Publicação
Palliative splenic irradiation for symptomatic splenomegaly in non-Hodgkin lymphoma
| Resumo: | INTRODUCTION AND AIMS: Splenic marginal zone lymphoma, an uncommon subtype of non-Hodgkin lymphoma (NHL), is usually present with symptomatic splenomegaly. Although splenectomy has long been considered the first-line therapy in symptomatic or cytopenic patients, it can lead to significant morbidity and mortality. Splenic irradiation is an option for patients who have a poor response to systemic therapy and/or are not surgical candidates. In this paper, we present a case report of a patient who received splenic radiotherapy for symptomatic splenomegaly. METHODS: An 85-year-old Caucasian man with a 4 year history of low-grade NHL presented with progressive pancytopenia, significant weight loss and symptomatic splenomegaly (abdominal discomfort, sense of fullness and limitation of mobility due to spleen size). The patient refused splenectomy and, in December 2017, was referred to palliative splenic radiotherapy. He was initially treated with five fractions of one Grey (Gy) in order to evaluate clinical and haematology response. After that, 1.5 Gy daily, 5 days a week for 3 weeks. 3D conformal radiotherapy, multiple fields and mixed energy (6 and 15 Mv) were used. RESULTS: Radiotherapy allowed significant splenic reduction to almost half the size, resolving abdominal discomfort and improving quality of life. There was no decline of haemoglobin, leukocytes and platelet counts; in fact, there was a marginal increase. CONCLUSION: Palliative splenic irradiation was well tolerated confirming that it is a safe treatment option for palliation of symptomatic splenomegaly. Thereby, splenic irradiation should be strongly considered in the management of symptomatic splenomegaly, for selected patients who are refractory to or unsuitable for other options or when the patient refuses other treatments. |
|---|---|
| Autores principais: | Oliveira, LC |
| Outros Autores: | Fardilha, C; Louro, M; Pinheiro, C; Sousa, A; Marques, H; Costa, P |
| Assunto: | Linfoma Não-Hodgkin Esplenomegalia |
| Ano: | 2018 |
| País: | Portugal |
| Tipo de documento: | artigo |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Hospital de Braga |
| Idioma: | inglês |
| Origem: | Repositório Científico do Hospital de Braga |
| _version_ | 1868351062624174080 |
|---|---|
| author | Oliveira, LC |
| author2 | Fardilha, C Louro, M Pinheiro, C Sousa, A Marques, H Costa, P |
| author2_role | author author author author author author |
| author_facet | Oliveira, LC Fardilha, C Louro, M Pinheiro, C Sousa, A Marques, H Costa, P |
| author_role | author |
| contributor_name_str_mv | Repositório Científico do Hospital de Braga |
| country_str | PT |
| creators_json_txt | [{\"Person.name\":\"Oliveira, LC\"},{\"Person.name\":\"Fardilha, C\"},{\"Person.name\":\"Louro, M\"},{\"Person.name\":\"Pinheiro, C\"},{\"Person.name\":\"Sousa, A\"},{\"Person.name\":\"Marques, H\"},{\"Person.name\":\"Costa, P\"}] |
| datacite.contributors.contributor.contributorName.fl_str_mv | Repositório Científico do Hospital de Braga |
| datacite.creators.creator.creatorName.fl_str_mv | Oliveira, LC Fardilha, C Louro, M Pinheiro, C Sousa, A Marques, H Costa, P |
| datacite.date.Accepted.fl_str_mv | 2018-01-01T00:00:00Z |
| datacite.date.available.fl_str_mv | 2019-03-01T11:11:59Z |
| datacite.date.embargoed.fl_str_mv | 2019-03-01T11:11:59Z |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| datacite.subjects.subject.fl_str_mv | Linfoma Não-Hodgkin Esplenomegalia |
| datacite.titles.title.fl_str_mv | Palliative splenic irradiation for symptomatic splenomegaly in non-Hodgkin lymphoma |
| dc.contributor.none.fl_str_mv | Repositório Científico do Hospital de Braga |
| dc.creator.none.fl_str_mv | Oliveira, LC Fardilha, C Louro, M Pinheiro, C Sousa, A Marques, H Costa, P |
| dc.date.Accepted.fl_str_mv | 2018-01-01T00:00:00Z |
| dc.date.available.fl_str_mv | 2019-03-01T11:11:59Z |
| dc.date.embargoed.fl_str_mv | 2019-03-01T11:11:59Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | http://hdl.handle.net/10400.23/1313 |
| dc.language.none.fl_str_mv | eng |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| dc.subject.none.fl_str_mv | Linfoma Não-Hodgkin Esplenomegalia |
| dc.title.fl_str_mv | Palliative splenic irradiation for symptomatic splenomegaly in non-Hodgkin lymphoma |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_6501 |
| description | INTRODUCTION AND AIMS: Splenic marginal zone lymphoma, an uncommon subtype of non-Hodgkin lymphoma (NHL), is usually present with symptomatic splenomegaly. Although splenectomy has long been considered the first-line therapy in symptomatic or cytopenic patients, it can lead to significant morbidity and mortality. Splenic irradiation is an option for patients who have a poor response to systemic therapy and/or are not surgical candidates. In this paper, we present a case report of a patient who received splenic radiotherapy for symptomatic splenomegaly. METHODS: An 85-year-old Caucasian man with a 4 year history of low-grade NHL presented with progressive pancytopenia, significant weight loss and symptomatic splenomegaly (abdominal discomfort, sense of fullness and limitation of mobility due to spleen size). The patient refused splenectomy and, in December 2017, was referred to palliative splenic radiotherapy. He was initially treated with five fractions of one Grey (Gy) in order to evaluate clinical and haematology response. After that, 1.5 Gy daily, 5 days a week for 3 weeks. 