Publicação
Lifestyle, metabolic disorders and male hypogonadism - a one-way ticket?
| Resumo: | Hypogonadism is more frequent among men with common metabolic diseases, notably obesity and type 2 diabetes. Indeed, endocrine disruption caused by metabolic diseases can trigger the onset of hypogonadism, although the underlying molecular mechanisms are not entirely understood. Metabolic diseases are closely related to unhealthy lifestyle choices, such as dietary habits and sedentarism. Therefore, hypogonadism is part of a pathological triad gathering unhealthy lifestyle, metabolic disease and genetic background. Additionally, hypogonadism harbors the potential to aggravate underlying metabolic disorders, further sustaining the mechanisms leading to disease. To what extent does lifestyle intervention in men suffering from these metabolic disorders can prevent, improve or reverse hypogonadism, is still controversial. Moreover, recent evidence suggests that the metabolic status of the father is related to the risk of inter and transgenerational inheritance of hypogonadism. In this review, we will address the proposed mechanisms of disease, as well as currently available interventions for hypogonadism. |
|---|---|
| Autores principais: | Crisóstomo, Luís |
| Outros Autores: | Pereira, Sara C.; Monteiro, Mariana P.; Raposo, João F.; Oliveira, Pedro F.; Alves, Marco G. |
| Assunto: | Hypogonadism Metabolic disorder Lifestyle Lifestyle intervention Transgenerational effects |
| Ano: | 2020 |
| País: | Portugal |
| Tipo de documento: | artigo |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Universidade de Aveiro |
| Idioma: | inglês |
| Origem: | RIA - Repositório Institucional da Universidade de Aveiro |
| _version_ | 1866173114905264128 |
|---|---|
| author | Crisóstomo, Luís |
| author2 | Pereira, Sara C. Monteiro, Mariana P. Raposo, João F. Oliveira, Pedro F. Alves, Marco G. |
| author2_role | author author author author author |
| author_facet | Crisóstomo, Luís Pereira, Sara C. Monteiro, Mariana P. Raposo, João F. Oliveira, Pedro F. Alves, Marco G. |
| author_role | author |
| country_str | PT |
| creators_json_txt | [{\"Person.name\":\"Crisóstomo, Luís\"},{\"Person.name\":\"Pereira, Sara C.\"},{\"Person.name\":\"Monteiro, Mariana P.\"},{\"Person.name\":\"Raposo, João F.\"},{\"Person.name\":\"Oliveira, Pedro F.\"},{\"Person.name\":\"Alves, Marco G.\"}] |
| datacite.creators.creator.creatorName.fl_str_mv | Crisóstomo, Luís Pereira, Sara C. Monteiro, Mariana P. Raposo, João F. Oliveira, Pedro F. Alves, Marco G. |
| datacite.date.Accepted.fl_str_mv | 2020-10-01T00:00:00Z |
| datacite.date.available.fl_str_mv | 2023-04-26T15:34:20Z |
| datacite.date.embargoed.fl_str_mv | 2023-04-26T15:34:20Z |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| datacite.subjects.subject.fl_str_mv | Hypogonadism Metabolic disorder Lifestyle Lifestyle intervention Transgenerational effects |
| datacite.titles.title.fl_str_mv | Lifestyle, metabolic disorders and male hypogonadism - a one-way ticket? |
| dc.creator.none.fl_str_mv | Crisóstomo, Luís Pereira, Sara C. Monteiro, Mariana P. Raposo, João F. Oliveira, Pedro F. Alves, Marco G. |
| dc.date.Accepted.fl_str_mv | 2020-10-01T00:00:00Z |
| dc.date.available.fl_str_mv | 2023-04-26T15:34:20Z |
| dc.date.embargoed.fl_str_mv | 2023-04-26T15:34:20Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | http://hdl.handle.net/10773/37366 |
| dc.language.none.fl_str_mv | eng |
| dc.publisher.none.fl_str_mv | Elsevier |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| dc.subject.none.fl_str_mv | Hypogonadism Metabolic disorder Lifestyle Lifestyle intervention Transgenerational effects |
| dc.title.fl_str_mv | Lifestyle, metabolic disorders and male hypogonadism - a one-way ticket? |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_6501 |
| description | Hypogonadism is more frequent among men with common metabolic diseases, notably obesity and type 2 diabetes. Indeed, endocrine disruption caused by metabolic diseases can trigger the onset of hypogonadism, although the underlying molecular mechanisms are not entirely understood. Metabolic diseases are closely related to unhealthy lifestyle choices, such as dietary habits and sedentarism. Therefore, hypogonadism is part of a pathological triad gathering unhealthy lifestyle, metabolic disease and genetic background. Additionally, hypogonadism harbors the potential to aggravate underlying metabolic disorders, further sustaining the mechanisms leading to disease. To what extent does lifestyle intervention in men suffering from these metabolic disorders can prevent, improve or reverse hypogonadism, is still controversial. Moreover, recent evidence suggests that the metabolic status of the father is related to the risk of inter and transgenerational inheritance of hypogonadism. In this review, we will address the proposed mechanisms of disease, as well as currently available interventions for hypogonadism. |
