Publicação
Effect of exercise on cardiometabolic health of adults with overweight or obesity: Focus on blood pressure, insulin resistance, and intrahepatic fat—A systematic review and meta‐analysis
| Resumo: | This systematic review examined the impact of exercise intervention programs on selected cardiometabolic health indicators in adults with overweight or obesity. Three electronic databases were explored for randomized controlled trials (RCTs) that included adults with overweight or obesity and provided exercise-training interventions. Effects on blood pressure, insulin resistance (homeostasis model of insulin resistance, HOMA-IR), and magnetic resonance measures of intrahepatic fat in exercise versus control groups were analyzed using random effects meta-analyses. Fifty-four articles matched inclusion criteria. Exercise training reduced systolic and diastolic blood pressure (mean difference, MD = -2.95 mmHg [95% CI -4.22, -1.68], p < 0.00001, I2 = 63% and MD = -1.93 mmHg [95% CI -2.73, -1.13], p < 0.00001, I2 = 54%, 60 and 58 study arms, respectively). Systolic and diastolic blood pressure decreased also when considering only subjects with hypertension. Exercise training significantly decreased HOMA-IR (standardized mean difference, SMD = -0.34 [-0.49, -0.18], p < 0.0001, I2 = 48%, 37 study arms), with higher effect size in subgroup of patients with type 2 diabetes (SMD = -0.50 [95% CI: -0.83, -0.17], p = 0.003, I2 = 39%). Intrahepatic fat decreased significantly after exercise interventions (SMD = -0.59 [95% CI: -0.78, -0.41], p < 0.00001, I2 = 0%), with a larger effect size after high-intensity interval training. In conclusion, exercise training is effective in improving cardiometabolic health in adults with overweight or obesity also when living with comorbitidies. |
|---|---|
| Autores principais: | Battista, Francesca |
| Outros Autores: | Ermolao, Andrea; Van Baak, Marleen; Beaulieu, Kristine; Blundell, John; Busetto, Luca; Carraça, Eliana V.; Encantado, Jorge; Dicker, Dror; Farpour-Lambert, Nathalie; Pramono, Adriyan; Bellicha, Alice; Oppert, Jean-Michel |
| Assunto: | Hypertension Insulin resistance Morbid obesity NAFLD Physical activity Morbid obesity, Type 2 diabetes |
| Ano: | 2021 |
| País: | Portugal |
| Tipo de documento: | artigo |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Ispa-Instituto Universitário |
| Idioma: | inglês |
| Origem: | Repositório do Ispa - Instituto Universitário |
| _version_ | 1866886742584328192 |
|---|---|
| author | Battista, Francesca |
| author2 | Ermolao, Andrea Van Baak, Marleen Beaulieu, Kristine Blundell, John Busetto, Luca Carraça, Eliana V. Encantado, Jorge Dicker, Dror Farpour-Lambert, Nathalie Pramono, Adriyan Bellicha, Alice Oppert, Jean-Michel |
| author2_role | author author author author author author author author author author author author |
| author_facet | Battista, Francesca Ermolao, Andrea Van Baak, Marleen Beaulieu, Kristine Blundell, John Busetto, Luca Carraça, Eliana V. Encantado, Jorge Dicker, Dror Farpour-Lambert, Nathalie Pramono, Adriyan Bellicha, Alice Oppert, Jean-Michel |
| author_role | author |
| contributor_name_str_mv | Repositório do ISPA |
| country_str | PT |
