Publicação
Solubility studies of trans-cinnamic acid in mixed solvents
| Resumo: | Phenolic acids are a subclass of phenolic compounds with chemical and biological properties of interest in the pharmaceutical and food industries. The design of their extraction and separation processes includes the knowledge of their thermophysical properties as well as multicomponent solid-liquid equilibria data. For these compounds, even essential solubility data in pure organic solvents and water are scarce. Therefore, in this work, trans-cinnamic acid was chosen as a model compound for which only a few solubility data in pure water and alcohols can be found in the literature [1-3]. The solubility of trans-cinnamic acid in the mixed solvents water + ethanol, and water + methanol was measured, at 298.15 K, using the isothermal shake-flask method and quantitative analysis either by gravimetry or UV spectrophotometry. As can be seen in Fig. 1, the solubility of the acid can significantly increase with the addition of the alcohol, with a more pronounced effect induced by ethanol. In a complementary approach and aiming to search for other methods to increase the aqueous solubility of trans-cinnamic acid, the phase-solubility diagram was determined for systems containing α-cyclodextrin. References [1] J. Li, Z. Zeng, L. Sun, W. Xue, H. Wang, Journal of Chemical and Engineering Data, 61 (2016) 1192−1198. [2] F. Mota, A. Queimada,, S. Pinho, E. Macedo, Industrial and Engineering Chemistry Research, 47 (2008) 5182-5189. [3] Solubilities of Organic Compounds in Organic Solvents, J. Bradley, C. Neylon, R. Guha, A. Williams, B. Hooker, A. Lang, B. Friesen, Open Notebook Science, 2009. |
|---|---|
| Autores principais: | Soares, Bruna de Paula |
| Outros Autores: | Ferreira, Olga; Leite, Priscilla G.; Pinho, Simão |
| Assunto: | Solubility Phenolic compounds Mixed solvents |
| Ano: | 2016 |
| País: | Portugal |
| Tipo de documento: | documento de conferência |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Instituto Politécnico de Bragança |
| Idioma: | inglês |
| Origem: | Biblioteca Digital do IPB |
| _version_ | 1863851376811966464 |
|---|---|
| author | Soares, Bruna de Paula |
| author2 | Ferreira, Olga Leite, Priscilla G. Pinho, Simão |
| author2_role | author author author |
| author_facet | Soares, Bruna de Paula Ferreira, Olga Leite, Priscilla G. Pinho, Simão |
| author_role | author |
| contributor_name_str_mv | Biblioteca Digital do IPB |
| country_str | PT |
| creators_json_str | [{\"Person.name\":\"Soares, Bruna de Paula\"},{\"Person.name\":\"Ferreira, Olga\",\"Person.identifier.orcid\":\"0000-0001-8414-3479\"},{\"Person.name\":\"Leite, Priscilla G.\"},{\"Person.name\":\"Pinho, Simão\",\"Person.identifier.orcid\":\"0000-0002-9211-857X\"}] |
| datacite.contributors.contributor.contributorName.fl_str_mv | Biblioteca Digital do IPB |
| datacite.creators.creator.creatorName.fl_str_mv | Soares, Bruna de Paula Ferreira, Olga Leite, Priscilla G. Pinho, Simão |
| datacite.date.Accepted.fl_str_mv | 2016-01-01T00:00:00Z |
| datacite.date.available.fl_str_mv | 2017-03-06T12:45:11Z |
| datacite.date.embargoed.fl_str_mv | 2017-03-06T12:45:11Z |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| datacite.subjects.subject.fl_str_mv | Solubility Phenolic compounds Mixed solvents |
| datacite.titles.title.fl_str_mv | Solubility studies of trans-cinnamic acid in mixed solvents |
| dc.contributor.none.fl_str_mv | Biblioteca Digital do IPB |
| dc.creator.none.fl_str_mv | Soares, Bruna de Paula Ferreira, Olga Leite, Priscilla G. Pinho, Simão |
