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Apparent diffusion coefficient in the analysis of prostate cancer: determination of optimal b-value pair to differentiate normal from malignant tissue

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Resumo:Purpose Determining optimal b-value pair for differentiation between normal and prostate cancer (PCa) tissues. Methods Forty-three patients with diagnosis or PCa symptoms were included. Apparent diffusion coefficient (ADC) was estimated using minimum and maximum b-values of 0, 50, 100, 150, 200, 500 s/mm2 and 500, 800, 1100, 1400, 1700 and 2000s/mm2, respectively. Diagnostic performances were evaluated when Area-under-the-curve (AUC) > 95%. Results 15 of the 35 b-values pair surpassed this AUC threshold. The pair (50, 2000 s/mm2) provided the highest AUC (96%) with ADC cutoff 0.89 × 10–3 mm2/s, sensitivity 95.5%, specificity 93.2% and accuracy 94.4%. Conclusions The best b-value pair was b = 50, 2000 s/mm2.
Autores principais:Adubeiro, Nuno
Outros Autores:Nogueira, Maria Luísa; Nunes, Rita G.; Ferreira, Hugo Alexandre; Ribeiro, Eduardo; La Fuente, José Maria Ferreira
Assunto:Diffusion weighted imaging Diffusion Magnetic Resonance Imaging Prostate Prostatic Neoplasms
Ano:2018
País:Portugal
Tipo de documento:artigo
Tipo de acesso:acesso aberto
Instituição associada:Instituto Politécnico do Porto
Idioma:inglês
Origem:Repositório Científico do Instituto Politécnico do Porto

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