| creators_json_txt | [{\"Person.name\":\"Battista, Francesca\",\"Person.identifier.orcid\":\"0000-0003-0760-1354\"},{\"Person.name\":\"Ermolao, Andrea\",\"Person.identifier.orcid\":\"0000-0002-0546-1514\"},{\"Person.name\":\"Van Baak, Marleen\",\"Person.identifier.orcid\":\"0000-0003-2592-6363\"},{\"Person.name\":\"Beaulieu, Kristine\",\"Person.identifier.orcid\":\"0000-0001-8926-6953\"},{\"Person.name\":\"Blundell, John\",\"Person.identifier.orcid\":\"0000-0002-7085-9596\"},{\"Person.name\":\"Busetto, Luca\",\"Person.identifier.orcid\":\"0000-0003-4883-8980\"},{\"Person.name\":\"Carraça, Eliana V.\",\"Person.identifier.orcid\":\"0000-0002-5789-811X\"},{\"Person.name\":\"Encantado, Jorge\",\"Person.identifier.orcid\":\"0000-0003-0542-8340\"},{\"Person.name\":\"Dicker, Dror\",\"Person.identifier.orcid\":\"0000-0001-8546-6245\"},{\"Person.name\":\"Farpour-Lambert, Nathalie\",\"Person.identifier.orcid\":\"0000-0001-6478-7269\"},{\"Person.name\":\"Pramono, Adriyan\",\"Person.identifier.orcid\":\"0000-0003-2159-4576\"},{\"Person.name\":\"Bellicha, Alice\",\"Person.identifier.orcid\":\"0000-0002-5572-487X\"},{\"Person.name\":\"Oppert, Jean-Michel\",\"Person.identifier.orcid\":\"0000-0003-0324-4820\"}] |
| datacite.contributors.contributor.contributorName.fl_str_mv | Repositório do ISPA |
| datacite.creators.creator.creatorName.fl_str_mv | Battista, Francesca Ermolao, Andrea Van Baak, Marleen Beaulieu, Kristine Blundell, John Busetto, Luca Carraça, Eliana V. Encantado, Jorge Dicker, Dror Farpour-Lambert, Nathalie Pramono, Adriyan Bellicha, Alice Oppert, Jean-Michel |
| datacite.date.Accepted.fl_str_mv | 2021-01-01T00:00:00Z |
| datacite.date.available.fl_str_mv | 2021-07-14T23:54:43Z |
| datacite.date.embargoed.fl_str_mv | 2021-07-14T23:54:43Z |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| datacite.subjects.subject.fl_str_mv | Hypertension Insulin resistance Morbid obesity NAFLD Physical activity Morbid obesity, Type 2 diabetes |
| datacite.titles.title.fl_str_mv | Effect of exercise on cardiometabolic health of adults with overweight or obesity: Focus on blood pressure, insulin resistance, and intrahepatic fat—A systematic review and meta‐analysis |
| dc.contributor.none.fl_str_mv | Repositório do ISPA |
| dc.creator.none.fl_str_mv | Battista, Francesca Ermolao, Andrea Van Baak, Marleen Beaulieu, Kristine Blundell, John Busetto, Luca Carraça, Eliana V. Encantado, Jorge Dicker, Dror Farpour-Lambert, Nathalie Pramono, Adriyan Bellicha, Alice Oppert, Jean-Michel |
| dc.date.Accepted.fl_str_mv | 2021-01-01T00:00:00Z |
| dc.date.available.fl_str_mv | 2021-07-14T23:54:43Z |
| dc.date.embargoed.fl_str_mv | 2021-07-14T23:54:43Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | http://hdl.handle.net/10400.12/8230 |
| dc.language.none.fl_str_mv | eng |
| dc.publisher.none.fl_str_mv | Wiley-Blackwell Publishing Ltd |
| dc.rights.cclincense.fl_str_mv | http://creativecommons.org/licenses/by/4.0/ |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| dc.subject.none.fl_str_mv | Hypertension Insulin resistance Morbid obesity NAFLD Physical activity Morbid obesity, Type 2 diabetes |
| dc.title.fl_str_mv | Effect of exercise on cardiometabolic health of adults with overweight or obesity: Focus on blood pressure, insulin resistance, and intrahepatic fat—A systematic review and meta‐analysis |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_6501 |
| description | This systematic review examined the impact of exercise intervention programs on selected cardiometabolic health indicators in adults with overweight or obesity. Three electronic databases were explored for randomized controlled trials (RCTs) that included adults with overweight or obesity and provided exercise-training interventions. Effects on blood pressure, insulin resistance (homeostasis model of insulin resistance, HOMA-IR), and magnetic resonance measures of intrahepatic fat in exercise versus control groups were analyzed using random effects meta-analyses. Fifty-four articles matched inclusion criteria. Exercise training reduced systolic and diastolic