Publicação
Evolutionarily conserved role of oxytocin in social fear contagion in zebrafish
| Resumo: | Emotional contagion is the most ancestral form of empathy. We tested to what extent the proximate mechanisms of emotional contagion are evolutionarily conserved by assessing the role of oxytocin, known to regulate empathic behaviors in mammals, in social fear contagion in zebrafish. Using oxytocin and oxytocin receptor mutants, we show that oxytocin is both necessary and sufficient for observer zebrafish to imitate the distressed behavior of conspecific demonstrators. The brain regions associated with emotional contagion in zebrafish are homologous to those involved in the same process in rodents (e.g., striatum, lateral septum), receiving direct projections from oxytocinergic neurons located in the pre-optic area. Together, our results support an evolutionary conserved role for oxytocin as a key regulator of basic empathic behaviors across vertebrates. Copyright © 2023 The Authors, some rights reserved. |
|---|---|
| Autores principais: | Akinrinade, Ibukun |
| Outros Autores: | Kareklas, Kyriacos; Teles, Magda C; Reis, Thais K.; Gliksberg, Michael; Petri, Giovanni; Levkowitz, Gil; Oliveira, Rui F. |
| Assunto: | Animals Emotions Empathy Fear Oxytocin Rodentia Social Behavior Zebrafish |
| Ano: | 2023 |
| País: | Portugal |
| Tipo de documento: | artigo |
| Tipo de acesso: | acesso restrito |
| Instituição associada: | Ispa-Instituto Universitário |
| Idioma: | inglês |
| Origem: | Repositório do Ispa - Instituto Universitário |
| _version_ | 1868077118652416000 |
|---|---|
| author | Akinrinade, Ibukun |
| author2 | Kareklas, Kyriacos Teles, Magda C Reis, Thais K. Gliksberg, Michael Petri, Giovanni Levkowitz, Gil Oliveira, Rui F. |
| author2_role | author author author author author author author |
| author_facet | Akinrinade, Ibukun Kareklas, Kyriacos Teles, Magda C Reis, Thais K. Gliksberg, Michael Petri, Giovanni Levkowitz, Gil Oliveira, Rui F. |
| author_role | author |
| contributor_name_str_mv | Repositório do ISPA |
| country_str | PT |
| creators_json_txt | [{\"Person.name\":\"Akinrinade, Ibukun\",\"Person.identifier.orcid\":\"0000-0002-4018-2641\"},{\"Person.name\":\"Kareklas, Kyriacos\",\"Person.identifier.orcid\":\"0000-0003-2453-9556\"},{\"Person.name\":\"Teles, Magda C\",\"Person.identifier.orcid\":\"0000-0002-3051-8332\"},{\"Person.name\":\"Reis, Thais K.\"},{\"Person.name\":\"Gliksberg, Michael\",\"Person.identifier.orcid\":\"0000-0002-4480-0494\"},{\"Person.name\":\"Petri, Giovanni\",\"Person.identifier.orcid\":\"0000-0003-1847-5031\"},{\"Person.name\":\"Levkowitz, Gil\",\"Person.identifier.orcid\":\"0000-0002-3896-1881\"},{\"Person.name\":\"Oliveira, Rui F.\",\"Person.identifier.orcid\":\"0000-0003-1528-618X\"}] |
| datacite.contributors.contributor.contributorName.fl_str_mv | Repositório do ISPA |
| datacite.creators.creator.creatorName.fl_str_mv | Akinrinade, Ibukun Kareklas, Kyriacos Teles, Magda C Reis, Thais K. Gliksberg, Michael Petri, Giovanni Levkowitz, Gil Oliveira, Rui F. |
| datacite.date.Accepted.fl_str_mv | 2023-01-01T00:00:00Z |
| datacite.date.available.fl_str_mv | 2024-04-04T15:36:27Z |
| datacite.date.embargoed.fl_str_mv | 2024-04-04T15:36:27Z |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_16ec |
| datacite.subjects.subject.fl_str_mv | Animals Emotions Empathy Fear Oxytocin Rodentia Social Behavior Zebrafish |
| datacite.titles.title.fl_str_mv | Evolutionarily conserved role of oxytocin in social fear contagion in zebrafish |
| dc.contributor.none.fl_str_mv | Repositório do ISPA |
| dc.creator.none.fl_str_mv | Akinrinade, Ibukun Kareklas, Kyriacos Teles, Magda C Reis, Thais K. Gliksberg, Michael Petri, Giovanni Levkowitz, Gil Oliveira, Rui F. |
| dc.date.Accepted.fl_str_mv | 2023-01-01T00:00:00Z |
| dc.date.available.fl_str_mv | 2024-04-04T15:36:27Z |
| dc.date.embargoed.fl_str_mv | 2024-04-04T15:36:27Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | http://hdl.handle.net/10400.12/9710 |
