Publication
Corneal Epithelium Remodelling After Eye Rubbing Discontinuation in Pediatric Allergic Patients
| Summary: | Introduction: Our purpose was to evaluate the effect of eye rubbing discontinuation on the epithelial thickness profile by spectral-domain AS-OCT (anterior segment optical coherence tomography) in allergic children with no tomographic sign of corneal ectasia. Methods: Right-handed boys (average age 11.2 years, 8-12 years) with history of eye rubbing and relatively normal Pentacam (Oculus; Wetzlar, Germany) exams were recruited for the study. Patients were evaluated using AS-OCT (Zeiss Cirrus 5000 HD-OCT, Carl Zeiss Meditec, Dublin, CA, USA) at the baseline and after 8 weeks of treatment. Treatment included education to avoid eye rubbing and preservative free 0.25 mg/mL topical ketotifen. Epithelial thickness (ET) and full corneal thickness (CT) parameters were compared with paired non-parametric Wilcoxon (signed-ranked) test. A p-value lower than 0.05 was considered for statistical significance. Results: Twenty-five boys completed the protocol. No eyes had tomographic criteria for keratoconus (Belin-Ambrosio Deviation Value < 1.22). Minimum epithelial location moved from the inferotemporal to superotemporal octant after treatment. The differences between minimum and maximum epithelial thickness (-2.8 µm vs -5.2 µm; p<0.01) and between nasal and temporal octants (N-T) (3.1 µm vs 1.4 µm; p<0.01) were higher at the baseline. The difference between inferior and superior (I-S) octants (1.1 µm vs 2.7 µm; p<0.01) was lower at the baseline. Conclusion: AS-OCT analyses reveal epithelial remodeling after allergy treatment and eye rubbing discontinuation, with marked inferotemporal thickening. The importance of educating against eye rubbing and treating allergy should consider its importance on corneal epithelial remodeling. Further studies should include patients with corneal ectatic conditions and to explore other clinical measurements such as biomechanical assessment. |
|---|---|
| Main Authors: | Loureiro, Tomás |
| Other Authors: | Rodrigues-Barros, Sandra; Carreira, Ana Rita; Moraes, Filipe; Carreira, Pedro; Vide Escada, Ana; Campos, Paul; Machado, Inês; Campos, Nuno; Ambrósio Jr, Renato |
| Subject: | Artigos Originais |
| Year: | 2021 |
| Country: | Portugal |
| Document type: | article |
| Access type: | open access |
| Associated institution: | Sociedade Portuguesa de Oftalmologia |
| Language: | English |
| Origin: | Revista Sociedade Portuguesa de Oftalmologia |
| _version_ | 1870266873035096064 |
|---|---|
| author | Loureiro, Tomás |
| author2 | Rodrigues-Barros, Sandra Carreira, Ana Rita Moraes, Filipe Carreira, Pedro Vide Escada, Ana Campos, Paul Machado, Inês Campos, Nuno Ambrósio Jr, Renato |
| author2_role | author author author author author author author author author |
| author_facet | Loureiro, Tomás Rodrigues-Barros, Sandra Carreira, Ana Rita Moraes, Filipe Carreira, Pedro Vide Escada, Ana Campos, Paul Machado, Inês Campos, Nuno Ambrósio Jr, Renato |
| author_role | author |
| country_str | PT |
| creators_json_txt | [{\"Person.name\":\"Loureiro, Tomás\"},{\"Person.name\":\"Rodrigues-Barros, Sandra\"},{\"Person.name\":\"Carreira, Ana Rita\"},{\"Person.name\":\"Moraes, Filipe\"},{\"Person.name\":\"Carreira, Pedro\"},{\"Person.name\":\"Vide Escada, Ana\"},{\"Person.name\":\"Campos, Paul\"},{\"Person.name\":\"Machado, Inês\"},{\"Person.name\":\"Campos, Nuno\"},{\"Person.name\":\"Ambrósio Jr, Renato\"}] |
| datacite.creators.creator.creatorName.fl_str_mv | Loureiro, Tomás Rodrigues-Barros, Sandra Carreira, Ana Rita Moraes, Filipe Carreira, Pedro Vide Escada, Ana Campos, Paul Machado, Inês Campos, Nuno Ambrósio Jr, Renato |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| datacite.subjects.subject.fl_str_mv | Artigos Originais |