blood pressure (mean difference, MD = -2.95 mmHg [95% CI -4.22, -1.68], p < 0.00001, I2 = 63% and MD = -1.93 mmHg [95% CI -2.73, -1.13], p < 0.00001, I2 = 54%, 60 and 58 study arms, respectively). Systolic and diastolic blood pressure decreased also when considering only subjects with hypertension. Exercise training significantly decreased HOMA-IR (standardized mean difference, SMD = -0.34 [-0.49, -0.18], p < 0.0001, I2 = 48%, 37 study arms), with higher effect size in subgroup of patients with type 2 diabetes (SMD = -0.50 [95% CI: -0.83, -0.17], p = 0.003, I2 = 39%). Intrahepatic fat decreased significantly after exercise interventions (SMD = -0.59 [95% CI: -0.78, -0.41], p < 0.00001, I2 = 0%), with a larger effect size after high-intensity interval training. In conclusion, exercise training is effective in improving cardiometabolic health in adults with overweight or obesity also when living with comorbitidies. |
| dirty | 0 |
| eu_rights_str_mv | openAccess |
| format | article |
| fulltext.url.fl_str_mv | https://repositorio.ispa.pt/bitstreams/0a6b7b93-a6e4-4eca-ac67-f9de68e518ff/download |
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| identifier.url.fl_str_mv | http://hdl.handle.net/10400.12/8230 |
| instacron_str | ispa |
| institution | Ispa-Instituto Universitário |
| instname_str | Ispa-Instituto Universitário |
| language | eng |
| network_acronym_str | ispa |
| network_name_str | Repositório do Ispa - Instituto Universitário |
| oai_identifier_str | oai:repositorio.ispa.pt:10400.12/8230 |
| organization_str_mv | urn:organizationAcronym:ispa |
| person_str_mv | Battista, Francesca Battista, Francesca http://orcid.org/0000-0003-0760-1354 0000-0003-0760-1354 Ermolao, Andrea Ermolao, Andrea http://orcid.org/0000-0002-0546-1514 0000-0002-0546-1514 Van Baak, Marleen Van Baak, Marleen http://orcid.org/0000-0003-2592-6363 0000-0003-2592-6363 Beaulieu, Kristine Beaulieu, Kristine http://orcid.org/0000-0001-8926-6953 0000-0001-8926-6953 Blundell, John Blundell, John http://orcid.org/0000-0002-7085-9596 0000-0002-7085-9596 Busetto, Luca Busetto, Luca http://orcid.org/0000-0003-4883-8980 0000-0003-4883-8980 Carraça, Eliana V. Carraça, Eliana V. https://www.ciencia-id.pt/CB16-DB29-5144 CB16-DB29-5144 http://orcid.org/0000-0002-5789-811X 0000-0002-5789-811X Encantado, Jorge Encantado, Jorge https://www.ciencia-id.pt/0611-B42E-407D 0611-B42E-407D http://orcid.org/0000-0003-0542-8340 0000-0003-0542-8340 Dicker, Dror Dicker, Dror http://orcid.org/0000-0001-8546-6245 0000-0001-8546-6245 Farpour-Lambert, Nathalie Farpour-Lambert, Nathalie http://orcid.org/0000-0001-6478-7269 0000-0001-6478-7269 Pramono, Adriyan Pramono, Adriyan http://orcid.org/0000-0003-2159-4576 0000-0003-2159-4576 Bellicha, Alice Bellicha, Alice http://orcid.org/0000-0002-5572-487X 0000-0002-5572-487X Oppert, Jean-Michel Oppert, Jean-Michel http://orcid.org/0000-0003-0324-4820 0000-0003-0324-4820 |
| publishDate | 2021 |
| publisher.none.fl_str_mv | Wiley-Blackwell Publishing Ltd |
| reponame_str | Repositório do Ispa - Instituto Universitário |
| repository_id_str | urn:repositoryAcronym:ispa |
| service_str_mv | urn:repositoryAcronym:ispa |