| dc.language.none.fl_str_mv | eng |
| dc.publisher.none.fl_str_mv | American Association for the Advancement of Science |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_16ec |
| dc.subject.none.fl_str_mv | Animals Emotions Empathy Fear Oxytocin Rodentia Social Behavior Zebrafish |
| dc.title.fl_str_mv | Evolutionarily conserved role of oxytocin in social fear contagion in zebrafish |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_6501 |
| description | Emotional contagion is the most ancestral form of empathy. We tested to what extent the proximate mechanisms of emotional contagion are evolutionarily conserved by assessing the role of oxytocin, known to regulate empathic behaviors in mammals, in social fear contagion in zebrafish. Using oxytocin and oxytocin receptor mutants, we show that oxytocin is both necessary and sufficient for observer zebrafish to imitate the distressed behavior of conspecific demonstrators. The brain regions associated with emotional contagion in zebrafish are homologous to those involved in the same process in rodents (e.g., striatum, lateral septum), receiving direct projections from oxytocinergic neurons located in the pre-optic area. Together, our results support an evolutionary conserved role for oxytocin as a key regulator of basic empathic behaviors across vertebrates. Copyright © 2023 The Authors, some rights reserved. |
| dirty | 0 |
| eu_rights_str_mv | restrictedAccess |
| format | article |
| fulltext.url.fl_str_mv | https://repositorio.ispa.pt/bitstreams/d6b2c35b-3dda-467e-96f5-01d5e89e52c6/download |
| id | ispa_838c19a572c1bbf59ef1279797ee898c |
| identifier.url.fl_str_mv | http://hdl.handle.net/10400.12/9710 |
| instacron_str | ispa |
| institution | Ispa-Instituto Universitário |
| instname_str | Ispa-Instituto Universitário |
| language | eng |
| network_acronym_str | ispa |
| network_name_str | Repositório do Ispa - Instituto Universitário |
| oai_identifier_str | oai:repositorio.ispa.pt:10400.12/9710 |
| organization_str_mv | urn:organizationAcronym:ispa |
| person_str_mv | Akinrinade, Ibukun Akinrinade, Ibukun http://orcid.org/0000-0002-4018-2641 0000-0002-4018-2641 Kareklas, Kyriacos Kareklas, Kyriacos http://orcid.org/0000-0003-2453-9556 0000-0003-2453-9556 Teles, Magda C Teles, Magda C https://www.ciencia-id.pt/E81E-61AE-44BC E81E-61AE-44BC http://orcid.org/0000-0002-3051-8332 0000-0002-3051-8332 Reis, Thais K. Gliksberg, Michael Gliksberg, Michael http://orcid.org/0000-0002-4480-0494 0000-0002-4480-0494 Petri, Giovanni Petri, Giovanni https://www.ciencia-id.pt/0319-D788-C2EC 0319-D788-C2EC http://orcid.org/0000-0003-1847-5031 0000-0003-1847-5031 Levkowitz, Gil Levkowitz, Gil https://www.ciencia-id.pt/5611-5DC0-F794 5611-5DC0-F794 http://orcid.org/0000-0002-3896-1881 0000-0002-3896-1881 Oliveira, Rui F. Oliveira, Rui F. https://www.ciencia-id.pt/611C-50AD-6CE7 611C-50AD-6CE7 http://orcid.org/0000-0003-1528-618X 0000-0003-1528-618X |
| publishDate | 2023 |
| publisher.none.fl_str_mv | American Association for the Advancement of Science |
| reponame_str | Repositório do Ispa - Instituto Universitário |
| repository_id_str | urn:repositoryAcronym:ispa |
| service_str_mv | urn:repositoryAcronym:ispa |
| spelling | engAmerican Association for the Advancement of Sciencept_PTEmotional contagion is the most ancestral form of empathy. We tested to what extent the proximate mechanisms of emotional contagion are evolutionarily conserved by assessing the role of oxytocin, known to regulate empathic behaviors in mammals, in social fear contagion in zebrafish. Using oxytocin and oxytocin receptor mutants, we show that oxytocin is both necessary and sufficient for observer zebrafish to imitate the distressed behavior of conspecific demonstrators. The brain regions associated with emotional contagion in zebrafish are homologous to those involved in the same process in rodents (e.g., striatum, lateral septum), receiving direct projections from oxytocinergic neurons located in the