| dc.date.Accepted.fl_str_mv | 2016-01-01T00:00:00Z |
| dc.date.available.fl_str_mv | 2017-03-06T12:45:11Z |
| dc.date.embargoed.fl_str_mv | 2017-03-06T12:45:11Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | http://hdl.handle.net/10198/14091 |
| dc.language.none.fl_str_mv | eng |
| dc.publisher.none.fl_str_mv | Sociedade Portuguesa de Química |
| dc.rights.cclincense.fl_str_mv | http://creativecommons.org/licenses/by/4.0/ |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| dc.subject.none.fl_str_mv | Solubility Phenolic compounds Mixed solvents |
| dc.title.fl_str_mv | Solubility studies of trans-cinnamic acid in mixed solvents |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_c94f |
| description | Phenolic acids are a subclass of phenolic compounds with chemical and biological properties of interest in the pharmaceutical and food industries. The design of their extraction and separation processes includes the knowledge of their thermophysical properties as well as multicomponent solid-liquid equilibria data. For these compounds, even essential solubility data in pure organic solvents and water are scarce. Therefore, in this work, trans-cinnamic acid was chosen as a model compound for which only a few solubility data in pure water and alcohols can be found in the literature [1-3]. The solubility of trans-cinnamic acid in the mixed solvents water + ethanol, and water + methanol was measured, at 298.15 K, using the isothermal shake-flask method and quantitative analysis either by gravimetry or UV spectrophotometry. As can be seen in Fig. 1, the solubility of the acid can significantly increase with the addition of the alcohol, with a more pronounced effect induced by ethanol. In a complementary approach and aiming to search for other methods to increase the aqueous solubility of trans-cinnamic acid, the phase-solubility diagram was determined for systems containing α-cyclodextrin. References [1] J. Li, Z. Zeng, L. Sun, W. Xue, H. Wang, Journal of Chemical and Engineering Data, 61 (2016) 1192−1198. [2] F. Mota, A. Queimada,, S. Pinho, E. Macedo, Industrial and Engineering Chemistry Research, 47 (2008) 5182-5189. [3] Solubilities of Organic Compounds in Organic Solvents, J. Bradley, C. Neylon, R. Guha, A. Williams, B. Hooker, A. Lang, B. Friesen, Open Notebook Science, 2009. |
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| identifier.url.fl_str_mv | http://hdl.handle.net/10198/14091 |
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| institution | Instituto Politécnico de Bragança |
| instname_str | Instituto Politécnico de Bragança |
| language | eng |
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| person_str_mv | Soares, Bruna de Paula Ferreira, Olga Ferreira, Olga https://www.ciencia-id.pt/9F1D-C75A-4A54 9F1D-C75A-4A54 http://orcid.org/0000-0001-8414-3479 0000-0001-8414-3479 Leite, Priscilla G. Pinho, Simão Pinho, Simão https://www.ciencia-id.pt/481D-73AD-8D0F 481D-73AD-8D0F http://orcid.org/0000-0002-9211-857X 0000-0002-9211-857X |
| publishDate | 2016 |
| publisher.none.fl_str_mv | Sociedade Portuguesa de Química |
| reponame_str | Biblioteca Digital do IPB |