| spelling | engWiley-Blackwell Publishing Ltdpt_PTThis systematic review examined the impact of exercise intervention programs on selected cardiometabolic health indicators in adults with overweight or obesity. Three electronic databases were explored for randomized controlled trials (RCTs) that included adults with overweight or obesity and provided exercise-training interventions. Effects on blood pressure, insulin resistance (homeostasis model of insulin resistance, HOMA-IR), and magnetic resonance measures of intrahepatic fat in exercise versus control groups were analyzed using random effects meta-analyses. Fifty-four articles matched inclusion criteria. Exercise training reduced systolic and diastolic blood pressure (mean difference, MD = -2.95 mmHg [95% CI -4.22, -1.68], p < 0.00001, I2 = 63% and MD = -1.93 mmHg [95% CI -2.73, -1.13], p < 0.00001, I2 = 54%, 60 and 58 study arms, respectively). Systolic and diastolic blood pressure decreased also when considering only subjects with hypertension. Exercise training significantly decreased HOMA-IR (standardized mean difference, SMD = -0.34 [-0.49, -0.18], p < 0.0001, I2 = 48%, 37 study arms), with higher effect size in subgroup of patients with type 2 diabetes (SMD = -0.50 [95% CI: -0.83, -0.17], p = 0.003, I2 = 39%). Intrahepatic fat decreased significantly after exercise interventions (SMD = -0.59 [95% CI: -0.78, -0.41], p < 0.00001, I2 = 0%), with a larger effect size after high-intensity interval training. In conclusion, exercise training is effective in improving cardiometabolic health in adults with overweight or obesity also when living with comorbitidies.application/pdfpt_PTEffect of exercise on cardiometabolic health of adults with overweight or obesity: Focus on blood pressure, insulin resistance, and intrahepatic fat—A systematic review and meta‐analysisPersonalBattista, FrancescaDSpacehttp://dspace.org/items/c2b4b901-f566-4800-8635-1edba4f6e151DSpacehttp://dspace.org/items/c2b4b901-f566-4800-8635-1edba4f6e151BattistaFrancescaORCIDhttp://orcid.org0000-0003-0760-1354Scopus Author IDhttps://www.scopus.com55270369800PersonalErmolao, AndreaDSpacehttp://dspace.org/items/b3bcd7d8-e8a3-4da2-85d4-f8508d9b371bDSpacehttp://dspace.org/items/b3bcd7d8-e8a3-4da2-85d4-f8508d9b371bErmolaoAndreaORCIDhttp://orcid.org0000-0002-0546-1514Researcher IDhttps://www.researcherid.comI-5463-2012Scopus Author IDhttps://www.scopus.com6506610351PersonalVan Baak, MarleenDSpacehttp://dspace.org/items/65baca88-2a48-465b-b646-afb939e11da0DSpacehttp://dspace.org/items/65baca88-2a48-465b-b646-afb939e11da0van BaakMarleenORCIDhttp://orcid.org0000-0003-2592-6363PersonalBeaulieu, KristineDSpacehttp://dspace.org/items/10e1da19-1875-4b73-bc08-c3aeb79bd587DSpacehttp://dspace.org/items/10e1da19-1875-4b73-bc08-c3aeb79bd587BeaulieuKristineORCIDhttp://orcid.org0000-0001-8926-6953PersonalBlundell, JohnDSpacehttp://dspace.org/items/bf03203f-5a6a-414d-b1fc-d11d504d044aDSpacehttp://dspace.org/items/bf03203f-5a6a-414d-b1fc-d11d504d044aBlundellJohnORCIDhttp://orcid.org0000-0002-7085-9596PersonalBusetto, LucaDSpacehttp://dspace.org/items/7ee5aadb-337f-469f-8573-98167162cf6aDSpacehttp://dspace.org/items/7ee5aadb-337f-469f-8573-98167162cf6aBusettoLucaORCIDhttp://orcid.org0000-0003-4883-8980Scopus Author IDhttps://www.scopus.com7005513943PersonalCarraça, Eliana V.DSpacehttp://dspace.org/items/fe2b115c-3a3d-491c-9bd6-22730245a975DSpacehttp://dspace.org/items/fe2b115c-3a3d-491c-9bd6-22730245a975CarraçaElianaCiência IDhttps://www.ciencia-id.ptCB16-DB29-5144ORCIDhttp://orcid.org0000-0002-5789-811XResearcher IDhttps://www.researcherid.comM-8843-2013Scopus Author IDhttps://www.scopus.com32867491100PersonalEncantado, JorgeDSpacehttp://dspace.org/items/a9747520-dfea-4eb3-bd33-ae9ba2f1a2d6DSpacehttp://dspace.org/items/a9747520-dfea-4eb3-bd33-ae9ba2f1a2d6Conde Encantado PauloJorge EduardoCiência