| dirty | 0 |
| eu_rights_str_mv | openAccess |
| format | article |
| id | ria_26fcbae77211c099ba07fc4fba714787 |
| identifier.url.fl_str_mv | http://hdl.handle.net/10773/37366 |
| instacron_str | ua |
| institution | Universidade de Aveiro |
| instname_str | Universidade de Aveiro |
| language | eng |
| network_acronym_str | ria |
| network_name_str | RIA - Repositório Institucional da Universidade de Aveiro |
| oai_identifier_str | oai:ria.ua.pt:10773/37366 |
| organization_str_mv | urn:organizationAcronym:ua |
| person_str_mv | Crisóstomo, Luís Pereira, Sara C. Monteiro, Mariana P. Raposo, João F. Oliveira, Pedro F. Alves, Marco G. |
| publishDate | 2020 |
| publisher.none.fl_str_mv | Elsevier |
| reponame_str | RIA - Repositório Institucional da Universidade de Aveiro |
| repository_id_str | urn:repositoryAcronym:ria |
| service_str_mv | urn:repositoryAcronym:ria |
| spelling | pt_PTHypogonadism is more frequent among men with common metabolic diseases, notably obesity and type 2 diabetes. Indeed, endocrine disruption caused by metabolic diseases can trigger the onset of hypogonadism, although the underlying molecular mechanisms are not entirely understood. Metabolic diseases are closely related to unhealthy lifestyle choices, such as dietary habits and sedentarism. Therefore, hypogonadism is part of a pathological triad gathering unhealthy lifestyle, metabolic disease and genetic background. Additionally, hypogonadism harbors the potential to aggravate underlying metabolic disorders, further sustaining the mechanisms leading to disease. To what extent does lifestyle intervention in men suffering from these metabolic disorders can prevent, improve or reverse hypogonadism, is still controversial. Moreover, recent evidence suggests that the metabolic status of the father is related to the risk of inter and transgenerational inheritance of hypogonadism. In this review, we will address the proposed mechanisms of disease, as well as currently available interventions for hypogonadism.application/pdfengElsevierpt_PTLifestyle, metabolic disorders and male hypogonadism - a one-way ticket?Crisóstomo, LuísPereira, Sara C.Monteiro, Mariana P.Raposo, João F.Oliveira, Pedro F.Alves, Marco G.Handlehttp://hdl.handle.net/10773/37366ISSNIsPartOf0303-7207DOIIsPartOf10.1016/j.mce.2020.1109452023-04-26T15:34:20Z2020-10-01T00:00:00Z2020-10-01http://purl.org/coar/access_right/c_abf2open accesspt_PTHypogonadismpt_PTMetabolic disorderpt_PTLifestylept_PTLifestyle interventionpt_PTTransgenerational effects1372392 byteshttp://purl.org/coar/access_right/c_abf2application/pdffulltexthttps://ria.ua.pt/bitstream/10773/37366/1/Lifestyle%2c%20metabolic%20disorders%20and%20male%20hypogonadism.pdfliteraturehttp://purl.org/coar/resource_type/c_6501journal article |
| spellingShingle | Lifestyle, metabolic disorders and male hypogonadism - a one-way ticket? Crisóstomo, Luís Hypogonadism Metabolic disorder Lifestyle Lifestyle intervention Transgenerational effects |
| status | SINGLETON |
| subject.fl_str_mv | Hypogonadism Metabolic disorder Lifestyle Lifestyle intervention Transgenerational effects |
| title | Lifestyle, metabolic disorders and male hypogonadism - a one-way ticket? |
| title_full | Lifestyle, metabolic disorders and male hypogonadism - a one-way ticket? |
| title_fullStr | Lifestyle, metabolic disorders and male hypogonadism - a one-way ticket? |
| title_full_unstemmed | Lifestyle, metabolic disorders and male hypogonadism - a one-way ticket? |
| title_short | Lifestyle, metabolic disorders and male hypogonadism - a one-way ticket? |
| title_sort | Lifestyle, metabolic disorders and male hypogonadism - a one-way ticket? |
| topic | Hypogonadism Metabolic disorder Lifestyle Lifestyle intervention Transgenerational effects |
| topic_facet | Hypogonadism Metabolic disorder Lifestyle Lifestyle intervention Transgenerational effects |
| url | http://hdl.handle.net/10773/37366 |
| visible | 1 |