Publicação
The effect of flaxseed in breast cancer: A Literature Review
| Resumo: | Breast cancer is one of the most common cancers and the second most responsible for cancer mortality worldwide. In 2014, in Portugal approximately 27,200 people died of cancer, of which 1,791 were women with breast cancer. Flaxseed has been one of the most studied foods, regarding possible relations to breast cancer, though mainly in experimental studies in animals, yet in few clinical trials. It is rich in omega-3 fatty acids, α-linolenic acid, lignan, and fibers. One of the main components of flaxseed is the lignans, of which 95% are made of the predominant secoisolariciresinol diglucoside (SDG). SDG is converted into enterolactone and enterodiol, both with antiestrogen activity and structurally similar to estrogen; they can bind to cell receptors, decreasing cell growth. Some studies have shown that the intake of omega-3 fatty acids is related to the reduction of breast cancer risk. In animal studies, α-linolenic acids have been shown to be able to suppress growth, size, and proliferation of cancer cells and also to promote breast cancer cell death. Other animal studies found that the intake of flaxseed combined with tamoxifen can reduce tumor size to a greater extent than taking tamoxifen alone. Additionally, some clinical trials showed that flaxseed can have an important role in decreasing breast cancer risk, mainly in postmenopausal women. Further studies are needed, specifically clinical trials that may demonstrate the potential benefits of flaxseed in breast cancer. |
|---|---|
| Autores principais: | Calado, Ana |
| Outros Autores: | Neves, Pedro Miguel; Santos, Teresa Cristina; Ravasco, Paula |
| Assunto: | Breast cancer Flaxseed Lignan Nutrition Omega-3 |
| Ano: | 2018 |
| País: | Portugal |
| Tipo de documento: | artigo |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Ispa-Instituto Universitário |
| Idioma: | inglês |
| Origem: | Repositório do Ispa - Instituto Universitário |
| _version_ | 1866252596160757760 |
|---|---|
| author | Calado, Ana |
| author2 | Neves, Pedro Miguel Santos, Teresa Cristina Ravasco, Paula |
| author2_role | author author author |
| author_facet | Calado, Ana Neves, Pedro Miguel Santos, Teresa Cristina Ravasco, Paula |
| author_role | author |
| contributor_name_str_mv | Repositório do ISPA |
| country_str | PT |
| creators_json_txt | [{\"Person.name\":\"Calado, Ana\"},{\"Person.name\":\"Neves, Pedro Miguel\"},{\"Person.name\":\"Santos, Teresa Cristina\"},{\"Person.name\":\"Ravasco, Paula\"}] |
| datacite.contributors.contributor.contributorName.fl_str_mv | Repositório do ISPA |
| datacite.creators.creator.creatorName.fl_str_mv | Calado, Ana Neves, Pedro Miguel Santos, Teresa Cristina Ravasco, Paula |
| datacite.date.Accepted.fl_str_mv | 2018-01-01T00:00:00Z |
| datacite.date.available.fl_str_mv | 2018-03-28T09:41:34Z |
| datacite.date.embargoed.fl_str_mv | 2018-03-28T09:41:34Z |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| datacite.subjects.subject.fl_str_mv | Breast cancer Flaxseed Lignan Nutrition Omega-3 |
| datacite.titles.title.fl_str_mv | The effect of flaxseed in breast cancer: A Literature Review |
| dc.contributor.none.fl_str_mv | Repositório do ISPA |
| dc.creator.none.fl_str_mv | Calado, Ana Neves, Pedro Miguel Santos, Teresa Cristina Ravasco, Paula |
| dc.date.Accepted.fl_str_mv | 2018-01-01T00:00:00Z |
| dc.date.available.fl_str_mv | 2018-03-28T09:41:34Z |
| dc.date.embargoed.fl_str_mv | 2018-03-28T09:41:34Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | http://hdl.handle.net/10400.12/6305 |
| dc.language.none.fl_str_mv | eng |
| dc.publisher.none.fl_str_mv | Frontiers Media |
| dc.rights.cclincense.fl_str_mv | http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| dc.subject.none.fl_str_mv | Breast cancer Flaxseed Lignan Nutrition Omega-3 |
| dc.title.fl_str_mv | The effect of flaxseed in breast cancer: A Literature Review |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_6501 |
| description | Breast cancer is one of the most common cancers and the second most responsible for cancer mortality worldwide. In 2014, in Portugal approximately 27,200 people died of cancer, of which 1,791 were women with breast cancer. Flaxseed has been one of the most studied foods, regarding possible relations to breast cancer, though mainly in experimental studies in animals, yet in few clinical trials. It is rich in omega-3 fatty acids, α-linolenic acid, lignan, and fibers. One of the main components of flaxseed is the lignans, of which 95% are made of the predominant secoisolariciresinol diglucoside (SDG). SDG is converted into enterolactone and enterodiol, both with antiestrogen activity and structurally similar to estrogen; they can bind to cell receptors, decreasing cell growth. Some studies have shown that the intake of omega-3 fatty acids is related to the reduction of breast cancer risk. In animal studies, α-linolenic acids have been shown to be able to suppress growth, size, and proliferation of cancer cells and also to promote breast cancer cell death. Other animal studies found that the intake of flaxseed combined with tamoxifen can reduce tumor size to a greater extent than taking tamoxifen alone. Additionally, some clinical trials showed that flaxseed can have an important role in decreasing breast cancer risk, mainly in postmenopausal women. Further studies are needed, specifically clinical trials that may demonstrate the potential benefits of flaxseed in breast cancer. |