| datacite.titles.title.fl_str_mv | Corneal Epithelium Remodelling After Eye Rubbing Discontinuation in Pediatric Allergic Patients Alterações Epiteliais da Córnea Após Descontinuação de Coçar os Olhos em Crianças Atópicas |
| dc.creator.none.fl_str_mv | Loureiro, Tomás Rodrigues-Barros, Sandra Carreira, Ana Rita Moraes, Filipe Carreira, Pedro Vide Escada, Ana Campos, Paul Machado, Inês Campos, Nuno Ambrósio Jr, Renato |
| dc.description.none.fl_str_mv | Introdução: O nosso objetivo foi fazer a avaliação do efeito de parar de coçar os olhos no perfil epitelial da córnea através de análise com tomografia de coerância ótica do segmento anterior (AS-OCT) em crianças atópicas sem sinais tomográficos de ectasia. Métodos: Rapazes dextros (idade média 11,2 anos) com hábito de coçar os olhos e tomografia de córnea (Pentacam, Oculus; Wetzlar, Germanh) sem alterações foram incluídos. Foi realizado AS-OCT (Zeiss Cirrus 5000 HD-OCT, Carl Zeiss Meditec, Dublin, CA, USA) na baseline e após 8 semanas de tratamento com cetotifeno tópico sem conservantes (0,25 mg/mL). A espessura epitelial e a espessura total da córnea foram comparadas através de testes não paramétricos emparelhados de Wilcoxon. Um p-value inferior a 0,05 foi considerado estatisticamente significativo. Resultados: Vinte e cinco rapazes completaram o estudo. Nenhum olho apresentou critérios tomográficos de ectasia (Belin-Ambrosio Deviation Value < 1,22). A espessura epitelial mínima deslocou-se da região inferotemporal para a região inferotemporal após o tratamento. As diferenças entre a espessura epitelial minima e máxima (-2,8 µm vs -5,2 µm; p<0,01) e entre as regiões nasal e temporal (N-T) (3,1 µm vs 1.4 µm; p<0,01) foram superiores na baseline. A diferença entre as regiões inferior e superior (I-S) (1,1 µm vs 2,7 µm; p<0,01) foi inferior na baseline. Conclusão: A análise do epitélio da córnea atráves de OCT do segmento anterior revelou um espessamento inferotemporal após tratamento antialérgico e consequente descontinuação do ato de coçar os olhos. Estes resultados parecem ilustrar o dano deste ato repetido sobre a córnea e salientam a importância de educação da população acerca dos riscos associados ao mesmo. |
| dc.identifier.none.fl_str_mv | https://doi.org/10.48560/rspo.25443 |
| dc.language.none.fl_str_mv | eng |
| dc.publisher.none.fl_str_mv | Ajnet |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| dc.subject.none.fl_str_mv | Artigos Originais |
| dc.title.fl_str_mv | Corneal Epithelium Remodelling After Eye Rubbing Discontinuation in Pediatric Allergic Patients Alterações Epiteliais da Córnea Após Descontinuação de Coçar os Olhos em Crianças Atópicas |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_6501 |
| description | Introduction: Our purpose was to evaluate the effect of eye rubbing discontinuation on the epithelial thickness profile by spectral-domain AS-OCT (anterior segment optical coherence tomography) in allergic children with no tomographic sign of corneal ectasia. Methods: Right-handed boys (average age 11.2 years, 8-12 years) with history of eye rubbing and relatively normal Pentacam (Oculus; Wetzlar, Germany) exams were recruited for the study. Patients were evaluated using AS-OCT (Zeiss Cirrus 5000 HD-OCT, Carl Zeiss Meditec, Dublin, CA, USA) at the baseline and after 8 weeks of treatment. Treatment included education to avoid eye rubbing and preservative free 0.25 mg/mL topical ketotifen. Epithelial thickness (ET) and full corneal thickness (CT) parameters were compared with paired non-parametric Wilcoxon (signed-ranked) test. A p-value lower than 0.05 was considered for statistical significance. Results: Twenty-five boys completed the protocol. No eyes had tomographic criteria for keratoconus (Belin-Ambrosio Deviation Value < 1.22). Minimum epithelial location moved from the inferotemporal to superotemporal octant after treatment. The differences between minimum and maximum epithelial thickness (-2.8 µm vs -5.2 µm; p<0.01) and between