Publicação
Hair cortisol concentration, weight loss maintenance and body weight variability: A prospective study based on data from the european nohow trial
| Resumo: | Several cross-sectional studies have shown hair cortisol concentration to be associated with adiposity, but the relationship between hair cortisol concentration and longitudinal changes in measures of adiposity are largely unknown. We included 786 adults from the NoHoW trial, who had achieved a successful weight loss of ≥5% and had a body mass index of ≥25 kg/m2 prior to losing weight. Hair cortisol concentration (pg/mg hair) was measured at baseline and after 12 months. Body weight and body fat percentage were measured at baseline, 6-month, 12-month and 18-month visits. Participants weighed themselves at home ≥2 weekly using a Wi-Fi scale for the 18-month study duration, from which body weight variability was estimated using linear and non-linear approaches. Regression models were conducted to examine log hair cortisol concentration and change in log hair cortisol concentration as predictors of changes in body weight, change in body fat percentage and body weight variability. After adjustment for lifestyle and demographic factors, no associations between baseline log hair cortisol concentration and outcome measures were observed. Similar results were seen when analysing the association between 12-month concurrent development in log hair cortisol concentration and outcomes. However, an initial 12-month increase in log hair cortisol concentration was associated with a higher subsequent body weight variability between month 12 and 18, based on deviations from a nonlinear trend (β: 0.02% per unit increase in log hair cortisol concentration [95% CI: 0.00, 0.04]; P =0.016). Our data suggest that an association between hair cortisol concentration and subsequent change in body weight or body fat percentage is absent or marginal, but that an increase in hair cortisol concentration during a 12-month weight loss maintenance effort may predict a slightly higher subsequent 6-months body weight variability. Clinical Trial Registration: ISRCTN registry, identifier ISRCTN88405328. [ABSTRACT FROM AUTHOR] |
|---|---|
| Autores principais: | Larsen, Sofus C. |
| Outros Autores: | Turicchi, Jake; Christensen, Gitte L.; Larsen, Charlotte S.; Jørgensen, Niklas R.; Mikkelsen, Marie-Louise K.; Horgan, Graham; O'Driscoll, Ruairi; Michalowska, Joanna; Duarte, Cristiana; Scott, Sarah E.; Santos, Inês; Encantado, Jorge; Palmeira, Antonio L.; Stubbs, R. James; Heitmann, Berit L. |
| Assunto: | Hair cortisol Obesity Stress Weight loss Weight loss maintenance |
| Ano: | 2021 |
| País: | Portugal |
| Tipo de documento: | artigo |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Ispa-Instituto Universitário |
| Idioma: | inglês |
| Origem: | Repositório do Ispa - Instituto Universitário |
| _version_ | 1866252743519240192 |
|---|---|
| author | Larsen, Sofus C. |
| author2 | Turicchi, Jake Christensen, Gitte L. Larsen, Charlotte S. Jørgensen, Niklas R. Mikkelsen, Marie-Louise K. Horgan, Graham O'Driscoll, Ruairi Michalowska, Joanna Duarte, Cristiana Scott, Sarah E. Santos, Inês Encantado, Jorge Palmeira, Antonio L. Stubbs, R. James Heitmann, Berit L. |
| author2_role | author author author author author author author author author author author author author author author |
| author_facet | Larsen, Sofus C. Turicchi, Jake Christensen, Gitte L. Larsen, Charlotte S. Jørgensen, Niklas R. Mikkelsen, Marie-Louise K. Horgan, Graham O'Driscoll, Ruairi Michalowska, Joanna Duarte, Cristiana Scott, Sarah E. Santos, Inês Encantado, Jorge Palmeira, Antonio L. Stubbs, R. James Heitmann, Berit L. |
| author_role | author |
| contributor_name_str_mv | Repositório do ISPA |
| country_str | PT |
