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Revisão sobre nanopartículas lipídicas para a encapsulação de extratos e compostos neuroprotetores

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Resumo:The biggest obstacle to the treatment of diseases that affect the central nervous system (CNS) is the passage of drugs across the blood-brain barrier (BBB), a physical barrier that regulates the entry of substances into the brain and assures the CNS’s homeostasis. In this dissertation, a review was done on the lipid-based nanoparticles for the nanoencapsulation of neuroprotective compounds, thus increasing their bioavailability and capacity to cross the BBB. The gastrointestinal absorption was also discussed, as it may pose some obstacles into the absorption of the neuroprotective compounds into the bloodstream. The BBB’s composition was explained, as well as the transport mechanisms through which the compounds may cross into the brain parenchyma. A survey on the different types of lipid-based nanoparticles - nanoemulsions (NEs), nanoliposomes / nanophytosomes and solid lipid nanoparticles (SLNs) / nanostructured lipid carriers (NLCs) - was performed in this thesis, giving particular emphasis for their unique characteristics, the most important parameters influencing the formulation of each one, and some examples of studies that have been carried out in the encapsulation of neuroprotective compounds with the use of these nanoparticles.
Autores principais:Fernandes, Filipe Jorge Ribeiro
Assunto:Blood-brain barrier Central nervous system Lipids Nanoparticles Nanoemulsions Nanoliposomes Nanophytosomes Natural products Solid lipid nanoparticles Nanostructured lipid carriers Barreira hematoencefálica Lípidos, nanopartículas Nanoemulsões Nanolipossomas Nanofitossomas Nanopartículas lipídicas sólidas Produtos naturais Sistema nervoso central Transportadores lipídicos nanoestruturados
Ano:2020
País:Portugal
Tipo de documento:dissertação de mestrado
Tipo de acesso:acesso aberto
Instituição associada:Instituto Politécnico do Porto
Idioma:inglês
Origem:Repositório Científico do Instituto Politécnico do Porto

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