nasal and temporal octants (N-T) (3.1 µm vs 1.4 µm; p<0.01) were higher at the baseline. The difference between inferior and superior (I-S) octants (1.1 µm vs 2.7 µm; p<0.01) was lower at the baseline. Conclusion: AS-OCT analyses reveal epithelial remodeling after allergy treatment and eye rubbing discontinuation, with marked inferotemporal thickening. The importance of educating against eye rubbing and treating allergy should consider its importance on corneal epithelial remodeling. Further studies should include patients with corneal ectatic conditions and to explore other clinical measurements such as biomechanical assessment. |
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| identifier.doi.fl_str_mv | https://doi.org/10.48560/rspo.25443 |
| inst_facet_str | urn:organizationAcronym:spo{{{_:::_}}}Sociedade Portuguesa de Oftalmologia |
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| institution | Sociedade Portuguesa de Oftalmologia |
| instname_str | Sociedade Portuguesa de Oftalmologia |
| language | eng |
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| organization_str_mv | urn:organizationAcronym:spo |
| person_str_mv | Loureiro, Tomás Rodrigues-Barros, Sandra Carreira, Ana Rita Moraes, Filipe Carreira, Pedro Vide Escada, Ana Campos, Paul Machado, Inês Campos, Nuno Ambrósio Jr, Renato |
| publishDate | 2021 |
| publisher.none.fl_str_mv | Ajnet |
| repo_facet_str | urn:repositoryAcronym:oftalmo{{{_:::_}}}Revista Sociedade Portuguesa de Oftalmologia |
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| spelling | AjnetenIntroduction: Our purpose was to evaluate the effect of eye rubbing discontinuation on the epithelial thickness profile by spectral-domain AS-OCT (anterior segment optical coherence tomography) in allergic children with no tomographic sign of corneal ectasia. Methods: Right-handed boys (average age 11.2 years, 8-12 years) with history of eye rubbing and relatively normal Pentacam (Oculus; Wetzlar, Germany) exams were recruited for the study. Patients were evaluated using AS-OCT (Zeiss Cirrus 5000 HD-OCT, Carl Zeiss Meditec, Dublin, CA, USA) at the baseline and after 8 weeks of treatment. Treatment included education to avoid eye rubbing and preservative free 0.25 mg/mL topical ketotifen. Epithelial thickness (ET) and full corneal thickness (CT) parameters were compared with paired non-parametric Wilcoxon (signed-ranked) test. A p-value lower than 0.05 was considered for statistical significance. Results: Twenty-five boys completed the protocol. No eyes had tomographic criteria for keratoconus (Belin-Ambrosio Deviation Value < 1.22). Minimum epithelial location moved from the inferotemporal to superotemporal octant after treatment. The differences between minimum and maximum epithelial thickness (-2.8 µm vs -5.2 µm; p<0.01) and between nasal and temporal octants (N-T) (3.1 µm vs 1.4 µm; p<0.01) were higher at the baseline. The difference between inferior and superior (I-S) octants (1.1 µm vs 2.7 µm; p<0.01) was lower at the baseline. Conclusion: AS-OCT analyses reveal epithelial remodeling after allergy treatment and eye rubbing discontinuation, with marked inferotemporal thickening. The importance of educating against eye rubbing and treating allergy should consider its importance on corneal epithelial remodeling. Further studies should include patients with corneal ectatic conditions and to explore other clinical measurements such as biomechanical assessment. ptIntrodução: O nosso objetivo foi fazer a avaliação do efeito de parar de coçar os olhos no perfil epitelial da córnea através de análise com tomografia de coerância ótica do segmento anterior (AS-OCT) em crianças atópicas sem sinais tomográficos de ectasia. Métodos: Rapazes dextros (idade média 11,2 anos) com hábito de coçar os olhos e tomografia de córnea (Pentacam, Oculus; Wetzlar, Germanh) sem alterações foram incluídos. Foi realizado