| creators_json_txt | [{\"Person.name\":\"Larsen, Sofus C.\",\"Person.identifier.orcid\":\"0000-0002-0838-9378\"},{\"Person.name\":\"Turicchi, Jake\",\"Person.identifier.orcid\":\"0000-0001-5504-9037\"},{\"Person.name\":\"Christensen, Gitte L.\"},{\"Person.name\":\"Larsen, Charlotte S.\"},{\"Person.name\":\"Jørgensen, Niklas R.\"},{\"Person.name\":\"Mikkelsen, Marie-Louise K.\"},{\"Person.name\":\"Horgan, Graham\",\"Person.identifier.orcid\":\"0000-0002-6048-1374\"},{\"Person.name\":\"O'Driscoll, Ruairi\",\"Person.identifier.orcid\":\"0000-0003-3995-0073\"},{\"Person.name\":\"Michalowska, Joanna\"},{\"Person.name\":\"Duarte, Cristiana\"},{\"Person.name\":\"Scott, Sarah E.\"},{\"Person.name\":\"Santos, Inês\"},{\"Person.name\":\"Encantado, Jorge\",\"Person.identifier.orcid\":\"0000-0003-0542-8340\"},{\"Person.name\":\"Palmeira, Antonio L.\"},{\"Person.name\":\"Stubbs, R. James\"},{\"Person.name\":\"Heitmann, Berit L.\"}] |
| datacite.contributors.contributor.contributorName.fl_str_mv | Repositório do ISPA |
| datacite.creators.creator.creatorName.fl_str_mv | Larsen, Sofus C. Turicchi, Jake Christensen, Gitte L. Larsen, Charlotte S. Jørgensen, Niklas R. Mikkelsen, Marie-Louise K. Horgan, Graham O'Driscoll, Ruairi Michalowska, Joanna Duarte, Cristiana Scott, Sarah E. Santos, Inês Encantado, Jorge Palmeira, Antonio L. Stubbs, R. James Heitmann, Berit L. |
| datacite.date.Accepted.fl_str_mv | 2021-01-01T00:00:00Z |
| datacite.date.available.fl_str_mv | 2022-07-20T13:30:26Z |
| datacite.date.embargoed.fl_str_mv | 2022-07-20T13:30:26Z |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| datacite.subjects.subject.fl_str_mv | Hair cortisol Obesity Stress Weight loss Weight loss maintenance |
| datacite.titles.title.fl_str_mv | Hair cortisol concentration, weight loss maintenance and body weight variability: A prospective study based on data from the european nohow trial |
| dc.contributor.none.fl_str_mv | Repositório do ISPA |
| dc.creator.none.fl_str_mv | Larsen, Sofus C. Turicchi, Jake Christensen, Gitte L. Larsen, Charlotte S. Jørgensen, Niklas R. Mikkelsen, Marie-Louise K. Horgan, Graham O'Driscoll, Ruairi Michalowska, Joanna Duarte, Cristiana Scott, Sarah E. Santos, Inês Encantado, Jorge Palmeira, Antonio L. Stubbs, R. James Heitmann, Berit L. |
| dc.date.Accepted.fl_str_mv | 2021-01-01T00:00:00Z |
| dc.date.available.fl_str_mv | 2022-07-20T13:30:26Z |
| dc.date.embargoed.fl_str_mv | 2022-07-20T13:30:26Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | http://hdl.handle.net/10400.12/8739 |
| dc.language.none.fl_str_mv | eng |
| dc.publisher.none.fl_str_mv | Frontiers Media S.A. |
| dc.rights.cclincense.fl_str_mv | http://creativecommons.org/licenses/by/4.0/ |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| dc.subject.none.fl_str_mv | Hair cortisol Obesity Stress Weight loss Weight loss maintenance |
| dc.title.fl_str_mv | Hair cortisol concentration, weight loss maintenance and body weight variability: A prospective study based on data from the european nohow trial |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_6501 |
| description | Several cross-sectional studies have shown hair cortisol concentration to be associated with adiposity, but the relationship between hair cortisol concentration and longitudinal changes in measures of adiposity are largely unknown. We included 786 adults from the NoHoW trial, who had achieved a successful weight loss of ≥5% and had a body mass index of ≥25 kg/m2 prior to losing weight. Hair cortisol concentration (pg/mg hair) was measured at baseline and after 12 months. Body weight and body fat percentage were measured at baseline, 6-month, 12-month and 18-month visits. Participants weighed themselves at home ≥2 weekly using a Wi-Fi scale for the 18-month study duration, from which body weight variability was estimated using linear and non-linear approaches. Regression models were conducted to examine log hair cortisol concentration and change in log hair cortisol concentration as predictors of changes in body weight, change in body fat percentage and body weight variability. After adjustment for lifestyle and demographic factors, no associations between baseline log hair cortisol concentration and outcome measures were observed. Similar results were seen when analysing the association between 12-month concurrent development in log hair cortisol concentration and outcomes. However, an initial 12-month increase