pre-optic area. Together, our results support an evolutionary conserved role for oxytocin as a key regulator of basic empathic behaviors across vertebrates. Copyright © 2023 The Authors, some rights reserved.application/pdfpt_PTEvolutionarily conserved role of oxytocin in social fear contagion in zebrafishPersonalAkinrinade, IbukunDSpacehttp://dspace.org/items/fbf3fb2f-3fdb-4499-ac06-2ba30eb849b0DSpacehttp://dspace.org/items/fbf3fb2f-3fdb-4499-ac06-2ba30eb849b0AkinrinadeIbukunORCIDhttp://orcid.org0000-0002-4018-2641Scopus Author IDhttps://www.scopus.com55923137600PersonalKareklas, KyriacosDSpacehttp://dspace.org/items/dcba9b58-8e19-4d94-a75b-a9d162d09985DSpacehttp://dspace.org/items/dcba9b58-8e19-4d94-a75b-a9d162d09985KareklasKyriacosORCIDhttp://orcid.org0000-0003-2453-9556PersonalTeles, Magda CDSpacehttp://dspace.org/items/56a9d10c-8d25-4635-a714-03a0eda7fcd4DSpacehttp://dspace.org/items/56a9d10c-8d25-4635-a714-03a0eda7fcd4TelesMagda CCiência IDhttps://www.ciencia-id.ptE81E-61AE-44BCORCIDhttp://orcid.org0000-0002-3051-8332Scopus Author IDhttps://www.scopus.com16200314100Reis, Thais K.PersonalGliksberg, MichaelDSpacehttp://dspace.org/items/013ee029-5d73-433a-a73c-077dedf09849DSpacehttp://dspace.org/items/013ee029-5d73-433a-a73c-077dedf09849GliksbergMichaelORCIDhttp://orcid.org0000-0002-4480-0494PersonalPetri, GiovanniDSpacehttp://dspace.org/items/bec3cfd8-e68b-4874-8968-5b65af38f172DSpacehttp://dspace.org/items/bec3cfd8-e68b-4874-8968-5b65af38f172PetriGiovanniCiência IDhttps://www.ciencia-id.pt0319-D788-C2ECORCIDhttp://orcid.org0000-0003-1847-5031PersonalLevkowitz, GilDSpacehttp://dspace.org/items/832c77f5-baab-447d-86d1-8f65f05bb774DSpacehttp://dspace.org/items/832c77f5-baab-447d-86d1-8f65f05bb774LevkowitzGilCiência IDhttps://www.ciencia-id.pt5611-5DC0-F794ORCIDhttp://orcid.org0000-0002-3896-1881Scopus Author IDhttps://www.scopus.com6602661063PersonalOliveira, Rui F.DSpacehttp://dspace.org/items/52f01205-dce9-433b-85c5-6390488b1eeeDSpacehttp://dspace.org/items/52f01205-dce9-433b-85c5-6390488b1eeeOliveiraRuiCiência IDhttps://www.ciencia-id.pt611C-50AD-6CE7ORCIDhttp://orcid.org0000-0003-1528-618XResearcher IDhttps://www.researcherid.comA-3581-2013Scopus Author IDhttps://www.scopus.com35561080400HostingInstitutionOrganizationalRepositório do ISPAe-mailmailto:repositorio@ispa.ptrepositorio@ispa.ptISSNIsPartOf10959203DOIIsPartOf10.1126/science.abq51582024-04-04T15:36:27Z20232023-01-01T00:00:00ZHandlehttp://hdl.handle.net/10400.12/9710http://purl.org/coar/access_right/c_16ecrestricted accessAnimalsEmotionsEmpathyFearOxytocinRodentiaSocial BehaviorZebrafish2858882 bytesliteraturehttp://purl.org/coar/resource_type/c_6501journal articlehttp://purl.org/coar/access_right/c_16ecapplication/pdffulltexthttps://repositorio.ispa.pt/bitstreams/d6b2c35b-3dda-467e-96f5-01d5e89e52c6/downloadScience379663812321237United States |
| spellingShingle | Evolutionarily conserved role of oxytocin in social fear contagion in zebrafish Akinrinade, Ibukun Animals Emotions Empathy Fear Oxytocin Rodentia Social Behavior Zebrafish |
| status | SINGLETON |
| subject.fl_str_mv | Animals Emotions Empathy Fear Oxytocin Rodentia Social Behavior Zebrafish |
| title | Evolutionarily conserved role of oxytocin in social fear contagion in zebrafish |
| title_full | Evolutionarily conserved role of oxytocin in social fear contagion in zebrafish |
| title_fullStr | Evolutionarily conserved role of oxytocin in social fear contagion in zebrafish |
| title_full_unstemmed | Evolutionarily conserved role of oxytocin in social fear contagion in zebrafish |
| title_short | Evolutionarily conserved role of oxytocin in social fear contagion in zebrafish |
| title_sort | Evolutionarily conserved role of oxytocin in social fear contagion in zebrafish |
| topic | Animals Emotions Empathy Fear Oxytocin Rodentia Social Behavior Zebrafish |
| topic_facet | Animals Emotions Empathy Fear Oxytocin Rodentia Social Behavior Zebrafish |
| url | http://hdl.handle.net/10400.12/9710 |
| visible | 1 |