IDhttps://www.ciencia-id.pt0611-B42E-407DORCIDhttp://orcid.org0000-0003-0542-8340PersonalDicker, DrorDSpacehttp://dspace.org/items/03d63c1a-d3b6-4500-a1c7-1b72ba96954aDSpacehttp://dspace.org/items/03d63c1a-d3b6-4500-a1c7-1b72ba96954aDickerDrorORCIDhttp://orcid.org0000-0001-8546-6245PersonalFarpour-Lambert, NathalieDSpacehttp://dspace.org/items/b1efdc01-b05d-4d08-8ea7-c7f0e0c885cbDSpacehttp://dspace.org/items/b1efdc01-b05d-4d08-8ea7-c7f0e0c885cbFarpour-LambertNathalieORCIDhttp://orcid.org0000-0001-6478-7269PersonalPramono, AdriyanDSpacehttp://dspace.org/items/58c39e4a-a54a-414d-ae0c-b9f994afcd68DSpacehttp://dspace.org/items/58c39e4a-a54a-414d-ae0c-b9f994afcd68PramonoAdriyanORCIDhttp://orcid.org0000-0003-2159-4576Scopus Author IDhttps://www.scopus.com56825779200PersonalBellicha, AliceDSpacehttp://dspace.org/items/ad3b7a54-b0fe-4cd6-aa60-aea6ce48353fDSpacehttp://dspace.org/items/ad3b7a54-b0fe-4cd6-aa60-aea6ce48353fBellichaAliceORCIDhttp://orcid.org0000-0002-5572-487XPersonalOppert, Jean-MichelDSpacehttp://dspace.org/items/15079c3f-77ff-4ef2-98d1-b6bfed577da7DSpacehttp://dspace.org/items/15079c3f-77ff-4ef2-98d1-b6bfed577da7OppertJean-MichelORCIDhttp://orcid.org0000-0003-0324-4820HostingInstitutionOrganizationalRepositório do ISPAe-mailmailto:repositorio@ispa.ptrepositorio@ispa.ptISSNIsPartOf14677881DOIIsPartOf10.1111/obr.132692021-07-14T23:54:43Z20212021-01-01T00:00:00ZHandlehttp://hdl.handle.net/10400.12/8230http://purl.org/coar/access_right/c_abf2open accessHypertensionInsulin resistanceMorbid obesityNAFLDPhysical activityMorbid obesity,Type 2 diabetes2947120 bytesliteraturehttp://purl.org/coar/resource_type/c_6501journal article2021http://creativecommons.org/licenses/by/4.0/http://purl.org/coar/access_right/c_abf2application/pdffulltexthttps://repositorio.ispa.pt/bitstreams/0a6b7b93-a6e4-4eca-ac67-f9de68e518ff/downloadObesity Reviews22S4115United Kingdom |
| spellingShingle | Effect of exercise on cardiometabolic health of adults with overweight or obesity: Focus on blood pressure, insulin resistance, and intrahepatic fat—A systematic review and meta‐analysis Battista, Francesca Hypertension Insulin resistance Morbid obesity NAFLD Physical activity Morbid obesity, Type 2 diabetes |
| status | SINGLETON |
| subject.fl_str_mv | Hypertension Insulin resistance Morbid obesity NAFLD Physical activity Morbid obesity, Type 2 diabetes |
| title | Effect of exercise on cardiometabolic health of adults with overweight or obesity: Focus on blood pressure, insulin resistance, and intrahepatic fat—A systematic review and meta‐analysis |
| title_full | Effect of exercise on cardiometabolic health of adults with overweight or obesity: Focus on blood pressure, insulin resistance, and intrahepatic fat—A systematic review and meta‐analysis |
| title_fullStr | Effect of exercise on cardiometabolic health of adults with overweight or obesity: Focus on blood pressure, insulin resistance, and intrahepatic fat—A systematic review and meta‐analysis |
| title_full_unstemmed | Effect of exercise on cardiometabolic health of adults with overweight or obesity: Focus on blood pressure, insulin resistance, and intrahepatic fat—A systematic review and meta‐analysis |
| title_short | Effect of exercise on cardiometabolic health of adults with overweight or obesity: Focus on blood pressure, insulin resistance, and intrahepatic fat—A systematic review and meta‐analysis |
| title_sort | Effect of exercise on cardiometabolic health of adults with overweight or obesity: Focus on blood pressure, insulin resistance, and intrahepatic fat—A systematic review and meta‐analysis |
| topic | Hypertension Insulin resistance Morbid obesity NAFLD Physical activity Morbid obesity, Type 2 diabetes |
| topic_facet | Hypertension Insulin resistance Morbid obesity NAFLD Physical activity Morbid obesity, Type 2 diabetes |
| url | http://hdl.handle.net/10400.12/8230 |
| visible | 1 |