in log hair cortisol concentration was associated with a higher subsequent body weight variability between month 12 and 18, based on deviations from a nonlinear trend (β: 0.02% per unit increase in log hair cortisol concentration [95% CI: 0.00, 0.04]; P =0.016). Our data suggest that an association between hair cortisol concentration and subsequent change in body weight or body fat percentage is absent or marginal, but that an increase in hair cortisol concentration during a 12-month weight loss maintenance effort may predict a slightly higher subsequent 6-months body weight variability. Clinical Trial Registration: ISRCTN registry, identifier ISRCTN88405328. [ABSTRACT FROM AUTHOR] |
| dirty | 0 |
| eu_rights_str_mv | openAccess |
| format | article |
| fulltext.url.fl_str_mv | https://repositorio.ispa.pt/bitstreams/84c15925-e1fd-4669-80fb-8c2ab2576e7a/download |
| id | ispa_e4357d1d5fdc4cce22cdd01664342dc0 |
| identifier.url.fl_str_mv | http://hdl.handle.net/10400.12/8739 |
| instacron_str | ispa |
| institution | Ispa-Instituto Universitário |
| instname_str | Ispa-Instituto Universitário |
| language | eng |
| network_acronym_str | ispa |
| network_name_str | Repositório do Ispa - Instituto Universitário |
| oai_identifier_str | oai:repositorio.ispa.pt:10400.12/8739 |
| organization_str_mv | urn:organizationAcronym:ispa |
| person_str_mv | Larsen, Sofus C. Larsen, Sofus C. http://orcid.org/0000-0002-0838-9378 0000-0002-0838-9378 Turicchi, Jake Turicchi, Jake http://orcid.org/0000-0001-5504-9037 0000-0001-5504-9037 Christensen, Gitte L. Larsen, Charlotte S. Jørgensen, Niklas R. Mikkelsen, Marie-Louise K. Horgan, Graham Horgan, Graham http://orcid.org/0000-0002-6048-1374 0000-0002-6048-1374 O'Driscoll, Ruairi O'Driscoll, Ruairi http://orcid.org/0000-0003-3995-0073 0000-0003-3995-0073 Michalowska, Joanna Duarte, Cristiana Scott, Sarah E. Santos, Inês Encantado, Jorge Encantado, Jorge https://www.ciencia-id.pt/0611-B42E-407D 0611-B42E-407D http://orcid.org/0000-0003-0542-8340 0000-0003-0542-8340 Palmeira, Antonio L. Stubbs, R. James Heitmann, Berit L. |
| publishDate | 2021 |
| publisher.none.fl_str_mv | Frontiers Media S.A. |
| reponame_str | Repositório do Ispa - Instituto Universitário |
| repository_id_str | urn:repositoryAcronym:ispa |
| service_str_mv | urn:repositoryAcronym:ispa |
| spelling | engFrontiers Media S.A.pt_PTSeveral cross-sectional studies have shown hair cortisol concentration to be associated with adiposity, but the relationship between hair cortisol concentration and longitudinal changes in measures of adiposity are largely unknown. We included 786 adults from the NoHoW trial, who had achieved a successful weight loss of ≥5% and had a body mass index of ≥25 kg/m2 prior to losing weight. Hair cortisol concentration (pg/mg hair) was measured at baseline and after 12 months. Body weight and body fat percentage were measured at baseline, 6-month, 12-month and 18-month visits. Participants weighed themselves at home ≥2 weekly using a Wi-Fi scale for the 18-month study duration, from which body weight variability was estimated using linear and non-linear approaches. Regression models were conducted to examine log hair cortisol concentration and change in log hair cortisol concentration as predictors of changes in body weight, change in body fat percentage and body weight variability. After adjustment for lifestyle and demographic factors, no associations between baseline log hair cortisol concentration and outcome measures were observed. Similar results were seen when analysing the association between 12-month concurrent development in log hair cortisol concentration and outcomes. However, an initial 12-month increase in log hair cortisol concentration was associated with a higher subsequent body weight variability between month 12 and 18, based on deviations from a nonlinear trend (β: 0.02% per unit increase in log hair cortisol concentration [95% CI: 0.00, 0.04]; P =0.016). Our data suggest that an association between hair cortisol concentration and subsequent change in body weight or body fat percentage is absent