3D conformal radiotherapy, multiple fields and mixed energy (6 and 15 Mv) were used. RESULTS: Radiotherapy allowed significant splenic reduction to almost half the size, resolving abdominal discomfort and improving quality of life. There was no decline of haemoglobin, leukocytes and platelet counts; in fact, there was a marginal increase. CONCLUSION: Palliative splenic irradiation was well tolerated confirming that it is a safe treatment option for palliation of symptomatic splenomegaly. Thereby, splenic irradiation should be strongly considered in the management of symptomatic splenomegaly, for selected patients who are refractory to or unsuitable for other options or when the patient refuses other treatments. |
| dirty | 0 |
| eu_rights_str_mv | openAccess |
| format | article |
| fulltext.url.fl_str_mv | https://repositorio.hospitaldebraga.pt/bitstreams/bef924f6-38f7-42f8-9ca1-ccece52405f1/download |
| id | rhb_9613c19087a975e01ec14ab690bb7b98 |
| identifier.url.fl_str_mv | http://hdl.handle.net/10400.23/1313 |
| instacron_str | hb |
| institution | Hospital de Braga |
| instname_str | Hospital de Braga |
| language | eng |
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| network_name_str | Repositório Científico do Hospital de Braga |
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| organization_str_mv | urn:organizationAcronym:hb |
| person_str_mv | Oliveira, LC Fardilha, C Louro, M Pinheiro, C Sousa, A Marques, H Costa, P |
| publishDate | 2018 |
| reponame_str | Repositório Científico do Hospital de Braga |
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| service_str_mv | urn:repositoryAcronym:rhb |
| spelling | engpt_PTINTRODUCTION AND AIMS: Splenic marginal zone lymphoma, an uncommon subtype of non-Hodgkin lymphoma (NHL), is usually present with symptomatic splenomegaly. Although splenectomy has long been considered the first-line therapy in symptomatic or cytopenic patients, it can lead to significant morbidity and mortality. Splenic irradiation is an option for patients who have a poor response to systemic therapy and/or are not surgical candidates. In this paper, we present a case report of a patient who received splenic radiotherapy for symptomatic splenomegaly. METHODS: An 85-year-old Caucasian man with a 4 year history of low-grade NHL presented with progressive pancytopenia, significant weight loss and symptomatic splenomegaly (abdominal discomfort, sense of fullness and limitation of mobility due to spleen size). The patient refused splenectomy and, in December 2017, was referred to palliative splenic radiotherapy. He was initially treated with five fractions of one Grey (Gy) in order to evaluate clinical and haematology response. After that, 1.5 Gy daily, 5 days a week for 3 weeks. 3D conformal radiotherapy, multiple fields and mixed energy (6 and 15 Mv) were used. RESULTS: Radiotherapy allowed significant splenic reduction to almost half the size, resolving abdominal discomfort and improving quality of life. There was no decline of haemoglobin, leukocytes and platelet counts; in fact, there was a marginal increase. CONCLUSION: Palliative splenic irradiation was well tolerated confirming that it is a safe treatment option for palliation of symptomatic splenomegaly. Thereby, splenic irradiation should be strongly considered in the management of symptomatic splenomegaly, for selected patients who are refractory to or unsuitable for other options or when the patient refuses other treatments.application/pdfpt_PTPalliative splenic irradiation for symptomatic splenomegaly in non-Hodgkin lymphomaOliveira, LCFardilha, CLouro, MPinheiro, CSousa, AMarques, HCosta, PHostingInstitutionOrganizationalRepositório Científico do Hospital de Bragae-mailmailto:bibliotecaria@hospitaldebraga.ptbibliotecaria@hospitaldebraga.ptDOIIsPartOf10.3332/ecancer.2018.8872019-03-01T11:11:59Z20182018-01-01T00:00:00ZHandlehttp://hdl.handle.net/10400.23/1313http://purl.org/coar/access_right/c_abf2open accessLinfoma Não-HodgkinEsplenomegalia839891 bytesliteraturehttp://purl.org/coar/resource_type/c_6501journal articlehttp://purl.org/coar/access_right/c_abf2application/pdffulltexthttps://repositorio.hospitaldebraga.pt/bitstreams/bef924f6-38f7-42f8-9ca1-ccece52405f1/download12887 |
| spellingShingle | Palliative splenic irradiation for symptomatic splenomegaly in non-Hodgkin lymphoma Oliveira, LC Linfoma Não-Hodgkin Esplenomegalia |
| status | SINGLETON |
| subject.fl_str_mv | Linfoma Não-Hodgkin Esplenomegalia |
| title | Palliative splenic irradiation for symptomatic splenomegaly in non-Hodgkin lymphoma |
| title_full | Palliative splenic irradiation for symptomatic splenomegaly in non-Hodgkin lymphoma |
| title_fullStr | Palliative splenic irradiation for symptomatic splenomegaly in non-Hodgkin lymphoma |
| title_full_unstemmed | Palliative splenic irradiation for symptomatic splenomegaly in non-Hodgkin lymphoma |
| title_short | Palliative splenic irradiation for symptomatic splenomegaly in non-Hodgkin lymphoma |
| title_sort | Palliative splenic irradiation for symptomatic splenomegaly in non-Hodgkin lymphoma |
| topic | Linfoma Não-Hodgkin Esplenomegalia |
| topic_facet | Linfoma Não-Hodgkin Esplenomegalia |
| url | http://hdl.handle.net/10400.23/1313 |
| visible | 1 |