| dirty | 0 |
| eu_rights_str_mv | openAccess |
| format | article |
| fulltext.url.fl_str_mv | https://repositorio.ispa.pt/bitstreams/544a44c9-3df3-4e1f-80fe-572104644e93/download |
| id | ispa_a00489d02603d2dd3a6a8d3cead1ce0f |
| identifier.url.fl_str_mv | http://hdl.handle.net/10400.12/6305 |
| instacron_str | ispa |
| institution | Ispa-Instituto Universitário |
| instname_str | Ispa-Instituto Universitário |
| language | eng |
| network_acronym_str | ispa |
| network_name_str | Repositório do Ispa - Instituto Universitário |
| oai_identifier_str | oai:repositorio.ispa.pt:10400.12/6305 |
| organization_str_mv | urn:organizationAcronym:ispa |
| person_str_mv | Calado, Ana Neves, Pedro Miguel Santos, Teresa Cristina Ravasco, Paula |
| publishDate | 2018 |
| publisher.none.fl_str_mv | Frontiers Media |
| reponame_str | Repositório do Ispa - Instituto Universitário |
| repository_id_str | urn:repositoryAcronym:ispa |
| service_str_mv | urn:repositoryAcronym:ispa |
| spelling | engFrontiers Mediapt_PTBreast cancer is one of the most common cancers and the second most responsible for cancer mortality worldwide. In 2014, in Portugal approximately 27,200 people died of cancer, of which 1,791 were women with breast cancer. Flaxseed has been one of the most studied foods, regarding possible relations to breast cancer, though mainly in experimental studies in animals, yet in few clinical trials. It is rich in omega-3 fatty acids, α-linolenic acid, lignan, and fibers. One of the main components of flaxseed is the lignans, of which 95% are made of the predominant secoisolariciresinol diglucoside (SDG). SDG is converted into enterolactone and enterodiol, both with antiestrogen activity and structurally similar to estrogen; they can bind to cell receptors, decreasing cell growth. Some studies have shown that the intake of omega-3 fatty acids is related to the reduction of breast cancer risk. In animal studies, α-linolenic acids have been shown to be able to suppress growth, size, and proliferation of cancer cells and also to promote breast cancer cell death. Other animal studies found that the intake of flaxseed combined with tamoxifen can reduce tumor size to a greater extent than taking tamoxifen alone. Additionally, some clinical trials showed that flaxseed can have an important role in decreasing breast cancer risk, mainly in postmenopausal women. Further studies are needed, specifically clinical trials that may demonstrate the potential benefits of flaxseed in breast cancer.application/pdfpt_PTThe effect of flaxseed in breast cancer: A Literature ReviewCalado, AnaNeves, Pedro MiguelSantos, Teresa CristinaRavasco, PaulaHostingInstitutionOrganizationalRepositório do ISPAe-mailmailto:repositorio@ispa.ptrepositorio@ispa.ptURNIsPartOf2296-861XDOIIsPartOf10.3389/fnut.2018.000042018-03-28T09:41:34Z20182018-01-01T00:00:00ZHandlehttp://hdl.handle.net/10400.12/6305http://purl.org/coar/access_right/c_abf2open accessBreast cancerFlaxseedLignanNutritionOmega-3457901 bytesliteraturehttp://purl.org/coar/resource_type/c_6501journal article2018http://creativecommons.org/licenses/by-nc-nd/4.0/http://purl.org/coar/access_right/c_abf2application/pdffulltexthttps://repositorio.ispa.pt/bitstreams/544a44c9-3df3-4e1f-80fe-572104644e93/downloadFrontiers in Nutrition517França |
| spellingShingle | The effect of flaxseed in breast cancer: A Literature Review Calado, Ana Breast cancer Flaxseed Lignan Nutrition Omega-3 |
| status | SINGLETON |
| subject.fl_str_mv | Breast cancer Flaxseed Lignan Nutrition Omega-3 |
| title | The effect of flaxseed in breast cancer: A Literature Review |
| title_full | The effect of flaxseed in breast cancer: A Literature Review |
| title_fullStr | The effect of flaxseed in breast cancer: A Literature Review |
| title_full_unstemmed | The effect of flaxseed in breast cancer: A Literature Review |
| title_short | The effect of flaxseed in breast cancer: A Literature Review |
| title_sort | The effect of flaxseed in breast cancer: A Literature Review |
| topic | Breast cancer Flaxseed Lignan Nutrition Omega-3 |
| topic_facet | Breast cancer Flaxseed Lignan Nutrition Omega-3 |
| url | http://hdl.handle.net/10400.12/6305 |
| visible | 1 |