or marginal, but that an increase in hair cortisol concentration during a 12-month weight loss maintenance effort may predict a slightly higher subsequent 6-months body weight variability. Clinical Trial Registration: ISRCTN registry, identifier ISRCTN88405328. [ABSTRACT FROM AUTHOR]application/pdfpt_PTHair cortisol concentration, weight loss maintenance and body weight variability: A prospective study based on data from the european nohow trialPersonalLarsen, Sofus C.DSpacehttp://dspace.org/items/5856245b-d14f-41e9-8c9f-d70e1ce11e4fDSpacehttp://dspace.org/items/5856245b-d14f-41e9-8c9f-d70e1ce11e4fLarsenSofus C.ORCIDhttp://orcid.org0000-0002-0838-9378Scopus Author IDhttps://www.scopus.com55649568975PersonalTuricchi, JakeDSpacehttp://dspace.org/items/03de3a48-8b2b-42c4-afa6-b28143f09f5eDSpacehttp://dspace.org/items/03de3a48-8b2b-42c4-afa6-b28143f09f5eturicchijakeORCIDhttp://orcid.org0000-0001-5504-9037Researcher IDhttps://www.researcherid.comL-4752-2017Christensen, Gitte L.Larsen, Charlotte S.Jørgensen, Niklas R.Mikkelsen, Marie-Louise K.PersonalHorgan, GrahamDSpacehttp://dspace.org/items/a5531bca-17af-4dd3-b69a-d653966097d6DSpacehttp://dspace.org/items/a5531bca-17af-4dd3-b69a-d653966097d6HorganGrahamORCIDhttp://orcid.org0000-0002-6048-1374PersonalO'Driscoll, RuairiDSpacehttp://dspace.org/items/c93cd4d6-ff2c-4b09-847d-3a7710863b3cDSpacehttp://dspace.org/items/c93cd4d6-ff2c-4b09-847d-3a7710863b3cO'DriscollRuairiORCIDhttp://orcid.org0000-0003-3995-0073Michalowska, JoannaDuarte, CristianaScott, Sarah E.Santos, InêsPersonalEncantado, JorgeDSpacehttp://dspace.org/items/a9747520-dfea-4eb3-bd33-ae9ba2f1a2d6DSpacehttp://dspace.org/items/a9747520-dfea-4eb3-bd33-ae9ba2f1a2d6Conde Encantado PauloJorge EduardoCiência IDhttps://www.ciencia-id.pt0611-B42E-407DORCIDhttp://orcid.org0000-0003-0542-8340Palmeira, Antonio L.Stubbs, R. JamesHeitmann, Berit L.HostingInstitutionOrganizationalRepositório do ISPAe-mailmailto:repositorio@ispa.ptrepositorio@ispa.ptISSNIsPartOf16642392DOIIsPartOf10.3389/fendo.2021.6551972022-07-20T13:30:26Z20212021-01-01T00:00:00ZHandlehttp://hdl.handle.net/10400.12/8739http://purl.org/coar/access_right/c_abf2open accessHair cortisolObesityStressWeight lossWeight loss maintenance392085 bytesliteraturehttp://purl.org/coar/resource_type/c_6501journal article2021http://creativecommons.org/licenses/by/4.0/http://purl.org/coar/access_right/c_abf2application/pdffulltexthttps://repositorio.ispa.pt/bitstreams/84c15925-e1fd-4669-80fb-8c2ab2576e7a/downloadFrontiers in Endocrinology12111Switzerland |
| spellingShingle | Hair cortisol concentration, weight loss maintenance and body weight variability: A prospective study based on data from the european nohow trial Larsen, Sofus C. Hair cortisol Obesity Stress Weight loss Weight loss maintenance |
| status | SINGLETON |
| subject.fl_str_mv | Hair cortisol Obesity Stress Weight loss Weight loss maintenance |
| title | Hair cortisol concentration, weight loss maintenance and body weight variability: A prospective study based on data from the european nohow trial |
| title_full | Hair cortisol concentration, weight loss maintenance and body weight variability: A prospective study based on data from the european nohow trial |
| title_fullStr | Hair cortisol concentration, weight loss maintenance and body weight variability: A prospective study based on data from the european nohow trial |
| title_full_unstemmed | Hair cortisol concentration, weight loss maintenance and body weight variability: A prospective study based on data from the european nohow trial |
| title_short | Hair cortisol concentration, weight loss maintenance and body weight variability: A prospective study based on data from the european nohow trial |
| title_sort | Hair cortisol concentration, weight loss maintenance and body weight variability: A prospective study based on data from the european nohow trial |
| topic | Hair cortisol Obesity Stress Weight loss Weight loss maintenance |
| topic_facet | Hair cortisol Obesity Stress Weight loss Weight loss maintenance |
| url | http://hdl.handle.net/10400.12/8739 |
| visible | 1 |