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| spelling | engSociedade Portuguesa de Químicapt_PTPhenolic acids are a subclass of phenolic compounds with chemical and biological properties of interest in the pharmaceutical and food industries. The design of their extraction and separation processes includes the knowledge of their thermophysical properties as well as multicomponent solid-liquid equilibria data. For these compounds, even essential solubility data in pure organic solvents and water are scarce. Therefore, in this work, trans-cinnamic acid was chosen as a model compound for which only a few solubility data in pure water and alcohols can be found in the literature [1-3]. The solubility of trans-cinnamic acid in the mixed solvents water + ethanol, and water + methanol was measured, at 298.15 K, using the isothermal shake-flask method and quantitative analysis either by gravimetry or UV spectrophotometry. As can be seen in Fig. 1, the solubility of the acid can significantly increase with the addition of the alcohol, with a more pronounced effect induced by ethanol. In a complementary approach and aiming to search for other methods to increase the aqueous solubility of trans-cinnamic acid, the phase-solubility diagram was determined for systems containing α-cyclodextrin. References [1] J. Li, Z. Zeng, L. Sun, W. Xue, H. Wang, Journal of Chemical and Engineering Data, 61 (2016) 1192−1198. [2] F. Mota, A. Queimada,, S. Pinho, E. Macedo, Industrial and Engineering Chemistry Research, 47 (2008) 5182-5189. [3] Solubilities of Organic Compounds in Organic Solvents, J. Bradley, C. Neylon, R. Guha, A. Williams, B. Hooker, A. Lang, B. Friesen, Open Notebook Science, 2009.application/pdfpt_PTSolubility studies of trans-cinnamic acid in mixed solventsSoares, Bruna de PaulaPersonalFerreira, OlgaDSpacehttp://dspace.org/items/59e0c608-0c21-4191-af5e-529d21970399DSpacehttp://dspace.org/items/59e0c608-0c21-4191-af5e-529d21970399FerreiraOlgaCiência IDhttps://www.ciencia-id.pt9F1D-C75A-4A54ORCIDhttp://orcid.org0000-0001-8414-3479Researcher IDhttps://www.researcherid.comM-4567-2013Scopus Author IDhttps://www.scopus.com57203083219Leite, Priscilla G.PersonalPinho, SimãoDSpacehttp://dspace.org/items/8ef7789a-34f3-4915-a666-4efe26272a30DSpacehttp://dspace.org/items/8ef7789a-34f3-4915-a666-4efe26272a30PinhoSimãoCiência IDhttps://www.ciencia-id.pt481D-73AD-8D0FORCIDhttp://orcid.org0000-0002-9211-857XResearcher IDhttps://www.researcherid.comD-4148-2013Scopus Author IDhttps://www.scopus.com7003570175HostingInstitutionOrganizationalBiblioteca Digital do IPBe-mailmailto:dspace@ipb.ptdspace@ipb.ptISBNIsPartOf978-989-8124-17-32017-03-06T12:45:11Z20162016-01-01T00:00:00ZHandlehttp://hdl.handle.net/10198/14091http://purl.org/coar/access_right/c_abf2open accessSolubilityPhenolic compoundsMixed solvents613048 bytesother research producthttp://purl.org/coar/resource_type/c_c94fconference object2016http://creativecommons.org/licenses/by/4.0/http://purl.org/coar/access_right/c_abf2application/pdffulltexthttps://bibliotecadigital.ipb.pt/bitstreams/981389b3-0b9c-49ec-827e-55670943009c/downloadXXII Encontro Luso-Galego de Química113Instituto Politécnico de Bragança |
| spellingShingle | Solubility studies of trans-cinnamic acid in mixed solvents Soares, Bruna de Paula Solubility Phenolic compounds Mixed solvents |
| subject.fl_str_mv | Solubility Phenolic compounds Mixed solvents |
| title | Solubility studies of trans-cinnamic acid in mixed solvents |
| title_full | Solubility studies of trans-cinnamic acid in mixed solvents |
| title_fullStr | Solubility studies of trans-cinnamic acid in mixed solvents |
| title_full_unstemmed | Solubility studies of trans-cinnamic acid in mixed solvents |
| title_short | Solubility studies of trans-cinnamic acid in mixed solvents |
| title_sort | Solubility studies of trans-cinnamic acid in mixed solvents |
| topic | Solubility Phenolic compounds Mixed solvents |
| topic_facet | Solubility Phenolic compounds Mixed solvents |
| url | http://hdl.handle.net/10198/14091 |
| visible | 1 |