AS-OCT (Zeiss Cirrus 5000 HD-OCT, Carl Zeiss Meditec, Dublin, CA, USA) na baseline e após 8 semanas de tratamento com cetotifeno tópico sem conservantes (0,25 mg/mL). A espessura epitelial e a espessura total da córnea foram comparadas através de testes não paramétricos emparelhados de Wilcoxon. Um p-value inferior a 0,05 foi considerado estatisticamente significativo. Resultados: Vinte e cinco rapazes completaram o estudo. Nenhum olho apresentou critérios tomográficos de ectasia (Belin-Ambrosio Deviation Value < 1,22). A espessura epitelial mínima deslocou-se da região inferotemporal para a região inferotemporal após o tratamento. As diferenças entre a espessura epitelial minima e máxima (-2,8 µm vs -5,2 µm; p<0,01) e entre as regiões nasal e temporal (N-T) (3,1 µm vs 1.4 µm; p<0,01) foram superiores na baseline. A diferença entre as regiões inferior e superior (I-S) (1,1 µm vs 2,7 µm; p<0,01) foi inferior na baseline. Conclusão: A análise do epitélio da córnea atráves de OCT do segmento anterior revelou um espessamento inferotemporal após tratamento antialérgico e consequente descontinuação do ato de coçar os olhos. Estes resultados parecem ilustrar o dano deste ato repetido sobre a córnea e salientam a importância de educação da população acerca dos riscos associados ao mesmo.engenCorneal Epithelium Remodelling After Eye Rubbing Discontinuation in Pediatric Allergic PatientsptAlterações Epiteliais da Córnea Após Descontinuação de Coçar os Olhos em Crianças AtópicasTranslatedTitleLoureiro, TomásLoureiroTomásHospital Garcia de Orta, Almada, PortugalRodrigues-Barros, SandraRodrigues-BarrosSandraHospital Garcia de Orta, Almada, Portugal; Hospital CUF Cascais, Lisboa, Portugal; Clínica CUF Almada, Almada, PortugalCarreira, Ana RitaCarreiraAna RitaHospital Garcia de Orta, Almada, PortugalMoraes, FilipeMoraesFilipeHospital Garcia de Orta, Almada, PortugalCarreira, PedroCarreiraPedroHospital Garcia de Orta, Almada, PortugalVide Escada, AnaVide EscadaAnaHospital Garcia de Orta, Almada, Portugal; Clínica CUF Almada, Almada, Portugal; Hospital da Luz Lisboa, Lisboa, PortugalCampos, PaulCamposPaulHospital Garcia de Orta, Almada, Portugal; Hospital da Luz Lisboa, Lisboa, PortugalMachado, InêsMachadoInêsHospital Garcia de Orta, Almada, Portugal; Clínica CUF Almada, Almada, Portugal; Hospital CUF TEJO, Lisboa, PortugalCampos, NunoCamposNunoClínica CUF Almada, Almada, Portugal; Hospital CUF TEJO, Lisboa, PortugalAmbrósio Jr, RenatoAmbrósio JrRenatoFederal University of the State of Rio de Janeiro, Rio de Janeiro, BrazilEISSN3051-6579IsPartOf2021-12-31DOIhttps://doi.org/10.48560/rspo.25443http://purl.org/coar/access_right/c_abf2open accessArtigos Originaishttp://purl.org/coar/resource_type/c_6501journal articlehttps://creativecommons.org/licenses/by-nc/4.02021-12-31fulltextapplication/pdfRevista Sociedade Portuguesa de Oftalmologia454210217 |
| spellingShingle | Corneal Epithelium Remodelling After Eye Rubbing Discontinuation in Pediatric Allergic Patients Loureiro, Tomás Artigos Originais |
| status | SINGLETON |
| subject.fl_str_mv | Artigos Originais |
| title | Corneal Epithelium Remodelling After Eye Rubbing Discontinuation in Pediatric Allergic Patients |
| title_full | Corneal Epithelium Remodelling After Eye Rubbing Discontinuation in Pediatric Allergic Patients |
| title_fullStr | Corneal Epithelium Remodelling After Eye Rubbing Discontinuation in Pediatric Allergic Patients |
| title_full_unstemmed | Corneal Epithelium Remodelling After Eye Rubbing Discontinuation in Pediatric Allergic Patients |
| title_short | Corneal Epithelium Remodelling After Eye Rubbing Discontinuation in Pediatric Allergic Patients |
| title_sort | Corneal Epithelium Remodelling After Eye Rubbing Discontinuation in Pediatric Allergic Patients |
| topic | Artigos Originais |
| topic_facet | Artigos Originais |
| url | https://doi.org/10.48560/rspo.25443 |
| visible | 1 |