, followed by quantitative analysis by Uv-vis spectrophotometry and/or gravimetry [1,2]. Alternatively, a synthetic method using DSC is being implemented, as this is faster and requires smaller amounts of solid. For a better understanding of the solubilization process, the corresponding melting properties were determined by DSC, with the exception of those phenolics that decompose upon melting, such as Do-coumaric, gallic and caffeic acids. For these, the Marrero and Gani group-contribution procedure [3] was used to generate estimates of the melting properties [1]. Since the studied molecules are organic acids, dissociation constants were also determined by potentiometric titratpon. As these compounds represent a class of associating molecules containing different associating groups such as hydroxyl and carboxyl (in many cases with, multiple substitutions), a new methodology for modeling these multifunctional compounds with the cubic-plus-association (CM) equation of state was developed. In this, the three cubic term parameters (a0, ci and b) are obtained from correlations involving the critical temperature and pressure, and van der Waals volumes, while the association term parameters depend on the nature and positron of each associating group (1,2]. Results showed that this methodology for the pure component parameters can lead to a good description of the aqueous solubility of phenolics using a single, small and temperature independent binary interaction parameter in the physical contribution of CPA. Further results for organic and supercritical solvents using the same methodology will be presented during the meeting.application/pdfptPhase equilibria of phenolic compounds in aqueous, organic and supercritical solventsQueimada, AntónioDireito, FilipeMota, Fátima L.PersonalPinho, SimãoDSpacehttp://dspace.org/items/8ef7789a-34f3-4915-a666-4efe26272a30DSpacehttp://dspace.org/items/8ef7789a-34f3-4915-a666-4efe26272a30PinhoSimãoCiência IDhttps://www.ciencia-id.pt481D-73AD-8D0FORCIDhttp://orcid.org0000-0002-9211-857XResearcher IDhttps://www.researcherid.comD-4148-2013Scopus Author IDhttps://www.scopus.com7003570175Macedo, Eugénia A.HostingInstitutionOrganizationalBiblioteca Digital do IPBe-mailmailto:dspace@ipb.ptdspace@ipb.pt2010-08-04T10:32:20Z20092009-01-01T00:00:00ZHandlehttp://hdl.handle.net/10198/2549http://purl.org/coar/access_right/c_abf2open accessPhenolic compoundsOrganic solventsSupercritical solventsSolubilityCPA843197 bytesother research producthttp://purl.org/coar/resource_type/c_c94fconference objecthttp://purl.org/coar/access_right/c_abf2application/pdffulltexthttps://bibliotecadigital.ipb.pt/bitstreams/3b060861-b97b-44e9-8e83-8583b48cb428/downloadEncontro Nacional de Química Física e 1st Iberian Meeting on Ionic LiquidsAveiro, Portugal |
| spellingShingle | Phase equilibria of phenolic compounds in aqueous, organic and supercritical solvents Queimada, António Phenolic compounds Organic solvents Supercritical solvents Solubility CPA |
| subject.fl_str_mv | Phenolic compounds Organic solvents Supercritical solvents Solubility CPA |
| title | Phase equilibria of phenolic compounds in aqueous, organic and supercritical solvents |
| title_full | Phase equilibria of phenolic compounds in aqueous, organic and supercritical solvents |
| title_fullStr | Phase equilibria of phenolic compounds in aqueous, organic and supercritical solvents |
| title_full_unstemmed | Phase equilibria of phenolic compounds in aqueous, organic and supercritical solvents |
| title_short | Phase equilibria of phenolic compounds in aqueous, organic and supercritical solvents |
| title_sort | Phase equilibria of phenolic compounds in aqueous, organic and supercritical solvents |
| topic | Phenolic compounds Organic solvents Supercritical solvents Solubility CPA |
| topic_facet | Phenolic compounds Organic solvents Supercritical solvents Solubility CPA |
| url | http://hdl.handle.net/10198/2549 |
| visible | 1 |